METASYS team
Integrated metabolism and dynamics of metabolic systems
Understanding to create, Creating to understand
The Metasys team is investigating and modifying microbial metabolism and its regulation with the aim of “understanding to create” and its complementary counterpart “creating to understand”- to deliver new fundamental knowledge on both natural and synthetic microorganisms while creating new industrially useful microorganisms. To do that the team integrates (i) a synthetic biology approach based on genome editing and adaptative laboratory evolution to engineer metabolic and/or regulatory systems in various microorganisms and (ii) a system-level approach based on in silico (reconstruction and modelling of metabolism) and experimental methods (transcriptomics, metabolomics, fluxomics) to understand and predict the behavior of the natural and synthetic strains.
The team's topics
- Autonomous University of Barcelona, Spain – Pau Ferrer
- BOKU, Austria – Diethard Mattanovisch
- INRAe MEDiS, France – Grégory Jubelin
- Michigan State University, United States – Josh V. Vermaas
- University of Kent, UK – Martin Warren
- University of Kiel, Germany – Andreas Tholey
- GeT-Biopuces Platform, Toulouse, France
- Integrative Electron Microscope Platform (METi), Toulouse, France
- Metatoul Platform, Toulouse, France
- Toulouse White Biotechnology, Toulouse, France
- Dorian Gregnanin – Project METHYLO
- Léa Breton – Project METHYLO