{"id":17853,"date":"2026-07-16T09:27:39","date_gmt":"2026-07-16T07:27:39","guid":{"rendered":"https:\/\/www.toulouse-biotechnology-institute.fr\/?p=17853"},"modified":"2026-10-08T14:54:15","modified_gmt":"2026-10-08T12:54:15","slug":"projet-calipso-un-premier-bilan-detape-valide-pour-la-biotech-francaise-et-la-chimie-verte","status":"publish","type":"post","link":"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/projet-calipso-un-premier-bilan-detape-valide-pour-la-biotech-francaise-et-la-chimie-verte\/","title":{"rendered":"The CALIPSO project: an initial progress report approved for the French biotech and green chemistry sectors"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"17853\" class=\"elementor elementor-17853\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7f65be5 e-flex e-con-boxed e-con e-parent\" data-id=\"7f65be5\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-70d90bb elementor-widget elementor-widget-text-editor\" data-id=\"70d90bb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<strong><em>Toulouse and Susville, July 2026<\/em><\/strong> <br> <br>\n\nTwo years after its launch, the CALIPSO project has successfully completed its first key milestone, validated by ADEME. Led by Naturamole in collaboration with the <em>Toulouse Biotech Alley<\/em> ecosystem (the Toulouse Biotechnology Institute (TBI) and Toulouse White Biotechnology (TWB) laboratories, as well as CRITT Bio-Industries) based on the INSA Toulouse campus, this project aims to replace traditional chemistry with environmentally responsible enzymatic processes. <br> <br>\n\n<strong>Towards the production of natural esters for industry<\/strong> <br>\n <br>\nCALIPSO aims to accelerate the energy transition in the chemical industry through the development of continuous enzymatic catalysis processes for the production of eight natural functional esters \u2013 high value-added molecules used in the agri-food, perfumery and cosmetics sectors. These alternative processes will contribute to the carbon neutrality target set for 2050, for which there is a vital need across Europe for industrial solutions that are high-performing, resilient, competitive and environmentally sound. <br> <br>\n\nOver the course of two years, the project team has turned its ambitions into tangible successes through three major achievements:\n<ul>\n \t<li><strong>The discovery of new biocatalysts:<\/strong> Using a bioinformatics approach, nearly 200 new enzymes derived from biodiversity were rigorously selected and then tested. For 7 of the 8 target esters, at least one enzyme capable of synthesising them was identified, whereas the scientific literature had previously reported no enzymatic solution for the majority of these molecules.<\/li>\n \t<li><strong>Robust and industrially scalable \u2018cellular factories\u2019:<\/strong> Four promising microorganisms have been selected as future systems for the industrial production of these innovative enzymes. The genetic engineering tools required to optimise them have already been developed, validated and are ready for deployment.<\/li>\n \t<li><strong>90 per cent attachment efficiency:<\/strong> The foundations for the enzyme immobilisation process have been laid. Of the 12 carriers tested, the best ones achieve a yield of nearly 90 per cent whilst preserving the enzyme\u2019s activity.<\/li>\n<\/ul> <br> <br>\n<strong>Moving on to Phase 2: industrial optimisation<\/strong>\n\nEverything is on track! The consortium is now moving into the second phase of the project, which focuses on engineering the selected enzymes to maximise their performance, ahead of the final assembly of all the technological building blocks in preparation for their industrial roll-out.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-757f6e9 e-flex e-con-boxed e-con e-parent\" data-id=\"757f6e9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5e7f6f7 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"5e7f6f7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-746179a elementor-position-inline-start elementor-view-default elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"746179a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-star\" viewbox=\"0 0 576 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M528.1 171.5L382 150.2 316.7 17.8c-11.7-23.6-45.6-23.9-57.4 0L194 150.2 47.9 171.5c-26.2 3.8-36.7 36.1-17.7 54.6l105.7 103-25 145.5c-4.5 26.3 23.2 46 46.4 33.7L288 439.6l130.7 68.7c23.2 12.2 50.9-7.4 46.4-33.7l-25-145.5 105.7-103c19-18.5 8.5-50.8-17.7-54.6zM388.6 312.3l23.7 138.4L288 385.4l-124.3 65.3 23.7-138.4-100.6-98 139-20.2 62.2-126 62.2 126 139 20.2-100.6 98z\"><\/path><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h2 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tAbout CALIPSO\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h2>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tLaunched in March 2024, CALIPSO (Development of new continuous production routes for aromatic esters using optimised lipases) is a four-year collaborative project, with funding of 4.2 million euros, managed by ADEME as part of the France 2030 investment plan.\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-24847f0 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"24847f0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-71d4f4b elementor-position-inline-start elementor-view-default elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"71d4f4b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-user-circle\" viewbox=\"0 0 496 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M248 104c-53 0-96 43-96 96s43 96 96 96 96-43 96-96-43-96-96-96zm0 144c-26.5 0-48-21.5-48-48s21.5-48 48-48 48 21.5 48 48-21.5 48-48 48zm0-240C111 8 0 119 0 256s111 248 248 248 248-111 248-248S385 8 248 8zm0 448c-49.7 0-95.1-18.3-130.1-48.4 14.9-23 40.4-38.6 69.6-39.5 20.8 6.4 40.6 9.6 60.5 9.6s39.7-3.1 60.5-9.6c29.2 1 54.7 16.5 69.6 39.5-35 30.1-80.4 48.4-130.1 48.4zm162.7-84.1c-24.4-31.4-62.1-51.9-105.1-51.9-10.2 0-26 9.6-57.6 9.6-31.5 0-47.4-9.6-57.6-9.6-42.9 0-80.6 20.5-105.1 51.9C61.9 339.2 48 299.2 48 256c0-110.3 89.7-200 200-200s200 89.7 200 200c0 43.2-13.9 83.2-37.3 115.9z\"><\/path><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h2 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tContact Presse\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h2>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\t- Guillaume Lepage, Naturamole, Susville. https:\/\/www.naturamole-green.com\/ <br>\n\n- Sophie Bozonnet, TBI, INSA Toulouse<br>\n\n- Carine Saux, CRITT BioIndustries, Toulouse<br>\n\n- Julieta Cabello, TWB, Toulouse\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Toulouse et Susville, juillet 2026 Deux ans apr\u00e8s son lancement, le projet CALIPSO franchit avec succ\u00e8s sa premi\u00e8re \u00e9tape cl\u00e9, valid\u00e9e par l\u2019ADEME. Port\u00e9 par la soci\u00e9t\u00e9 Naturamole en synergie avec l\u2019\u00e9cosyst\u00e8me de la Toulouse Biotech Alley (les laboratoires Toulouse Biotechnology Institute (TBI) et Toulouse White Biotechnology (TWB) ainsi que le CRITT Bio-Industries) situ\u00e9 sur [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":17863,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12],"tags":[35],"class_list":["post-17853","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-resultat-scientifique","tag-equipe-cimes"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Projet CALIPSO : un premier bilan d&#039;\u00e9tape valid\u00e9 pour la biotech fran\u00e7aise et la chimie verte | TBI, Toulouse Biotechnology Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/projet-calipso-un-premier-bilan-detape-valide-pour-la-biotech-francaise-et-la-chimie-verte\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Projet CALIPSO : un premier bilan d&#039;\u00e9tape valid\u00e9 pour la biotech fran\u00e7aise et la chimie verte | TBI, Toulouse Biotechnology Institute\" \/>\n<meta property=\"og:description\" content=\"Toulouse et Susville, juillet 2026 Deux ans apr\u00e8s son lancement, le projet CALIPSO franchit avec succ\u00e8s sa premi\u00e8re \u00e9tape cl\u00e9, valid\u00e9e par l\u2019ADEME. Port\u00e9 par la soci\u00e9t\u00e9 Naturamole en synergie avec l\u2019\u00e9cosyst\u00e8me de la Toulouse Biotech Alley (les laboratoires Toulouse Biotechnology Institute (TBI) et Toulouse White Biotechnology (TWB) ainsi que le CRITT Bio-Industries) situ\u00e9 sur [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/projet-calipso-un-premier-bilan-detape-valide-pour-la-biotech-francaise-et-la-chimie-verte\/\" \/>\n<meta property=\"og:site_name\" content=\"TBI, Toulouse Biotechnology Institute\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/TBI-Toulouse-Biotechnology-Institute-Bio-Chemical-Engineering-360428497952306\" \/>\n<meta property=\"article:published_time\" content=\"2026-07-16T07:27:39+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-10-08T12:54:15+00:00\" \/>\n<meta property=\"og:image\" 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