{"id":12504,"date":"2023-06-01T14:50:36","date_gmt":"2023-06-01T12:50:36","guid":{"rendered":"https:\/\/www.toulouse-biotechnology-institute.fr\/?p=12504"},"modified":"2023-06-01T14:52:30","modified_gmt":"2023-06-01T12:52:30","slug":"une-bacterie-capable-de-diminuer-la-douleur-viscerale","status":"publish","type":"post","link":"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/une-bacterie-capable-de-diminuer-la-douleur-viscerale\/","title":{"rendered":"A bacterium capable of reducing visceral pain"},"content":{"rendered":"
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Lactococcus lactis<\/em> is a bacterium that naturally produces a pain-relieving neuromediator. Scientists at the Toulouse Biotechnology Institute (TBI-INSA Toulouse\/INRAE\/CNRS) and Toxicologie alimentaire (Toxalim-INRAE\/ENVT\/INP-Purpan\/UT3 Paul Sabatier) laboratories at the INRAE Occitanie-Toulouse center have proven its value in relieving visceral pain, such as that felt in irritable bowel syndrome.<\/strong><\/p>\n\n\n\n

Published May 31, 2023 - sur le site INRAE<\/a><\/p>\n\n\n\n

Stress and anxiety exacerbate visceral pain, particularly for patients suffering from irritable bowel syndrome. Until now, symptomatic treatment of pain has been unsatisfactory. It is therefore important to provide new therapeutic solutions. By acting on the microbiota-gut-brain axis, certain probiotic lactic acid bacteria are able to reduce visceral pain. In fact, through decarboxylation mechanisms, they can synthesize neuromediators that reduce visceral pain hypersensitivity.<\/p>\n\n\n\n

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Scanning electron microscopy image of L. lactis (\u00a9 MERCIER-BONIN Muriel et CARTIER Christel - INRAE)<\/figcaption><\/figure>\n\n\n\n

By studying a collection of over 150 lactococci, scientists from the Toulouse Biotechnology Institute and the Toxalim laboratory have demonstrated, in a preclinical model, that certain strains of Lactococcus lactis<\/em>, when administered orally, have a highly interesting visceral pain-relieving effect. In fact, these particular bacteria can produce significant quantities of a central nervous system inhibitory neuromediator: y-aminobutyric acid or GABA. \"This molecule has been shown to be effective in preventing and treating visceral pain\", explains Muriel Cocaign-Bousquet, an INRAE researcher at TBI. Bacteria of the L. lactis<\/em> species are considered non-pathogenic (generally recognized as safe) and are widely used in the agri-food industry for the manufacture of dairy products.<\/p>\n\n\n\n

A confirmed pain-relieving effect<\/h2>\n\n\n\n

\"In our studies, we administered the L. lactis<\/em> strain orally on a daily basis for 10 days. And it was shown, for the first time, that this bacterium exerts significant effects against visceral hypersensitivity in a preclinical model of acute stress, thanks to its ability to produce high levels of GABA\", shares Muriel Cocaign-Bousquet.<\/p>\n\n\n\n

This discovery opens up promising prospects for the prevention or treatment of visceral pain. A patent has been filed to protect the use of L. lactis<\/em> strains. The scientists are continuing their joint work to better understand the mechanisms behind the antinociceptive effect of these GABA-hyperproducing bacteria.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\n\t\t\t\t\t\tLaroute V, Beaufrand C, Gomes P, Nouaille S, Daveran-Mingot M-L, Theodorou V, Eutamene H, Mercier-Bonin M, Cocaign-Bousquet M (2022) Lactococcus lactis NCDO2118 exerts visceral antinociceptive properties in rat via GABA production in the gastro-intestinal tract. Elife. Jun 21;11:e77100. https:\/\/doi.org\/10.7554\/eLife.77100\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tInternational patent\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t

\n\t\t\t\t\t\tPatent n\u00b0 WO 2020\/157297 \u00ab Lactococcus lactis strains for the prevention and\/or the treatment of visceral pain \u00bb\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\tMuriel Cocaign-Bousquet\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

Lactococcus lactis est une bact\u00e9rie qui produit naturellement un neurom\u00e9diateur \u00e0 effet anti-douleur. Des scientifiques des laboratoires Toulouse Biotechnology Institute (TBI – INSA Toulouse\/INRAE\/CNRS) et de Toxicologie alimentaire (Toxalim \u2013 INRAE\/ENVT\/INP-Purpan\/UT3 Paul Sabatier) du centre INRAE Occitanie-Toulouse ont prouv\u00e9 son int\u00e9r\u00eat pour soulager les douleurs visc\u00e9rales, comme celles ressenties par les personnes qui souffrent du […]<\/p>\n","protected":false},"author":1,"featured_media":12505,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12],"tags":[27],"class_list":["post-12504","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-resultat-scientifique","tag-equipe-blade"],"yoast_head":"\nUne bact\u00e9rie capable de diminuer la douleur visc\u00e9rale | TBI, Toulouse Biotechnology Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/une-bacterie-capable-de-diminuer-la-douleur-viscerale\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Une bact\u00e9rie capable de diminuer la douleur visc\u00e9rale | TBI, Toulouse Biotechnology Institute\" \/>\n<meta property=\"og:description\" content=\"Lactococcus lactis est une bact\u00e9rie qui produit naturellement un neurom\u00e9diateur \u00e0 effet anti-douleur. Des scientifiques des laboratoires Toulouse Biotechnology Institute (TBI – INSA Toulouse\/INRAE\/CNRS) et de Toxicologie alimentaire (Toxalim \u2013 INRAE\/ENVT\/INP-Purpan\/UT3 Paul Sabatier) du centre INRAE Occitanie-Toulouse ont prouv\u00e9 son int\u00e9r\u00eat pour soulager les douleurs visc\u00e9rales, comme celles ressenties par les personnes qui souffrent du […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/une-bacterie-capable-de-diminuer-la-douleur-viscerale\/\" \/>\n<meta property=\"og:site_name\" content=\"TBI, Toulouse Biotechnology Institute\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/TBI-Toulouse-Biotechnology-Institute-Bio-Chemical-Engineering-360428497952306\" \/>\n<meta property=\"article:published_time\" content=\"2023-06-01T12:50:36+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-06-01T12:52:30+00:00\" \/>\n<meta property=\"og:image\" 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