Production scientifique
Articles
- E. Masoumzadeh, J.M. Courtney, C. Charlier, J. Ying, P. Anfinrud, & A. Bax,. Structure of a transient protein-folding intermediate by pressure-jump NMR spectroscopy, Proc. Natl. Acad. Sci. U.S.A. 122 (41) e2519493122, https://doi.org/10.1073/pnas.2519493122 (2025).
- Pierre Millard, Loïc Le Grégam, Svetlana Dubiley, Valeria Gabrielli, Thomas Gosselin-Monplaisir, Guy Lippens, Cyril Charlier, MultiNMRFit: a software to fit 1D and pseudo-2D NMR spectra, Bioinformatics, Volume 41, Issue 9, September 2025, btaf463, https://doi.org/10.1093/bioinformatics/btaf463
- Multinuclear non-heme iron dependent oxidative enzymes: Landscape of their substrates, partner proteins and biosynthetic gene clustersAntoine R, Leprevost L, Jünger S, Zirah S, Lippens G, Li Y, Dubiley S, Jacob-Dubuisson F Microbial Genomics, in press.
- Bacillus subtilis utilizes decarboxylated S-adenosylmethionine for the biosynthesis of tandem aminopropylated microcin C, a potent inhibitor of bacterial aspartyl tRNA synthetase.Kulikovsky A, Yagmurov E, Grigoreva A, Popov A, Severinov K, Nair S, Lippens G, Serebryakova M, Borukhov S, Dubiley S. J Am Chem Soc 2025, 47(14):11998-12011. doi: 10.1021/jacs.4c18468.
- A widespread family of ribosomal peptide metallophores involved in bacterial adaptation to metal stressLeprevost L , Jünger S, Lippens G, Guillaume C, Sicolid G, Oliveira L, Falcone E , de Santis E , Rivera-Millot A, Billon G , Stellato F , Henry C , Antoine R , Zirah S, Dubiley S, Li Y, Jacob-Dubuisson F, PNAS 2024, 121 (49), e2408304121 doi : 10.1073/pnas.2408304121
- The structure of a Tau fragment bound to tubulin prompts new hypotheses on Tau mechanism and oligomerization. Ammar Khodja L, Campanacci V, Lippens G, Gigant B. PNAS Nexus 2024. doi: 1093/pnasnexus/pgae487)
- Biochemical characterization of a SusD-like protein involved in β-1,3-glucan utilization by an uncultured cow rumen Bacteroides. Li X, Lippens G, Parrou J-L, Cioci G, Esque J, Wang Z, Laville E, Potocki-Veronese G, Labourel A. 2024, 9(8):e0027824. doi: 10.1128/msphere.00278-24
- Exploring the pH dependence of an improved PETase. Charlier C, Gavalda S, Grga J, Perrot L, Gabrielli V, Löhr F, Schörghuber J, Lichtenecker R, Arnal G, Marty A, Tournier V, Lippens G. Biophys J. 2024 123(12):1542-1552. doi: 10.1016/j.bpj.2024.04.026.
- New route to a pyrazoline scaffold featuring original substitutions and its crystal structure. Jean-Bart N; Lippens G and Gras E. Monatshefte fur Chemie 2024, 155 (2), 183-188, doi : 10.1007/s00706-023-03169-x
- Catalytic enantiospecific deuteration of complex amino acid mixtures with ruthenium nanoparticles. Mencia G., Rouan P., Fazzini PF., Kulyk H., Varela-Izquierdo V., Lippens G., Chaudret B. Catalysis Science & Technology 2024, 24 (17), 4904-4911, doi :1039/d4cy00588k
- Characterization of a Family of Scorpion Toxins Modulating Ca2+-Activated Cl- Current in Vascular Myocytes Morel JL; Mokrzycki N; Lippens G; Drobecq H; Sautiere P; Hugues M. Toxins 2023, 11, 780, doi : 3390/toxins14110780
- Proline-Rich Region II (PRR2) Plays an Important Role in Tau-Glycan Interaction: An NMR Study Murray A; Yan LF; Gibson JM; Liu J ; Eliezer D; Lippens G; Zhang FM; Linhardt RJ; Zhao J; Wang CY Biomolecules 2023, 12(11), 1573 doi : 3390/biom12111573
- Structural and Biochemical Characterization of a Nonbinding SusD-Like Protein Involved in Xylooligosaccharide Utilization by an Uncultured Human Gut Bacteroides Strain Tauzin AS; Wang Z; Cioci G; Li XQ; Labourel A; Machado B; Lippens G; Potocki-Veronese G. mSphere 2022, 7(5) e00244-22 doi : 10.1128/msphere.00244-22
- An NMR look at an engineered PET depolymerase. Charlier C., Gavalda S., Borsenberger V, Duquesne S, Marty A, Tournier V, Lippens G. Biophysical Journal 2022, 121(15), 2882-2894 doi : 10.1016/j.bpj.2022.07.002
- The covalent complex of Jo-In results from a long-lived, non-covalent intermediate state with near-native structure. Cox N, Charlier C, Vijayaraj R, De La Mare M, Barbe S, André I, Lippens G, Montanier CY. Biochem Biophys Res Commun. 2022 Jan 22;589:223-228. doi: 10.1016/j.bbrc.2021.12.028.
- The Jo-In protein welding system is a relevant tool to create CBM-containing plant cell wall degrading enzymes. Badruna L, Burlat V, Roblin P, Enjalbert T, Lippens G, Venditto I, O’Donohue MJ, Montanier CY, New Biotechnology 2021, doi :10.1016/j.nbt.2021.07.004)
- Virtual decoupling to break the Simplification Versus Resolution Trade Off in NMR of Complex Metabolic Mixtures Charlier C, Cox N, Prud’homme SM, Geffard A, Nuzillard JM, Luy B, Lippens G, Magnetic Resonance 2021, doi : 10.5194/mr-2021-48
- IsoSolve: An Integrative Framework to Improve Isotopic Coverage and Consolidate Isotopic Measurements by Mass Spectrometry and/or Nuclear Magnetic Resonance. Millard P, Sokol S, Kohlstedt M, Wittmann C, Létisse F, Lippens G & Portais JC Anal. Chem. 2021, 93, 27, 9428–9436 doi : 10.1021/acs.analchem.1c01064
- Identification and characterization of andalusicin: N-terminally dimethylated class III lantibiotic from Bacillus thuringiensis sv. Andalousiensis Grigoreva A, Andreeva J, Bikmetov D, Rusanova A, Serebryakova M, Garcia AH, Slonova D, Nair SK, Lippens G, Severinov K, Dubiley S iScience 2021, 24(5), 102480 doi : 1016/j.isci.2021.102480
- Improved NMR Detection of Phospho-Metabolites in a Complex Mixture Cox N, Millard P, Charlier C & Lippens G Chem. 2021, 93, 11, 4818–4824 doi : 10.1021/acs.analchem.0c04056
- The Zebra Mussel (Dreissena polymorpha) as a Model Organism for Ecotoxicological Studies: A Prior 1H NMR Spectrum Interpretation of a Whole Body Extract for Metabolism Monitoring. Prud’homme SM, Hani YMI, Cox N, Lippens G, Nuzillard JM, Geffard A. Metabolites. 2020 Jun 18;10(6):E256. doi: 10.3390/metabo10060256. PMID: 32570933
- Increasing field strength versus advanced isotope labeling for NMR-based fluxomics. Dinclaux M, Cahoreau E, Millard P, Létisse F, Lippens G. Magn Reson Chem. 2020 Apr;58(4):305-311. doi: 10.1002/mrc.4988. Epub 2020 Jan 16. PMID: 31909497
- 3-O-Sulfation of Heparan Sulfate Enhances Tau Interaction and Cellular Uptake. Zhao J, Zhu Y, Song X, Xiao Y, Su G, Liu X, Wang Z, Xu Y, Liu J, Eliezer D, Ramall TF, Lippens G, Gibson J, Zhang F, Linhardt RJ, Wang L, Wang C. Angew Chem Int Ed Engl. 2020 Jan 27;59(5):1818-1827. doi: 10.1002/anie.201913029. Epub 2019 Dec 10. PMID: 31692167
- Efficient in vivo synthesis of lasso peptide pseudomycoidin proceeds in the absence of both the leader and the leader peptidase. Zyubko T, Serebryakova M, Andreeva J, Metelev M, Lippens G, Dubiley S, Severinov K. Chem Sci. 2019 Aug 30;10(42):9699-9707. doi: 10.1039/c9sc02370d.
- Tuning the catalytic activity and selectivity of water-soluble bimetallic RuPt nanoparticles by modifying their surface metal distribution. Bouzouita D, Lippens G, Baquero EA, Fazzini PF, Pieters G, Coppel Y, Lecante P, Tricard S, Martínez-Prieto LM, Chaudret B. Nanoscale. 2019 Sep 21;11(35):16544-16552. doi: 10.1039/c9nr04149d. Epub 2019 Aug 28. PMID: 31455954
- Cyclophilin A allows the allosteric regulation of a structural motif in the disordered domain 2 of NS5A and thereby fine-tunes HCV RNA replication. Dujardin M, Madan V, Gandhi NS, Cantrelle FX, Launay H, Huvent I, Bartenschlager R, Lippens G, Hanoulle X. J Biol Chem. 2019 Aug 30;294(35):13171-13185. doi: 10.1074/jbc.RA119.009537. Epub 2019 Jul 17. PMID: 31315928
- Futile Encounter Engineering of the DSR-M Dextransucrase Modifies the Resulting Polymer Length. Claverie M, Cioci G, Guionnet M, Schörghuber J, Lichtenecker R, Moulis C, Remaud-Simeon M, Lippens G. Biochemistry. 2019 Jun 25;58(25):2853-2859. doi: 10.1021/acs.biochem.9b00373. Epub 2019 Jun 7. PMID: 31140266
- Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in Vitro Phosphorylated Tau and Their Modulation by Potential Inhibitors. Despres C, Di J, Cantrelle FX, Li Z, Huvent I, Chambraud B, Zhao J, Chen J, Chen S, Lippens G, Zhang F, Linhardt R, Wang C, Klärner FG, Schrader T, Landrieu I, Bitan G, Smet-Nocca C. ACS Chem Biol. 2019 Jun 21;14(6):1363-1379. doi: 10.1021/acschembio.9b00325.
- Elucidating Tau function and dysfunction in the era of cryo-EM. Lippens G, Gigant B. J Biol Chem. 2019 Jun 14;294(24):9316-9325. doi: 10.1074/jbc.REV119.008031. Epub 2019 May 14. PMID: 31088912
- Efficient Access to Deuterated and Tritiated Nucleobase Pharmaceuticals and Oligonucleotides using Hydrogen-Isotope Exchange. Palazzolo A, Feuillastre S, Pfeifer V, Garcia-Argote S, Bouzouita D, Tricard S, Chollet C, Marcon E, Buisson DA, Cholet S, Fenaille F, Lippens G, Chaudret B, Pieters G. Angew Chem Int Ed Engl. 2019 Apr 1;58(15):4891-4895. doi: 10.1002/anie.201813946.
- Integrated pH Measurement during Reaction Monitoring with Dual-Reception 1H-31P NMR Spectroscopy. Cox N, Kuemmerle R, Millard P, Cahoreau E, François JM, Parrou JL, Lippens G. Anal Chem. 2019 Mar 19;91(6):3959-3963. doi: 10.1021/acs.analchem.8b05147.
- Backbone chemical shift assignment of macrophage infectivity potentiator virulence factor of Trypanosoma cruzi. Lopez JM, Antiparra R, Lippens G, Zimic M, Sheen P, Maruenda H. Biomol NMR Assign. 2019 Apr;13(1):21-25. doi: 10.1007/s12104-018-9844-1
- The Neuronal Tau Protein Blocks in Vitro Fibrillation of the Amyloid-β (Aβ) Peptide at the Oligomeric Stage. Wallin C, Hiruma Y, Wärmländer SKTS, Huvent I, Jarvet J, Abrahams JP, Gräslund A, Lippens G, Luo J. J Am Chem Soc. 2018 Jul 5;140(26):8138-8146. doi: 10.1021/jacs.7b13623.
- Improved Isotopic Profiling by Pure Shift Heteronuclear 2D J-Resolved NMR Spectroscopy. Sinnaeve D, Dinclaux M, Cahoreau E, Millard P, Portais JC, Létisse F, Lippens G. Anal Chem. 2018 Mar 20;90(6):4025-4031. doi:10.1021/acs.analchem.7b05206.
- In-cell NMR: from metabolites to macromolecules. Lippens G, Cahoreau E, Millard P, Charlier C, Lopez J, Hanoulle X, Portais JC. Analyst. 2018 Feb 7;143(3):620-629. doi: 10.1039/c7an01635b.
- Interaction study between HCV NS5A-D2 and NS5B using 19F NMR. Dujardin M, Cantrelle FX, Lippens G, Hanoulle X. J Biomol NMR. 2018 Jan;70(1):67-76. doi: 10.1007/s10858-017-0159-9.
- Interact: Automated analysis of protein-ligand interactions by 1D and 2D NMR Millard P, Lippens G Biorciv 2018. doi: https://doi.org/10.1101/215194
Brevets
WO/2024/236009A2 NOVEL ESTERASES AND USES THEREOF
- WO/2023/088909 ESTERASES AND USES THEREOF
- NOVEL ESTERASES AND USES THEREOF. Patent application EP21306590.7 , 16/11/2021.
Ferrage F., Cousin S., Charlier C., Marquardsen T., Tyburn J.M., Method for two field nuclear magnetic resonance measurements. Patent application EP15290102, 3 Aug. 2018