Topic "Biological variability and cellular adaptation"

Genetic, epigenetic and gene expression variability (the so-called expression noise) are generally considered independently in their relationship with phenotypic variation. However, they appear to be intrinsically interconnected and influence it in combination. In this topic, we ask whether these three sources of biological variability influence each other, and whether their interplay modulates phenotypic variability and cellular adaptation in the yeast Saccharomyces cerevisiae. Through single-cell approaches, we focus on various genomic and epigenomic phenomena (homologous recombination rate and transgene stability, epigenetic silencing...) and on various phenotypic traits related to biotechnological issues, such stress resistance, single-cell growth rate, cellular aging…