{"id":7619,"date":"2022-04-22T13:13:51","date_gmt":"2022-04-22T11:13:51","guid":{"rendered":"http:\/\/v2tbi.christelle-labruyere.com\/?page_id=7619"},"modified":"2022-06-08T19:26:14","modified_gmt":"2022-06-08T17:26:14","slug":"philippe-urban","status":"publish","type":"page","link":"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/philippe-urban\/","title":{"rendered":"Philippe URBAN"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"7619\" class=\"elementor elementor-7619\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1b37fa63 elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"1b37fa63\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;,&quot;shape_divider_bottom&quot;:&quot;waves&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t<div class=\"elementor-shape elementor-shape-bottom\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 1000 100\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M421.9,6.5c22.6-2.5,51.5,0.4,75.5,5.3c23.6,4.9,70.9,23.5,100.5,35.7c75.8,32.2,133.7,44.5,192.6,49.7\n\tc23.6,2.1,48.7,3.5,103.4-2.5c54.7-6,106.2-25.6,106.2-25.6V0H0v30.3c0,0,72,32.6,158.4,30.5c39.2-0.7,92.8-6.7,134-22.4\n\tc21.2-8.1,52.2-18.2,79.7-24.2C399.3,7.9,411.6,7.5,421.9,6.5z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-125cd54\" data-id=\"125cd54\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4239c945 elementor-widget elementor-widget-heading\" data-id=\"4239c945\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Philippe URBAN<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-762e9b9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"762e9b9\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-2f523c4\" data-id=\"2f523c4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-feae8ca elementor-position-left elementor-vertical-align-top elementor-widget elementor-widget-image-box\" data-id=\"feae8ca\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img fetchpriority=\"high\" decoding=\"async\" width=\"542\" height=\"542\" src=\"https:\/\/www.toulouse-biotechnology-institute.fr\/wp-content\/uploads\/2022\/04\/Philippe-URBAN.png\" class=\"attachment-full size-full wp-image-7621\" alt=\"Philippe URBAN\" srcset=\"https:\/\/www.toulouse-biotechnology-institute.fr\/wp-content\/uploads\/2022\/04\/Philippe-URBAN.png 542w, https:\/\/www.toulouse-biotechnology-institute.fr\/wp-content\/uploads\/2022\/04\/Philippe-URBAN-12x12.png 12w\" sizes=\"(max-width: 542px) 100vw, 542px\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Philippe URBAN <\/h3><p class=\"elementor-image-box-description\">CNRS Charg\u00e9 de Recherche Hors Classe <br>\nI2M Team leader<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c285827 elementor-widget elementor-widget-button\" data-id=\"c285827\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-xs\" href=\"https:\/\/www.toulouse-biotechnology-institute.fr\/poles\/equipe-i2m\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Equipe I2M<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-92c1b19\" data-id=\"92c1b19\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-19daa50 elementor-align-start elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"19daa50\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-phone\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">+33 6 60 23 7 08 or +33 5 67 04 88 13<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-mail-bulk\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">urban@insa-toulouse.fr<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/orcid.org\/0000-0003-0557-839X\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg 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c-0.19-68.64-0.01-137.28-0.32-205.92c-0.13-29.56-2.88-58.87-12.88-87.03c-10.82-30.47-30.21-53.05-60.89-64.68 c-27.19-10.31-55.51-12.75-84.05-8.34c-35.84,5.53-64.55,22.98-83.81,54.48c-0.59,0.96-0.95,2.44-2.39,2.1 c-1.54-0.37-0.98-1.91-0.99-2.98c-0.04-13.83-0.19-27.66,0.08-41.48c0.08-4.24-1.25-5.27-5.34-5.25 c-32.49,0.15-64.98,0.18-97.47-0.02c-4.46-0.03-5.51,1.19-5.5,5.57C296.76,350.3,296.71,409.12,296.71,467.93z M225.26,468.62 c0-59.13-0.04-118.25,0.09-177.38c0.01-4.1-1.01-5.33-5.23-5.31c-34.14,0.17-68.29,0.17-102.44,0c-4.1-0.02-5.31,1.01-5.31,5.22 c0.11,117.92,0.11,235.84,0,353.76c0,4.14,1.06,5.29,5.24,5.27c33.98-0.17,67.96-0.18,101.94,0c4.47,0.02,5.83-0.99,5.82-5.69 C225.2,585.87,225.26,527.25,225.26,468.62z M235.05,171.19c0.43-35.86-29.15-65.81-65.48-66.29 c-35.93-0.48-65.66,29.02-66.08,65.57c-0.41,35.76,28.98,65.58,65.1,66.07C204.49,237.02,234.62,207.39,235.05,171.19z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Linkedin<\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.researchgate.net\/profile\/Philippe-Urban\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" id=\"Calque_1\" x=\"0px\" y=\"0px\" viewBox=\"0 0 123.54 129.06\" style=\"enable-background:new 0 0 123.54 129.06;\" xml:space=\"preserve\"><style type=\"text\/css\">\t.st0{fill:#3D4459;}<\/style><path class=\"st0\" d=\"M123.71-1.36c0,74.98-0.44,55.9-0.44,130.88c-74.52-0.01-48.75,0.01-123.26,0c-0.07-0.84,0,0.84,0,0 C0.02,55.4-0.46,73.22-0.43-0.91C74.13-0.91,49.15-1.36,123.71-1.36z M10.35,41.43L10.35,41.43c0,0.01,1.19,0.61,2.29,0.8 c5.83,1.02,6.94,6.35,6.93,11.65C19.54,70.59,19.6,87.3,19.56,104c-0.02,7.12-1.53,9.28-8.03,11.76c-1.34,0.51-2.53,1.1-2.61,2.62 c-0.1,1.75,0.57,2.91,2.52,2.83c9.3-0.52,18.59-0.56,27.9-0.26c1.45,0.05,4.07,0.34,4.13-1.87c0.08-2.71-2.29-2.32-4.01-2.59 c-6.67-1.05-7.95-2.23-8.19-8.85c-0.24-6.8-0.1-13.61-0.1-20.42c0-1.28-0.28-2.66,1.33-3.41c3.14-1.45,8.9,0.31,10.69,3.34 c5.55,9.44,11.17,18.83,18.37,27.16c5.31,6.15,12.17,8.41,20.08,7.82c1.55-0.12,3.51-0.11,3.76-2.43c0.24-2.13-1.44-2.29-2.85-2.72 c-4.26-1.32-7.59-3.93-10.53-7.22c-6.43-7.2-11.82-15.16-17.24-23.11c-1.43-2.09-0.92-3.81,0.86-5.17c1.44-1.11,3.16-1.83,4.69-2.83 c13.64-8.93,15.07-29.56,0.54-37.81c-2.17-1.53-3.5-1.69-5.68-2.3c-0.65-0.14-1.31-0.28-1.96-0.42c-1.19-0.47-1.35-0.39-3.03-0.57 c-1.02-0.11-2.04-0.22-3.06-0.34c-11.83-1.74-23.74,0.19-35.61-0.54C9.42,36.55,7.37,38.96,10.35,41.43z M80.42,34.52 c0.1,1.72,0.2,4.38,0.43,7.02c1.21,14.03,15.05,19.25,26.4,11.92c5.03-3.25,8.86-14.88,6-20.32c-2.27-4.32-7.21-1.2-10.89-1.83 c-1.98-0.34-4.49-0.63-4.61,2.83c-0.12,3.69,2.36,3.51,4.69,3.31c3.46-0.31,4.38,1.13,3.88,4.37c-0.8,5.12-3.92,8.08-9,8.15 c-5.12,0.08-8.5-2.62-9.19-7.89c-0.73-5.61-0.57-11.28-0.09-16.9c0.35-4.08,2.19-7.52,6.4-8.59c4.05-1.03,7.94-0.57,10.47,3.55 c1.82,2.96,4.19,1.52,5.97,0.17c2.24-1.7,0.15-3.29-0.87-4.58c-4.32-5.47-10.24-6.44-16.65-5.3c-6.34,1.13-10.38,4.94-11.91,11.26 C80.51,25.6,80.48,29.59,80.42,34.52z\"><\/path><path class=\"st0\" d=\"M31.12,60.14c0-3.82,0.26-7.66-0.07-11.45c-0.38-4.32,1.46-5.64,5.45-5.22c1.97,0.21,3.99,0.04,5.98,0.08 c10.26,0.19,16.44,5.63,17.04,14.98c0.65,10.12-5.18,17.35-15.15,18.79C32.08,79.1,31.14,78.3,31.14,66.11c0-1.99,0-3.98,0-5.98 C31.14,60.14,31.13,60.14,31.12,60.14z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Research gate <\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-bc836c5 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"bc836c5\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-07a549e\" data-id=\"07a549e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5879caf elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"5879caf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4c71302 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4c71302\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-889e2b0\" data-id=\"889e2b0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-dfd8563 elementor-widget elementor-widget-heading\" data-id=\"dfd8563\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Actual position and research subject<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2e9438f elementor-widget elementor-widget-text-editor\" data-id=\"2e9438f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Since October 1984, I am a scientist at ISB (Institut des Sciences Biologiques) of the CNRS, and I depend on its Section 20: \u201cMolecular and Structural Biology and Biochemistry\u201d. ISince 2011, I am working at the <em>Toulouse Biotechnology Institute<\/em> as head of research group i2m (Metabolic and Molecular Engineering).<\/p><p>\u00a0<\/p><p>My research interests are cytochromes P450, a superfamily of heme-thiolate monooxygenases that are found in all kingdoms of Nature.\u00a0 A recent search in the PDB with P450 as a keyword retrieved some 539,610 entries in the UniProtKB TrEMBL database. Since their discovery in the late 1950s, these heme\u2013thiolate proteins have been found in both prokaryotes and eukaryotes with a very few exceptions (less than 10 organisms such as <em>E. coli<\/em>). Recently, cytochrome P450s have also been spotted in viruses.<\/p><p>My research concerns the enzymology and structural biology of P450s. Identification and functional studies have shown that some P450s are specific to one substrate while others are able to accommodate a vast array of organic molecules. In humans, some P450s are involved in the critical metabolism of drug metabolism and pollutant detoxification. Others are involved in steroid and eicosanoid biosyntheses. In plants, most of the secondary metabolism pathways include one or several cytochrome P450s. Surprisingly, all these numerous P450 enzymes share a very similar 3D fold, and a similar catalytic cycle, though they accepts thousands of substrates very different in size and in nature. This apparent antinomy is appealing to the enzymologist I think I am.<\/p><p>\u00a0<\/p><p>Being membrane-bound, eukaryotic P450s are difficult to crystallize. Most of them lack a known experimental 3D structure. The very recent advent of the deep-learning artificial intelligence AlphaFold2 has opened fast access to the 3D structures of all membrane-bound P50s. I am currently working with some poorly documented properties of AlphaFold2_advanced, the latest version of AlphaFold2. The power of this AI tool is appealing to the structural biologist I hope I am.<\/p><p>\u00a0<\/p><p>My research concerns also electron transfer properties of flavoenzymes belonging to the family of diflavine reductases that oxidize NADPH and transfers the electrons to FAD then to FMN (bot flavins being on a single polypeptide chain) and from FMN to various protein acceptors, including P450 enzymes. How does the dynamics between the different flavin-containing domains of this flavoenzyme regulate the flow of electron and, hence, its kinetic properties is an interesting question that I try to look at.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8a6f373 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8a6f373\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2cf13c6\" data-id=\"2cf13c6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-cbe7f0d elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"cbe7f0d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-eba8b04 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"eba8b04\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8b5e687\" data-id=\"8b5e687\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-86b9cdc elementor-widget elementor-widget-heading\" data-id=\"86b9cdc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Education and Diploma<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-beda416 elementor-tabs-view-horizontal elementor-widget elementor-widget-tabs\" data-id=\"beda416\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"tabs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-tabs\">\n\t\t\t<div class=\"elementor-tabs-wrapper\" role=\"tablist\" >\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-2001\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"elementor-tab-content-2001\" aria-expanded=\"false\">1983<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-2002\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2002\" aria-expanded=\"false\">2002<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"elementor-tabs-content-wrapper\" role=\"tablist\" aria-orientation=\"vertical\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"elementor-tab-content-2001\" aria-expanded=\"false\">1983<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2001\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2001\" tabindex=\"0\" hidden=\"false\"><p>PhD in Biochemistry-Enzymology at Universit\u00e9 de Paris &#8211; Sud Orsay.<\/p><p>La catalyse flavinique dans le flavocytochrome <em>b<\/em><sub>2<\/sub> de levure<\/p><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2002\" aria-expanded=\"false\">2002<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2002\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2002\" tabindex=\"0\" hidden=\"hidden\"><p>HDR Universit\u00e9 de Paris \u2013 Sud Orsay.<\/p><p>Souplesse adaptative de la sp\u00e9cificit\u00e9 de substrat des cytochromes P450<\/p><\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3253b9c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3253b9c\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0660aec\" data-id=\"0660aec\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-540bb2c elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"540bb2c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-25ed5ca elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"25ed5ca\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ef30f39\" data-id=\"ef30f39\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-99ba7aa elementor-widget elementor-widget-heading\" data-id=\"99ba7aa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Others<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-88c3bbf elementor-widget elementor-widget-text-editor\" data-id=\"88c3bbf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Membre nomm\u00e9 de la Commission Scientifique Sp\u00e9cialis\u00e9e 1 de l\u2019Inserm pour la mandature 2022-2026.<\/li><li>Editeur \u00e0 <em>Biomolecules<\/em>.<\/li><li>Guest-Editor for a Special issue on: \u201cNew Insights in Cytochromes P450\u201d in 2021-2022.<\/li><li>Guest-Editor for a Special Issue on: \u201cAlphaFold2 and Structural Biology\u201d in 2022-2023.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-26aa7ce elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"26aa7ce\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0900ee2\" data-id=\"0900ee2\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-25dce21 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"25dce21\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a76ee75 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a76ee75\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c8a37c6\" data-id=\"c8a37c6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f8d64f2 elementor-widget elementor-widget-heading\" data-id=\"f8d64f2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">List of selected publications<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-79d3ae9 elementor-widget elementor-widget-text-editor\" data-id=\"79d3ae9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>P. Urban and D Pompon. Confrontation of AlphaFold2 models with cryo-EM and crystal structures enlightens alternate geometries of the CYP102A1 multidomain protein. bioRxiv (2022) https:\/\/doi.org\/10.1101\/2022.03.21.485149.<\/li><li>D. Pompon, B Loouerat, A Bronine, and P. Urban. Yeast expression of animal and plant P450s in optimized redox environments. Methods in Enzymology (1996) 272, 51-64.<\/li><li>P. Urban, and F Lederer. Baker&#8217;s yeast flavocytochrome <em>b<\/em>2 A mechanistic study of the dehydrohalogenation reaction. Eur J Biochem (1984) 144, 345-351.<\/li><li>P. Urban, G. Truan, and D Pompon. Access channels to the buried active site control substrate specificity in CYP1A P450 enzymes. Biochim Biophys Acta (2015) 1850, 696-707.<\/li><li>F Tesson, I Limon-Boulez, P Urban et al. Localization of I2-Imidazoline Binding Sites on Monoamine Oxidases. J Biol Chem (1995) 270, 9856-9861.<\/li><li>P Urban, C Mignotte, M Kazmaier, F Delorme, and D Pompon. Cloning, yeast expression, and characterization of the coupling of two distantly related <em>Arabidopsis thaliana<\/em> NADPH-cytochrome P450 reductases with P450 CYP73A5. J Biol Chem (1997) 272, 19176-19186.<\/li><li>G Truan, C Cullin, P Reisdorf, P Urban, and \u00a0D Pompon. Enhanced in vivo monooxygenase activities of mammalian P450s in engineered yeast cells producing high levels of NADPH-P450 reductase and human cytochrome <em>b<\/em><sub>5<\/sub>. Gene (1993) 125, 49-55.<\/li><li>P Urban, D Werck-Reichhart et al. Characterization of recombinant plant cinnamate 4\u2010hydroxylase produced in yeast: Kinetic and spectral properties of the major plant P450 of the phenylpropanoid pathway. Eur J Biochem (1994) 222, 843-850.<\/li><li>C Muller, D Pompon, P Urban, and R Morfin. Inter-conversion of 7\u03b1-and 7\u03b2-hydroxy-dehydroepiandrosterone by the human 11\u03b2-hydroxysteroid dehydrogenase type 1. J Steroid Biochem Mol Biol (2006) 99, 215-222.<\/li><li>JC Gautier, S Lecoeur, J Cosme, A Perret, P Urban, P Beaune, and D Pompon. Contribution of human cytochrome P450 to benzo[a]pyrene and benzo[<em>a<\/em>]pyrene-7,8-dihydrodiol metabolism, as predicted from heterologous expression in yeast. Pharmacogenet (1999) 6, 489-499.<\/li><li>D Pompon, G Truan, and P Urban. L\u2019ing\u00e9nierie des cytochromes P450. Biofutur (200) 34-58.<\/li><li>P Urban, XO Breakfield, and D Pompon. Expression of membrane-bound flavoenzymes in yeast. Flavins and Flavoproteins (1990) 869-872.<\/li><li>F Esteves, P Urban, J Rueff, G Truan, and M Kranendonk. Interaction modes of microsomal cytochrome P450s with its reductase and the role of substrate binding. Int J Mol Sci (2020) 21, e6669.<\/li><li>F Esteves, D Campelo, BC Gomes, P Urban et al. The role of the FMN-domain of human cytochrome P450 oxidoreductase in its promiscuous interactions with structurally diverse redox partners. Front Pharmacol (2020) 11, e299.<\/li><li>P Urban, G Truan, and D Pompon. High-throughput enzymology and combinatorial mutagenesis for mining cytochrome P450 functions. Exp Opin Drug Metab Toxicol (2008) 4, 733-747.<\/li><li>T Lautier, P Urban, J Loeper, L Jezequel, D Pompon, and G Truan. Ordered chimerogenesis applied to CYP2B P450 enzymes. Biochim Biophys Acta (2016) 1860, 1395-1403.<\/li><li>S Casta\u00f1o-Cerezo, M Fourni\u00e9, P Urban, JL Faulon, and G Truan. Development of a biosensor for detection of benzoic acid derivatives in <em>Saccharomyces cerevisiae<\/em>. Front Bioeng Biotech (2020) e372.<\/li><li>TEM Parente, P Urban, D Pompon, and MF Rebelo. Altered substrate specificity of the Pterygoplichthys sp.(Loricariidae) CYP1A enzyme. Aquat Toxicol (2014) 154, 193-199.<\/li><li>KS Shohdy, WA Rashad, MK Fargoun, and P Urban. The morphogen behind primary congenital glaucoma and the dream of targeting. J Morphol Embryol 58, 351-361.<\/li><li>D Pompon, JC Gautier, A Perret, G Truan, and P Urban. Simulation of human xenobiotic metabolism in microorganisms: yeast a good compromise between E. coli and human cells. J Hepatol (1997) 26, 81-85.<\/li><li>P Urban and F Lederer. Inactivation of flavocytochrome <em>b<\/em><sub>2<\/sub> with fluoropyruvate: Reaction at the active\u2010site histidine. Eur J Biochem (1988) 173, 155-162.<\/li><\/ul><p>\u00a0<\/p><p>\u00a0<\/p><p>Google Scholar: Philippe Urban\u2019s all publications<\/p><p><a href=\"https:\/\/scholar.google.com\/citations?hl=fr&amp;user=u8FuS9kAAAAJ\">https:\/\/scholar.google.com\/citations?hl=fr&amp;user=u8FuS9kAAAAJ<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Philippe URBAN Philippe URBAN CNRS Charg\u00e9 de Recherche Hors Classe I2M Team leader Equipe I2M +33 6 60 23 7 08 or +33 5 67 04 88 13 urban@insa-toulouse.fr Orcid Linkedin Research gate Actual position and research subject Since October 1984, I am a scientist at ISB (Institut des Sciences Biologiques) of the CNRS, and [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-7619","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - 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