METASYS team

The Metasys team is investigating and modifying microbial metabolism and its regulation with the aim of “understanding to create” and its complementary counterpart “creating to understand”- to deliver new fundamental knowledge on both natural and synthetic microorganisms while creating new industrially useful microorganisms. To do that the team integrates (i) a synthetic biology approach based on genome editing and adaptative laboratory evolution to engineer metabolic and/or regulatory systems in various microorganisms, and (ii) a system-level approach based on in silico (reconstruction and modelling of metabolism) and experimental methods (transcriptomics, metabolomics, fluxomics) to understand and predict the behavior of the natural and synthetic strains.