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Production scientifique


  • Gomes P, V Laroute, C  Beaufrand, M-L Daveran-Mingot, N Aubry, C Liebgott, N Ballet, S Legrain-Raspaud, V Theodorou, M Mercier-Bonin, M Cocaign-Bousquet, H Eutamene 2023. Lactococcus lactis CNCM I-5388 versus NCDO2118 by its GABA hyperproduction ability, counteracts faster stress-induced intestinal hypersensitivity in rats. FASEB J. 37(11):e23264.doi: 10.1096/fj.202301588R. doi: 10.1186/s12934-023-02181-4.
  • Millard P, T Gosselin-Monplaisir, S Uttenweiler-Joseph, B Enjalbert. 2023. Acetate is a beneficial nutrient for E. coli at low glycolytic flux. EMBO J. 42(15):e113079. doi: 10.15252/embj.2022113079
  • Laroute V, N Aubry, M  Audonnet, M Mercier-Bonin, M-L Daveran-Mingot, M Cocaign-Bousquet. 2023. Natural diversity of lactococci in γ-aminobutyric acid (GABA) production and genetic and phenotypic determinants. Microb Cell Fact. 22(1):178. doi: 10.1186/s12934-023-02181-4.
  • Hadjeras L, M Bouvier, I Canal, L Poljak, Q Morin-Ogier, C Froment, O Burlet-Schlitz, L Hamouche, L Girbal, M Cocaign-Bousquet, AJ Carpousis. 2023. Attachment of the RNA degradosome to the bacterial inner cytoplasmic membrane prevents wasteful degradation of rRNA in ribosome assembly intermediates. Plos Biology, 21(1):e3001942
  • Duviau MP, Chen F, Emile A, Cocaign-Bousquet M, Girbal L, Nouaille S. 2023. When translation elongation is impaired, the mRNA is uniformly destabilized by the RNA degradosome, while the concentration of mRNA is altered along the molecule. Nucleic Acids Research, 51(6):2877-2890.
  • Lautier T, DJ Smith, LK Yang, X Chen, C Zhang, G Truan, ND Lindley.  2023. Cytochrome P450 Surface Domains Prevent the β-Carotene Monohydroxylase CYP97H1 of Euglena gracilis from Acting as a Dihydroxylase.  Biomolecules, Feb 15;13(2):366.
  • Chen F, M Cocaign-Bousquet, L Girbal, Nouaille S. 2022. 5’UTR sequences influence protein levels in Escherichia coli by regulating translation initiation and mRNA stability. Front Microbiol. 13:1088941.
  • Laroute V, Beaufrand C, Gomes P, Nouaille S, Tondereau V, Daveran-Mingot ML, Theodorou V, Eutamene H, Mercier-Bonin M, M Cocaign-Bousquet. 2022. Lactococcus lactis NCDO2118 exerts visceral antinociceptive properties in rat via GABA production in the gastro-intestinal tract. Elife 21;11:e77100.
  • Smith DJ, M Helmy, ND Lindley, K Selvarajoo. 2022. The transformation of our food system using cellular agriculture: What lies ahead and who will lead it? Trends in Food Science & Technology, 127:368-376.
  • Couderc C, Laroute V, Coddeville M, Caillaud MA, Jard G, Raynaud C, Cocaign-Bousquet M, Tormo H, Daveran-Mingot ML. 2022. Harnessing diversity of Lactococcus lactis raw goat milk: design of an indigenous starter for the production of Rocamadour, a french PDO cheese. Int J Food Microbiol, 16:379:109837.
  • Daboussi F & ND Lindley. 2022. Challenges to ensure a better translation of metabolic engineering for industrial applications. Dans Methods in Molecular Biology Vol 2553, Computational Biology  and Machine Learning for Metabolic Engineering, Ed K Selvarajoo, Springer Protocols, Humana Press pp 1-20.
  • Nguyen HL, Duviau MP, Laguerre S, Nouaille S, Cocaign-Bousquet M#, Girbal L#. 2022. Synergistic regulation of transcription and translation in Escherichia coli revealed by co-directional increases in mRNA concentration and translation efficiency. Microbiology Spectrum 10(1):e0204121.
  • Roux C, Etienne TA, Hajnsdorf E, Ropers D, Carpousis AJ, Cocaign-Bousquet M#, Girbal L#. 2022. The essential role of mRNA degradation in understanding and engineering E. coli metabolism. Biotechnol. Adv. 2022 Jan-Feb;54:107805.

  • Hamouche L, Poljak L, Carpousis AJ. 2021. Ribosomal RNA degradation induced by the bacterial RNA polymerase inhibitor rifampicin. 2021 Jun 7;27(8):946–58. doi: 10.1261/rna.078776.121.
  • Hamouche L, Poljak L, Carpousis AJ. 2021.Polyribosome-Dependent Clustering of Membrane-Anchored RNA Degradosomes To Form Sites of mRNA Degradation in Escherichia coli. 2021 Oct 26;12(5):e0193221. doi: 10.1128/mBio.01932-21.
  • Pelus A, Bordes G, Barbe S, Bouchiba Y, Burnard C, Cortés J, Enjalbert B, Esque J, Estaña A, Fauré R, Henras AK, Heux S, Le Men C, Millard P, Nouaille S, Pérochon J, Toanen M, Truan G, Verdier A, Wagner C, Romeo Y, Montanier CY. 2021. A tripartite carbohydrate-binding module to functionalize cellulose nanocrystals.  Biomater Sci. 2021 Nov 9;9(22):7444-7455. doi: 10.1039/d1bm01156a.
  • Bardou P, Laguerre S, Maman Haddad S, Legoueix Rodriguez S, Laville E, Dumon C, Potocki-Veronese G, Klopp C. 2021. MINTIA: a metagenomic INserT integrated assembly and annotation tool. PeerJ 9:e11885
  • Millard P, Enjalbert B, Uttenweiler-Joseph S, Portais JC, Létisse F. 2021. Control and regulation of acetate overflow in Escherichia coli. Elife. 2021 Mar 15;10:e63661. doi: 10.7554/eLife.63661.
  • Bergès C, Cahoreau E, Millard P, Enjalbert B, Dinclaux M, Heuillet M, Kulyk H, Gales L, Butin N, Chazalviel M, Palama T, Guionnet M, Sokol S, Peyriga L, Bellvert F, Heux S, Portais JC. 2021. Exploring the Glucose Fluxotype of the E. coli y-ome Using High-Resolution Fluxomics Metabolites. 2021 Apr 26;11(5):271. doi: 10.3390/metabo11050271.
  • Laroute V, Mazzoli  R,  Loubière P, Pessione E, Cocaign-Bousquet M. 2021. Environmental conditions affecting GABA production in Lactococcus lactis NCDO 2118. 9(1):122,
  • Nebbia S, Lamberti C, Lo Bianco G, Cirrincione S, Laroute V, Cocaign-Bousquet M, Cavallarin L, Giuffrida MG, Pessione E. 2021. Antimicrobial potential of food lactic acid bacteria: bioactive peptide decrypting from caseins and bacteriocin production. Microorganisms. 9(1):65,
  • Barthe M, Tchouanti J, Henrique-Gomes P, Bideaux C, Lestrade D, Graham C, Steyer J-P, Meleard S, Harmand J, Gorret N, Cocaign-Bousquet M#, Enjalbert B#. 2020.  Availability of the molecular switch XylR controls phenotypic heterogeneity and lag duration during Escherichia coli adaptation from glucose to xylose. MBio 2020 Dec 22;11(6):e02938-20. doi: 10.1128/mBio.02938-20.
  • Caillaud M-A, Abeilhou M, Gonzalez I, Audonnet M, Gaucheron F, Cocaign-Bousquet M, Tormo H, Daveran-Mingot M-L. 2020. Precise populations’ description in dairy ecosystems using digital droplet PCR: the case of Lactococcus lactis group in starters. Front Microbiol. 11:1906,
  • Canon F, Mariadassou M, Maillard M-B, Falentin H, Parayre S, Madec M-N, Valence F, Henry G, Laroute V, Daveran-Mingot M-L, Cocaign-Bousquet M, Thierry A#, Gagnaire V#. 2020. Function driven design of lactic acid bacteria co-cultures to produce new fermented foods associating milk and lupin. Front Microbiol. 11:584163,
  • Etienne T, Cocaign-Bousquet M, Ropers D. 2020. Competitive effects in bacterial mRNA decay. Theor Biol. 504:110333, doi:10.1016/j.jtbi.2020.110333.
  • Leroy S, Even S, Micheau P, La Foye A, Laroute V, Le Loir Y, Talon R. 2020. Transcriptomic analysis of Staphylococcus xylosus in solid dairy matrix reveals an aerobic lifestyle adapted to rind. 8(11):1807,
  • Morin M, Enjalbert B, Ropers D, Girbal L, Cocaign-Bousquet M. 2020. Genome-wide stabilization of mRNA during a ‘feast-to-famine’ growth transition in Escherichia coli. mSphere 5(3):e00276-20, doi:1128/mSphere.00276-20
  • Tauzin AS, Pereira MR, Van Vliet LD, Colin PY, Laville E, Esque J, Laguerre S, Henrissat B, Terrapon N, Lombard V, Leclerc M, Doré J, Hollfelder F, Potocki-Veronese G. 2020. Investigating host-microbiome interactions by droplet based microfluidics. Microbiome. 8(1):141.
  • Nguyen TNA, V Anton-Leberre, TVA Nguyen, A-L Bañuls. Molecular Diagnosis of Drug-resistant Tuberculosis; a Literature Review. Frontiers in Microbiology, section Infectious Diseases, doi: 10.3389/fmicb.2019.00794.
  • Hadjeras L, L Poljak, M Bouvier, Q Morin-Ogier, I Canal, M Cocaign-Bousquet, L Girbal, AJ Carpousis. 2019. Detachment of the RNA degradosome from the inner membrane of Escherichia coli results in a global slowdown of mRNA degradation, proteolysis of RNase E and increased turnover of ribosome-free transcripts. Molecular Microbiology 111(6):1715-1731.
  • Nguyen HL, Duviau MP, Cocaign-Bousquet M, Nouaille S, Girbal L. 2019. Multiplexing polysome profiling experiments to study translation in Escherichia coliPLoS One. 14(2):e0212297, doi: 10.1371/journal.pone.0212297.


Debatisse K, M. Cocaign-Bousquet, P. Le Bourgeois. AttP mv4-derived site-specific recombination and its use for integration of sequence of interest. EP22305825.6 et extension PCT/EP2023/064892

Cocaign-Bousquet M, ML Daveran Mingot, V Laroute, V Theodorou, MH Eutamene, M Mercier-Bonin. Lactococcus lactis strains for the prevention and/or the treatment of visceral pain.  Patent n° WO 2020/157297 Extension PCT

Mercier-Bonin. Lactococcus lactis strains for the prevention and/or the treatment of visceral pain.  Patent EP 19 305 125.7-1112, fev2, 2019.