{"id":8094,"date":"2022-04-22T20:37:26","date_gmt":"2022-04-22T18:37:26","guid":{"rendered":"http:\/\/v2tbi.christelle-labruyere.com\/?page_id=8094"},"modified":"2022-09-22T11:24:04","modified_gmt":"2022-09-22T09:24:04","slug":"cyril-charlier","status":"publish","type":"page","link":"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/cyril-charlier\/","title":{"rendered":"Cyril CHARLIER"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"8094\" class=\"elementor elementor-8094\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1b37fa63 elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"1b37fa63\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;,&quot;shape_divider_bottom&quot;:&quot;waves&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t<div class=\"elementor-shape elementor-shape-bottom\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 1000 100\" preserveaspectratio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M421.9,6.5c22.6-2.5,51.5,0.4,75.5,5.3c23.6,4.9,70.9,23.5,100.5,35.7c75.8,32.2,133.7,44.5,192.6,49.7\tc23.6,2.1,48.7,3.5,103.4-2.5c54.7-6,106.2-25.6,106.2-25.6V0H0v30.3c0,0,72,32.6,158.4,30.5c39.2-0.7,92.8-6.7,134-22.4\tc21.2-8.1,52.2-18.2,79.7-24.2C399.3,7.9,411.6,7.5,421.9,6.5z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-125cd54\" data-id=\"125cd54\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4239c945 elementor-widget elementor-widget-heading\" data-id=\"4239c945\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Cyril CHARLIER<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-762e9b9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"762e9b9\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-2f523c4\" data-id=\"2f523c4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-feae8ca elementor-position-left elementor-vertical-align-top elementor-widget elementor-widget-image-box\" data-id=\"feae8ca\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img fetchpriority=\"high\" decoding=\"async\" width=\"232\" height=\"308\" src=\"https:\/\/www.toulouse-biotechnology-institute.fr\/wp-content\/uploads\/2022\/04\/Cyril-Charlier-.jpg\" class=\"attachment-full size-full wp-image-8025\" alt=\"Cyril Charlier\" srcset=\"https:\/\/www.toulouse-biotechnology-institute.fr\/wp-content\/uploads\/2022\/04\/Cyril-Charlier-.jpg 232w, https:\/\/www.toulouse-biotechnology-institute.fr\/wp-content\/uploads\/2022\/04\/Cyril-Charlier--9x12.jpg 9w\" sizes=\"(max-width: 232px) 100vw, 232px\" \/><\/figure><div class=\"elementor-image-box-content\"><h2 class=\"elementor-image-box-title\">Cyril CHARLIER<\/h2><p class=\"elementor-image-box-description\">CR CNRS <\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f467e73 elementor-align-left elementor-widget elementor-widget-button\" data-id=\"f467e73\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-xs\" href=\"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/poles\/equipe-rmn-2\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">MNR team<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-92c1b19\" data-id=\"92c1b19\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-19daa50 elementor-align-start elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"19daa50\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-phone\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">+33 (0)5 31 96 89 88<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-mail-bulk\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">charlier@insa-toulouse.fr<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/orcid.org\/0000-0002-4821-3166\" target=\"_blank\" rel=\"nofollow\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<span 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type=\"text\/css\">\t.st0{fill:#3D4459;}<\/style><path class=\"st0\" d=\"M123.71-1.36c0,74.98-0.44,55.9-0.44,130.88c-74.52-0.01-48.75,0.01-123.26,0c-0.07-0.84,0,0.84,0,0 C0.02,55.4-0.46,73.22-0.43-0.91C74.13-0.91,49.15-1.36,123.71-1.36z M10.35,41.43L10.35,41.43c0,0.01,1.19,0.61,2.29,0.8 c5.83,1.02,6.94,6.35,6.93,11.65C19.54,70.59,19.6,87.3,19.56,104c-0.02,7.12-1.53,9.28-8.03,11.76c-1.34,0.51-2.53,1.1-2.61,2.62 c-0.1,1.75,0.57,2.91,2.52,2.83c9.3-0.52,18.59-0.56,27.9-0.26c1.45,0.05,4.07,0.34,4.13-1.87c0.08-2.71-2.29-2.32-4.01-2.59 c-6.67-1.05-7.95-2.23-8.19-8.85c-0.24-6.8-0.1-13.61-0.1-20.42c0-1.28-0.28-2.66,1.33-3.41c3.14-1.45,8.9,0.31,10.69,3.34 c5.55,9.44,11.17,18.83,18.37,27.16c5.31,6.15,12.17,8.41,20.08,7.82c1.55-0.12,3.51-0.11,3.76-2.43c0.24-2.13-1.44-2.29-2.85-2.72 c-4.26-1.32-7.59-3.93-10.53-7.22c-6.43-7.2-11.82-15.16-17.24-23.11c-1.43-2.09-0.92-3.81,0.86-5.17c1.44-1.11,3.16-1.83,4.69-2.83 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c10.26,0.19,16.44,5.63,17.04,14.98c0.65,10.12-5.18,17.35-15.15,18.79C32.08,79.1,31.14,78.3,31.14,66.11c0-1.99,0-3.98,0-5.98 C31.14,60.14,31.13,60.14,31.12,60.14z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">RESEARCH GATE <\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.linkedin.com\/in\/cyril-charlier-16453511a\/\" target=\"_blank\" rel=\"nofollow\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" id=\"Calque_1\" x=\"0px\" y=\"0px\" viewbox=\"0 0 761.55 763.27\" style=\"enable-background:new 0 0 761.55 763.27;\" xml:space=\"preserve\"><style type=\"text\/css\">\t.st0{fill:#3D4459;}<\/style><path class=\"st0\" d=\"M762.8,381.12c0,107.8,0.02,215.59-0.01,323.39c-0.01,26.01-13.09,46.07-35.7,54.9 c-6.58,2.57-13.41,3.91-20.49,3.91c-217.1,0-434.21,0.01-651.31-0.01c-30.56,0-54.93-23.68-56.08-54.29 c-0.07-1.83-0.11-3.66-0.11-5.49c0-214.92,0.04-429.85-0.07-644.77c0-22.15,8.24-39.46,27.41-51.03c8.6-5.19,18.07-7.76,28.09-7.76 c217.6-0.04,435.21-0.06,652.81,0.01c30.33,0.01,54.33,23.54,55.35,53.76c0.2,5.99,0.11,11.99,0.12,17.99 C762.81,174.86,762.8,277.99,762.8,381.12z M296.71,467.93c0,58.81,0.05,117.62-0.1,176.44c-0.01,4.46,0.96,5.87,5.67,5.84 c33.66-0.22,67.31-0.21,100.97,0c4.73,0.03,6.1-1.02,6.09-5.95c-0.19-58.48-0.21-116.96-0.06-175.44 c0.04-17.34,1.17-34.64,6.83-51.27c6.53-19.19,18.67-32.78,38.71-38.37c9.74-2.72,19.69-3.22,29.71-2.5 c22.66,1.62,37.8,13.18,45.37,34.64c5.17,14.66,6.57,29.93,6.62,45.26c0.22,62.64,0.18,125.29,0.02,187.93 c-0.01,4.71,1.36,5.71,5.82,5.69c34.16-0.18,68.31-0.17,102.47-0.01c4.02,0.02,5.35-0.8,5.34-5.12 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class=\"elementor-icon-list-text\">Linkedin<\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-bc836c5 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"bc836c5\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-07a549e\" data-id=\"07a549e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5879caf elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"5879caf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4c71302 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4c71302\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-889e2b0\" data-id=\"889e2b0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-dfd8563 elementor-widget elementor-widget-heading\" data-id=\"dfd8563\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Actual position and research subject<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2e9438f elementor-widget elementor-widget-text-editor\" data-id=\"2e9438f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>I joined the TBI in November 2019 as a CNRS researcher in NMR team (EAD17). My main goal is to apply NMR in the framework of biotechnologies focusing on the question of catalysis ranging from the catalysis of reactions in metabolic network to the catalysis of enzymatic reactions in a bioreactor. On one hand I develop tools to maintain the spectral resolution in complex spectra and to follow such spectra as function of time to further investigate metabolism by NMR. On the other hand, I use liquid state NMR spectroscopy to study the relationship structure-dynamics-function on enzymes.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8a6f373 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8a6f373\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2cf13c6\" data-id=\"2cf13c6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-cbe7f0d elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"cbe7f0d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-eba8b04 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"eba8b04\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8b5e687\" data-id=\"8b5e687\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-86b9cdc elementor-widget elementor-widget-heading\" data-id=\"86b9cdc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Education and Diploma<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-beda416 elementor-tabs-view-horizontal elementor-widget elementor-widget-tabs\" data-id=\"beda416\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"tabs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-tabs\">\n\t\t\t<div class=\"elementor-tabs-wrapper\" role=\"tablist\" >\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-2001\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"elementor-tab-content-2001\" aria-expanded=\"false\">2012<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-2002\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2002\" aria-expanded=\"false\">2012-2016<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-2003\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2003\" aria-expanded=\"false\">2016 \u2013 2019<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"elementor-tabs-content-wrapper\" role=\"tablist\" aria-orientation=\"vertical\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"elementor-tab-content-2001\" aria-expanded=\"false\">2012<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2001\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2001\" tabindex=\"0\" hidden=\"false\"><p><strong>Master\u2019s Degree<\/strong> Universit\u00e9 Paris Sud (Orsay, France)<\/p><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2002\" aria-expanded=\"false\">2012-2016<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2002\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2002\" tabindex=\"0\" hidden=\"hidden\"><ul><li><strong>PhD Student &amp; Post-Doctoral fellow<\/strong>,<ul><li>Laboratoire des biomol\u00e9cules, D\u00e9partement de Chimie de l\u2019\u00c9cole Normale Sup\u00e9rieure de Paris &amp; Universit\u00e9 Pierre et Marie Curie (Paris, France)<\/li><li>Topic: Protein Dynamics from Nuclear Spin Relaxation: High- Resolution Relaxometry, Disordered Proteins and Applications to the C-Terminal Region of the Protein Artemis<\/li><li>Supervisors: Dr. Fabien Ferrage and Dr. Ludovic Carlier<\/li><\/ul><\/li><\/ul><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2003\" aria-expanded=\"false\">2016 \u2013 2019<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2003\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2003\" tabindex=\"0\" hidden=\"hidden\"><ul><li><strong>Post-Doctoral Fellow<\/strong><ul><li>Laboratory of Chemical Physics, National Institute of Diabetes and Digestive &amp; Kidney Diseases (NIDDK), National Institutes of Health (NIH, Bethesda, USA)<\/li><li>Topic: New Insights into Protein Folding by Fast Pressure Jump NMR Spectroscopy and its application to Ubiquitin<\/li><li>Supervisor: Dr. Adriaan Bax<\/li><li>\u00a0<\/li><\/ul><\/li><\/ul><\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3253b9c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3253b9c\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0660aec\" data-id=\"0660aec\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-540bb2c elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"540bb2c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a76ee75 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a76ee75\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c8a37c6\" data-id=\"c8a37c6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f8d64f2 elementor-widget elementor-widget-heading\" data-id=\"f8d64f2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">List of selected publications<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-79d3ae9 elementor-widget elementor-widget-text-editor\" data-id=\"79d3ae9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Cox, N.; <strong>Charlier, C.<\/strong>; Vijayaraj, R.; De La Mare, M.; Barbe, S.; Andr\u00e9, I.; Lippens, G.; Montanier, C., The Covalent Complex of Jo-In Results from a Long-Lived, Non-Covalent Intermediate State with near-Native Structure, <em>BBRC, <\/em><strong>2022<\/strong>, 589, 223\u201328.<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.bbrc.2021.12.028\">https:\/\/doi.org\/10.1016\/j.bbrc.2021.12.028<\/a>.<\/li><li><strong>Charlier, C.<\/strong>; Cox, N.; Martine Prud\u2019homme, S.; Geffard, A.; Nuzillard, J-M.; Luy, B.; Lippens, G., Virtual Decoupling to Break the Simplification versus Resolution Trade-off in Nuclear Magnetic Resonance of Complex Metabolic Mixtures. <em>Magnetic Resonance<\/em> <strong>2021, <\/strong>2, (2), 619\u201327. <a href=\"https:\/\/doi.org\/10.5194\/mr-2-619-2021\">https:\/\/doi.org\/10.5194\/mr-2-619-2021<\/a>.<\/li><li>Cox, N.; Millard P.; <strong>Charlier, C.<\/strong>, Lippens, G., Improved NMR Detection of Phospho-Metabolites in a Complex Mixture. <em>Anal. Chem. <\/em><strong>2021<\/strong>, 93, (11), 4818\u201324. <a href=\"https:\/\/doi.org\/10.1021\/acs.analchem.0c04056\">https:\/\/doi.org\/10.1021\/acs.analchem.0c04056<\/a>.<\/li><li>Ramanujam, V.<sup>\u2020<\/sup>, <strong>Charlier, C.<\/strong><sup>\u2020*<\/sup>, and Bax, A., Observation and Kinetic Characterization of Transient Schiff Base Intermediates by CEST NMR Spectroscopy. <em>Angew Chem Int Ed Engl<\/em> <strong>2019<\/strong> 58, (43), 15309\u201312. <a href=\"https:\/\/doi.org\/10.1002\/anie.201908416\">https:\/\/doi.org\/10.1002\/anie.201908416<\/a>.<\/li><li><strong>Charlier, C.<\/strong><sup>\u2020<\/sup>; Courtney, J. M<sup> \u2020<\/sup>; Anfinrud, P.; Bax, A., Interrupted Pressure-Jump NMR Experiments Reveal Resonances of Protein On-Pathway Folding Intermediate. <em>J Phys Chem B <\/em><strong>2018<\/strong>, 122, no 49, 11792\u201399 <a href=\"https:\/\/doi.org\/10.1021\/acs.jpcb.8b08456\">https:\/\/doi.org\/10.1021\/acs.jpcb.8b08456<\/a>.\u00a0\u00a0<\/li><li>Cousin, S. F.<sup>\u2020<\/sup>; Kaderavek, P.<sup>\u2020<\/sup>; Bolik-Coulon, N.<sup>\u2020<\/sup>; Gu, Y.; <strong>Charlier, C.<\/strong>; Carlier, L.; Bruschweiler-Li, L.; Marquardsen, T.; Tyburn, J. M.; Bruschweiler, R.; Ferrage, F., Time-Resolved Protein Side-Chain Motions Unraveled by High-Resolution Relaxometry and Molecular Dynamics Simulations. <em>J Am Chem Soc <\/em><strong>2018<\/strong>. <a href=\"https:\/\/doi.org\/10.1021\/jacs.8b09107\">https:\/\/doi.org\/10.1021\/jacs.8b09107<\/a>.<\/li><li><strong>Charlier, C.<\/strong>; Courtney, J. M.; Alderson, T. R.; Anfinrud, P.; Bax, A., Monitoring <sup>15<\/sup>N Chemical Shifts During Protein Folding by Pressure-Jump NMR. <em>J Am Chem Soc <\/em><strong>2018,<\/strong> <em>140<\/em> (26), 8096-8099. <a href=\"https:\/\/doi.org\/10.1021\/jacs.8b04833\">https:\/\/doi.org\/10.1021\/jacs.8b04833<\/a>.<\/li><li><strong>Charlier, C.<\/strong>; Alderson, T. R.; Courtney, J. M.; Ying, J.; Anfinrud, P.; Bax, A., Study of protein folding under native conditions by rapidly switching the hydrostatic pressure inside an NMR sample cell. <em>Proceedings of the National Academy of Sciences of the United States of America <\/em><strong>2018,<\/strong> <em>115<\/em> (18), E4169-E4178. <a href=\"https:\/\/doi.org\/10.1073\/pnas.1803642115\">https:\/\/doi.org\/10.1073\/pnas.1803642115<\/a>.<\/li><li>Lippens, G.; Cahoreau, E., Millard, R.; <strong>Charlier, C.<\/strong>; Lopez, J.; Hanoulle, X.; Portais, J.C., In-cell NMR: from metabolites to macromolecules. <em>Analyst<\/em> <strong>2018<\/strong>, 143 (3), 620-629. <a href=\"https:\/\/doi.org\/10.1039\/C7AN01635B\">https:\/\/doi.org\/10.1039\/C7AN01635B<\/a>.<\/li><li>Alderson, T. R.; Lee, J. H.; <strong>Charlier, C.<\/strong>; Ying, J.; Bax, A., Propensity for cis-Proline Formation in Unfolded Proteins. <em>Chembiochem <\/em><strong>2018,<\/strong> 19 (1), 37-42. <a href=\"https:\/\/doi.org\/10.1002\/cbic.201700548\">https:\/\/doi.org\/10.1002\/cbic.201700548<\/a><\/li><li><strong>Charlier, C.<\/strong>; Bouvignies, G.; Pelupessy, P.; Walrant, A.; Marquant, R.; Kozlov, M.; De Ioannes, P.; Bolik-Coulon, N.; Sagan, S.; Cortes, P.; Aggarwal, A. K.; Carlier, L.; Ferrage, F., Structure and dynamics of an intrinsically disordered protein region that partially folds upon binding by chemical-exchange NMR. <em>J Am Chem Soc<\/em> <strong>2017<\/strong>, <em>139<\/em> (35), 12219-12227. <a href=\"https:\/\/doi.org\/10.1021\/jacs.7b05823\">https:\/\/doi.org\/10.1021\/jacs.7b05823<\/a>.<\/li><li>Alderson, T. R.<sup>\u2020<\/sup>; <strong>Charlier, C.<sup>\u2020<\/sup><\/strong>; Torchia, D. A.; Anfinrud, P.; Bax, A., Monitoring Hydrogen Exchange During Protein Folding by Fast Pressure Jump NMR Spectroscopy. <em>J Am Chem Soc<\/em> <strong>2017, <\/strong><em>139<\/em> (32), 11036-11039. <a href=\"https:\/\/doi.org\/10.1021\/jacs.7b06676\">https:\/\/doi.org\/10.1021\/jacs.7b06676<\/a><\/li><li>Kaderavek, P.; Strouk, L.; Cousin, S. F.; <strong>Charlier, C.<\/strong>; Bodenhausen, G.; Marquardsen, T.; Tyburn, J. M.; Bovier, P. A.; Engelke, F.; Maas, W.; Ferrage, F., Full Correlations across Broad NMR Spectra by Two-Field Total Correlation Spectroscopy. <em>Chemphyschem<\/em> <strong>2017<\/strong>, <em>18<\/em> (19), 2772-2776. <a href=\"https:\/\/doi.org\/10.1002\/cphc.201700369\">https:\/\/doi.org\/10.1002\/cphc.201700369<\/a>.<\/li><li>Cousin, S. F.; Kaderavek, P.; Haddou, B.; <strong>Charlier, C.<\/strong>; Marquardsen, T.; Tyburn, J. M.; Bovier, P. A.; Engelke, F.; Maas, W.; Bodenhausen, G.; Pelupessy, P.; Ferrage, F., Recovering Invisible Signals by Two-Field NMR Spectroscopy. <em>Angew Chem Int Ed Engl<\/em> <strong>2016<\/strong>, 55 (34), 9886-9. <a href=\"https:\/\/doi.org\/10.1002\/anie.201602978\">https:\/\/doi.org\/10.1002\/anie.201602978<\/a>.<\/li><li><strong>Charlier, C.<sup>\u2020<\/sup><\/strong>; Cousin, S. F.<sup>\u2020<\/sup>; Ferrage, F., Protein dynamics from nuclear magnetic relaxation. <em>Chem Soc Rev<\/em> <strong>2016<\/strong>, 45 (9), 2410-22. <a href=\"https:\/\/doi.org\/10.1039\/C5CS00832H\">https:\/\/doi.org\/10.1039\/C5CS00832H<\/a>.<\/li><li>Cousin, S. F.<sup>\u2020<\/sup>; <strong>Charlier, C.<sup>\u2020<\/sup><\/strong>; Kaderavek, P.; Marquardsen, T.; Tyburn, J. M.; Bovier, P. A.; Ulzega, S.; Speck, T.; Wilhelm, D.; Engelke, F.; Maas, W.; Sakellariou, D.; Bodenhausen, G.; Pelupessy, P.; Ferrage, F., High-resolution two-field nuclear magnetic resonance spectroscopy. <em>Phys Chem Chem Phys<\/em> <strong>2016<\/strong>, 18 (48), 33187-33194. <a href=\"https:\/\/doi.org\/10.1039\/C6CP05422F\">https:\/\/doi.org\/10.1039\/C6CP05422F<\/a>.<\/li><li>Khan, S. N.<sup>\u2020<\/sup>; <strong>Charlier, C.<sup>\u2020<\/sup><\/strong>; Augustyniak, R.; Salvi, N.; Dejean, V.; Bodenhausen, G.; Lequin, O.; Pelupessy, P.; Ferrage, F., Distribution of Pico- and Nanosecond Motions in Disordered Proteins from Nuclear Spin Relaxation. <em>Biophys J<\/em> <strong>2015<\/strong>, 109 (5), 988-99. <a href=\"https:\/\/doi.org\/10.1016\/j.bpj.2015.06.069\">https:\/\/doi.org\/10.1016\/j.bpj.2015.06.069<\/a>.<\/li><li><strong>Charlier, C.<sup>\u2020<\/sup><\/strong>; Khan, S. N.<sup>\u2020<\/sup>; Marquardsen, T.; Pelupessy, P.; Reiss, V.; Sakellariou, D.; Bodenhausen, G.; Engelke, F.; Ferrage, F., Nanosecond time scale motions in proteins revealed by high-resolution NMR relaxometry. <em>J Am Chem Soc<\/em> <strong>2013<\/strong>, 135 (49), 18665-72. <a href=\"https:\/\/doi.org\/10.1021\/ja409820g\">https:\/\/doi.org\/10.1021\/ja409820g<\/a>.<\/li><\/ul><div>\u00a0<\/div><div>\u00a0<\/div><div><p><u>Patents:<\/u><br \/>1.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Ferrage F., Cousin S., <strong>Charlier C.<\/strong>, Marquardsen T., Tyburn J.M., Method for two field nuclear magnetic resonance measurements. Patent application EP15290102, 3 Aug. 2018<\/p><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Cyril CHARLIER Cyril CHARLIER CR CNRS Equipe RMN +33 (0)5 31 96 89 88 charlier@insa-toulouse.fr ORCID RESEARCH GATE Linkedin Actual position and research subject I joined the TBI in November 2019 as a CNRS researcher in NMR team (EAD17). My main goal is to apply NMR in the framework of biotechnologies focusing on the question [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-8094","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Cyril CHARLIER | TBI, Toulouse Biotechnology Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/cyril-charlier\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cyril CHARLIER | TBI, Toulouse Biotechnology Institute\" \/>\n<meta property=\"og:description\" content=\"Cyril CHARLIER Cyril CHARLIER CR CNRS Equipe RMN +33 (0)5 31 96 89 88 charlier@insa-toulouse.fr ORCID RESEARCH GATE Linkedin Actual position and research subject I joined the TBI in November 2019 as a CNRS researcher in NMR team (EAD17). My main goal is to apply NMR in the framework of biotechnologies focusing on the question [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/cyril-charlier\/\" \/>\n<meta property=\"og:site_name\" content=\"TBI, Toulouse Biotechnology Institute\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/TBI-Toulouse-Biotechnology-Institute-Bio-Chemical-Engineering-360428497952306\" \/>\n<meta property=\"article:modified_time\" content=\"2022-09-22T09:24:04+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.toulouse-biotechnology-institute.fr\/wp-content\/uploads\/2022\/04\/Cyril-Charlier-.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@TBI_Biotech\" \/>\n<meta name=\"twitter:label1\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/cyril-charlier\\\/\",\"url\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/cyril-charlier\\\/\",\"name\":\"Cyril CHARLIER | TBI, Toulouse Biotechnology Institute\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/cyril-charlier\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/cyril-charlier\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/wp-content\\\/uploads\\\/2022\\\/04\\\/Cyril-Charlier-.jpg\",\"datePublished\":\"2022-04-22T18:37:26+00:00\",\"dateModified\":\"2022-09-22T09:24:04+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/cyril-charlier\\\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/cyril-charlier\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/cyril-charlier\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/wp-content\\\/uploads\\\/2022\\\/04\\\/Cyril-Charlier-.jpg\",\"contentUrl\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/wp-content\\\/uploads\\\/2022\\\/04\\\/Cyril-Charlier-.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/cyril-charlier\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Cyril CHARLIER\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/#website\",\"url\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/\",\"name\":\"TBI, Toulouse Biotechnology Institute\",\"description\":\"Bio &amp; 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