{"id":7100,"date":"2022-04-16T14:37:03","date_gmt":"2022-04-16T12:37:03","guid":{"rendered":"http:\/\/v2tbi.christelle-labruyere.com\/?page_id=7100"},"modified":"2026-03-05T12:16:08","modified_gmt":"2026-03-05T11:16:08","slug":"prod","status":"publish","type":"page","link":"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/poles\/equipe-phyge\/prod\/","title":{"rendered":"Production scientifique PHYGE"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"7100\" class=\"elementor elementor-7100\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2ec79ae8 elementor-section-height-min-height elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"2ec79ae8\" data-element_type=\"section\" data-e-type=\"section\" 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data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-bf57318 elementor-widget elementor-widget-heading\" data-id=\"bf57318\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Equipe PHYGE<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-f4529a1\" data-id=\"f4529a1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3b180dd elementor-align-right elementor-widget elementor-widget-button\" data-id=\"3b180dd\" data-element_type=\"widget\" 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data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Production scientifique<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2d91756 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2d91756\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e4c0e78\" data-id=\"e4c0e78\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9dc752a elementor-widget elementor-widget-heading\" data-id=\"9dc752a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Articles<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8883498 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8883498\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2a1283d\" data-id=\"2a1283d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2b7c32e elementor-widget elementor-widget-toggle\" data-id=\"2b7c32e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-4551\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-4551\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">2026<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-4551\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-4551\"><ul><li>Pijpstra P, Guillouet SE, Heidinger P, Kourist R, Gorret N. 2026. <b>Considerations of Bacterial Robustness and Stability to Improve Bioprocess Design<\/b>. Fermentation 12:54.<\/li><li>Joris P, Lombard E, Paillet A, Navarro G, Guillouet SE, Gorret N. 2026. <b>Investigation of Nitrate Respiration in Cupriavidus necator for Application in Life Support System<\/b>. Fermentation 12:81.<\/li><li><strong>Bisceglie FD, Lombard E, Kratzer R, Gorret N, Lorain O, Guillouet SE.<\/strong> Aerobic autotrophic isopropanol production under low H2 atmosphere in Hollow Fiber Membrane Bioreactor. Bioresource Technology <strong>440:<\/strong>133407.<\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-4552\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-4552\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">2025<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-4552\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-4552\"><ul><li><strong>Malfoy T, Alkim C, Fran\u00e7ois JM.<\/strong> 2025. Enzyme promiscuity in the field of synthetic biology applied to white biotechnology: Opportunities and weaknesses. BIODESIGN RESEARCH <strong>7<\/strong>.<\/li><li><strong>La Rosa AD, Francois JM, Auriol C.<\/strong> 2025, Ex-ante LCA of a novel biodegradable polymer based on 2,4-dihydroxybutyric acid produced from renewable carbon feedstock. IFAC PAPERSONLINE<\/li><li><strong>Ismail S, Giacinti G, Raynaud CD, Alfenore S, Guillouet SE, Gorret N.<\/strong> 2025. Characterization of Single Cell Protein produced by Cupriavidus necator grown on various nitrogen and carbon sources. Journal of Biotechnology <strong>408:<\/strong>288-304.<\/li><li><strong>Gonzalez IC, Gorret N, Lauterbach L, Guillouet SE.<\/strong> 2025. Glycerol-supplemented medium promotes transition of Cupriavidus necator from heterotrophic to lithoautotrophic growth. BIOTECHNOLOGY LETTERS <strong>48<\/strong>.<\/li><li><strong>Gelain L, Yeoh JW, Hossain GS, Alfenore S, Guillouet S, Ling H, Poh CL, Gorret N, Foo JL.<\/strong> 2025. Identification and monitoring of cell heterogeneity from plasmid recombination during limonene production. Appl. Microbiol. Biotechnol. <strong>109:<\/strong>15.<\/li><li><strong>Buron-Moles G, Vandenbossche V, Gorret N, Santonja-Blasco L, Gonz\u00e1lez-Aranda T, Cameleyre X, Guillouet S.<\/strong> 2025. Biodegradation of pre-treated Low-Density Polyethylene (LDPE) by Yarrowia lipolytica determined by oxidation and molecular weight reduction. Polymer Degradation and Stability<strong>:<\/strong>111292.<\/li><li><strong>Alhafiza H, Di Bisceglie F, F. MHP, Weickardt I, Castro Gonz\u00e1lezc GA, J. GN, Schoenmakersc P, Oyenf SJ, Lettauc E, Lombard E, Corderoc PRF, Konarzycka-Besslerf M, Gorret N, Schmidte S, Schillbergf S, Mannh M, Guillouet S. E., Kratzer R, Lauterbach L.<\/strong> 2025. C. necator as a model organism for CO2-based biotechnology. Methodes in Enzymology.<\/li><li><strong>Bisceglie FD, Lombard E, Kratzer R, Gorret N, Lorain O, Guillouet SE.<\/strong> Aerobic autotrophic isopropanol production under low H2 atmosphere in Hollow Fiber Membrane Bioreactor. Bioresource Technology <strong>440:<\/strong>133407.<\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-4553\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"button\" aria-controls=\"elementor-tab-content-4553\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">2024<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-4553\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"region\" aria-labelledby=\"elementor-tab-title-4553\"><ul><li><strong>Schiavone M, Dagkesamanskaya A, Vieu PG, Duperray M, Duplan-Eche V, Fran\u00e7ois JM.<\/strong> 2024. A flow cytometry method for quantitative measurement and molecular investigation of the adhesion of bacteria to yeast cells. SCIENTIFIC REPORTS <strong>14<\/strong>.<\/li><li><strong>Joris P, Lombard E, Paillet A, Navarro G, Guillouet SE, Gorret N.<\/strong> 2024. Recycling potential of Cupriavidus necator for life support in space: Production of SCPs from volatile fatty acid and urea mixture. Journal of Biotechnology <strong>396:<\/strong>18-27.<\/li><li><strong>Ismail S, Giacinti G, Raynaud CD, Cameleyre X, Alfenore S, Guillouet S, Gorret N.<\/strong> 2024. Impact of the environmental parameters on single cell protein production and composition by Cupriavidus necator. Journal of Biotechnology <strong>388:<\/strong>83-95.<\/li><li><strong>El Meouche I, Jain P, Jolly MK, Capp JP.<\/strong> 2024. Drug tolerance and persistence in bacteria, fungi and cancer cells: Role of non-genetic heterogeneity. TRANSLATIONAL ONCOLOGY <strong>49<\/strong>.<\/li><li><strong>Duperray M, Delvenne M, Fran\u00e7ois JM, Delvigne F, Capp JP.<\/strong> 2024. Genomic and metabolic instability during long-term fermentation of an industrial Saccharomyces cerevisiae strain engineered for C5 sugar utilization. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY <strong>12<\/strong>.<\/li><li>\u00a0<\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-4554\" class=\"elementor-tab-title\" data-tab=\"4\" role=\"button\" aria-controls=\"elementor-tab-content-4554\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">2023<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-4554\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"4\" role=\"region\" aria-labelledby=\"elementor-tab-title-4554\"><ul><li><strong>Tissot S, Guimard L, Meliani J, Boutry J, Dujon AM, Capp J-P, T\u00f6k\u00f6lyi J, Biro PA, Beckmann C, Fontenille L, Do Khoa N, Hamede R, Roche B, Ujvari B, Nedelcu AM, Thomas F.<\/strong> 2023. The impact of food availability on tumorigenesis is evolutionarily conserved. Scientific Reports <strong>13:<\/strong>19825.<\/li><li><strong>Schiavone M, Fran\u00e7ois JM, Zerbib D, Capp JP.<\/strong> 2023. Emerging relevance of cell wall components from non-conventional yeasts as functional ingredients for the food and feed industry. CURRENT RESEARCH IN FOOD SCIENCE <strong>7<\/strong>.<\/li><li><strong>Rawling M, Schiavone M, Mugnier A, Leclercq E, Merrifield D, Foey A, Apper E.<\/strong> 2023. Modulation of Zebrafish (Danio rerio) Intestinal Mucosal Barrier Function Fed Different Postbiotics and a Probiotic from Lactobacilli. MICROORGANISMS <strong>11<\/strong>.<\/li><li><strong>Rawling M, Schiavone M, Apper E, Merrifield DL, Castex M, Leclercq E, Foey A.<\/strong> 2023. Yeast cell wall extracts from Saccharomyces cerevisiae varying in structure and composition differentially shape the innate immunity and mucosal tissue responses of the intestine of zebrafish (Danio rerio). FRONTIERS IN IMMUNOLOGY <strong>14<\/strong>.<\/li><li><strong>Holyavkin C, Turanli-Yildiz B, Yilmaz \u00dc, Alkim C, Arslan M, Topaloglu A, Kisakesen HI, de Billerbeck G, Fran\u00e7ois JM, \u00c7akar ZP.<\/strong> 2023. Genomic, transcriptomic, and metabolic characterization of 2-Phenylethanol-resistant Saccharomyces cerevisiae obtained by evolutionary engineering. FRONTIERS IN MICROBIOLOGY <strong>14<\/strong>.<\/li><li><strong>Francois JM, Atsumi S.<\/strong> 2023. Editorial: Insights into synthetic biology 2021: Novel developments, current challenges, and future perspectives. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY <strong>11<\/strong>.<\/li><li><strong>Fran\u00e7ois JM.<\/strong> 2023. Progress advances in the production of bio-sourced methionine and its hydroxyl analogues. BIOTECHNOLOGY ADVANCES <strong>69<\/strong>.<\/li><li><strong>Duperray M, Francois JM, Capp JP.<\/strong> 2023. Tuning the expression of the bacterial relBE toxin-antitoxin system in Saccharomyces cerevisiae allows characterizing the subsequent growth inhibition. FEMS YEAST RESEARCH <strong>23<\/strong>.<\/li><li><strong>Demir-Yilmaz I, Schiavone M, Esvan J, Guiraud P, Dague CF.<\/strong> 2023. Combining AFM, XPS and chemical hydrolysis to understand the complexity and dynamics of C. vulgaris cell wall composition and architecture. ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS <strong>72<\/strong>.<\/li><li><strong>Batista M, Donker EIM, Bon C, Guillien M, Caisso A, Mourey L, Francois JM, Maveyraud L, Zerbib D.<\/strong> 2023. The Conserved Yeast Protein Knr4 Involved in Cell Wall Integrity Is a Multi-domain Intrinsically Disordered Protein. JOURNAL OF MOLECULAR BIOLOGY <strong>435<\/strong>.<\/li><li><strong>Anton A, Plinet M, Peyret T, Cazaudarr\u00e9 T, Pesant S, Rouquet Y, Tricoteaux MA, Bernier M, Bayette J, Fournier R, Marguerettaz M, Rolland P, Bayol T, Abbaoui N, Berry A, Iriart X, Cassaing S, Chauvin P, Bernard E, Fabre R, Fran\u00e7ois JM.<\/strong> 2023. Rapid and Accurate Diagnosis of Dermatophyte Infections Using the DendrisCHIP\u00ae Technology. DIAGNOSTICS <strong>13<\/strong>.<\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-4555\" class=\"elementor-tab-title\" data-tab=\"5\" role=\"button\" aria-controls=\"elementor-tab-content-4555\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">2022<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-4555\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"5\" role=\"region\" aria-labelledby=\"elementor-tab-title-4555\"><ul><li><strong>Tan, M., Caro Y., Lebeau, J., Shum-Cheong-Sing, A. Fran\u00e7ois, J., Regnier, T. and Petit T.<\/strong> (2022) Screening of the yeasts biodiversity from South-African wild animal faeces for the production of volatile \u03b1-unsaturated esters.<em> Life 12, 1999. <\/em><a href=\"https:\/\/doi.org\/10.3390\/life12121999\" target=\"_blank\" rel=\"noopener\">org\/10.3390\/life12121999<\/a><\/li><li><strong>Alkim, C., Farias, D.,Fredonnet, J., Serrano-Bataille, H., Herviou, P., Marc Picot, M., Slama, N., Dejean, S., Morin, N., Enjalbert, B. and Fran\u00e7ois, J.M<\/strong>. (2022) Toxic effect and inability of L-homoserine to be a nitrogen source for growth of <em>Escherichia coli<\/em> resolved by a combination of <em>in vivo <\/em>evolution engineering and omics analyses. <em>Front Microbiol<\/em> DOI: <a href=\"https:\/\/doi.org\/10.3389\/fmicb.2022.1051425\" target=\"_blank\" rel=\"noopener\">10.3389\/fmicb.2022.1051425<\/a><\/li><li><strong>Fran\u00e7ois J. M <\/strong>(2022) How White Biotechnology can contribute to BioEconomy. A personal consideration. <em>The Journal Ecological Eng &amp; Env Protect<\/em>. 2, 5-17.<\/li><li><strong>Tan M, Caro Y, Lebeau J, Shum-Cheong-Sing A, Fran\u00e7ois JM, Regnier T, Petit T.<\/strong> 2022. Screening for Volatile \u03b1-Unsaturated Ester-Producing Yeasts from the Feces of Wild Animals in South Africa. LIFE-BASEL <strong>12<\/strong>.<\/li><li><strong>Bernard E, Peyret T, Plinet M, Contie Y, Cazaudarr\u00e9 T, Rouquet Y, Bernier M, Pesant S, Fabre R, Anton A, Maugis-Rabusseau C, Fran\u00e7ois JM.<\/strong> 2022. The DendrisCHIP\u00ae Technology as a New, Rapid and Reliable Molecular Method for the Diagnosis of Osteoarticular Infections. DIAGNOSTICS <strong>12<\/strong>.<\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-4556\" class=\"elementor-tab-title\" data-tab=\"6\" role=\"button\" aria-controls=\"elementor-tab-content-4556\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">2021<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-4556\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"6\" role=\"region\" aria-labelledby=\"elementor-tab-title-4556\"><ul><li><strong>Arabaciyan, S.<\/strong>, <strong>Saint-Antoine, M., Maugis-Rabusseau, C., Fran\u00e7ois, J., Singh, A., Parrou, JL &amp; Capp, JP<\/strong> (2021) Insight on the control of yeast single-cell growth variability by members of the trehalose phosphate synthase (TPS) complexe. <em>Front. Cell Dev. Biol\u00a0<\/em>, 9, 607628\u00a0; DOI 10.3389\/fcell.2021.607628<\/li><li><strong>Tan, M.<\/strong>, <strong>Caro, Y., Shum-Cheong-Sing, A., Robert, L., Fran\u00e7ois, J. &amp; Petit Thomas<\/strong> (2021) Evaluation of mixed-fermentation of <em>Saccharomyces cerevisiae<\/em> with <em>Saprochete swaveolens<\/em> to produce natural fruity beer from industrial wort. <em>Food Chem<\/em> 2021 Jan 5;346:128804. doi: 10.1016\/j.foodchem.2020.128804<\/li><li><strong>Agboola JO, Schiavone M, \u00d8verland M, Morales-Lange B, Lagos L, Arntzen M\u00d8, Lape\u00f1a D, Eijsink VGH, Horn SJ, Mydland LT, Fran\u00e7ois JM, Mercado L, Hansen J\u00d8<\/strong>. (2021) Impact of down\u2011stream processingon functional properties of yeastsand the implications on gut healthof Atlantic salmon (Salmo salar). <em>Sci. Report, 11, 4496. <\/em>DOI: 10.1038\/s41598-021-83764-2<\/li><li><strong>Bouyx, C., Schiavone, M., Teste, M-A., Swierckowki, N., Julien, A. and Francois, J. <\/strong>(2021). The dual role of amyloid \u03b2-sheet interaction sequences in the cell surface properties of FLO11-encoded flocculins in the yeast <em>Saccharomyces cerevisiae<\/em>. <em>Elife, Sep 1;10:e68592. DOI 10.7554\/eLife.68592. Online ahead of print.<\/em><\/li><li><strong>Wang, M., Yang, C., Fran\u00e7ois, JM, Wan, X., Ni, W., Tu, X., Feang, D., Chen, S. &amp; Huang, F.<\/strong> (2021) Improving microbial conversion efficiency of rapeseed meal by a two-stage strategy combining fungal treatment followed by extraction of phenolic compounds. <em>Frontiers Bioeng Biotech<\/em>. <em>9; e735714<\/em>; <em>DOI 10.3389\/fbioe.2021.735714<\/em><\/li><li><strong>Tan, M., Crao, Y., Shum-Cheong Sing A., Reiss, H., Francois, J M &amp; Petit, T<\/strong>. (2021) Selection by UV mutagenesis and physiological characterization of mutant strains of the yeast <em>Saprochete suaveolens<\/em> (former <em>Geotrichum fragrans<\/em>) with higher capacity to produce flavour compounds.<em> J. of Fung<\/em>i., 7, 1031 DOI: 10.3390\/jof7121031<\/li><li><strong>Bouyx, C.<\/strong>, <strong>Schiavone, M &amp; Fran\u00e7ois J M<\/strong> (2021) FLO11, a developmental gene conferring impressive adaptive plasticity to the yeast <em>Saccharomyces cerevisiae<\/em>. <em>Pathogens<\/em> 10<em>, e1059; Doi.org\/10.3390\/pathogens10111509<\/em><\/li><li><strong>Capp, JP <\/strong>(2021) Interplay between genetic, epigenetic and gene expression variability: considering complexity in evolvability. Evol<em> App<\/em>, <em>14(4):893-901; doi: 10.1111\/eva.13204<\/em><\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-4557\" class=\"elementor-tab-title\" data-tab=\"7\" role=\"button\" aria-controls=\"elementor-tab-content-4557\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">2021<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-4557\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"7\" role=\"region\" aria-labelledby=\"elementor-tab-title-4557\"><p>.\u00a0\u00a0\u00a0\u00a0 <strong>Wang M, Yang C, Fran\u00e7ois JM, Wan X, Deng QC, Feng DY, Deng SY, Chen SW, Huang FH, Chen WC, Gong YM.<\/strong> 2021. A Two-step Strategy for High-Value-Added Utilization of Rapeseed Meal by Concurrent Improvement of Phenolic Extraction and Protein Conversion for Microbial Iturin A Production. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY <strong>9<\/strong>.<\/p><ul><li><strong>Tan MLS, Caro Y, Sing ASC, Reiss H, Francois JM, Petit T.<\/strong> 2021. Selection by UV Mutagenesis and Physiological Characterization of Mutant Strains of the Yeast Saprochaete suaveolens (Former Geotrichum fragrans) with Higher Capacity to Produce Flavor Compounds. JOURNAL OF FUNGI <strong>7<\/strong>.<\/li><li><strong>Tan M, Caro Y, Shum-Cheong-Sing A, Robert L, Fran\u00e7ois JM, Petit T.<\/strong> 2021. Evaluation of mixed-fermentation of Saccharomyces cerevisiae with Saprochaete suaveolens to produce natural fruity beer from industrial wort. FOOD CHEMISTRY <strong>346<\/strong>.<\/li><li><strong>Hansen JO, Lagos L, Lei P, Reveco-Urzua FE, Morales-Lange B, Hansen LD, Schiavone M, Mydland LT, Arntzen MO, Mercado L, Benicio RT, Overland M.<\/strong> 2021. Down-stream processing of baker&#8217;s yeast (Saccharomyces cerevisiae) &#8211; Effect on nutrient digestibility and immune response in Atlantic salmon (Salmo salar). AQUACULTURE <strong>530<\/strong>.<\/li><li><strong>Capp JP.<\/strong> 2021. Interplay between genetic, epigenetic, and gene expression variability: Considering complexity in evolvability. Evol Appl <strong>14:<\/strong>893-901.<\/li><li><strong>Bouyx C, Schiavone M, Teste MA, Dague E, Sieczkowski N, Julien A, Fran\u00e7ois JM.<\/strong> 2021. The dual role of amyloid-\u03b2-sheet sequences in the cell surface properties of FLO11-encoded flocculins in Saccharomyces cerevisiae. ELIFE <strong>10<\/strong>.<\/li><li><strong>Bouyx C, Schiavone M, Fran\u00e7ois JM.<\/strong> 2021. FLO11, a Developmental Gene Conferring Impressive Adaptive Plasticity to the Yeast Saccharomyces cerevisiae. PATHOGENS <strong>10<\/strong>.<\/li><li><strong>Arabaciyan S, Saint-Antoine M, Maugis-Rabusseau C, Fran\u00e7ois JM, Singh A, Parrou JL, Capp JP.<\/strong> 2021. Insights on the Control of Yeast Single-Cell Growth Variability by Members of the Trehalose Phosphate Synthase (TPS) Complex. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY <strong>9<\/strong>.<\/li><li><strong>Agboola JO, Schiavone M, Overland M, Morales-Lange B, Lagos L, Arntzen MO, Lape\u00f1a D, Eijsink VGH, Horn SJ, Mydland LT, Fran\u00e7ois JM, Mercado L, Hansen JO.<\/strong> 2021. Impact of down-stream processing on functional properties of yeasts and the implications on gut health of Atlantic salmon (Salmo salar). SCIENTIFIC REPORTS <strong>11<\/strong>.<\/li><li><strong>Agboola JO, Schiavone M, Overland M, Morales-Lange B, Lagos L, Arntzen MO, Lape\u00f1a D, Eijsink VGH, Horn SJ, Mydland LT, Fran\u00e7ois JM, Mercado L, Hansen JO.<\/strong> 2021. Impact of down-stream processing on functional properties of yeasts and the implications on gut health of Atlantic salmon (Salmo salar) (vol 11, 4496, 2021). SCIENTIFIC REPORTS <strong>11<\/strong>.<\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-4558\" class=\"elementor-tab-title\" data-tab=\"8\" role=\"button\" aria-controls=\"elementor-tab-content-4558\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">2020<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-4558\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"8\" role=\"region\" aria-labelledby=\"elementor-tab-title-4558\"><ul><li><strong>Liu J, Mosser L, Botanch C, Francois JM, Capp JP.<\/strong> 2020. SIR2 Expression Noise Can Generate Heterogeneity in Viability but Does Not Affect Cell-to-Cell Epigenetic Silencing of Subtelomeric URA3 in Yeast. G3-GENES GENOMES GENETICS <strong>10:<\/strong>3435-3443.<\/li><li><strong>Fran\u00e7ois JM, Lachaux C, Morin N.<\/strong> 2020. Synthetic Biology Applied to Carbon Conservative and Carbon Dioxide Recycling Pathways. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY <strong>7<\/strong>.<\/li><li><strong>Fran\u00e7ois JM, Jantti J, Daboussi F.<\/strong> 2020. Editorial: 4th Applied Synthetic Biology in Europe. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY <strong>8<\/strong>.<\/li><li><strong>Francois JM, Alkim C, Morin N.<\/strong> 2020. Engineering microbial pathways for production of bio-based chemicals from lignocellulosic sugars: current status and perspectives. BIOTECHNOLOGY FOR BIOFUELS <strong>13<\/strong>.<\/li><li><strong>Chuppa-Tostain G, Tan M, Adelard L, Shum-Cheong-Sing A, Fran\u00e7ois JM, Caro Y, Petit T.<\/strong> 2020. Evaluation of Filamentous Fungi and Yeasts for the Biodegradation of Sugarcane Distillery Wastewater. MICROORGANISMS <strong>8<\/strong>.<\/li><li><strong>Capp J-P, Thomas F.<\/strong> 2020. A Similar Speciation Process Relying on Cellular Stochasticity in Microbial and Cancer Cell Populations. iScience <strong>23:<\/strong>101531.<\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-4559\" class=\"elementor-tab-title\" data-tab=\"9\" role=\"button\" aria-controls=\"elementor-tab-content-4559\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">2019<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-4559\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"9\" role=\"region\" aria-labelledby=\"elementor-tab-title-4559\"><ul><li><strong>Rawling MD, Pontefract N, Rodiles A, Anagnostara I, Leclercq E, Schiavone M, Castex M, Merrifield DL.<\/strong> 2019. The effect of feeding a novel multistrain yeast fraction on European seabass (Dicentrachus labrax) intestinal health and growth performance. JOURNAL OF THE WORLD AQUACULTURE SOCIETY <strong>50:<\/strong>1108-1122.<\/li><li><strong>Paloque L, Perez-Berezo T, Abot A, Dalloux-Chioccioli J, Bourgeade-Delmas S, Le Faouder P, Pujo J, Teste MA, Fran\u00e7ois JM, Schebb NH, Mainka M, Rolland C, Blanpied C, Dietrich G, Bertrand-Michel J, Deraison C, Valentin A, Cenac N.<\/strong> 2019. Polyunsaturated fatty acid metabolites: biosynthesis in Leishmania and role in parasite\/host interaction[S]. JOURNAL OF LIPID RESEARCH <strong>60:<\/strong>636-647.<\/li><li><strong>Liu J, Francois JM, Capp JP.<\/strong> 2019. Gene Expression Noise Produces Cell-to-Cell Heterogeneity in Eukaryotic Homologous Recombination Rate. FRONTIERS IN GENETICS <strong>10<\/strong>.<\/li><li><strong>Lachaux C, Frazao CJR, Krausser F, Morin N, Walther T, Fran\u00e7ois JM.<\/strong> 2019. A New Synthetic Pathway for the Bioproduction of Glycolic Acid From Lignocellulosic Sugars Aimed at Maximal Carbon Conservation. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY <strong>7<\/strong>.<\/li><li><strong>Frazao CJR, Trichez D, Serrano-Bataille H, Dagkesamanskaia A, Topham CM, Walther T, Fran\u00e7ois JM.<\/strong> 2019. Construction of a synthetic pathway for the production of 1,3-propanediol from glucose. SCIENTIFIC REPORTS <strong>9<\/strong>.<\/li><li><strong>Deshors M, Guais O, Neugnot-Roux V, Cameleyre X, Fillaudeau L, Francois JM.<\/strong> 2019. Combined in situ Physical and ex-situ Biochemical Approaches to Investigate in vitro Deconstruction of Destarched Wheat Bran by Enzymes Cocktail Used in Animal Nutrition. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY <strong>7<\/strong>.<\/li><li><strong>Cox N, Kuemmerle R, Millard P, Cahoreau E, Fran\u00e7ois JM, Parrou JL, Lippens G.<\/strong> 2019. Integrated pH Measurement during Reaction Monitoring with Dual Reception 1H-31P NMR Spectroscopy. ANALYTICAL CHEMISTRY <strong>91:<\/strong>3959-3963.<\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-45510\" class=\"elementor-tab-title\" data-tab=\"10\" role=\"button\" aria-controls=\"elementor-tab-content-45510\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">2018<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-45510\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"10\" role=\"region\" aria-labelledby=\"elementor-tab-title-45510\"><ul><li><strong>Walther, T.<\/strong>, <strong>Calvayrac F., Malbert, Y., Alkim, C., Dressaire, C., Cordier, H., and Francois, J.M<\/strong> (2018) Construction of a synthetic pathway for the production of 2,4-dihydroxybutyric acid from homoserine. <em>Metab. Eng<\/em> 45, 237-245 DOI\/10.1016\/j.ymben.2017.12.005<\/li><li><strong>Irague, R., Topham, C., Martineau N, Baylac A, , Stodel M., Auriol C., Walther,Th., Fran\u00e7ois Jean M., ,Andr\u00e9 I. &amp; Remaud-Sim\u00e9on M. <\/strong>(2018) Conversion of an aspartate kinase into a malate kinase using a generic HTS assay for kinase screening<strong>. <\/strong><em>PlosOne<\/em> 13 (2) e0193036<\/li><li><strong>Chuppa-<\/strong><strong>Tostain, G., Hoarau, J., Watson, M., Adelard, L., Cheong Sing, A., Caro, Y., Grondin, I., Bourven, I., Francois, J.M., Girbal-Neuhauser, E. &amp; Petit T. <\/strong>(2018) Production of <em>Aspergillus niger<\/em> biomass on sugarcan distillery wastemwater: physiological aspects and potential for biodiesel production. <em>Fungal Biol. Biotechnol.,<\/em> 5: 1 <em>doi.org\/10.1186\/s40694-018-0045-6<\/em><\/li><li><strong>Jian, L.<\/strong><strong>, Fran\u00e7ois, J. &amp; Capp, JP <\/strong>(2018) Bimodality of gene expression from yeast promoter can be instigated by DNA context, inducing condition and strain background. <em>FEMS Yeast Res<\/em>., 18 (4). doi: 10.1093\/femsyr\/foy047.<\/li><li><strong>Trichez, D., Auriol, C., Baylac, A., Irague, R., Dressaire, C., Carnicer-Heras, M., Heux, S., Fran\u00e7ois, JM &amp; Walther, T <\/strong>(2018). Engineering of Escherichia coli for Krebs cycle dependent production of malic acid. <em>Microbial Cell Fact<\/em>.17: 113, <em>DOI: 10.1186\/s12934-018-0959-y<\/em><\/li><li><strong>Jian, L. Lestrade, D., Cescut, J. Fran\u00e7ois, J &amp; Capp, JP <\/strong>(2018) A <em>GRX1<\/em> promoter variant confers constitutive noisy bimodal expression that increases oxidtaive stress resistance in yeast. <em>Frontiers in Microbiology, 9, 2158. <\/em>DOI 10.3384\/fmicb.2018.02158<\/li><li><strong>Lopez, R.V., Gomez, J.L., Spina, L., Dejean, S., Parrou, JL &amp; Fran\u00e7ois, J M. <\/strong>(2018). Trehalose-6-phosphate promotes fermentation and glucose repression in <em>Saccharomyces cerevisiae<\/em>. <em>Microbial Cell<\/em> <strong><em>5<\/em><\/strong><em>, 444-459. DOI: 10.15698\/mic2018.10.651<\/em><\/li><li><strong>Frazao C.R, Maton, V., Walther, T. &amp; Fran\u00e7ois J.M <\/strong>(2018) Development of a metabolite sensor for high-throughput detection of aldehydes in <em>Escherichia coli. Front. Bioeng Biotechnol, section Synth. Biol., 6: 118, <\/em>DOI:<em> 10.3389\/fbioe.2018.00118<\/em><\/li><li><strong>Frazao C.R., Topham, C., Malbert, Y., Fran\u00e7ois, J.M. &amp; Walther, T. <\/strong>(2018). Rational engineering of a malate dehydrogenase for microbial production of 2,4 dihydroxybutyric acid production via homoserine pathway. <em>Biochem. J.<\/em> <em>475: 3887-3901<\/em>. DOI: 10.1042\/BCJ20180765<\/li><li><strong>Llanos, A., Dejean, S., Neugnot-Roux, V., Fran\u00e7ois, J.M. &amp; Parrou, JL <\/strong>(2019) Carbon sources and XlnR\u2014dependent transcriptional landscape of CAZymes in the industrial fungus Talaromyces versatilis: when exception seems to be the rule. <em>Microbial Cell Fact.<\/em>doi.org\/10.1186\/s12934-019-1062-8<\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-45511\" class=\"elementor-tab-title\" data-tab=\"11\" role=\"button\" aria-controls=\"elementor-tab-content-45511\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">2017<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-45511\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"11\" role=\"region\" aria-labelledby=\"elementor-tab-title-45511\"><ul><li><strong>Grondin, E., Shum Cheong Sing, A., Caroa, Y., James, S., Nueno-Palop,C., Fran\u00e7ois, JM.&amp; <\/strong><strong>Petit, T<\/strong> (2017) Flavour production by <em>Saprochaete <\/em>and <em>Geotrichum <\/em>yeasts and their close relatives. <em>Food Chem<\/em>. 237: 677-684.<\/li><li><strong>Turanl\u0131-Y\u0131ld\u0131z, B., Benbadis, L., Alk\u0131m, C., Sezgin, T.,\u00a0 Aksit, A., G\u00f6k\u00e7e, A., \u00d6zt\u00fcrk,Y., Tar\u0131k Baykal, A., \u00c7akar, Z.P. and Fran\u00e7ois J<\/strong> <strong>M<\/strong> (2017) In vivo evolutionary engineering for ethanol-tolerance of Saccharomyces cerevisiae haploid cells triggers diploidization. J Biosci. Bioeng. <a href=\"https:\/\/doi.org\/10.1016\/j.jbiosc.2017.04.012\">https:\/\/doi.org\/10.1016\/j.jbiosc.2017.04.012<\/a><\/li><li><strong>Walther Th., Topham, C.M., Irague, R., Auriol, C., Baylac, A., Cordier, H., Dressaire, C., Lozano-Huguet, L., Tarrat, N., Martineau, N., Stodel, M., Malbert, Y., Maestracci, M., Huet, R., Andr\u00e9, I., Remaud-Sim\u00e9on, M &amp; Fran\u00e7ois J M. <\/strong>(2017) Construction of a synthetic metabolic pathway for biosynthesis of the non-natural methionine precursor 2,4-dihydroxybutyric acid. <em>Nature Comm<\/em>., 8, 15828 doi:10.1038\/ncomms15828.<\/li><li><strong>Schiavone, M., D\u00e9jean<sup>, <\/sup>S., Sieczkowski, N., Castex<sup>, <\/sup>M., Dague, E. and Fran\u00e7ois J M <\/strong>(2017) Integration of biochemical, biophysical and transcriptomics data for investigating the structural and nanomechanical properties of the yeast cell wall. <em>Frontiers in Microbiology,<\/em> 8: 1809; DOI: 10.3389\/fmicb.2017.01806<\/li><li><strong>Yang DD., De Billerberck, G., Zhang J-J , Rosenzweig, F. &amp; Fran\u00e7ois, J M.<\/strong> (2017) Deciphering the origin, evolutionary fate and the physiological function of the subtelomeric multi-aryl-alcohol dehydrogenases encoded genes family in the yeast <em>Saccharomyces cerevisiae<\/em><em>. Applied Env. Microbiol <\/em>DOI.org\/ 10.1128\/AEM.01553.17<\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-04686b6 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"04686b6\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-44800ac\" data-id=\"44800ac\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-654fec4 elementor-widget elementor-widget-heading\" data-id=\"654fec4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Brevets<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5db2a2c elementor-widget elementor-widget-toggle\" data-id=\"5db2a2c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-9821\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-9821\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">2020<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-9821\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-9821\"><ul><li>Lachaux C., Walther, T &amp; Fran\u00e7ois J. Microorganismes et proc\u00e9d\u00e9 pour la production d\u2019acide glycolique \u00e0 partir de pentoses et d\u2019hexoses. Demande de d\u00e9position n\u00b0 FR1856511 13\/07\/2018, publi\u00e9 17 January 2020 as WO 2020\/012138 A1<\/li><li>Daniel Johannes KOCH, Lucas Pedersen PARIZZI, Felipe GALZERANI, Jean Marie FRANCOIS; Sophie LAJUS\u00a0: Title: DEGRADATION PATHWAY FOR PENTOSE AND HEXOSE SUGARS U.S. Patent Application No. 16\/796,426 and PCT\/BR2020\/050053 Data filed: February 20, 2020 and published 20<sup>th<\/sup> August 2020 as WO2020\/168408<\/li><li>Daniel Johannes KOCH, Paulo ALEXANDRINO, Felipe GALZERANI, Jean Marie FRANCOIS, and Nicolas MORIN Title: MICROORGANISMS AND METHODS FOR THE PRODUCTION OF GLYCOLIC ACID AND GLYCINE VIA REVERSE GLYOXYLATE SHUNT. S. Patent Application No. 16\/791,556 and PCT\/BR2020\/050041 Data filed February 14, 2020. Published 20<sup>th<\/sup> August 2020 as WO 2020\/163935 A1<\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-9822\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-9822\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">2019<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-9822\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-9822\"><ul><li>Francois, JM Microorganismes et proc\u00e9d\u00e9 pour la production de mol\u00e9cules d\u2019inter\u00eat \u00e0 partir de pentoses et hexoses. D\u00e9claration d\u2019invention DI-RV-18-0128 aupr\u00e8s de INRA transfert 12 mars 2019<\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Equipe PHYGE Retour vers l&#8217;\u00e9quipe Production scientifique Articles 2026 Pijpstra P, Guillouet SE, Heidinger P, Kourist R, Gorret N. 2026. Considerations of Bacterial Robustness and Stability to Improve Bioprocess Design. Fermentation 12:54. Joris P, Lombard E, Paillet A, Navarro G, Guillouet SE, Gorret N. 2026. Investigation of Nitrate Respiration in Cupriavidus necator for Application in [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":5061,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-7100","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Production scientifique PHYGE | TBI, Toulouse Biotechnology Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/poles\/equipe-phyge\/prod\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Production scientifique PHYGE | TBI, Toulouse Biotechnology Institute\" \/>\n<meta property=\"og:description\" content=\"Equipe PHYGE Retour vers l&#8217;\u00e9quipe Production scientifique Articles 2026 Pijpstra P, Guillouet SE, Heidinger P, Kourist R, Gorret N. 2026. 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