METASYS team

The Metasys team is investigating and modifying microbial metabolism and its regulation with the aim of “understanding to create” and its complementary counterpart “creating to understand”- to deliver new fundamental knowledge on both natural and synthetic microorganisms while creating new industrially useful microorganisms. To do that the team integrates (i) a synthetic biology approach based on genome editing and adaptative laboratory evolution to engineer metabolic and/or regulatory systems in various microorganisms, (ii) a system-level approach based on in silico (reconstruction and modelling of metabolism) and experimental methods (transcriptomics, metabolomics, fluxomics) to understand and predict the behavior of the natural and synthetic strains, and (iii) a top-down systemic approach from the bioreactor to the microorganism based on kinetic analysis of the microbial behavior to decipher metabolic bottlenecks under intensive fermentation constraints (high titers, productivity and yield).