CIMES team

Catalysis and Enzyme Molecular Engineering

Catalysis and Enzyme Molecular Engineering

CIMEs research is focused on in-depth mechanistic and structure-activity relationship studies of a broad range of enzymes. It also covers strategic developments in enzyme discovery, directed evolution, (semi-)rational engineering and computational protein design.

By developing fundamental knowledge of enzyme function, and sharing staff expertise and experimental facilities giving priority to integrative and multidisciplinary approaches, the aim is to deliver naturally-potent or optimized tailor-made catalysts for industrial biotechnology and synthetic biology.

The team focuses on four thematic fields:

  • Enzyme discovery, data mining, functional genomics and functional metagenomics are exploited to provide access to novel and original enzymes, as well as multigenic systems.
  • Enzyme structure-function study, design and engineering
  • Comprehension of cooperation and interplay between enzymes that must act together to degrade or synthesize complex molecules
  • Target Enzymes

Team leader

Fields of application

Bring the benefits of enzyme-catalyzed processes to the development of products for the food, feed, health, chemicals, energy or environmental sectors.

Valorization of agro-feedstocks into added-value products.

Integration of newly discovered or engineered enzymes into :

Modélisation & Design Moléculaires
MetaOmiques pour la Découverte de Fonctions Microbiennes
Enzymes pour les Carbohydrates

The team's topics

The CIMEs team is organized into 5 thematic groups and benefits from the technical support of the ICEO High-Throughput screening facility PICT-ICEO.

Académique :

TIMC-IMAG (Grenoble), DSIMB (Univ. Paris Diderot, Sorbonne Paris Cité), MIAT-INRAE (Toulouse), LAAS-CNRS (Toulouse), BIA-INRAE (Nantes), MICALIS-INRAE (Jouy-en-Josas), IPREM (Pau), AFMB (Marseille),University of Cambridge (UK)

Industriel :

Resicare by Michelin, Carbios, Servier, Roquette, Solvay, Pili, Sweetech, Adisseo

  • Maxime Artico – (TBI – IMRCP)- ELASTIC – Modulation de l’activité d’enzymes hémicellulolytiques à l’aide de surfaces élastiques à géométrie contrôlable pour la valorisation de la biomasse végétale
  • Elodie Bascans – (TBI – IPREM) – New biomaterials and glycosylation of marine compounds
  • Sarah Blosse – (TBI – IMFT) – TOPAZ – Suivi in-situ par TOmographie X sur PAille de blé brute des mécanismes de dégradation enZymatique de la biomasse végétale : une approche combinant génie enzymatique et physique des milieux poreux
  • Younes Bouchiba – (TBI – LAAS-CNRS) – Computational design of proteins taking into account molecular flexibility: approach combining molecular modelling and artificial intelligence
  • Marianne Defresne – (TBI – MIAT-INRAE) – Computational protein design with automated reasoning and deep learning
  • Ahmed Khamassi – (TBI – IPBS)- DECO – Caractérisation Structure-Fonction et Co-ingénierie d’enzymes impliquées dans la dégradation de la biomasse Lignocellulosique.
  • Thibaud Laffargue –(TBI) – Enzymatic routes for polysaccharide functionalization
  • Romain Launay – (TBI) – Caractérisation et compréhension fonctionnelle d’assemblages enzymatiques
  • Awilda Maccow – (Pili – TBI) – Chemo-enzymatic pathways for dyeing cellulosic materials
  • Maike Pertermann – (CIMES – TIM) – Transport and diffusion of lignocellulolytic enzymes in their polymeric substrate
  • Agata Raczynska – (TBI – Silesian University of Technology, Pologne) – Biodegradation of synthetic polymers with the use of enzymes
  • Xiaoqian LI (TBI) – Engineering of oligosaccharide transporters
  • Maxant Vivier (TBI-SweeTech) – Synthèse in cellulo d’oligosaccharides pour la santé humaine

European: EvoXUL (MSCA)

European : RadicalZ (2021-2025)- RIA

ANR DECO (2019-2023)

ANR CONCERTO (2022 – 2026)

ANR Deepen (2020-2024)

ANR Grafting (2019-2022)

ANR Cazibd (2021-2025)

ANR Mobidyc (2022-2026)

ADEME Bioimpulse (2019-2025)


Projet prématuration INRAE Plateforme logicielle (2022)