{"id":8478,"date":"2022-05-06T16:09:17","date_gmt":"2022-05-06T14:09:17","guid":{"rendered":"http:\/\/v2tbi.christelle-labruyere.com\/?page_id=8478"},"modified":"2023-06-08T14:04:29","modified_gmt":"2023-06-08T12:04:29","slug":"evolution-adaptative","status":"publish","type":"page","link":"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/poles\/equipe-peep\/evolution-adaptative\/","title":{"rendered":"Evolution adaptative des bact\u00e9ries sous contraintes m\u00e9taboliques pour la s\u00e9lection d\u2019enzymes ou de voies m\u00e9taboliques poss\u00e9dant de nouvelles fonctionnalit\u00e9s"},"content":{"rendered":"\t\t
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Equipe PEEP<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Th\u00e8me \"Evolution adaptative des bact\u00e9ries sous contraintes m\u00e9taboliques\"<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Quelques mots sur le th\u00e8me<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Pour la s\u00e9lection d\u2019enzymes ou de voies m\u00e9taboliques poss\u00e9dant de nouvelles fonctionnalit\u00e9s<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Pour am\u00e9liorer les performances des nouvelles usines cellulaires microbiennes dont le m\u00e9tabolisme a \u00e9t\u00e9 rationnellement modifi\u00e9, une m\u00e9thodologie d\u2019\u00e9volution adaptative sous contraintes m\u00e9taboliques est appliqu\u00e9e. Les mutations g\u00e9n\u00e9tiques responsables du ph\u00e9nom\u00e8ne d\u2019\u00e9volution observ\u00e9 sont ensuite identifi\u00e9es et caract\u00e9ris\u00e9es, afin de proposer un m\u00e9canisme d\u2019adaptation et \u00e9valuer la robustesse et la flexibilit\u00e9 des r\u00e9seaux m\u00e9taboliques des bact\u00e9ries.<\/p>

Cette m\u00e9thodologie d\u2019\u00e9volution adaptative in vivo<\/em> est appliqu\u00e9e, par exemple, pour le d\u00e9veloppement d\u2019une voie synth\u00e9tique glycolytique non oxydative (NOG) fonctionnelle en ana\u00e9robiose (Projet SynBiochem) ou de production d\u2019hydrog\u00e8ne (H2<\/sub>) (Projet Hydrog\u00e9nase).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Les projets<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Projet SYNBIOCHEM<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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–<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Projet Hydrog\u00e9nase<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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–<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Equipe PEEP Retour vers l’\u00e9quipe Th\u00e8me “Evolution adaptative des bact\u00e9ries sous contraintes m\u00e9taboliques” Quelques mots sur le th\u00e8me Pour la s\u00e9lection d\u2019enzymes ou de voies m\u00e9taboliques poss\u00e9dant de nouvelles fonctionnalit\u00e9s Pour am\u00e9liorer les performances des nouvelles usines cellulaires microbiennes dont le m\u00e9tabolisme a \u00e9t\u00e9 rationnellement modifi\u00e9, une m\u00e9thodologie d\u2019\u00e9volution adaptative sous contraintes m\u00e9taboliques est appliqu\u00e9e. […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":5021,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-8478","page","type-page","status-publish","hentry"],"yoast_head":"\nEvolution adaptative des bact\u00e9ries sous contraintes m\u00e9taboliques pour la s\u00e9lection d\u2019enzymes ou de voies m\u00e9taboliques poss\u00e9dant de nouvelles fonctionnalit\u00e9s | TBI, Toulouse Biotechnology Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/poles\/equipe-peep\/evolution-adaptative\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Evolution adaptative des bact\u00e9ries sous contraintes m\u00e9taboliques pour la s\u00e9lection d\u2019enzymes ou de voies m\u00e9taboliques poss\u00e9dant de nouvelles fonctionnalit\u00e9s | TBI, Toulouse Biotechnology Institute\" \/>\n<meta property=\"og:description\" content=\"Equipe PEEP Retour vers l’\u00e9quipe Th\u00e8me “Evolution adaptative des bact\u00e9ries sous contraintes m\u00e9taboliques” Quelques mots sur le th\u00e8me Pour la s\u00e9lection d\u2019enzymes ou de voies m\u00e9taboliques poss\u00e9dant de nouvelles fonctionnalit\u00e9s Pour am\u00e9liorer les performances des nouvelles usines cellulaires microbiennes dont le m\u00e9tabolisme a \u00e9t\u00e9 rationnellement modifi\u00e9, une m\u00e9thodologie d\u2019\u00e9volution adaptative sous contraintes m\u00e9taboliques est appliqu\u00e9e. 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