EnzyOne theme
Enzymes and Molecular Assemblies for One Health

The aim of EnzyOne is to study and develop biotechnological solutions dedicated to human health, food/feed and well-being while preserving the environment, according to the "OneHealth" approach that recognizes the interconnection and interdependence of these different topics. Our research involves diverse models of study with a wide range of enzymatic functions that are primarily involved in the synthesis or the modification of molecules. A significant research axis deals with the customized synthesis of oligosaccharides, polysaccharides and glycoconjugates using bacterial transglycosylases and glycoside-phosphorylases. These enzymes come from natural diversity and/or are tailor-made engineered. The second major area of research is the development and implementation of methods and tools that combine molecular modelling and artificial intelligence to decipher structure-dynamics-function relationships and to protein design (redesign or de novo design). These approaches enable new avenues for the tailor-made engineering of enzymes, nano-/antibodies, protein binders, as well as multi-protein or protein-polysaccharide assemblies.