{"id":14774,"date":"2024-07-19T10:09:01","date_gmt":"2024-07-19T08:09:01","guid":{"rendered":"https:\/\/www.toulouse-biotechnology-institute.fr\/?p=14774"},"modified":"2024-11-28T15:01:38","modified_gmt":"2024-11-28T14:01:38","slug":"biodegradation-controlee-du-pla","status":"publish","type":"post","link":"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/biodegradation-controlee-du-pla\/","title":{"rendered":"[Nature Publication] Biod\u00e9gradation contr\u00f4l\u00e9e du PLA par incorporation d\u2019une enzyme optimis\u00e9e"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"14774\" class=\"elementor elementor-14774\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e1591cc elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e1591cc\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-93a67f8\" data-id=\"93a67f8\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8073225 elementor-widget elementor-widget-text-editor\" data-id=\"8073225\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>The Toulouse Biotechnology Institute (TBI), a joint INSA Toulouse\/ INRAE\/ CNRS research unit, and Carbios, <\/strong><strong>a French green chemistry company pioneering the world of bioplasturgy, <\/strong><strong>publish this Wednesday <\/strong><strong>July 17, 2024,<\/strong><strong> in the online version of the journal Nature, a scientific article <\/strong><strong>entitled \u201d\u00a0<\/strong><strong><em>An engineered enzyme embedded into PLA to make self-biodegradable plastic<\/em><\/strong><strong>\u00a0\u00bb (<\/strong><a href=\"https:\/\/www.nature.com\/articles\/s41586-024-07709-1\">https:\/\/www.nature.com\/articles\/s41586-024-07709-1<\/a><strong>). This study reinforces Carbios and TBI's pioneering work in the field of enzymatic degradation of plastics, which had already led to an article published in April 2020 on the enzymatic depolymerization of PET (<\/strong><a href=\"https:\/\/www.nature.com\/articles\/s41586-020-2149-4\">https:\/\/www.nature.com\/articles\/s41586-020-2149-4<\/a><strong>).<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cc60907 elementor-widget elementor-widget-text-editor\" data-id=\"cc60907\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>This work describes the engineering strategies deployed to ensure the development of an enzyme capable of biologically depolymerizing polylactic acid (PLA)-based plastic materials over a wide temperature and pH range, reflecting the natural variations found in the life cycle of domestic compost.<\/p><p>This study also describes the methodologies and challenges involved in obtaining homogeneous incorporation of the enzyme into PLA films at high temperatures (170\u00b0C), while retaining sufficient activity to enable the plastic produced to degrade completely and rapidly under domestic and industrial composting conditions, as well as in anaerobic digestion (methanization). The article highlights the optimization process used to obtain an enzyme capable of withstanding the 170\u00b0C required to melt it into PLA by extrusion. The new enzymatic material is shown to disintegrate and biodegrade at a much faster rate than the 26 weeks required for certification for use in home composting, and also to help produce more biomethane, another source of waste recovery. It is also stated that the enzymatic material remains intact during long-term storage, and that its degradation will only be activated when transferred to composting or methanization conditions, thus guaranteeing its compatibility with PLA-based commercial applications such as flexible packaging or short-life items like food containers.<\/p><p><em>This work was mainly carried out within the INSA\/Carbios PoPlaB (Polymers, Plastics and Biotechnology) cooperative laboratory at TBI and was supported by a grant for scientific research (THANAPLAST project, OSEO ISI contract number I 1206040W).<\/em><\/p><p>To consult this publication, go to the Nature website from July 17, 2024 5pm (Paris time):<\/p><p><a href=\"https:\/\/www.nature.com\/articles\/s41586-024-07709-1\">https:\/\/www.nature.com\/articles\/s41586-024-07709-1<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0871571 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0871571\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-491f04b\" data-id=\"491f04b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-46329c0 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"46329c0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d7f6a1b elementor-position-inline-start elementor-view-default elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"d7f6a1b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1038\/s41586-024-07709-1\" class=\"elementor-icon\" tabindex=\"-1\" aria-label=\"References\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-star\"><\/i>\t\t\t\t<\/a>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h2 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<a href=\"https:\/\/doi.org\/10.1038\/s41586-024-07709-1\" >\n\t\t\t\t\t\t\tReferences\t\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/h2>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tGuicherd, M., Ben Khaled, M., Gu\u00e9roult, M. et al. An engineered enzyme embedded into PLA to make self-biodegradable plastic. Nature (2024). https:\/\/doi.org\/10.1038\/s41586-024-07709-1\n\n\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-739e86b elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"739e86b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6d6193a elementor-position-inline-start elementor-view-default elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"6d6193a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-user-circle\"><\/i>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h2 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tContact \t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h2>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tAlain Marty, Scientific Director, Carbios<br> alain.marty@carbios.com<br><br>\nIsabelle Andr\u00e9, CNRS Research Director, TBI<br> isabelle.andre@insa-toulouse.fr\n\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e571d23 elementor-widget elementor-widget-button\" data-id=\"e571d23\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.carbios.com\/newsroom\/une-nouvelle-publication-dans-nature-confirme-lavance-de-carbios-dans-la-degradation-enzymatique-du-plastique\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">CARBIOS press release<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e423c83 elementor-widget elementor-widget-button\" data-id=\"e423c83\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.insis.cnrs.fr\/fr\/cnrsinfo\/plastiques-un-acide-polylactique-biodegradable-en-composteur-domestique\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Read the article on CNRS INSIS<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b4f3af0 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b4f3af0\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a24cfa5\" data-id=\"a24cfa5\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2bd8927 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"2bd8927\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2569459 elementor-widget elementor-widget-heading\" data-id=\"2569459\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Press review<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-82550c8 elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"82550c8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.radiofrance.fr\/francebleu\/podcasts\/planete-bleu-france-bleu-occitanie\/planete-bleu-occitanie-des-chercheurs-toulousains-trouvent-comment-composter-du-plastique-1366310\" target=\"_blank\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-circle\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">France Bleu - Plan\u00e8te Bleu Occitanie : des chercheurs toulousains trouvent comment composter du plastique<\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.esrf.fr\/home\/news\/general\/content-news\/general\/new-enzyme-embedded-plastic-degrades-rapidly-in-home-compost.html\" target=\"_blank\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-circle\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">www.esrf.fr \uff5c New enzyme-embedded plastic degrades rapidly, overcoming current obstacles<\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e7914f7 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"e7914f7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Le Toulouse Biotechnology Institute (TBI), Unit\u00e9 mixte de recherche INSA Toulouse\/ INRAE\/ CNRS, et la soci\u00e9t\u00e9 Carbios, soci\u00e9t\u00e9 fran\u00e7aise de chimie verte pionni\u00e8re dans le monde de la bioplasturgie, publient ce mercredi 17 Juillet 2024, dans la version en ligne de la revue Nature, un article scientifique intitul\u00e9 \u00ab\u00a0An engineered enzyme embedded into PLA to [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":14775,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12],"tags":[35],"class_list":["post-14774","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-resultat-scientifique","tag-equipe-cimes"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>[Nature Publication] Biod\u00e9gradation contr\u00f4l\u00e9e du PLA par incorporation d\u2019une enzyme optimis\u00e9e | TBI, Toulouse Biotechnology Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/biodegradation-controlee-du-pla\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta 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