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Scientific production

Articles

  • Duperray, M., Francois, J., Capp, JP (2023) Tuning the expression of a bacterial relBE toxin-antitoxin system in yeast allows characterizating the subsequent growth inhibition. FEMS Yeast Res1093/femsyr/foad009
  • Batista, M., Donker, E.I.M., Bon, C., Guillien, M., Caisso, A., Mourey, L., François, J.M., Maveyraud, L., Zerbib, D. (2023). The conserved yeast protein Knr4 involved in cell wall integrity is a multi-domain intrinxically disordered protein. Mol. Biol., 435, e168048 DOI.org/10.1016/J.jmb.2023.168048
  • Holyavkin, C., Burcu, C., Turanlı-Yıldız B., Yılmaz, Ü., Ceren Alkım, C., Mevlüt Arslan, M., Topaloğlu, A., Kısakesen, I., de Billerbeck, G. François, J & Petek Çakar Z. (2023) Genomic, Transcriptomic and Metabolic Characterization of 2-Phenylethanol-resistant Saccharomyces cerevisiae obtained by Evolutionary Engineering. Front Microbiol 3389/fmicb.2023.1148065
  • François J. M (2023) Progress advances in the biosourced production of methionine and its hydroxyl analogues. Biotech Adv. 69, 1208259, https://doi.org/10.1016/j.biotechadv.2023.108259
  • Schiavone, M., François, J.M., Zerbib, D. & Capp. J.P. (2023) Emerging relevance of cell wall components from non-conventional yeasts as functional ingredients for the food and feed industry. Res Food Sci., https://doi.org/10.1016/J.crfs.2026.100603
  • Tan, M., Caro Y., Lebeau, J., Shum-Cheong-Sing, A. François, J., Regnier, T. and Petit T. (2022) Screening of the yeasts biodiversity from South-African wild animal faeces for the production of volatile α-unsaturated esters. Life 12, 1999. org/10.3390/life12121999
  • Alkim, C., Farias, D.,Fredonnet, J., Serrano-Bataille, H., Herviou, P., Marc Picot, M., Slama, N., Dejean, S., Morin, N., Enjalbert, B. and François, J.M. (2022) Toxic effect and inability of L-homoserine to be a nitrogen source for growth of Escherichia coli resolved by a combination of in vivo evolution engineering and omics analyses. Front Microbiol DOI: 10.3389/fmicb.2022.1051425
  • François J. M (2022) How White Biotechnology can contribute to BioEconomy. A personal consideration. The Journal Ecological Eng & Env Protect. 2, 5-17.
  • Arabaciyan, S., Saint-Antoine, M., Maugis-Rabusseau, C., François, J., Singh, A., Parrou, JL & Capp, JP (2021) Insight on the control of yeast single-cell growth variability by members of the trehalose phosphate synthase (TPS) complexe. Front. Cell Dev. Biol , 9, 607628 ; DOI 10.3389/fcell.2021.607628
  • Tan, M., Caro, Y., Shum-Cheong-Sing, A., Robert, L., François, J. & Petit Thomas (2021) Evaluation of mixed-fermentation of Saccharomyces cerevisiae with Saprochete swaveolens to produce natural fruity beer from industrial wort. Food Chem 2021 Jan 5;346:128804. doi: 10.1016/j.foodchem.2020.128804
  • Agboola JO, Schiavone M, Øverland M, Morales-Lange B, Lagos L, Arntzen MØ, Lapeña D, Eijsink VGH, Horn SJ, Mydland LT, François JM, Mercado L, Hansen JØ. (2021) Impact of down‑stream processingon functional properties of yeastsand the implications on gut healthof Atlantic salmon (Salmo salar). Sci. Report, 11, 4496. DOI: 10.1038/s41598-021-83764-2
  • Bouyx, C., Schiavone, M., Teste, M-A., Swierckowki, N., Julien, A. and Francois, J. (2021). The dual role of amyloid β-sheet interaction sequences in the cell surface properties of FLO11-encoded flocculins in the yeast Saccharomyces cerevisiae. Elife, Sep 1;10:e68592. DOI 10.7554/eLife.68592. Online ahead of print.
  • Wang, M., Yang, C., François, JM, Wan, X., Ni, W., Tu, X., Feang, D., Chen, S. & Huang, F. (2021) Improving microbial conversion efficiency of rapeseed meal by a two-stage strategy combining fungal treatment followed by extraction of phenolic compounds. Frontiers Bioeng Biotech. 9; e735714; DOI 10.3389/fbioe.2021.735714
  • Tan, M., Crao, Y., Shum-Cheong Sing A., Reiss, H., Francois, J M & Petit, T. (2021) Selection by UV mutagenesis and physiological characterization of mutant strains of the yeast Saprochete suaveolens (former Geotrichum fragrans) with higher capacity to produce flavour compounds. J. of Fungi., 7, 1031 DOI: 10.3390/jof7121031
  • Bouyx, C., Schiavone, M & François J M (2021) FLO11, a developmental gene conferring impressive adaptive plasticity to the yeast Saccharomyces cerevisiae. Pathogens 10, e1059; Doi.org/10.3390/pathogens10111509
  • Capp, JP (2021) Interplay between genetic, epigenetic and gene expression variability: considering complexity in evolvability. Evol App, 14(4):893-901; doi: 10.1111/eva.13204
  • Arabaciyan, S., Saint-Antoine, M., Maugis-Rabusseau, C., François, J., Singh, A., Parrou, JL & Capp, JP (2021) Insight on the control of yeast single-cell growth variability by members of the trehalose phosphate synthase (TPS) complexe. Front. Cell Dev. Biol , 9, 607628 ; DOI 10.3389/fcell.2021.607628
  • Tan, M., Caro, Y., Shum-Cheong-Sing, A., Robert, L., François, J. & Petit Thomas (2021) Evaluation of mixed-fermentation of Saccharomyces cerevisiae with Saprochete swaveolens to produce natural fruity beer from industrial wort. Food Chem 2021 Jan 5;346:128804. doi: 10.1016/j.foodchem.2020.128804
  • Agboola JO, Schiavone M, Øverland M, Morales-Lange B, Lagos L, Arntzen MØ, Lapeña D, Eijsink VGH, Horn SJ, Mydland LT, François JM, Mercado L, Hansen JØ. (2021) Impact of down‑stream processingon functional properties of yeastsand the implications on gut healthof Atlantic salmon (Salmo salar). Sci. Report, 11, 4496. DOI: 10.1038/s41598-021-83764-2
  • Bouyx, C., Schiavone, M., Teste, M-A., Swierckowki, N., Julien, A. and Francois, J. (2021). The dual role of amyloid β-sheet interaction sequences in the cell surface properties of FLO11-encoded flocculins in the yeast Saccharomyces cerevisiae. Elife, Sep 1;10:e68592. DOI 10.7554/eLife.68592. Online ahead of print.
  • Wang, M., Yang, C., François, JM, Wan, X., Ni, W., Tu, X., Feang, D., Chen, S. & Huang, F. (2021) Improving microbial conversion efficiency of rapeseed meal by a two-stage strategy combining fungal treatment followed by extraction of phenolic compounds. Frontiers Bioeng Biotech. 9; e735714; DOI 10.3389/fbioe.2021.735714
  • Tan, M., Crao, Y., Shum-Cheong Sing A., Reiss, H., Francois, J M & Petit, T. (2021) Selection by UV mutagenesis and physiological characterization of mutant strains of the yeast Saprochete suaveolens (former Geotrichum fragrans) with higher capacity to produce flavour compounds. J. of Fungi., 7, 1031 DOI: 10.3390/jof7121031
  • Bouyx, C., Schiavone, M & François J M (2021) FLO11, a developmental gene conferring impressive adaptive plasticity to the yeast Saccharomyces cerevisiae. Pathogens 10, e1059; Doi.org/10.3390/pathogens10111509
  • Capp, JP (2021) Interplay between genetic, epigenetic and gene expression variability: considering complexity in evolvability. Evol App, 14(4):893-901; doi: 10.1111/eva.13204
  • Liu, J., Mosser, L., Botanch, C., François, J.M & Capp JP (2020) SIR2 expression nois can generate heterogeneity in viability but does not affect cell-to-cell epigenetic silencing at subtelomeric URA3 in yeast. G3, 10, 3435 doi: 10.1534/g3.120.401589
  • Chuppa-Tostain, G., Tan, M., Shum-Cheong Sing, A., Adelard, L., François, J., Caro, Y. & Petit Thomas (2020). Evaluation of filamentous fungi and yeast for the biodegradation of sugarcane distillery wasterwater. Microorganisms, 8: 1588 doi: 10.339/microorganisms8101588
  • François J., Alkim, C & Morin, N. (2020). Engineering microbial pathways for production of bio-based chemicals from lignocellulosic sugars: Current status and perspectives. BMC Biotechnology for Biofuels. 13:118. DOI : 10.1186/s13068-020-01744-6
  • Frazao, C.R; Trichez, D., Spina, L., Lozano-Huguet, L., Serrano-Bataillé, H., Dagkesamankaya, A., Topham, C., Walther, T & Francois, J. (2019). Construction of a synthetic pathway for the production of 1,3-propanediol from glucose. Sci. Rep 9: 11576. DOI/ 10.1038/s41598-019-48091-7
  • Deshors, M., Guais, O., Neugnot-Roux, V., Cameleyre, X., Fillaudeau, L., Francois, J.M. (2019). Enzymatic deconstruction mechanism of complex polysaccharides in wheat revealed by combined in situ physical and ex-situ biochemical studies. Front. Bioeng. Biotechnol. 7: 158, doi: 10.3389/fbioe.2019.00158
  • Jian, L., François, J. M & Capp, JP (2019) Gene expression noise produces cell-to-cell heterogeneity in eukaryotic homologous recombination rate. Front. Genet. 10, 475, DOI : 10.3389/fgene.2019.00475
  • Cox, N., Kuemmerle, R., Millard, P., Cahoreau, E., François, J.M., Parrou, J.L. & Lippens, G. (2019). An integrated pH meter during reaction monoitoring with dual reception 1H, 31P NMR spectroscopy. Anal. Chem. 91, 3959 -3963.
  • Paloque, L., Père-Berezo, T., Abot, A., Dalloux-Chioccioli, J., Bourgeade-Delmas, S. ? Le Faouder, P., Pijo, J., Teste, MA., Francois, J., Helge Schebb, N, Mainka, M., Rolland, C., Blanpied, C., Dietrich, G., Bretrand-Michel, J., Deraison, C., Valentin, A. & Cenas. N. (2019) Polyinsaturate fatty metabolites : biosynthesis in Leishmania and role in parasite/host invasion. J. lipid Res., 60, 2019, DOI 10.1194/jlr.M091736.
  • Schiavone, M., Sieczkowski, N., Castex, M., Dague, E. & François J.M (2019) AFM dendritips functionalized with molecular probes specific to cell wall polysaccharides as a tool to investigate cell surface structure and organization. The Cell Surface, 5: 100027. DOI: 10.1016/j.tcsw.2019.100027
  • Lachaux C., Frazao, C.R., Morin, N., Walther, T & François J.M. (2019) Design, construction and validation of a synthetic pathway for glycolic acid production from lignocellulosic sugars with optimal carbon conservation. Front. Bioeng Biotech., 7, 359. DOI: 10.3389/fbioe.2019.00359
  • François J.M., Lachaux, C. & Morin Nicolas (2019). Synthetic biology applied to carbon conserving pathways: a mini-review. Front. Bioeng Biotech.7: 446; DOI 10.3389/fbioe.2019.00446
  • Walther, T., Calvayrac F., Malbert, Y., Alkim, C., Dressaire, C., Cordier, H., and Francois, J.M (2018) Construction of a synthetic pathway for the production of 2,4-dihydroxybutyric acid from homoserine. Metab. Eng 45, 237-245 DOI/10.1016/j.ymben.2017.12.005
  • Irague, R., Topham, C., Martineau N, Baylac A, , Stodel M., Auriol C., Walther,Th., François Jean M., ,André I. & Remaud-Siméon M. (2018) Conversion of an aspartate kinase into a malate kinase using a generic HTS assay for kinase screening. PlosOne 13 (2) e0193036
  • Chuppa-Tostain, G., Hoarau, J., Watson, M., Adelard, L., Cheong Sing, A., Caro, Y., Grondin, I., Bourven, I., Francois, J.M., Girbal-Neuhauser, E. & Petit T. (2018) Production of Aspergillus niger biomass on sugarcan distillery wastemwater: physiological aspects and potential for biodiesel production. Fungal Biol. Biotechnol., 5: 1 doi.org/10.1186/s40694-018-0045-6
  • Jian, L., François, J. & Capp, JP (2018) Bimodality of gene expression from yeast promoter can be instigated by DNA context, inducing condition and strain background. FEMS Yeast Res., 18 (4). doi: 10.1093/femsyr/foy047.
  • Trichez, D., Auriol, C., Baylac, A., Irague, R., Dressaire, C., Carnicer-Heras, M., Heux, S., François, JM & Walther, T (2018). Engineering of Escherichia coli for Krebs cycle dependent production of malic acid. Microbial Cell Fact.17: 113, DOI: 10.1186/s12934-018-0959-y
  • Jian, L. Lestrade, D., Cescut, J. François, J & Capp, JP (2018) A GRX1 promoter variant confers constitutive noisy bimodal expression that increases oxidtaive stress resistance in yeast. Frontiers in Microbiology, 9, 2158. DOI 10.3384/fmicb.2018.02158
  • Lopez, R.V., Gomez, J.L., Spina, L., Dejean, S., Parrou, JL & François, J M. (2018). Trehalose-6-phosphate promotes fermentation and glucose repression in Saccharomyces cerevisiae. Microbial Cell 5, 444-459. DOI: 10.15698/mic2018.10.651
  • Frazao C.R, Maton, V., Walther, T. & François J.M (2018) Development of a metabolite sensor for high-throughput detection of aldehydes in Escherichia coli. Front. Bioeng Biotechnol, section Synth. Biol., 6: 118, DOI: 10.3389/fbioe.2018.00118
  • Frazao C.R., Topham, C., Malbert, Y., François, J.M. & Walther, T. (2018). Rational engineering of a malate dehydrogenase for microbial production of 2,4 dihydroxybutyric acid production via homoserine pathway. Biochem. J. 475: 3887-3901. DOI: 10.1042/BCJ20180765
  • Llanos, A., Dejean, S., Neugnot-Roux, V., François, J.M. & Parrou, JL (2019) Carbon sources and XlnR—dependent transcriptional landscape of CAZymes in the industrial fungus Talaromyces versatilis: when exception seems to be the rule. Microbial Cell Fact.doi.org/10.1186/s12934-019-1062-8
  • Grondin, E., Shum Cheong Sing, A., Caroa, Y., James, S., Nueno-Palop,C., François, JM.& Petit, T (2017) Flavour production by Saprochaete and Geotrichum yeasts and their close relatives. Food Chem. 237: 677-684.
  • Turanlı-Yıldız, B., Benbadis, L., Alkım, C., Sezgin, T.,  Aksit, A., Gökçe, A., Öztürk,Y., Tarık Baykal, A., Çakar, Z.P. and François J M (2017) In vivo evolutionary engineering for ethanol-tolerance of Saccharomyces cerevisiae haploid cells triggers diploidization. J Biosci. Bioeng. https://doi.org/10.1016/j.jbiosc.2017.04.012
  • Walther Th., Topham, C.M., Irague, R., Auriol, C., Baylac, A., Cordier, H., Dressaire, C., Lozano-Huguet, L., Tarrat, N., Martineau, N., Stodel, M., Malbert, Y., Maestracci, M., Huet, R., André, I., Remaud-Siméon, M & François J M. (2017) Construction of a synthetic metabolic pathway for biosynthesis of the non-natural methionine precursor 2,4-dihydroxybutyric acid. Nature Comm., 8, 15828 doi:10.1038/ncomms15828.
  • Schiavone, M., Déjean, S., Sieczkowski, N., Castex, M., Dague, E. and François J M (2017) Integration of biochemical, biophysical and transcriptomics data for investigating the structural and nanomechanical properties of the yeast cell wall. Frontiers in Microbiology, 8: 1809; DOI: 10.3389/fmicb.2017.01806
  • Yang DD., De Billerberck, G., Zhang J-J , Rosenzweig, F. & François, J M. (2017) Deciphering the origin, evolutionary fate and the physiological function of the subtelomeric multi-aryl-alcohol dehydrogenases encoded genes family in the yeast Saccharomyces cerevisiae. Applied Env. Microbiol DOI.org/ 10.1128/AEM.01553.17

Patents

  • Lachaux C., Walther, T & François J. Microorganismes et procédé pour la production d’acide glycolique à partir de pentoses et d’hexoses. Demande de déposition n° FR1856511 13/07/2018, publié 17 January 2020 as WO 2020/012138 A1
  • Daniel Johannes KOCH, Lucas Pedersen PARIZZI, Felipe GALZERANI, Jean Marie FRANCOIS; Sophie LAJUS : Title: DEGRADATION PATHWAY FOR PENTOSE AND HEXOSE SUGARS U.S. Patent Application No. 16/796,426 and PCT/BR2020/050053 Data filed: February 20, 2020 and published 20th August 2020 as WO2020/168408
  • Daniel Johannes KOCH, Paulo ALEXANDRINO, Felipe GALZERANI, Jean Marie FRANCOIS, and Nicolas MORIN Title: MICROORGANISMS AND METHODS FOR THE PRODUCTION OF GLYCOLIC ACID AND GLYCINE VIA REVERSE GLYOXYLATE SHUNT. S. Patent Application No. 16/791,556 and PCT/BR2020/050041 Data filed February 14, 2020. Published 20th August 2020 as WO 2020/163935 A1
  • Francois, JM Microorganismes et procédé pour la production de molécules d’interêt à partir de pentoses et hexoses. Déclaration d’invention DI-RV-18-0128 auprès de INRA transfert 12 mars 2019