{"id":8465,"date":"2022-05-06T15:48:06","date_gmt":"2022-05-06T13:48:06","guid":{"rendered":"http:\/\/v2tbi.christelle-labruyere.com\/?page_id=8465"},"modified":"2023-06-08T14:04:18","modified_gmt":"2023-06-08T12:04:18","slug":"amelioration-de-la-connaissance","status":"publish","type":"page","link":"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/poles\/equipe-peep\/amelioration-de-la-connaissance\/","title":{"rendered":"Improvement of the knowledge of bacterial metabolism and its regulation"},"content":{"rendered":"\t\t
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Equipe PEEP<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Th\u00e8me \"Am\u00e9lioration de la connaissance du m\u00e9tabolisme bact\u00e9rien et de sa r\u00e9gulation\"<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Quelques mots sur le th\u00e8me<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Am\u00e9lioration de la connaissance du m\u00e9tabolisme bact\u00e9rien et de sa r\u00e9gulation<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Les travaux men\u00e9s sur l\u2019am\u00e9lioration de la connaissance du m\u00e9tabolisme central bact\u00e9rien sont r\u00e9alis\u00e9s principalement sur deux bact\u00e9ries mod\u00e8les d\u2019int\u00e9r\u00eat industriel\u00a0: C. acetobutylicum<\/em> (bact\u00e9rie ana\u00e9robie stricte) et E. coli <\/em>(bact\u00e9rie ana\u00e9robie facultative). La strat\u00e9gie appliqu\u00e9e combine i) une approche globale et quantitative de biologie des syst\u00e8mes, \u00e0 ii) l\u2019identification et la caract\u00e9risation de nouvelles enzymes m\u00e9taboliques clefs et \u00e0 iii) la validation du r\u00f4le de ces enzymes clefs par la cr\u00e9ation et la caract\u00e9risation de mutants. L\u2019ensemble des r\u00e9sultats obtenus sont ensuite incorpor\u00e9s dans le m\u00e9tabolisme central, afin d\u2019am\u00e9liorer la pr\u00e9cision de mod\u00e8les \u00e0 l\u2019\u00e9chelle du g\u00e9nome.<\/p>

Un savoir-faire et une m\u00e9thodologie ont \u00e9t\u00e9 acquis et sont aujourd\u2019hui appliqu\u00e9s \u00e0 d\u2019autres bact\u00e9ries. Par exemple, l\u2019analyse du m\u00e9tabolisme central d\u2019Eubacterium limosum<\/em> bact\u00e9rie ana\u00e9robie capable de m\u00e9taboliser des substrats de faible co\u00fbt \u00e0 un atome de carbone (C1) tels que le m\u00e9thanol ou les syngaz est actuellement en cours (projet BIOMETCHEM).<\/p>

\u00a0<\/p>

L\u2019am\u00e9lioration de la connaissance du m\u00e9tabolisme central permet de proposer des strat\u00e9gies rationnelles d\u2019ing\u00e9nierie m\u00e9tabolique pour concevoir, puis construire \u00e0 l\u2019aide d\u2019outils de biologie synth\u00e9tique de nouvelles usines cellulaires, capables de convertir des mati\u00e8res premi\u00e8res renouvelables en produits de base d\u2019int\u00e9r\u00eat pour la chimie, l\u2019\u00e9nergie \u2026 (projets SYNBIOCHEM, SynConsor4Butanol, EcoChem).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"M\u00e9tabolisme\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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M\u00e9tabolisme central de Clostridium acetobutylicum.<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Les projets<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Projet SYNBIOCHEM<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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–<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Projet SynConsor4Butanol<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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–<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Projet EcoChem<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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–<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Equipe PEEP Retour vers l’\u00e9quipe Th\u00e8me “Am\u00e9lioration de la connaissance du m\u00e9tabolisme bact\u00e9rien et de sa r\u00e9gulation” Quelques mots sur le th\u00e8me Am\u00e9lioration de la connaissance du m\u00e9tabolisme bact\u00e9rien et de sa r\u00e9gulation Les travaux men\u00e9s sur l\u2019am\u00e9lioration de la connaissance du m\u00e9tabolisme central bact\u00e9rien sont r\u00e9alis\u00e9s principalement sur deux bact\u00e9ries mod\u00e8les d\u2019int\u00e9r\u00eat industriel\u00a0: C. […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":5021,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-8465","page","type-page","status-publish","hentry"],"yoast_head":"\nAm\u00e9lioration de la connaissance du m\u00e9tabolisme bact\u00e9rien et de sa r\u00e9gulation | TBI, Toulouse Biotechnology Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/poles\/equipe-peep\/amelioration-de-la-connaissance\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Am\u00e9lioration de la connaissance du m\u00e9tabolisme bact\u00e9rien et de sa r\u00e9gulation | TBI, Toulouse Biotechnology Institute\" \/>\n<meta property=\"og:description\" content=\"Equipe PEEP Retour vers l’\u00e9quipe Th\u00e8me “Am\u00e9lioration de la connaissance du m\u00e9tabolisme bact\u00e9rien et de sa r\u00e9gulation” Quelques mots sur le th\u00e8me Am\u00e9lioration de la connaissance du m\u00e9tabolisme bact\u00e9rien et de sa r\u00e9gulation Les travaux men\u00e9s sur l\u2019am\u00e9lioration de la connaissance du m\u00e9tabolisme central bact\u00e9rien sont r\u00e9alis\u00e9s principalement sur deux bact\u00e9ries mod\u00e8les d\u2019int\u00e9r\u00eat industriel\u00a0: C. 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