{"id":13885,"date":"2023-12-13T10:48:59","date_gmt":"2023-12-13T09:48:59","guid":{"rendered":"https:\/\/www.toulouse-biotechnology-institute.fr\/?p=13885"},"modified":"2023-12-13T11:05:31","modified_gmt":"2023-12-13T10:05:31","slug":"soutance-de-these-de-romain-launay","status":"publish","type":"post","link":"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/soutance-de-these-de-romain-launay\/","title":{"rendered":"PhD Defence Romain Launay"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"13885\" class=\"elementor elementor-13885\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-df92101 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"df92101\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6a4a533\" data-id=\"6a4a533\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5fe1a7e elementor-widget elementor-widget-text-editor\" data-id=\"5fe1a7e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The thesis defense will take place on Wednesday, December 20 at 9am in the meeting rooms 400-401 of TBI.<\/p><p>Intitul\u00e9e : \u00ab\u00a0Caract\u00e9risation et compr\u00e9hension d&rsquo;assemblages prot\u00e9iques: le cas du m\u00e9tabolon Ubi de Escherichia coli impliqu\u00e9 dans la biosynth\u00e8se de l&rsquo;ubiquinone\u00a0\u00bb et sera d\u00e9fendue en fran\u00e7ais.<\/p><p>\u00a0<\/p><p>Jury composition:<\/p><ul><li>Mme Isabelle Callebaut, Directrice de Recherche CNRS, Rapporteur<\/li><li>Manuel Dauchez, Professeur Universit\u00e9 de Reims-Champagne Ardenne, Rapporteur<\/li><li>Mme Catherine Etchebest, Professeure Universit\u00e9 Paris Cit\u00e9, Examinatrice<\/li><li>Rapha\u00ebl Guerois, Directeur de Recherche CEA, Examinateur<\/li><li>Fabien Pierrel,Directeur de Recherche CNRS, Membre invit\u00e9<\/li><li>Mme Isabelle Andr\u00e9, Directrice de Recherche CNRS, Directrice de th\u00e8se<\/li><li>J\u00e9r\u00e9my Esque, Ing\u00e9nieur de Recherche INRAe, Co-directeur de th\u00e8se<\/li><\/ul><p>\u00a0<\/p><p>Abstract:<br \/>Protein-protein interactions (PPIs) and supramolecular assemblies are essential for the functions of living cells. They play an important role in various biological functions, such as signal transduction, cell-cell communication, transcription, replication and membrane transport. Determining and characterizing such interfaces remains a challenge in structural biology. However, advances in the development of computational methods and the power of the computing resources available today have led to a considerable improvement in the accuracy of in silico predictions of three-dimensional models of protein assemblies.<br \/>In this thesis, the aim was to predict the structure of a supramolecular assembly, called the Ubi metabolon, involved in the ubiquinone (UQ8) biosynthesis pathway in Escherichia coli. Ubiquinone is a prenol with oxido-reducing properties, localized in membranes, and highly conserved throughout evolution but also in different cells of organisms. It is composed of two main parts, an aromatic group with oxido-reducing properties, known as quinone or polar head, and a polyisoprenoid tail which is hydrophobic in nature. In this study, we are interested in the final stages of the biosynthetic pathway, in particular the modifications (methylations and hydroxylations) of the polar head. These reactions take place within the Ubi metabolon. The latter is made up of seven different proteins (UbiE, UbiG, UbiF, UbiH, UbiI, UbiJ, UbiK) catalysing six consecutive enzymatic reactions.<br \/>Dans ce travail, nous avons cherch\u00e9 \u00e0 pr\u00e9dire la structure du m\u00e9tabolon et nous avons ainsi \u00e9t\u00e9 capable de proposer un sous-ensemble prot\u00e9ique que nous avons nomm\u00e9 \u00ab\u00a0sous-unit\u00e9 centrale\u00a0\u00bb. Cette sous-unit\u00e9 comprend l\u2019ensemble des partenaires et pourrait \u00eatre biologiquement fonctionnelle. En parall\u00e8le, une \u00e9tude a \u00e9t\u00e9 men\u00e9e sur l\u2019h\u00e9t\u00e9rotrim\u00e8re UbiJ-UbiK2, une brique mol\u00e9culaire essentielle du m\u00e9tabolon Ubi. Un mod\u00e8le tri-dimensionnel de UbiJ-UbiK2 a \u00e9t\u00e9 propos\u00e9. A l\u2019aide d\u2019une \u00e9tude par mod\u00e9lisation multi-\u00e9chelles, il a pu \u00eatre montr\u00e9 qu\u2019il pouvait \u00eatre impliqu\u00e9 dans le relargage de l\u2019ubiquinone au sein des membranes. Enfin, la derni\u00e8re partie de ce travail a port\u00e9 sur l\u2019\u00e9tude du comportement d\u2019une famille particuli\u00e8re d\u2019enzymes, les mono-oxyg\u00e9nases \u00e0 flavine de classe A, \u00e0 laquelle appartiennent UbiF, UbiH et UbiI. Une \u00e9tude comparative entre une enzyme mod\u00e8le de cette famille enzymatique, appel\u00e9e PHBH, et UbiI a \u00e9t\u00e9 r\u00e9alis\u00e9e et concluant \u00e0 la n\u00e9cessit\u00e9 d\u2019interactions avec des partenaires, permettant de stabiliser ces prot\u00e9ines au sein du m\u00e9tabolon Ubi.<br \/>Taken together, this work and the proposed hypotheses provide a new insight into the supramolecular organization of the Ubi metabolon, both structurally and functionally. Our results open up new prospects for their experimental study.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>December 20th, 2023<\/p>","protected":false},"author":1,"featured_media":13886,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10,75],"tags":[35],"class_list":["post-13885","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-evenement","category-soutenance","tag-equipe-cimes"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Soutenance de th\u00e8se de Romain Launay | TBI, Toulouse Biotechnology Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link 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