Sandrine UTTENWEILLER

Sandrine UTTENWEILER
CNRS Researcher
- +33 (0) 5 61 55 93 49
- sandrine.uttenweiler@insa-toulouse.fr
- Research Gate
- Orcid
- Google Scholar
- Hal
Actual position and research subject
My work contributes to the understanding of the acetate metabolism in E. coli for basic and applied research. In particular, the research project ACEMOD aims to explain how acetyl-phosphate, an intermediate of the acetate pathway that can modify proteins by acetylation or phosphorylation, regulates bacterial metabolism through protein acetylation. The knowledge of the E. coli metabolic acetate pathway and its regulation are fundamental to design industrially useful strains as cell factories for innovative biotechnological applications. One example is the COBIOMACE project which goal is to produce biomolecules from CO2 via acetate using a two-stage microbial system. In the first stage, the CO2 is converted to acetate by anaerobic microbial consortia and this acetate is used in the second stage as carbon source by metabolically engineered E. coli to produce various biomolecules. By coupling these two stages, we aim to develop a sustainable biotechnological process using microorganisms as cell factory for upgrading renewable carbon resources into bioproducts.
Education and Diploma
Habilitation à Diriger des Recherches. Université Toulouse III, Doctoral school Biology-Health-Biotechnologies, Toulouse
PhD thesis in Molecular and Cellular Biology. Louis Pasteur University, Strasbourg
Master degree in Molecular and Cellular Biology. Louis Pasteur University, Strasbourg.
List of selected publications
To see all my publications, please check my research gate profile = https://www.researchgate.net/profile/Sandrine-Uttenweiler-Joseph/research
Selected publications:
- 6‐Phosphogluconolactonase is critical for the efficient functioning of the pentose phosphate pathway
L Phégnon, J Pérochon, S Uttenweiler‐Joseph, E Cahoreau, P Millard, F Létisse
2024 The FEBS Journal 291 (20), 4459-4472
- Acetate is a beneficial nutrient for E. coli at low glycolytic flux
P Millard, T Gosselin‐Monplaisir, S Uttenweiler‐Joseph, B Enjalbert
2023 The EMBO Journal 42 (15), e113079
- Control and regulation of acetate overflow in Escherichia coli
P Millard, B Enjalbert, S Uttenweiler-Joseph, JC Portais, F Létisse
2021 Elife 10, e63661
- Asb2α–Filamin A axis is essential for actin cytoskeleton remodeling during heart development
A Métais, I Lamsoul, A Melet, S Uttenweiler-Joseph, R Poincloux, …
2018 Circulation research 122 (6), e34-e48
- Substrates of the ASB2α E3 ubiquitin ligase in dendritic cells
CA Spinner, S Uttenweiler-Joseph, A Metais, A Stella, O Burlet-Schiltz, …
2015 Scientific reports 5 (1), 1-12
- Phosphorylation of serine 323 of ASB2α is pivotal for the targeting of filamin A to degradation
R Zakaria, I Lamsoul, S Uttenweiler-Joseph, M Erard, B Monsarrat, …
2013 Cellular signalling 25 (12), 2823-2830
- Quantitative proteomic analysis to decipher the differential apoptotic response of bortezomib‐treated APL cells before and after retinoic acid differentiation reveals …
S Uttenweiler‐Joseph, D Bouyssié, D Calligaris, PG Lutz, B Monsarrat, …
2013 Proteomics 13 (1), 37-47
- A label-free quantitative proteomics strategy to identify E3 ubiquitin ligase substrates targeted to proteasome degradation
CF Burande, ML Heuze, I Lamsoul, B Monsarrat, S Uttenweiler-Joseph, …
2009 Molecular & Cellular Proteomics 8 (7), 1719-1727
- Toward a full characterization of the human 20S proteasome subunits and their isoforms by a combination of proteomic approaches
S Uttenweiler-Joseph, S Claverol, L Sylvius, MP Bousquet-Dubouch, …
2008 Functional Proteomics, 111-130
- A quantitative proteomic approach using two‐dimensional gel electrophoresis and isotope‐coded affinity tag labeling for studying human 20S proteasome heterogeneity
C Froment, S Uttenweiler‐Joseph, MP Bousquet‐Dubouch, M Matondo, …
2005 Proteomics 5 (9), 2351-2363
- Automated de novo sequencing of proteins using the differential scanning technique
S Uttenweiler‐Joseph, G Neubauer, S Christoforidis, M Zerial, M Wilm
2001 PROTEOMICS: International Edition 1 (5), 668-682
- Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain
E Nielsen, S Christoforidis, S Uttenweiler-Joseph, M Miaczynska, …
2000 The Journal of cell biology 151 (3), 601-612
- Differential display of peptides induced during the immune response of Drosophila: a matrix-assisted laser desorption ionization time-of-flight mass spectrometry study
S Uttenweiler-Joseph, M Moniatte, M Lagueux, A Van Dorsselaer, …
1998 Proceedings of the National Academy of Sciences 95 (19), 11342-11347