{"id":14387,"date":"2024-05-02T16:25:55","date_gmt":"2024-05-02T14:25:55","guid":{"rendered":"https:\/\/www.toulouse-biotechnology-institute.fr\/?p=14387"},"modified":"2024-07-19T10:12:40","modified_gmt":"2024-07-19T08:12:40","slug":"ocssigen-atteindre-les-niches-metabolomiques-grace-a-la-miniaturisation-des-experiences-de-rmn-1d-du-proton","status":"publish","type":"post","link":"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/ocssigen-atteindre-les-niches-metabolomiques-grace-a-la-miniaturisation-des-experiences-de-rmn-1d-du-proton\/","title":{"rendered":"Atteindre les niches m\u00e9tabolomiques gr\u00e2ce \u00e0 la miniaturisation d’exp\u00e9riences de RMN"},"content":{"rendered":"
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Through the OCSSIGEN project (Offre de Comp\u00e9tences et de Services pour la Sant\u00e9 et l'Innovation sur les plateformes Genotoul) funded by the Occitanie Region as part of the European REACT-EU recovery plan, TBI's MetaToul-FluxoMet platform has been able to strengthen its research and innovation potential in the field of NMR metabolomics. In 2022, it received a new-generation nuclear magnetic resonance console to drive its 800 MHz cryomagnet.<\/strong><\/p>

Ce nouvel \u00e9quipement coupl\u00e9 \u00e0 une micro-cryosonde permet d\u2019acc\u00e9l\u00e9rer les profilages de m\u00e9tabolites tout en augmentant la sensibilit\u00e9 et en parall\u00e9lisant les acquisitions.\u00a0Le spectrom\u00e8tre RMN 800 MHz, situ\u00e9 sur le site INSA TBI, est d\u00e9di\u00e9 \u00e0 l\u2019analyse fonctionnelle du m\u00e9tabolisme\u00a0\u00e0 l\u2019\u00e9chelle cellulaire, tissulaire ou d\u2019organismes plus complexes. Ce dispositif technique, unique en r\u00e9gion, est\u00a0utilis\u00e9 et d\u00e9velopp\u00e9 dans le cadre de ce projet, dans un contexte de biotechnologie et de sant\u00e9 humaine,\u00a0pour des approches de profilage m\u00e9tabolique quantitatif et de profilage isotopique (13C). L’objectif \u00e9tant de porposer \u00e0 la communaut\u00e9 scientifique de nouveaux services avec l’analyse potentielle de nouvelles niches biologique (type et\/ou quantit\u00e9 de matrices) et d\u2019augmenter ainsi le d\u00e9bit d\u2019analyse et la quantit\u00e9 d\u2019information r\u00e9colt\u00e9e sur un m\u00eame \u00e9chantillon<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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La spectroscopie RMN est utilis\u00e9e en m\u00e9tabolomique notamment pour la richesse des informations qu’elle fournit, sa robustesse et son caract\u00e8re quantitatif. En revanche, son manque de sensibilit\u00e9 est un frein \u00e0 son utilisation pour des \u00e9chantillons limit\u00e9s en quantit\u00e9. Cela remet en cause son utilisation pour des \u00e9tudes cin\u00e9tiques sur des quantit\u00e9s faibles de cellules, et surtout si l’on pr\u00e9voit une analyse multi-omique. Tr\u00e8s souvent, ces \u00e9chantillons doivent \u00eatre dilu\u00e9s et les exp\u00e9riences doivent \u00eatre prolong\u00e9es pour accumuler une quantit\u00e9 suffisante de signal, ce qui n’est pas souhaitable pour une analyse \u00e0 haut d\u00e9bit. L’utilisation de microsondes avec des tubes RMN de 1,7 mm pourrait permettre l’analyse \u00e0 haut d\u00e9bit de petites quantit\u00e9s d’\u00e9chantillons avec une dilution limit\u00e9e, ainsi que la r\u00e9alisation d’\u00e9tudes multi-omique afin de r\u00e9pondre au besoin d’\u00e9tude de population h\u00e9t\u00e9rog\u00e8ne, d’holobiontes ou encore d’etudes de grand nombre de variants g\u00e9n\u00e9tiques, cultiv\u00e9s dans de faibles volumes.<\/p>

\u00a0<\/p>

Des exp\u00e9riences RMN de moins de 10 minutes sur diff\u00e9rentes matrices biologiques (E.Coli, S.Cerevisiae) ont montr\u00e9 une augmentation de la sensibilit\u00e9 pour des quantit\u00e9s limit\u00e9es de surnageant de culture (25 \u00b5L) et d’extrait de cellules (1 \u00e0 5 mL \u00e0 DO 1) avec des tubes de 1,7 mm utilis\u00e9s dans des microsondes par rapport \u00e0 des tubes conventionnels de 3 mm utilis\u00e9s dans des sondes de 5 mm.<\/p>

Les r\u00e9sultats de ces exp\u00e9riences confirment que lorsque les quantit\u00e9s d’\u00e9chantillons sont limit\u00e9es, la miniaturisation offre de r\u00e9els avantages qui ouvrent en outre la possibilit\u00e9 d’analyser de petites quantit\u00e9 d’\u00e9chantillon avec la spectroscopie RMN.<\/p>

\u00a0<\/p>

Les perspectives de ce d\u00e9veloppement seraient autour de la mise en pratique des protocoles et des analyses sur des probl\u00e9matique d’\u00e9tude d’\u00e9cosyst\u00e8me cellulaire pour appr\u00e9hender le dialogue m\u00e9taboliques entres diff\u00e9rentes cellules\/souches dans les compartiments extracellulaire, compl\u00e9mentairement \u00e0 ce qui est en cours de d\u00e9volppement sur la plateforme MetaToul-FluxoMet autour du single cell, de la m\u00e9tabolomique en temps r\u00e9el et de l’imagerie par spectrom\u00e9trie de masse.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\n\t\t\t\t\t\tMason S, Terburgh K, Louw R. Miniaturized 1H-NMR method for analyzing limited-quantity samples applied to a mouse model of Leigh disease. Metabolomics. 2018 May 21;14(6):74. \nFratila RM, Velders AH. Small-volume nuclear magnetic resonance spectroscopy. Annu Rev Anal Chem (Palo Alto Calif). 2011;4:227-49. \t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\tM.Maravat - Conf\u00e9rence orale \u00e0 la journ\u00e9e G\u00e9notoul - D\u00e9cembre 2022\nM. Maravat & al - Communication poster au 15 JS du RFMF Mai 2023 Perpignan\n\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tContact TBI\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t

\n\t\t\t\t\t\tLindsay Peyriga & Marion Maravat\npeyriga@insa-toulouse.fr, maravat@insa-toulouse.fr\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

\u00c0 travers le projet OCSSIGEN (Offre de Comp\u00e9tences et de Services pour la Sant\u00e9 et l\u2019Innovation sur les\u00a0plateformes Genotoul) financ\u00e9 par la R\u00e9gion Occitanie dans le cadre du plan de relance europ\u00e9en REACT-EU,\u00a0la plateforme MetaToul-FluxoMet de TBI, a pu renforcer son potentiel de\u00a0recherche et d\u2019innovation dans le domaine de la m\u00e9tabolomique par RMN. Elle a […]<\/p>\n","protected":false},"author":1,"featured_media":14388,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12],"tags":[32],"class_list":["post-14387","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-resultat-scientifique","tag-metatoul"],"yoast_head":"\nAtteindre les niches m\u00e9tabolomiques gr\u00e2ce \u00e0 la miniaturisation d'exp\u00e9riences de RMN | TBI, Toulouse Biotechnology Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/ocssigen-atteindre-les-niches-metabolomiques-grace-a-la-miniaturisation-des-experiences-de-rmn-1d-du-proton\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Atteindre les niches m\u00e9tabolomiques gr\u00e2ce \u00e0 la miniaturisation d'exp\u00e9riences de RMN | TBI, Toulouse Biotechnology Institute\" \/>\n<meta property=\"og:description\" content=\"\u00c0 travers le projet OCSSIGEN (Offre de Comp\u00e9tences et de Services pour la Sant\u00e9 et l\u2019Innovation sur les\u00a0plateformes Genotoul) financ\u00e9 par la R\u00e9gion Occitanie dans le cadre du plan de relance europ\u00e9en REACT-EU,\u00a0la plateforme MetaToul-FluxoMet de TBI, a pu renforcer son potentiel de\u00a0recherche et d\u2019innovation dans le domaine de la m\u00e9tabolomique par RMN. Elle a […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/ocssigen-atteindre-les-niches-metabolomiques-grace-a-la-miniaturisation-des-experiences-de-rmn-1d-du-proton\/\" \/>\n<meta property=\"og:site_name\" content=\"TBI, Toulouse Biotechnology Institute\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/TBI-Toulouse-Biotechnology-Institute-Bio-Chemical-Engineering-360428497952306\" \/>\n<meta property=\"article:published_time\" content=\"2024-05-02T14:25:55+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-07-19T08:12:40+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.toulouse-biotechnology-institute.fr\/wp-content\/uploads\/2024\/05\/IMG_4078.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"900\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" 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