Pierre MILLARD

My research works aim at a better understanding of the organization, functioning and regulation of natural and synthetic metabolic. I develop systems biology strategies that combine experimental (growth phenotyping, metabolomics, ¹³C-metabolic flux analysis, etc) and computational (stoichiometric and kinetic modeling, statistics, etc) tools. In particular, I build, validate and exploit explicative and predictive models that integrate a broad range of functional data (such as thermodynamics, metabolite pools, enzyme activities and kinetics, metabolic fluxes, and isotopic measurements) to investigate the control and regulation of metabolic fluxes. I use this knowledge to understand the role of metabolism in the adaptation of Escherichia coli to its environment, and to design robust and efficient strains as cell factories for innovative and original biotechnological applications.