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Guy LIPPENS

Guy Lippens

Guy LIPPENS

DR1 CNRS
Team leader

MNR team

Actual position and research subject

Currently head of the NMR team at the Toulouse Biotechnology Institute, my main research is directed towards two axes. First, improved NMR methods for following the microbial metabolism, with notable exploitation of the simultaneous 1H and 31P detection of glycolytic intermediates. And secondly, the use of protein NMR to understand and optimize the enzymes that are studied in the laboratory. Simultaneously, I have applied NMR to the study of deuteration reactions catalyzed by Ruthenium nanoparticles.

Education and Diploma

Teaching

Bio-informatics, L2 Biology, University of Ghent, Belgium (1996-2000)

Structural Biology, Masters Degree Biochemistry, University of Lille, France (1998-2008)

NMR spectroscopy, L2 Chemistry, Université de l’Artois, Lens, France (1999-2002)

NMR: Quantum mechanics and Applications. L2 Physis, University of Lille (2011-2012)

NMR spectroscopy, L3 Biochemistry, INSA Toulouse, France (2018 – present)

Others

  • Supervised or co-supervised: 16 PhD students (15 in Lille – 1 in Toulouse) and 22 post-doc
  • Stays as a visiting scientist: Harvard Medical School – Systems Biology (June 2012)
  • Responsible IR-RMN Lille, 1995- 2015. Project Leader 1.2GHz NMR spectrometer for the IR-RMN till 2015, actually “chargé de mission CNRS”
  • Protein folding, misfolding aggregation and disease, Training and Mobility Network (HPRN-CT2002-00241 2002-2006 ; member – coordinator A Mark, Groningen, Pays-Bas)
  • Tau et Pin1, Association internationale de Recherche contre la maladie d’Alzheimer (AIRMA) (2005-2007, coordinator)
  • ANR-05-Blanc-6320-01 Tau :tubuline  (2009-2013, coordinator).
  • ANR-11-MALZ-0008 TAF Tau association with FKBP52 (2010-2014, participant – coordinator EE Baulieu)
  • LabEx Distalz, Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer’s disease (2012- 2022) (member – coordinator P Amouyel).
  • ANR-18-CE07-0016 Catsamy – Catalytic Scaffolds based on Amyloid aggregates (2018-2022, member – coordinator E Gras)
  • Flexible Isotope Exchange, programme FET-open européen, 2019-2024 (member – coordinator S Feuillastre, CEA, Saclay)
  • ANR 20-AMRA-0005 MustArt. Multiparametric Strategies against. Antibiotic Resistance in Tuberculosis (2021-2024, member – coordinator A Baulard).

List of selected publications

  • MAS NMR in solid-phase peptide synthesis, Dhalluin C, Boutillon C, Tartar A, Lippens G J. Am. Chem. Soc.119, 10494-10500 (1997)
  • High Resolution Magic Angle Spinning NMR Study of Resin-bound Poly-alanine Peptides. Warrass R, Wieruszeski JM, Boutillon C, Lippens G. J. Am. Chem. Soc., 122, 1789-1795 (2000)
  • HRMAS NMR as an analytical tool in combinatorial chemistry, Lippens G, Warrass R, Rousselot-Pailley P, Martins J, Chessari G, Wieruszeski, JM Pittsburg Conference (PITCON), New Orleans, USA (2002)
  • NMR analysis of a Tau phosphorylation pattern. Landrieu I, Lacosse L, Leroy L,  Wieruszeski JM, Trivelli X, Sillen A, Sibille N, Schwalbe H, Saxena K, Langer T, Lippens G J. Am. Chem. Soc. 128, 3575–3583 (2006)
  • NMR observation of Tau in Xenopus oocytes. Bodart JF, Wieruszeski JM, Amniai L, Leroy A, Landrieu I, Rousseau-Lescuyer A, Vilain JP, Lippens G. J Magn Reson. 2008, 192(2):252
  • NMR meets Tau : Insights in physiology and pathology Lippens G, Conférence Jacques Monod 2016, Roscoff
  • Identification of the Tau phosphorylation pattern that drives its aggregation. Despres C, Byrne C, Qi H, Cantrelle FX, Huvent I, Chambraud B, Baulieu EE, Jacquot Y, Landrieu I, Lippens G., Smet-Nocca C. Proc Natl Acad Sci U S A. 2017;114(34):9080-9085.
  • Verstraete K, Peelman F, Braun H, Lopez J, Van Rompaey D, Dansercoer A, Vandenberghe I, Pauwels K, Tavernier J, Lambrecht BN, Hammad H, De Winter H, Beyaert R, Lippens G, Savvides SN. Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma. Nat Commun. 2017, 8:14937.
  • (15)N-NMR-Based Approach for Amino Acids-Based (13)C-Metabolic Flux Analysis of Metabolism. . P Millard, E Cahoreau, M Heuillet, JC Portais, G Lippens. Anal Chem. 2017, 89(3):2101-2106.
  • Sinnaeve D, Dinclaux M, Cahoreau E, Millard P, Portais JC, Létisse F, Lippens Improved Isotopic Profiling by Pure Shift Heteronuclear 2D J-Resolved NMR Spectroscopy. Anal Chem. 2018, 90(6):4025-4031.
  • Futile Encounter Engineering of the DSR-M Dextransucrase Modifies the Resulting Polymer Length. Claverie M, Cioci G, Guionnet M, Schörghuber J, Lichtenecker R, Moulis C, Remaud-Simeon M, Lippens G. Biochemistry. 2019 Jun 25;58(25):2853-2859.
  • Palazzolo, A. , Feuillastre, S. , Pfeifer, V. , Garcia‐Argote, S. , Bouzouita, D. , Tricard, S. , Chollet, C. , Marcon, E. , Buisson, D. , Cholet, S. , Fenaille, F. , Lippens, G. , Chaudret, B. and Pieters, G., Efficient Access to Deuterated and Tritiated Nucleobase Pharmaceuticals and Oligonucleotides using Hydrogen‐Isotope Exchange. Chem. 2019, 58(15):4891-4895.
  • Improved NMR Detection of Phospho-Metabolites in a Complex Mixture Cox N, Millard P, Charlier C & Lippens G Anal. Chem. 2021, 93, 11, 4818–4824