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Laurence GIRBAL

Laurence GIRBAL

Laurence GIRBAL

CNRS Researcher

Actual position and research subject

I am interested in genome-wide post-transcriptional regulations in bacteria and their role in the regulation of gene expression

Education and Diploma


  • Supervised or co-supervised: 8 PhD students and 3 post-doct
  • 2018-2022 : Leader of the Work-Package “ coli cell adaptation in lag phase” in the ANR RIB-ECO « Engineering RNA life cycle to optimize economy of microbial energy: application to the bioconversion of biomass-derived carbon sources».
  • 2020-2022 : Participation in the TOPs project « Translation Optimization of Protein synthesis » project funded as a pre-competitive project by Toulouse White Biotechnology
  • 2020-2022: Participation in the EcoCTs Intra-CREATE project (CNRS/National University of Singapore) « Engineering biology for a bio-inspired circular economy » in the work-package « Developping new methods for pathway design and optimization ».

List of selected publications

  • Nguyen H.L., Duviau M.P., Laguerre S., Nouaille S., Cocaign-Bousquet M., GIRBAL L. 2022. Synergistic regulation of transcription and translation in Escherichia coli revealed by co-directional increases in mRNA concentration and translation efficiency. Microbiol Spectr. 2022 Feb 9:e0204121. doi: 10.1128/spectrum.02041-21.
  • Roux C., Etienne T.A., Hajnsdorf E., Ropers D., Carpousis A.J., Cocaign-Bousquet M., GIRBAL L. 2022. The essential role of mRNA degradation in understanding and engineering E. coli metabolism. Biotechnol Adv. 2022 Jan-Feb;54:107805.
  • Morin M., Enjalbert B., Ropers D., GIRBAL L., Cocaign-Bousquet M. 2020. Genome-wide stabilization of mRNA during a ‘feast-to-famine’ growth transition in Escherichia coli. mSphere, 00276-20.
  • Hadjeras L., Poljak L., Bouvier M., Morin-Ogier Q., Canal I., Cocaign-Bousquet M., GIRBAL L., Carpousis A.J. 2019. Detachment of the RNA degradosome from the inner membrane of Escherichia coli results in a global slowdown of mRNA degradation, proteolysis of RNase E and increased turnover of ribosome-free transcripts. Molecular Microbiology, 111(6):1715-1731.
  • Nguyen H.L., Duviau M.P., Cocaign-Bousquet M., Nouaille S., GIRBAL L 2019. Multiplexing polysome profiling experiments to study translation in Escherichia coli. PLoS One, 14(2):e0212297.
  • Dressaire C., Pobre V., Laguerre S., GIRBAL L., Arraiano C.M., Cocaign-Bousquet M. 2018. PNPase is involved in the coordination of mRNA degradation and expression in stationary phase cells of Escherichia coli. BMC Genomics, 19(1):848.
  • Laguerre S., González I., Nouaille S., Moisan A., Villa-Vialaneix N., Gaspin C., Bouvier M., Carpousis A.J., Cocaign-Bousquet M., GIRBAL L. 2018. Large-scale measurement of mRNA degradation in Escherichia coli: to delay or not to delay. Methods in Enzymology, 612:47-66.
  • Nouaille S., Mondeil S., Finoux A-L., Moulis C., GIRBAL L., Cocaign-Bousquet M. 2017. The stability of an mRNA is influenced by its concentration: a potential physical mechanism to regulate gene expression. Nucleic Acids Research, 45(20):11711-11724.
  • Esquerré T., Bouvier M., Turlan C., Carpousis A.J., GIRBAL L., Cocaign-Bousquet M. 2016. The Csr system regulates genome-wide mRNA stability and transcription and thus gene expression in Escherichia coli. Scientific Reports, 6:25057.
  • Esquerré T., Moisan A., Chiapello H., Arike L., Vilu R., Gaspin C., Cocaign-Bousquet M., GIRBAL L. 2015. Genome-wide investigation of mRNA lifetime determinants in Escherichia coli cells cultured at different growth rates. BMC Genomics, 16:275.
  • Saulou-Bérion C., Gonzalez I., Enjalbert B., Audinot J.N., Fourquaux I., Jamme F., Cocaign-Bousquet M., Mercier-Bonin M., GIRBAL L. 2015. Escherichia coli under ionic silver stress: an integrative approach to explore transcriptional, physiological and biochemical responses. PLoS One, Dec 22;10(12):e0145748.
  • Esquerré T., Laguerre S., Turland C., Carpousis A.J., GIRBAL L., Cocaign−Bousquet M. 2014. Dual role of transcription and transcript stability in the regulation of gene expression in Escherichia coli cells cultured on glucose at different growth rates. Nucleic acids research, 42:2460−2472.
  • Racle J., Picard F., GIRBAL L., Cocaign−Bousquet M., Hatzimanikatis V. 2013. A genome−scale integration and analysis of Lactococcus lactis translation data. PLoS Comput Biol. 9(10): e1003240.
  • Dressaire C., Picard F., Redon E., Loubière P., Queinnec I., GIRBAL L. and Cocaign−Bousquet M. 2013. Role of mRNA stability during bacterial adaptation. PloS One, 8(3):e59059.
  • Picard F., Loubière P., GIRBAL L., Cocaign−Bousquet M. 2013. The significance of translation regulation in the stress response. BMC Genomics, 14:588.
  • Picard F., Milhem H., Loubière P., Laurent B., Cocaign-Bousquet M., GIRBAL L. 2012. Bacterial translational regulations: high diversity between all mRNAs and major role in gene expression. BMC Genomics, 13:528.