Topic "Adaptation mechanisms and engineering"

Research in the theme "Adaptation mechanisms and engineering" aims at modifying the adaptive performance of bacterial platforms through nutritional and metabolic engineering strategies (synthetic biology). Different strategies are used to modulate gene expression and more particularly at the level of post-transcriptional regulations in the model bacterium E. coli (shuffling of untranslated mRNA sequences, genome reduction for better ribosome allocation, modification of the mRNA life cycle, etc.). Genome engineering tools are also developed for unconventional bacteria.