Luc FILLAUDEAU

Luc FILLAUDEAU

INRAE Research Director

Equipe TIM

Actual position and research subject

INRAE scientist (Dr. -Eng) since 1996 and works at Toulouse Biotechnology Institute, Bio & Chemical Engineering (TBI) with disciplinary competences in Life Sciences and Engineering Sciences. His activity is focused on Bioprocess and Food process engineering. His research field explores the coupled transfers and transfer limitations in (bio)process to meet the challenges of the bioeconomy with public and private collaborators. This activity embraces 3 keywords: cell culture (polyphasic and reactive medium), bioreactor, physical characterization. His expertise is related to food processing/safety and bioprocess engineering (industrial biotechnology). His scientific production deals with membrane process, heat treatment, bioreaction/biocatalysts, complex biological matrices and biorefinery. He acts as food process and bioprocess expert at ANSES since 2003 and scientific director of Carnot 3BCAR (Biomolecule, Bioenergy, Biomaterial) since 2021 to promote and to sustain private-public research and partnership for bio-economy.

  • Research: Irreducible couplings between heat transfer, mass transfer and fluid mechanics in complex and evolving biosystems (microbial and enzymatic biocatalysts) in bioreactor.
  • Investigation: bio-catalytic reaction, characterization of complex products (fermentation broth, transfer, solid-liquid suspension, rheological behavior), dedicated in-situ and ex-situ physical measurements (instrumentation and bioprocess design), membrane process (alternative technology, loss reduction, water management), heat treatment (conventional and alternative technologies, Indirect and direct Joule effect heater
  • Area of expertise: bioeconomy/biorefinery, food process and bioprocess engineering, food safety

Education and Diploma

Teaching

  • Practical works (unit operation) : Heat treatment, membrane process, drying, evaporation, distillation, pressure drop, mixing, fluid mechanics,..
  • Courses: Food and Process Engineering, Heat treatment and Technology, Non-Newtonian fluid mechanics, Drying, Filtration and Separation, Fundamentals in Bioprocess engineering, Irreducible couplings in bioreactors, Bibliographic work, Project management.
  • Formations: IUT Applied biology (Bac+2), CESIA (Food and Agro-industry), IAAL (Institut Agro-Alimentaire de Lille, engineer cycle), HEI (Hautes Etudes Industrielles, engineer cycle), INSA Toulouse Biological Eng., Mechanical Eng, Mathematical and Modelling Eng. dept, INSA-Master Bioséparation-Microbiologie, Industry (formation center, SME), MSc and PhD schools (Thematic school IBCP in France).
  • International MSc and PhD schools: ISBS/ENIS and CBS in Tunisia, Dept Chemical Engineering UP Diliman in Philippines, USJ Lebanon.

Others

  • Mentoring experience: 8 Post-PhD, 27 PhD, 26 MSc and 21 Engineers/Technicians
  • Scientific production : 5 patents, 73 publications, 193 communications, 10 chapters.
  • International experiences: USA (18 months), research projects and collaborative networks (EC, SEA, NAME)

List of selected publications

  1. Boukazia, G. Delaplace, M. Cadé, F. Bellouard, M. Bégué, N. Semmar, L. Fillaudeau. Metrological performances of fouling sensorsbased on steady thermal excitation applied to bioprocess. Food and Bioproducts Processing 119 (2020) 226–237. https://doi.org/10.1016/j.fbp.2019.11.007
  2. Susana María Alonso Villela, Hazar Kraïem, Balkiss Bouhaouala-Zahar, Carine Bideaux, César Arturo Aceves Lara, Luc Fillaudeau. Protocol for recombinant protein quantification by densitometry. MicrobiologyOpen. (2020) 1-8. https://doi.org/10.1002/mbo3.1027
  3. Wafa Jallouli, Fatma Driss, Luc Fillaudeau, Souad Rouis. Review on biopesticide production by Bacillus thuringiensis subsp. Kurstaki since 1990: Focus on bioprocess parameters. Process Biochemistry 98 (2020) 224–232, https://doi.org/10.1016/j.procbio.2020.07.023
  4. Boukazia Y., G. Delaplace, M. Cadé, F. Bellouard, L. Fillaudeau. On-line biofouling monitoring and qualification based on local thermal and periodic excitation with MEMS sensor. Food and Bioproducts Processing, Volume 126, 2021, Pages 12-22, ISSN 0960-3085. https://doi.org/10.1016/j.fbp.2020.12.003
  5. Cheng Ming, Xie Xiaomin, Schmitz Philippe, Fillaudeau Luc. Extensive review about industrial and laboratory dynamic filtration modules: scientific production, configurations and performances. Separation and Purification Technology, 2021, 118293, ISSN 1383-5866, https://doi.org/10.1016/j.seppur.2020.118293
  6. Alonso Villela SM, Ghezal-Kraïem H, Bouhaouala-Zahar B, Bideaux C, Aceves Lara CA, Fillaudeau L. Effect of temperature on the production of a recombinant antivenom in fed-batch mode. Appl Microbiol Biotechnol. 2021 Feb; 105(3):1017-1030. https://doi:10.1007/s00253-021-11093-5
  7. Nguyen, T.C.; Fillaudeau, L.; Anne-Archard, D.; Chu-Ky, S.; Luong, H.N.; Vu, T.T.; Nguyen, T.H.D.; Nguyen, V.H. Impact of Particle Size on the Rheological Properties and Amylolysis Kinetics of Ungelatinized Cassava Flour Suspensions. Processes 2021, 9, 989. https://doi.org/10.3390/pr9060989
  8. DUMON Claire, FILLAUDEAU Luc, MONTANIER Cédric Y., Biotechnologies et bioprocédés : clé de voute de la chimie verte. Revue IAA, n°03-04 (Avril 2021), pp.20-23, 2021.
  9. Cheng, M., Le Men, C., Line, A., Schmitz, P., Fillaudeau, L. Methodology to investigate instantaneous and local transmembrane pressure within Rotating and Vibrating Filtration (RVF) module. Separation and Purification Technology, 2021, 272, 118955. https://doi.org/10.1016/j.seppur.2021.118955
  10. Monroy, T.S.; Abdelmalek, N.; Rouis, S.; Kallassy, M.; Saad, J.; Abboud, J.; Cescut, J.; Bensaid, N.; Fillaudeau, L.; Aceves-Lara, C.A. Dynamic Model for Biomass and Proteins Production by Three Bacillus Thuringiensis ssp Kurstaki Strains. Processes 2021, 9, 2147. https://doi.org/10.3390/pr9122147
  11. Robles Rodriguez, C.E., Abboud, J., Abdelmalek, N., Fillaudeau, L., Aceves-Lara, C.A. Soft-Sensors for Monitoring B. Thuringiensis Bioproduction Lecture Notes in Networks and Systems (DCAI2021), 2022, 327 LNNS, pp. 129–136
  12. Cheng, M., Le Men, C., Line, A., Schmitz, P., Fillaudeau, L. Investigation of instantaneous and local transmembrane pressure in rotating and vibrating filtration (RVF) module: Comparison of three impellers. Separation and Purification Technology, 2022, 280, 119827. https://doi.org/10.1016/j.seppur.2021.119827
  13. Estelle Bonnin, Maud Joseph-Aimé, Luc Fillaudeau, Sylvie Durand, Xavier Falourd, Sophie Le Gall, Luc Saulnier. Structure of heteroxylans from vitreous and floury endosperms of maize grain and impact on the enzymatic degradation. Carbohydrate Polymers, Volume 278, 2022, 118942, ISSN 0144-8617, https://doi.org/10.1016/j.carbpol.2021.118942.
  14. Asma Timoumi, Tien Cuong Nguyen, Tuan Le, Hazar Kraiem, Julien Cescut, Dominique Anne-Archard, Nathalie Gorret, Carole Molina-Jouve, Kim Anh To, Luc Fillaudeau. Comparison of methods to explore the morphology and granulometry of biological particles with complex shapes: Interpretation and limitations. Powder Technology. Volume 415, 1 February 2023, 118067. https://doi.org/10.1016/j.powtec.2022.118067
  15. Rita Barssoum, Gabrielle Al Kassis, Rayan Nassereddine, Jihane Saad, Meriem El Ghoul, Joanna Abboud, Nancy Fayad, Stephanie Dupoiron, Julien Cescut, Cesar Arturo Aceves-Lara, Luc Fillaudeau, Mireille Kallassy Awad. Biochemical limitations of Bacillus thuringiensis based biopesticides production in a wheat bran culture medium. Research in Microbiology 174 (2023) 104043. https://doi.org/10.1016/j.resmic.2023.104043
  16. Nancy Fayad, Rita Barssoum, Nathalie Marsaud, Rayan Nasseredine, Nouha Abdelmalek, Souad Rouis, Marie Ange Teste, Vincent Pailler, Veronique Gautier, Elodie Belmonte, César Arturo Aceves Lara, Julien Cescut, Luc Fillaudeau, Mireille Kallassy-Awad. Complete genome sequences of two Bacillus thuringiensis serovar kurstaki strains isolated from Lebanon and Tunisia, highly toxic against lepidopteran larvae. Microbiology Resource Announcements (2023). https://doi.org/10.1128/MRA.00060-23
  17. Susana María Alonso Villela, Hazar Kraïem‑Ghezal, Balkiss Bouhaouala‑Zahar, Carine Bideaux, César Arturo Aceves Lara, Luc Fillaudeau. Production of recombinant scorpion antivenoms in E. coli: current state and perspectives. Applied Microbiology and Biotechnology (2023). https://doi.org/10.1007/s00253-023-12578-1
  18. CAO-XUAN Bach, LE Tuan, PHAM Tuan-Anh, ANNE-ARCHARD Dominique, LOMBARD Eric, CAMEYLERE Xavier, NGUYEN Tien Cuong, TO Kim Anh, FILLAUDEAU Luc. Integrated rheological, morphological and biochemical approaches to investigate performances of an enzymatic secretome from Talaromyces sp. BRG1 to degrade pretreated sugarcane bagasse and paper-pulp. Biochemical Engineering Journal 203 (2024) 109196. https://doi.org/10.1016/j.bej.2023.109196
  19. Amel Chammam, Luc Fillaudeau, Mehrez Romdhane and Jalloul Bouajila. Chemical Composition and In Vitro Bioactivities of Extracts from Cones of P. halepensis, P. brutia, and P. pinea: Insights into Pharmaceutical and Cosmetic Potential. Plants. 2024-06, 13(13), 1802. https://doi.org/10.3390/plants13131802
  20. Chammam, A.; Romdhane, M.; Fillaudeau, L.; Bouajila, J. Phytochemical Composition and Characterization of In Vitro Bioactivities from Pinus Using Green Process. Molecules 2024, 29, 5295. https://doi.org/10.3390/molecules29225295
  21. René Hanke, Jonas Lohr, Leon Poduschnick, Sebastian Tesche, Luc Fillaudeau, Jochen Büchs, Rainer Krull. Rheology and culture reproducibility of filamentous microorganisms: Impact of flow behavior and oxygen transfer during salt-enhanced cultivation of the actinomycete Actinomadura namibiensis. Engineering in Life Sciences. 2024. pp1-13. https://doi.org/10.1002/elsc.202400078
  22. Chammam, A., Bouajila, J., Romdhane, M. and Fillaudeau Luc. Pinecones valorization: process intensification and eco-friendly extraction of antioxidant compounds. Euro-Mediterr J Environ Integr (2025), pp1-15. https://doi.org/10.1007/s41207-024-00707-9
  23. Claraz Pauline, Fillaudeau Luc, Jadoul Chloé, Storme Thomas, Guillemot Coralie, Puisset Florent, Arellano Cécile. A comparative study of gellan gum and xanthan gum versus commercial vehicles as pharmaceutical thickening agents in oral suspensions. European European Journal of Pharmaceutics and Biopharmaceutics. Volume 207, February 2025, 114622. https://doi.org/10.1016/j.ejpb.2024.114622

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