{"id":11881,"date":"2023-04-02T07:00:07","date_gmt":"2023-04-02T05:00:07","guid":{"rendered":"https:\/\/www.toulouse-biotechnology-institute.fr\/?p=11881"},"modified":"2023-04-04T10:08:01","modified_gmt":"2023-04-04T08:08:01","slug":"synthetiser-des-oligosaccharides-pour-ameliorer-la-sante-de-demain","status":"publish","type":"post","link":"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/synthetiser-des-oligosaccharides-pour-ameliorer-la-sante-de-demain\/","title":{"rendered":"Synth\u00e9tiser des oligosaccharides pour am\u00e9liorer la sant\u00e9 de demain"},"content":{"rendered":"
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Article publi\u00e9 le 07 mars 2023 sur le site INRAE<\/a><\/p>\n

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Les oligosaccharides (glucides) sont naturellement pr\u00e9sents dans les cellules v\u00e9g\u00e9tales, animales et microbiennes. Composants essentiels de l\u2019alimentation, ils jouent un r\u00f4le majeur dans de nombreux processus biologiques, impactant la sant\u00e9 humaine. Une \u00e9quipe de scientifiques du laboratoire Toulouse Biotechnology Institute (TBI – INRAE\/INSA\/CNRS) du centre INRAE Occitanie – Toulouse travaille \u00e0 synth\u00e9tiser ses mol\u00e9cules d\u2019int\u00e9r\u00eat gr\u00e2ce \u00e0 de nouvelles enzymes. Leurs r\u00e9sultats sont parus dans la revue International Journal of Molecular Sciences en mars 2022, et font partie des innovations majeures \u00e0 l\u2019\u00e9chelle europ\u00e9enne.<\/strong><\/p>\n

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Des enzymes capables de synth\u00e9tiser les oligosaccharides<\/h2>\n

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Les oligosaccharides sont des mol\u00e9cules compos\u00e9es d\u2019une association de 2 \u00e0 20 sucres simples. Ces mol\u00e9cules sont essentielles \u00e0 la vie, et jouent des r\u00f4les divers dans les organismes o\u00f9 elles se trouvent, y compris chez l\u2019humain.<\/p>\n

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L\u2019importance des oligosaccharides dans l\u2019alimentation et la sant\u00e9 humaine, et la difficult\u00e9 de leur production par voie chimique, font de leur synth\u00e8se par voie biologique un r\u00e9el enjeu. Ils ont plusieurs r\u00f4les dans le corps humain. Ils peuvent \u00eatre utilis\u00e9s comme source d\u2019\u00e9nergie par les microorganismes pr\u00e9sents dans le microbiote intestinal. D\u2019autres pr\u00e9sents \u00e0 la surface des membranes cellulaires, remplissent des fonctions de reconnaissance, de signalisation et d\u2019adh\u00e9sion. Certains oligosaccharides ont ainsi des propri\u00e9t\u00e9s antig\u00e9niques, comme par exemple les antig\u00e8nes sp\u00e9cifiques des groupes sanguins A, B et O.<\/p>\n

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Au vu de l\u2019int\u00e9r\u00eat certain que rev\u00eatent ces mol\u00e9cules pour la sant\u00e9, et de la difficult\u00e9 \u00e0 les produire par voie chimique, les scientifiques ont donc cherch\u00e9 un moyen d\u2019en synth\u00e9tiser en laboratoire, par voie biologique, gr\u00e2ce \u00e0 certaines enzymes d\u2019origine bact\u00e9rienne, appel\u00e9es glycoside-phosphorylases. Naturellement, elles servent surtout aux bact\u00e9ries qui les produisent \u00e0 d\u00e9grader les oligosaccharides, mais dans certaines conditions, elles sont aussi capables de les synth\u00e9tiser. On peut donc se dire, qu\u2019il n\u2019y a qu\u2019\u00e0 les utiliser en laboratoire pour obtenir les oligosaccharides souhait\u00e9s.<\/p>\n

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Or, ce n\u2019est pas si simple ! En effet, \u00e0 ce jour, tr\u00e8s peu de glycoside-phosphorylases ont \u00e9t\u00e9 caract\u00e9ris\u00e9es. Leurs s\u00e9quences ne sont pas faciles \u00e0 diff\u00e9rencier de celles d\u2019autres enzymes impliqu\u00e9es dans le m\u00e9tabolisme des sucres. Gr\u00e2ce \u00e0 une approche combin\u00e9e explorant de larges espaces de s\u00e9quences bact\u00e9riennes issues notamment du microbiote intestinal humain, et des approches de d\u00e9tection de l\u2019activit\u00e9 des glycoside-phosphorylases, l\u2019\u00e9quipe a pu acc\u00e9l\u00e9rer la d\u00e9couverte de ces enzymes d\u2019int\u00e9r\u00eat.<\/p>\n

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Aider \u00e0 am\u00e9liorer la sant\u00e9 gr\u00e2ce \u00e0 ces oligosaccharides<\/h2>\n

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Une fois ces enzymes d\u00e9tect\u00e9es et leur potentiel v\u00e9rifi\u00e9, l\u2019\u00e9quipe les a \u00e9tudi\u00e9es pour bien comprendre leurs sp\u00e9cificit\u00e9s et leur fonctionnement. Cela leur a ainsi permis de synth\u00e9tiser des oligosaccharides d\u2019int\u00e9r\u00eat pour la sant\u00e9 humaine in vitro<\/em> (en dehors d\u2019un \u00eatre vivant), mais aussi in cellulo<\/em> (dans des cellules cultiv\u00e9es en laboratoire). Ces recherches ont fait l\u2019objet d\u2019un brevet international d\u00e9pos\u00e9 par Toulouse Tech Transfert, et exploit\u00e9 par la soci\u00e9t\u00e9 Sweetech<\/a>.<\/p>\n

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Ces travaux ouvrent de nouvelles perspectives pour am\u00e9liorer la d\u00e9tection et la connaissance des glycoside-phosphorylases en s\u2019appuyant notamment sur des processus d\u2019apprentissage automatique, en lien avec l\u2019intelligence artificielle, afin de pouvoir produire un large panel d\u2019oligosaccharides d\u2019int\u00e9r\u00eat pour la sant\u00e9 humaine.<\/p>\n

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\n\t\t\t\t\t\tLi, A.; Benkoulouche, M.; Ladeveze, S.; Durand, J.; Cioci, G.; Laville, E.; Potocki-Veronese, G. Discovery and Biotechnological Exploitation of Glycoside- Phosphorylases. Int. J. Mol. Sci. 2022, 23, 3043.\n\nhttps:\/\/doi.org\/10.3390\/ijms23063043\n\nEnzymes for the production of poly- and oligosaccharides\u2019. European Commission's Innovation Radar (Ready for the market, Noteworthy level of Market Creation Potential, Women-led innovation). https:\/\/www.innoradar.eu\/innovation\/39498\n\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\tGabrielle Potocki-Veronese \nDirectrice de recherche INRAE\n\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

Article publi\u00e9 le 07 mars 2023 sur le site INRAE Les oligosaccharides (glucides) sont naturellement pr\u00e9sents dans les cellules v\u00e9g\u00e9tales, animales et microbiennes. Composants essentiels de l\u2019alimentation, ils jouent un r\u00f4le majeur dans de nombreux processus biologiques, impactant la sant\u00e9 humaine. Une \u00e9quipe de scientifiques du laboratoire Toulouse Biotechnology Institute (TBI – INRAE\/INSA\/CNRS) du centre […]<\/p>\n","protected":false},"author":1,"featured_media":11882,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12],"tags":[35],"class_list":["post-11881","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-resultat-scientifique","tag-equipe-cimes"],"yoast_head":"\nSynth\u00e9tiser des oligosaccharides pour am\u00e9liorer la sant\u00e9 de demain | TBI, Toulouse Biotechnology Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/synthetiser-des-oligosaccharides-pour-ameliorer-la-sante-de-demain\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Synth\u00e9tiser des oligosaccharides pour am\u00e9liorer la sant\u00e9 de demain | TBI, Toulouse Biotechnology Institute\" \/>\n<meta property=\"og:description\" content=\"Article publi\u00e9 le 07 mars 2023 sur le site INRAE Les oligosaccharides (glucides) sont naturellement pr\u00e9sents dans les cellules v\u00e9g\u00e9tales, animales et microbiennes. Composants essentiels de l\u2019alimentation, ils jouent un r\u00f4le majeur dans de nombreux processus biologiques, impactant la sant\u00e9 humaine. 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