{"id":11371,"date":"2023-01-25T08:00:00","date_gmt":"2023-01-25T07:00:00","guid":{"rendered":"https:\/\/www.toulouse-biotechnology-institute.fr\/?p=11371"},"modified":"2023-04-04T10:08:58","modified_gmt":"2023-04-04T08:08:58","slug":"soutenance-de-these-de-sarah-blosse","status":"publish","type":"post","link":"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/soutenance-de-these-de-sarah-blosse\/","title":{"rendered":"PhD defence Sarah Blosse"},"content":{"rendered":"<p>La soutenance aura lieu le&nbsp;mercredi&nbsp;25 Janvier \u00e0 9h30 dans l\u2019amphith\u00e9\u00e2tre Nougaro \u00e0 l&#8217;Institut de M\u00e9canique des Fluides de Toulouse (IMFT &#8211; 2 all\u00e9e du professeur Camille Soula, 31400 Toulouse).<\/p>\n\n\n\n<p>La th\u00e8se s&#8217;intitule :&nbsp;<em>La biomasse lignocellulosique, un milieu poreux particulier : \u00e9tude exp\u00e9rimentale de sa d\u00e9gradation par hydrolyse enzymatique.<\/em><\/p>\n\n\n\n<p><em>Title : Lignocellulosic biomass as a porous media : experimental study of its degradation by enzymatic hydrolysis<\/em><\/p>\n\n\n\n<p>Cette th\u00e8se est un travail en collaboration entre l&#8217;IMFT et TBI sous la direction de Paul Duru (IMFT) et C\u00e9dric Montanier (TBI) et avec l&#8217;aide pr\u00e9cieuse d&#8217;Antoine Bouchoux (TBI).<\/p>\n\n\n\n<p>Ce travail sera \u00e9valu\u00e9 par C\u00e9cile Herv\u00e9, Laurent Oxarango, Johnny Beaugrand et Vincent Burlat.<\/p>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<p>Le r\u00e9sum\u00e9 de la th\u00e8se :<\/p>\n\n\n\n<p><em>La valorisation de la biomasse v\u00e9g\u00e9tale repr\u00e9sente un enjeu environnemental et industriel consid\u00e9rable au regard de notre demande croissante en \u00e9nergie renouvelable et en mol\u00e9cules d\u2019int\u00e9r\u00eat pour l\u2019industrie chimique. Acc\u00e9der \u00e0 cette ressource n\u00e9cessite de d\u00e9construire cette biomasse particuli\u00e8rement r\u00e9calcitrante de mani\u00e8re contr\u00f4l\u00e9e. Cette \u00e9tape reste \u00e0 ce jour un verrou majeur au d\u00e9veloppement de proc\u00e9d\u00e9s viable et \u00e9conomiquement pertinents. Dans la Nature, bact\u00e9ries et champignons ont d\u00e9velopp\u00e9 tout un panel d\u2019enzymes \u00e0 la modularit\u00e9 tr\u00e8s variable, permettant de m\u00e9taboliser les mol\u00e9cules carbon\u00e9es pr\u00e9sentes dans les parois v\u00e9g\u00e9tales. Ce travail de th\u00e8se a pour ambition d\u2019am\u00e9liorer notre compr\u00e9hension des m\u00e9canismes biochimiques et biophysiques mis en \u0153uvre lors de cette d\u00e9gradation enzymatique de la biomasse v\u00e9g\u00e9tale.&nbsp; Son originalit\u00e9 est d\u2019\u00e9tudier l\u2019action enzymatique par l\u2019utilisation de m\u00e9trologies et techniques issues de l\u2019\u00e9tude des milieux poreux. Ces techniques sont particuli\u00e8rement bien adapt\u00e9es au type d\u2019\u00e9chantillons qui nous int\u00e9resse (paille de bl\u00e9) et permettent ainsi de consid\u00e9rer la paroi v\u00e9g\u00e9tale dans toute sa complexit\u00e9 (un milieu poreux complexe et tridimensionnel).<br><br>Dans une premi\u00e8re partie, nous montrons que la microtomographie \u00e0 rayons X (\u00b5CT) permet le suivi temporel, en 3 dimensions, de la d\u00e9gradation enzymatique d&#8217;une biomasse lignocellulosique mod\u00e8le, la paille de bl\u00e9.&nbsp; Gr\u00e2ce \u00e0 un traitement des images 3D sp\u00e9cifique, d\u00e9velopp\u00e9 au cours de la th\u00e8se, nous observons en particulier la disparition progressive de certaines parois cellulaires riches en cellulose, au fur et \u00e0 mesure de l\u2019attaque enzymatique.<br>Dans un second temps, et dans le but de sonder les effets de l\u2019action enzymatique \u00e0 des \u00e9chelles spatiales non r\u00e9solues par la visualisation en \u00b5CT (inf\u00e9rieures au micron), nous avons effectu\u00e9 des exp\u00e9riences d\u2019\u00e9lution d\u2019un traceur radio-opacifiant saturant initialement la paille de bl\u00e9, notamment par un suivi en radiographie X. Un mod\u00e8le simple de transport diffusif au sein de la paille est utilis\u00e9 pour extraire un coefficient de diffusion effectif des traceurs au sein de la paille.&nbsp; Des r\u00e9sultats pr\u00e9liminaires sont obtenus pour diff\u00e9rents types de traceurs, pour des \u00e9chantillons natifs ou ayant subi une attaque enzymatique.<br><br>En r\u00e9sum\u00e9, durant cette th\u00e8se nous nous sommes attel\u00e9s \u00e0 adapter des techniques et des m\u00e9thodologies issues de l\u2019\u00e9tude des milieux poreux pour affiner n\u00f4tre compr\u00e9hension des m\u00e9canismes mis en&nbsp;jeu&nbsp;lors de la d\u00e9gradation de la paille de bl\u00e9 par des enzymes.<\/em><\/p>\n\n\n\n<p><em>Abstract :<\/em><\/p>\n\n\n\n<p><em>The valorisation of plant biomass represents a considerable environmental and industrial challenge in view of our growing demand for renewable energy and molecules of interest for the chemical industry. Access to this resource requires the controlled deconstruction of this particularly recalcitrant biomass. This step remains a major obstacle to the development of viable and economically relevant processes. In Nature, bacteria and fungi have developed a whole panel of enzymes with very variable modularity, allowing them to metabolise the carbonated molecules present in the plant cell walls. This thesis aims to improve our understanding of the biochemical and biophysical mechanisms involved in this enzymatic degradation of plant biomass. Its originality is to study the enzymatic attack by using metrology and techniques from the study of porous media. These techniques are particularly well adapted to the type of samples we are interested in (wheat straw) and thus make it possible to consider the plant cell wall in all its complexity (a complex and three-dimensional porous medium).<br><br>In the first part, we show that X-ray microtomography (\u00b5CT) allows the temporal monitoring, in 3 dimensions, of the enzymatic degradation of a model lignocellulosic biomass, wheat straw.&nbsp; Thanks to a specific 3D image processing, developed during the thesis, we observe in particular the progressive disappearance of certain cell walls rich in cellulose, as the enzymatic attack progresses.<br>In a second step, and with the aim of probing the effects of the enzymatic action at spatial scales not resolved by \u00b5CT visualisation (sub-micron), we carried out elution experiments of a radio-opacifying tracer initially saturating the wheat straw, notably by X-ray monitoring. A simple model of diffusive transport within the wheat straw is used to extract an effective diffusion coefficient of the tracers within the straw. Preliminary results are obtained for different types of tracers, for native and enzymatically degraded samples.<br><br>In summary, during this thesis we have adapted techniques and methodologies from the study of porous media to refine our understanding of the mechanisms involved in the enzymatic degradation of wheat straw.<br>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>January 25th, 2023<\/p>","protected":false},"author":1,"featured_media":11372,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10,75],"tags":[35],"class_list":["post-11371","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-evenement","category-soutenance","tag-equipe-cimes"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - 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