INRAE Research Director (TRANSFORM division)

Actual position and research subject

I am presently leading the Enzyme Molecular Engineering and Catalysis team of the Toulouse Biotechnology Institute. Our core of expertise is to investigate the relationships between protein structure, function and stability, and to utilize this knowledge in order to identify and design powerful enzymes for industrial biotechnologies, applied either to the health or environmental sectors.


In this large team of ~70 persons, my research focuses on exploring the natural diversity of carbohydrate-active enzymes to understand what roles they play in microbial ecosystems. In particular, I show substantial interest regarding the importance of such enzymes in the interactions between gut microbes and dietary fibers, as well as the host itself, including in pathological contexts. Furthermore, being an biotechnology engineer, I cannot resist mining the remarkable sources of enzymes that are gut microbiomes, for biocatalysts that we exploit in synthetic biology for the production of glycosides for human health.  

In terms of methodologies, with a great team of PhD students, engineers, young researchers and collaborators, we are continuously developping novel sequence- as well as activity-based screening approaches, in order to efficiently identify smart enzymes within microbiomes. Currently, we are enthusiastically exploring the potential of droplet-microfluidics for functional metagenomics and culturomics. We seek to integrate this biochemical data acquired at ultra-high-throughput by microfluidics to sequence and structural data, in order to investigate, from molecular to ecosytemic scales, the processes of glycoside catabolism and anabolism taking place in gut microbes.

Education and Diploma


Lectures in Metagenomics at the EMBL (young researchers, since 2017, Heidelberg, Germany) and at the University Paul Sabatier (Msc. students, since 2019, Toulouse, France), in Ethics and Scientific Integrity at the University of Toulouse (PhD students, since 2018), and in Enzyme Engineering at INSAT (corporates, 2005-2013; international Master BioEco, since 2021).


  • Supervised or co-supervised 10 PhD students and 10 post-doctoral researchers
  • Contribution to research projects:
    • Coordinator of the projects H2020_Catsys (2015-2017), ANR_ASPIRE (2014-2017) and ANR_CAZIBD (2020-2024), INRAE_MetaScreen (2012-2014), MetaCAZymes (2011-2012), and MetaPrebiotics (2009-2011), Toulouse White Biotechnology_SubtilCarbs (2014-2016) and CultissimDrop (2019-2022), Chinese Scholarship Council (2 x 2016-2020, 2020-2024), and of bilateral industrial projects (2013-2015, 2014-2016, 2022-2023, 2022-2025).
    • Scientific leader for INSAT-TBI in the projects Horizon_Bluetools (2022-2026), H2020_MetaFluidics (2016-2020) and Zelcor (2016-2020), ANR_ Oligomet (2016-2020) and Glycoballs (2009- 2012), INRAE_EvolMat (2012-2013).
    • Participation in the projects H2020_RadicalZ (2021-2025), ANR_Reflex (2011-2015), AlimIntest (2007-2010), Toulouse White Biotechnology_Droopy (2017-2019) and OSEO_Thanaplast (2012-2014)
  • Other:
    • Panel-Expert at the HCERES (2022) and President of an HCERES evaluation committee (2021)
    • Vice-chair of the ANR scientific evaluation committee « Biology of animals, plants and micro-organisms/biotechnologies» (2015-2018)
    • Member of the coordination committee of the INRAE metaprogram ‘Meta-omics for microbial ecosystems’, a transversal program covering all the INRAE activities in this field (2011-2017)
    • Member of the Scientific Advisory Boards of TBI (since 2017, in charge of the ‘Biotechnologies for human health’ activities), of INSAT (2014-2018)
    • Member of the INSAT Prospective think-tank (2019)
    • Member of the panel of evaluation of INRAE researcher’s careers (CSS, 2007-2015), and in 8 recruitment panels (INRAE, University of Aix-Marseilles, University of Lille, INSAT).

List of selected publications

Full list of publications @

  • Alfonso-Prieto M., Potocki-Véronèse G., Cuxart I., André I., Rovira C. (2023). Substrate-Assisted Mechanism for the Degradation of N-glycans by a Gut Bacterial Mannoside Phosphorylase. ACS Catalysis DOI:10.1021/acscatal.3c00451 (JCR 13.70)
  • Labourel, A., Parrou, J. L., Deraison, C., Mercier-Bonin, M., Lajus, S., & Potocki-Veronese, G. (2023). O-Mucin-degrading carbohydrate-active enzymes and their possible implication in inflammatory bowel diseases. Essays in Biochemistry 2023, EBC20220153 DOI: 10.1042/EBC20220153 (JCR 7.26).
  • Li A., Benkoulouche M., Ladeveze S., Durand J., Cioci G., Laville E. and Potocki Veronese G.  (2022). Discovery and Biotechnological Exploitation of Glycoside-Phosphorylases. Int. J. Mol. Sci. 23(6), 3043; (JCR 6.208)
  • Ollivier S., Tarquis L., Fanuel M., Li A., Durand J., Laville E., Potocki-Veronese G., Ropartz D., Rogniaux H. (2021). Anomeric Retention of Carbohydrates in Multistage Cyclic Ion Mobility (IMSn): De Novo Structural Elucidation of Enzymatically Produced Mannosides. Anal. Chem., 93, 6254-6261. doi :10.1021/acs.analchem.1c00673 (JCR 6.785)
  • Khanh Le C. A., Ogawa Y., Dubreuil F., Grimaud F., Mazeau K., Ziegler G. R., Tanwar S., Nishiyama Y., Potocki-Veronese G., Choisnard L., Wouessidjewe D., Putaux J.L.. (2021) Crystal and molecular structure of V-amylose complexed with ibuprofen. Carbohydrate Polymers 261, 117885. (JCR 10.723)
  • Tauzin A.S., Rangel Pereira M.,Van Vliet L.D., Colin P.Y., Laville E.,  Esque J., Laguerre S., Henrissat B, Terrapon N., Lombard V., Leclerc M., Doré J., Hollfelder F. and Potocki-Veronese G. (2020). Investigating host-microbiome interactions by droplet based microfluidics. Microbiome 8, 141 doi :10.1186/s40168-020-00911-z (JCR 11.61)
  • Li J., Zhong H., Ramayo-Caldas Y., Terrapon N., Lombard V., Potocki-Veronese G., Estelle-Fabrellas J., Popova M., Yang Z., Zhang H., Li F., Tang S., Chen W., Chen B., Li J., Guo J.,  Martin C., Maguin E., Xu X., Yang H., Wang J., Madsen L., Kristiansen K., Henrissat B., Ehrlich S. D.,  Morgavi D.P. (2020). A catalog of microbial genes from the bovine rumen reveals the determinants of herbivory. Gigascience 9 (6). (JCR 6.95)
  • Li A., Laville E., Tarquis L., Lombard V., Ropartz D., Terrapon N., Ropartz D., Terrapon N., Henrissat B., Guieysse D., Esque J., Durand J., Morgavi D.P., Potocki-Veronese G. (2020). Analysis of the diversity of the glycoside hydrolase family 130 in mammal gut microbiomes reveals a novel mannoside-phosphorylase function. Microbial Genomics, mgen000404. doi/org/10.1099/mgen.0.000404. (JCR 5.52)
  • Wang Z., Tauzin A. S., Laville E., Tedesco P., Létisse F., Terrapon N., Lepercq P., Mercade M. and Potocki-Veronese G. (2020). Harvesting of prebiotic fructooligosaccharides by non-beneficial human gut bacteria. mSPHERE 5 (1). (JCR 4.48)
  • Grimaud, F., Faucard, P., Tarquis, L., Pizzut-Serin, S., Roblin, P., Morel, S., Le Gall S., Falourd X., Rolland-Sabaté A., Lourdin D., Moulis C., Remaud-Simeon M. and Potocki-Veronese G.  (2018). Enzymatic synthesis of polysaccharide-based copolymers. Green Chemistry, 20(17), 4012-4022. (JCR 8.59)
  • Grimaud F, Pizzut-Serin S, Tarquis L, Ladevèze S, Morel S, Putaux J.L., Potocki-Veronese G. (2018).  In Vitro Synthesis and Crystallization of β-1,4-Mannan. Biomacromolecules. doi/org/10.1021/acs.biomac.8b01457 (JCR 5.74)
  • Ladeveze S., Laville E., Despres J., Mosoni P., Potocki Veronese G. (2016). Mannoside recognition and degradation by bacteria. Biological Reviews. (JCR 10.73)
  • Ladeveze, S., Cioci, G., Roblin, P., Mourey, L., Tranier, S., Potocki-Veronese, G. (2015). Structural bases for N-glycan processing by mannoside phosphorylase. Acta Crystallographica. Section D, Biological Crystallography, 71 (Part 6), 1335-1346. (JCR 7.23)
  • Ufarte L., Laville E., Duquesne S., Potocki Veronese G. (2015). Metagenomics for the discovery of pollutant degrading enzymes. Biotechnology Advances, 33 (8), 1845-1854. (JCR 8.85)
  • Roblin P., Potocki-Veronese G., Guieysse D., Guerin F., Axelos M.A.V., M., Perez J., Buleon A. (2013). SAXS Conformational Tracking of Amylose Synthesized by Amylosucrases. Biomacromolecules, 14 (1), 232 – 239. (JCR 5.79)
  • Cecchini D., Laville E., Laguerre S., Robe P., Leclerc M., Dore J., Henrissat B., Remaud Simeon M., Monsan P., Potocki-Veronese G. (2013). Functional metagenomics reveals novel pathways of prebiotic breakdown by human gut bacteria. Plos One, 8 (9). (JCR 3.53)
  • Irague R, Massou S, Moulis C, Saurel O, Milon A, Monsan P, Remaud-Siméon M, Portais JC, Potocki-Veronese G. (2011). NMR-Based Structural Glycomics for High-Throughput Screening of Carbohydrate-Active Enzyme Specificity. Anal Chem. 83(4), 1202-1206. (JCR 5.87)
  • Tasse, L., J. Bercovici, S. Pizzut-Serin, P. Robe, J. Tap, C. Klopp, B.L. Cantarel, P.M. Coutinho, B. Henrissat, M. Leclerc, J. Doré, P. Monsan, M. Remaud-Simeon, and G. Potocki-Veronese. (2010). Functional metagenomics to mine the human gut microbiome for dietary fiber catabolic enzymes. Genome Research 20: 1605-1612. (JCR 13.59)
  • Deriano L., Guipaud O., Merle-Beral H., Binet JL., Ricoul M., Potocki-Veronese G., Favaudon V., Maciorowski Z., Muller C., Salles B., Sabatier L., Delic J. (2005). Human chronic lymphocytic leukemia B cells can escape DNA damage-induced apoptosis through the non-homologous end-joining DNA repair pathway. Blood, 105, 4776-4783. (JCR 10.56)
  • Potocki de Montalk G., Remaud M., Willemot R.M., Planchot V. and Monsan P. (1999). Sequence analysis of the gene encoding amylosucrase from Neisseria polysaccharea and characterization of the recombinant enzyme. J. Bacteriol. 181, 375-381. (IF 3.73)