Thème "PixCELLS"
Enzymes for Cell Factories & Plastics

PixCELLS focuses its research on the in-depth investigation and development of efficient and tailored enzymes for in vitro and in vivo applications. Using multi-scale integrative and multidisciplinary approaches combining closely sequence-based and structure-based, molecular modelling and computational design approaches to enzyme and metabolic engineering, PixCELLS tackles various challenges in collaboration with public and private partners that aim at:

• Gaining fundamental knowledge on the relationships between sequence, structural organization, dynamics and enzyme properties (activity, specificity and stability) and interactions with partners (molecular assemblies, enzyme-polymer systems, enzyme-ligand, …)
• Providing guidelines for reasoned in silico computer-aided conception of tailored enzymes for different biotechnological applications
• Improving in cellulo production of value-added molecules by redirecting fluxes, enhancing enzymes performances and protein-protein interactions
• Developing efficient in vitro enzyme-based solutions for different applications, notably to address environmental challenges (plastics, phyto-pathogens, …) but not exclusively