Major breakthrough in biology: hybrid generative AI designs new molecules

PRESS RELEASE - Predict protein structure, create new ones. Protein design is a field of research that is undergoing a revolution thanks to the possibilities offered by AI, with the aim of designing new proteins and enzymes with direct applications in health and the environment. INRAE mathematics researchers have developed an AI that combines learning and reasoning. This hybrid AI is capable of designing proteins according to rules learned through deep learning, but also derived from physics or made explicit by designers. These results contribute to the panorama of protein design methods presented in the journal Nature Reviews Methods Primers.

Published on March 03, 2025 on the INRAE website

References

Albanese K.I., Barbe S., Tagami S. et al. (2025). Computational Protein Design. Nature Reviews Methods Primers, DOI : https://doi.org/10.1038/s43586-025-00383-1

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Sophie BARBE

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