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CIMES team

Catalysis and Enzyme Molecular Engineering

Catalysis and Enzyme Molecular Engineering

The objective of our research is to identify or design efficient enzymes, whether it involves understanding their role in ecosystems, or exploiting them for sustainable biotechnological processes, particularly for health and environment. 

Our scientific questions focus on the catalytic mechanisms and the relationships between sequence, structure, dynamics, specificity, efficiency and stability of our target proteins and multi-protein assemblies, as well as on enzyme-polymer interactions and the optimization of enzymatic processes, in vitro and in cellulo .

To address these questions, we combine our expertise and equipment to develop, adapt to our targets and integrate, as much as possible, computational and structural biology, protein engineering, high-throughput screening, and reaction engineering. 

Our expertise mainly targets enzymes active on glycosides, plastic polymers and lipids. Our approaches being generic, they are also applied to other families of enzymes and non-catalytic proteins. Our team is built around three thematic axes, and is enriched by numerous inter-axial transversal projects, as well as by strong collaborations with the Carbios and SweeTech companies hosted at the TBI. The CIMEs team also benefits from the expertise and equipment of the PICT-ICEO platform.

Team leader

Les axes de l'équipe

Academic partners  

AFMB Marseille, BBF Marseille, IPBS Toulouse, IMRCP Toulouse, CEA Genoscope Evry, IPREM Pau, CERMAV Grenoble, TOXALIM Toulouse, IRSD Toulouse, INRAE MIAT Toulouse, LISM Marseille, TIMC Grenoble, Genethon, DSIMB Université Paris, LBM Bordeaux, MICALIS Jouy-en-Josas  


University of Cambridge UK, ICREA Université de Barcelone Espagne, University of Alicante Espagne, IQS University Ramon Llull Barcelone Espagne, IQAC-CSIC Barcelona Espagne, CNRS@CREATE A*star- Singapore Institute of Food and Biotechnology Innovation National National University of Singapore, Singapore University of Groningen, Groningen, Netherlands, University of Toronto, Canada & Aalto University, Espoo Finland, NREL USA, University of Padoue Italy, ETH  Zürich Swiss.


Private partners 

Carbios, Sweetech, Resicare, Gene&GreenTK, Servier, Greentech, Sanofi, Roquette, Clarins 

  • Maxime ARTICO (2020-2023) – Surfaces polymères à Activité Enzymatique modulable. 
  • Elodie BASCANS (2020-2023) – Assemblages de biopolymères et glycosylation de composés d’origine marine selon une approche biomimétique. 
  • Younes BOUCHIBA (2019 – 2023) – Considérer la flexibilité dans le design de protéines en combinant modélisation moléculaire et intelligence artificielle. 
  • Nina COOPER (2022-2025) – Etude de la dynamique d’enzymes de synthèse et de fonctionnalisation de biopolymères.  
  • Marianne DEFRESNE (2020-2023) – Design Computationnel de protéines par raisonnement automatique et apprentissage profond.  
  • Vincent DULAU (2023-2026) – Développement de voies enzymatiques pour la glycosylation à façon d’actifs d’origine végétale à partir de saccharose.  
  • Ahmed KHAMASSI (2019-2023) – Caractérisation structure-fonction et ingénierie d’enzymes impliquées dans la dégradation des polysaccharides. 
  • Romain LAUNAY (2020-2023) – Caractérisation et compréhension fonctionnelle d’assemblages protéiques. 
  • Jérémy LE REUN (2022-2025) – Ingénieries enzymatique et microbienne pour la production de lipides à façon.  
  • Xiaoqian LI (2020-2024) – Ingénierie de transporteurs d’oligosaccharides.  
  • Iker PARDO-LARABEITI (2022-2025) – Contrôle de la proximité spatiale pour des cascades enzymatiques innovantes afin d’améliorer la déconstruction de la biomasse. 
  • Agata RACZYNSKA (2020-2024) – Dégradation de polymères synthétiques par voies enzymatiques. 
  • Maxant VIVIER (2022-2025) – Production d’oligosaccharides in cellulo pour la santé humaine. 
  • FNR16 -2020 – RADICALZ (2021-2025): Rapid discovery and development of enzymes for novel and greener consumer products 
  • Horizon BLUETOOLS (2023-2027): Innovative tools for sustainable exploration of marine microbiomes: towards a circular blue bioeconomy and healthier marine environments 
  • ADEME OPTI-ZYME (2023-2027) & Private contracts (2022-2023) : Enzymes for the recycling and biosynthesis of plastic polymers 
  • ADEME Bioimpulse (2019-2025): Bio-sourced production of a molecule for the development of non-toxic adhesives and resins 
  • PEPR B-BEST Projet 2.1 Nanonmachines (2023-2028): Multi-enzymatic Nanomachines for the controlled transformation of terrestrial plant biomass 
  • ANR CONCERTO (2022-2025): Controlled spatial proximity for innovating enzymatic cascades to enhance biomass deconstruction 
  • ANR LABEL (2023-2026) : Conception d’assemblages moléculaires pour évaluer le rôle de la glycosylation sur l’activité d’hémicellulases 
  • ANR CAZIBD (2021-2024) : Mucus-degrading enzymes and their role in intestinal inflammation 
  • ANR GRAFTING (2019-2023) : Green Routes for the Functionalization of alpha-Glucans 
  • ANR ANDES (2023 – 2026) : Artificial Intelligence-based methods for the design of nanobodies 
  • ANR PRCE BACTSQUEEZ (2022-2026) : Bacterial signal quenching of plant pathogens with engineered enzymes 
  • ANR PRC DEEPEN (2020-2024) : Molecular and evolutionary principles governing enzyme regioselectivity 
  • TWB Precompetitive DIVA (2022-2024): Development of various green routes for the functionalization of alpha-glucans 
  • Collaborative Project (France/ Spain) (2022-2024) : QM/MM investigation of enzymes involved in plant lipid production 
  • IntraCREATE EcoCTs (France/Singapore) (2020-2024)- Engineering biology for a circular bioeconomy – Towards urban sustainability