{"id":15235,"date":"2024-11-21T14:29:05","date_gmt":"2024-11-21T13:29:05","guid":{"rendered":"https:\/\/www.toulouse-biotechnology-institute.fr\/?p=15235"},"modified":"2024-11-21T14:36:22","modified_gmt":"2024-11-21T13:36:22","slug":"evolution-darwinienne-de-ladn-auto-replique-dans-une-proto-cellule-synthetique","status":"publish","type":"post","link":"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/evolution-darwinienne-de-ladn-auto-replique-dans-une-proto-cellule-synthetique\/","title":{"rendered":"Darwinian Evolution of Self-Replicating DNA in a Synthetic Protocell"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"15235\" class=\"elementor elementor-15235\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4edccf3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4edccf3\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3a73d87\" data-id=\"3a73d87\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ea71e10 elementor-widget elementor-widget-text-editor\" data-id=\"ea71e10\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The emergence of life on earth was only possible after the appearance of a genetic replicator capable of evolving. The group led by Christophe Danelon at TBI and the University of Delft (Netherlands) has developed a synthetic cell that produces proteins from self-replicating DNA. The system evolves by fixing mutations that confer a replicative advantage in a population of genetic variants, mimicking the principles of natural selection. The creation of an autonomous synthetic cell will require the integration of essential genes into this minimal self-replicator. These results were published in Nature Communications.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4da3305 elementor-widget elementor-widget-button\" data-id=\"4da3305\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/doi.org\/10.1038\/s41467-024-53226-0\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Read the article<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-55dc8a4 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"55dc8a4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-305714b elementor-position-inline-start elementor-view-default elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"305714b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1038\/s41467-024-53226-0\" target=\"_blank\" class=\"elementor-icon\" tabindex=\"-1\" aria-label=\"References\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-star\"><\/i>\t\t\t\t<\/a>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h2 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<a href=\"https:\/\/doi.org\/10.1038\/s41467-024-53226-0\" target=\"_blank\" >\n\t\t\t\t\t\t\tReferences\t\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/h2>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tAbil, Z., Restrepo Sierra, A.M., Stan, A.R. et al. Darwinian Evolution of Self-Replicating DNA in a Synthetic Protocell. Nat Commun 15, 9091 (2024). https:\/\/doi.org\/10.1038\/s41467-024-53226-0\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a29f958 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"a29f958\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-283ded7 elementor-position-inline-start elementor-view-default elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"283ded7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<a href=\"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/christophe-danelon\/\" target=\"_blank\" class=\"elementor-icon\" tabindex=\"-1\" aria-label=\"Contact \">\n\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-user-circle\"><\/i>\t\t\t\t<\/a>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h2 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<a href=\"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/christophe-danelon\/\" target=\"_blank\" >\n\t\t\t\t\t\t\tContact \t\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/h2>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tChristophe DANELON\n\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0980ef8 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"0980ef8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cae5a17 elementor-widget elementor-widget-text-editor\" data-id=\"cae5a17\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>L\u00e9gende de la photo : Image de microscopie \u00e0 fluorescence de protocellules artificielles qui synth\u00e9tisent des prot\u00e9ines et r\u00e9pliquent leur mat\u00e9riel g\u00e9n\u00e9tique (ici en vert).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>L&#8217;\u00e9mergence de la vie sur terre n&#8217;a \u00e9t\u00e9 possible qu&#8217;apr\u00e8s l&#8217;apparition d&#8217;un r\u00e9plicateur g\u00e9n\u00e9tique capable d&#8217;\u00e9voluer. Le groupe dirig\u00e9 par Christophe Danelon \u00e0 TBI et \u00e0 l&#8217;universit\u00e9 de Delft (Pays-Bas) a d\u00e9velopp\u00e9 une cellule synth\u00e9tique qui produit des prot\u00e9ines \u00e0 partir d&#8217;un ADN auto-r\u00e9plicatif. Le syst\u00e8me \u00e9volue par fixation de mutations qui conf\u00e8rent un avantage [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":15236,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12],"tags":[36],"class_list":["post-15235","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-resultat-scientifique","tag-equipe-i2m"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u00c9volution darwinienne de l&#039;ADN auto-r\u00e9pliqu\u00e9 dans une proto-cellule synth\u00e9tique | TBI, Toulouse Biotechnology Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/evolution-darwinienne-de-ladn-auto-replique-dans-une-proto-cellule-synthetique\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c9volution darwinienne de l&#039;ADN auto-r\u00e9pliqu\u00e9 dans une proto-cellule synth\u00e9tique | TBI, Toulouse Biotechnology Institute\" \/>\n<meta property=\"og:description\" content=\"L&#8217;\u00e9mergence de la vie sur terre n&#8217;a \u00e9t\u00e9 possible qu&#8217;apr\u00e8s l&#8217;apparition d&#8217;un r\u00e9plicateur g\u00e9n\u00e9tique capable d&#8217;\u00e9voluer. Le groupe dirig\u00e9 par Christophe Danelon \u00e0 TBI et \u00e0 l&#8217;universit\u00e9 de Delft (Pays-Bas) a d\u00e9velopp\u00e9 une cellule synth\u00e9tique qui produit des prot\u00e9ines \u00e0 partir d&#8217;un ADN auto-r\u00e9plicatif. Le syst\u00e8me \u00e9volue par fixation de mutations qui conf\u00e8rent un avantage [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/evolution-darwinienne-de-ladn-auto-replique-dans-une-proto-cellule-synthetique\/\" \/>\n<meta property=\"og:site_name\" content=\"TBI, Toulouse Biotechnology Institute\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/TBI-Toulouse-Biotechnology-Institute-Bio-Chemical-Engineering-360428497952306\" \/>\n<meta property=\"article:published_time\" content=\"2024-11-21T13:29:05+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-11-21T13:36:22+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.toulouse-biotechnology-institute.fr\/wp-content\/uploads\/2024\/11\/Picture1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"602\" \/>\n\t<meta property=\"og:image:height\" content=\"445\" \/>\n\t<meta property=\"og:image:type\" 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