{"id":7046,"date":"2022-04-15T17:31:31","date_gmt":"2022-04-15T15:31:31","guid":{"rendered":"http:\/\/v2tbi.christelle-labruyere.com\/?page_id=7046"},"modified":"2026-01-09T11:44:57","modified_gmt":"2026-01-09T10:44:57","slug":"heterogeneite-cellulaire","status":"publish","type":"page","link":"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/poles\/equipe-phyge\/heterogeneite-cellulaire\/","title":{"rendered":"H\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 cellulaire"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"7046\" class=\"elementor elementor-7046\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-87eb17e elementor-section-height-min-height elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"87eb17e\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;,&quot;shape_divider_bottom&quot;:&quot;waves&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t<div class=\"elementor-shape elementor-shape-bottom\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 1000 100\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M421.9,6.5c22.6-2.5,51.5,0.4,75.5,5.3c23.6,4.9,70.9,23.5,100.5,35.7c75.8,32.2,133.7,44.5,192.6,49.7\n\tc23.6,2.1,48.7,3.5,103.4-2.5c54.7-6,106.2-25.6,106.2-25.6V0H0v30.3c0,0,72,32.6,158.4,30.5c39.2-0.7,92.8-6.7,134-22.4\n\tc21.2-8.1,52.2-18.2,79.7-24.2C399.3,7.9,411.6,7.5,421.9,6.5z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c1288a5\" data-id=\"c1288a5\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-c0837f0 elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c0837f0\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-7557d6e\" data-id=\"7557d6e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-44a8efe\" data-id=\"44a8efe\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5be37ad elementor-widget elementor-widget-heading\" data-id=\"5be37ad\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Equipe PHYGE<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-aec7136\" data-id=\"aec7136\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fcd2a01 elementor-align-right elementor-widget elementor-widget-button\" data-id=\"fcd2a01\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-xs\" href=\"https:\/\/www.toulouse-biotechnology-institute.fr\/poles\/equipe-phyge\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-left\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Retour vers l'\u00e9quipe<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-adde25f elementor-widget elementor-widget-heading\" data-id=\"adde25f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Th\u00e8me \"Understanding cell heterogeneity for mastering robustness in bioproduction\"<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c1f29a3 elementor-reverse-mobile elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"c1f29a3\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-92250cc\" data-id=\"92250cc\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9fb5f99 elementor-widget elementor-widget-heading\" data-id=\"9fb5f99\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Quelques mots sur le th\u00e8me<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8cddff0 elementor-widget elementor-widget-heading\" data-id=\"8cddff0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;motion_fx_motion_fx_scrolling&quot;:&quot;yes&quot;,&quot;motion_fx_translateY_effect&quot;:&quot;yes&quot;,&quot;motion_fx_translateY_speed&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;0.5&quot;,&quot;sizes&quot;:[]},&quot;motion_fx_translateY_affectedRange&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:{&quot;start&quot;:&quot;0&quot;,&quot;end&quot;:&quot;50&quot;}},&quot;motion_fx_opacity_effect&quot;:&quot;yes&quot;,&quot;motion_fx_opacity_range&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:{&quot;start&quot;:&quot;0&quot;,&quot;end&quot;:&quot;50&quot;}},&quot;motion_fx_opacity_direction&quot;:&quot;out-in&quot;,&quot;motion_fx_opacity_level&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:10,&quot;sizes&quot;:[]},&quot;motion_fx_devices&quot;:[&quot;desktop&quot;,&quot;tablet&quot;,&quot;mobile&quot;]}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Compr\u00e9hension de l'h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 cellulaire <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c090f9a elementor-widget elementor-widget-text-editor\" data-id=\"c090f9a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Cet axe concerne <strong>la compr\u00e9hension de l&#8217;h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 cellulaire pour ma\u00eetriser la robustesse des souches microbiennes en condition de bioproduction intensive<\/strong>.<\/p><p>Les recherches d\u00e9velopp\u00e9es dans cet axe portent sur la caract\u00e9risation et la quantification des stabilit\u00e9s g\u00e9n\u00e9tique (g\u00e9nome et\/ou plasmide) et non-g\u00e9n\u00e9tique (\u00e9pig\u00e9n\u00e9tique, expression de g\u00e8nes, m\u00e9tabolisme) ainsi qu\u2019aux variabilit\u00e9s des \u00e9tats physiologiques (capacit\u00e9 d\u2019accumulation, viabilit\u00e9, int\u00e9grit\u00e9 membranaire, etc) dans le cadre de proc\u00e9d\u00e9s biotechnologiques. L\u2019objectif est de quantifier les dynamiques de la r\u00e9ponse microbienne et de la robustesse des souches (\u00e0 l\u2019\u00e9chelle de la population globale et des sous-populations) \u00e0 des fluctuations d\u2019environnement, des conditions de stress et des conditions de production intensive afin d\u2019intensifier \/ optimiser les bioproc\u00e9d\u00e9s et leur changement d\u2019\u00e9chelle. De plus, l\u2019\u00e9tude des cons\u00e9quences de la variabilit\u00e9 d\u2019origine mol\u00e9culaire sur l\u2019h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 ph\u00e9notypique intercellulaire est \u00e9tudi\u00e9e. Les travaux de cet axe sont r\u00e9alis\u00e9s dans la perspective de pouvoir utiliser l\u2019ensemble de ces informations pour r\u00e9tro-ing\u00e9ni\u00e9rer des souches microbiennes et am\u00e9liorer leur comportement et robustesse en condition de bioproduction mais aussi, par la prise en compte de la distribution des sous-populations au cours du bioproc\u00e9d\u00e9, de mettre en place des boucles de r\u00e9trocontr\u00f4le sur les strat\u00e9gies de conduite des bior\u00e9acteurs. Il s\u2019agit notamment de caract\u00e9riser finement les cons\u00e9quences des conditions de productions intensive (h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9s dans les bior\u00e9acteurs, nombre de g\u00e9n\u00e9rations et densit\u00e9 cellulaire \u00e9lev\u00e9e) sur l\u2019h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 intercellulaire, afin de d\u00e9velopper des outils de contr\u00f4le\/r\u00e9trocontr\u00f4le.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-fa10e96\" data-id=\"fa10e96\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7541c29 elementor-widget elementor-widget-image\" data-id=\"7541c29\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;motion_fx_motion_fx_scrolling&quot;:&quot;yes&quot;,&quot;motion_fx_translateY_effect&quot;:&quot;yes&quot;,&quot;motion_fx_translateY_speed&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;0.7&quot;,&quot;sizes&quot;:[]},&quot;motion_fx_devices&quot;:[&quot;desktop&quot;],&quot;motion_fx_translateY_affectedRange&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:{&quot;start&quot;:0,&quot;end&quot;:100}}}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"500\" height=\"500\" src=\"https:\/\/www.toulouse-biotechnology-institute.fr\/wp-content\/uploads\/2025\/08\/phyge2-1.png\" class=\"attachment-full size-full wp-image-16502\" alt=\"\" srcset=\"https:\/\/www.toulouse-biotechnology-institute.fr\/wp-content\/uploads\/2025\/08\/phyge2-1.png 500w, https:\/\/www.toulouse-biotechnology-institute.fr\/wp-content\/uploads\/2025\/08\/phyge2-1-12x12.png 12w, https:\/\/www.toulouse-biotechnology-institute.fr\/wp-content\/uploads\/2025\/08\/phyge2-1-50x50.png 50w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a79f477 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a79f477\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-28bb29d\" data-id=\"28bb29d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6907df3 elementor-widget elementor-widget-heading\" data-id=\"6907df3\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;motion_fx_motion_fx_scrolling&quot;:&quot;yes&quot;,&quot;motion_fx_translateY_effect&quot;:&quot;yes&quot;,&quot;motion_fx_translateY_speed&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;0.5&quot;,&quot;sizes&quot;:[]},&quot;motion_fx_translateY_affectedRange&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:{&quot;start&quot;:&quot;0&quot;,&quot;end&quot;:&quot;50&quot;}},&quot;motion_fx_opacity_effect&quot;:&quot;yes&quot;,&quot;motion_fx_opacity_range&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:{&quot;start&quot;:&quot;0&quot;,&quot;end&quot;:&quot;50&quot;}},&quot;motion_fx_opacity_direction&quot;:&quot;out-in&quot;,&quot;motion_fx_opacity_level&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:10,&quot;sizes&quot;:[]},&quot;motion_fx_devices&quot;:[&quot;desktop&quot;,&quot;tablet&quot;,&quot;mobile&quot;]}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Les projets<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-654a1fa elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"654a1fa\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-ac2791e\" data-id=\"ac2791e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9f22d8a elementor-widget elementor-widget-heading\" data-id=\"9f22d8a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Projet ConCO2rde<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-093e7e7\" data-id=\"093e7e7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-72948bc elementor-widget elementor-widget-text-editor\" data-id=\"72948bc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>H2020-MSCA-ITN ConCO2rde (2021-2025) <\/strong>: <em>Training network on the conversion of CO<sub>2 <\/sub>by smart autotrophic biorefineries<\/em> (H2020-MSCA-ITN ConCO<sub>2<\/sub>rde)<\/p><p>L&#8217;ITN CONCO<sub>2<\/sub>RDE EJD est un r\u00e9seau de formation par la recherche de 11 doctorants sur des projets de recherche de pointe alliant biologie synth\u00e9tique, ing\u00e9nierie m\u00e9tabolique et g\u00e9nie des bioproc\u00e9d\u00e9s pour la transformation microbienne du CO<sub>2<\/sub>\/H<sub>2<\/sub>\/air en mol\u00e9cules d&#8217;int\u00e9r\u00eat diverses. L&#8217;objectif final sera d&#8217;\u00e9tablir une feuille de route pour la mise en \u0153uvre des biotransformations autotrophes \u00e0 l&#8217;\u00e9chelle industrielle.<\/p><p><a href=\"https:\/\/www.conco2rde.eu\/\">https:\/\/www.conco2rde.eu<\/a><\/p><p><strong>Partenaires<\/strong>\u00a0: 5 Universit\u00e9s (INSA, Groningen, Aahen, Graz, Porto), 9 industriels (Total, Suez, Polymem, Evonik, Silantes, Zeta, ..)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-015f5c2 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"015f5c2\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5607cbd\" data-id=\"5607cbd\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9ff3e79 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"9ff3e79\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-db78c44 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"db78c44\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-72b6fe0\" data-id=\"72b6fe0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b0be743 elementor-widget elementor-widget-heading\" data-id=\"b0be743\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Projet Collimator<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-b07f5ce\" data-id=\"b07f5ce\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6c16c8d elementor-widget elementor-widget-text-editor\" data-id=\"6c16c8d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>ANR-22-PEBB-004 (PEPR B BEST) (2023-2028): <em>COntroLLIng MetAbolic sTabilize Optimize pRoduction<\/em>. <\/strong><\/p><p>Le projet vise \u00e0 d\u00e9velopper des outils et des approches pour le d\u00e9veloppement de bioproc\u00e9d\u00e9s stables et robustes dans le temps. Pour ce faire, les niveaux de production doivent \u00eatre adapt\u00e9s en permanence pour contrebalancer les d\u00e9rives g\u00e9n\u00e9tiques\/m\u00e9taboliques ou les changements de population microbienne. Le projet a ainsi pour objectif :<\/p><ol><li>de concevoir une r\u00e9gulation g\u00e9n\u00e9tique autonome, assist\u00e9e ou contr\u00f4l\u00e9e par l&#8217;utilisateur, du m\u00e9tabolisme microbien dans les bior\u00e9acteurs,<\/li><li>de construire divers types de capteurs capables de mesurer les param\u00e8tres des cellules ou des esp\u00e8ces et<\/li><li>de contr\u00f4ler, en temps r\u00e9el, les orientations m\u00e9taboliques des microorganismes \u00e0 l&#8217;aide de d\u00e9clencheurs externes utilisables dans les bior\u00e9acteurs industriels.<\/li><\/ol><p>Dans le cadre de ce projet, l\u2019\u00e9quipe est impliqu\u00e9e plus particuli\u00e8rement dans le WP1 avec pour objectif de d\u00e9velopper une approche de caract\u00e9risation <em>in situ<\/em> qualitative et quantitative des \u00e9tats physiologiques des cellules par cytom\u00e9trie en flux coupl\u00e9e \u00e0 une boucle de r\u00e9trocontr\u00f4le sur un actionneur du bior\u00e9acteur afin de mieux prendre en compte le comportement d\u2019une population microbienne et pouvoir ajuster en cons\u00e9quence les param\u00e8tres de conduites du fermenteur. Le microorganisme, par une mesure de son comportement, deviendrait en quelque sorte le pilote du bior\u00e9acteur. Le mod\u00e8le d\u2019\u00e9tude repose sur la mise en \u0153uvre de souches de <em>S. cerevisiae<\/em> g\u00e9n\u00e9tiquement modifi\u00e9es dont l\u2019induction de la voie de synth\u00e8se h\u00e9t\u00e9rologue est sous le contr\u00f4le d\u2019un promoteur photo-inductible (optog\u00e9n\u00e9tique) offrant ainsi un actionneur suppl\u00e9mentaire, la lumi\u00e8re, compl\u00e9mentaire des actionneurs plus classiques des bior\u00e9acteurs (pompe, balance, mol\u00e9cules chimiques).<\/p><p><a href=\"https:\/\/www.insa-toulouse.fr\/fiche-projet\/31131-2\/\"><em>https:\/\/www.insa-toulouse.fr\/fiche-projet\/31131-2\/<\/em><\/a><em>\u00a0<\/em><\/p><p><strong>Partenaires <\/strong>: INSA Toulouse (Coord.), Aix Marseille Universit\u00e9, Institut Curie, CNRS, INRAE<\/p><ul><li>Pour INSA (TBI (Coord.)<\/li><li>Pour L\u2019institut Curie (PCC-UMR168)<\/li><li>Pour CNRS (BIP-UMR7281)<\/li><li>Pour INRAE (LBE)<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8b0441c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8b0441c\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f88a221\" data-id=\"f88a221\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5df43c5 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"5df43c5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-be44045 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"be44045\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-f2a263c\" data-id=\"f2a263c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c915db0 elementor-widget elementor-widget-heading\" data-id=\"c915db0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Projet OptisFuel<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-ac63992\" data-id=\"ac63992\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4b6a085 elementor-widget elementor-widget-text-editor\" data-id=\"4b6a085\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li><strong>22-PEBB-0011 (PEPR B BEST) (2023-2028)<\/strong>: <em>New Proofs of Concept to OPTImize Sustainable FUEL production<\/em><strong>. <\/strong>Le projet OptisFuel propose de diminuer fortement les \u00e9missions globales de CO<sub>2<\/sub> des proc\u00e9d\u00e9s industriels de production de biocarburants de deuxi\u00e8me g\u00e9n\u00e9ration, en valorisant les mol\u00e9cules de carbone r\u00e9siduelles et en travaillant sur des r\u00e9acteurs \u00e0 assistance \u00e9lectrique. Dans ce contexte, ce projet vise \u00e0 d\u00e9velopper des strat\u00e9gies innovantes pour am\u00e9liorer l&#8217;\u00e9tape de fermentation de la production de biocarburants dans la bioraffinerie, d\u00e9velopper de nouvelles alternatives pour la valorisation des effluents gazeux et proposer de nouvelles strat\u00e9gies pour la valorisation de la lignine. Dans le cadre de ce projet, l\u2019\u00e9quipe est particuli\u00e8rement impliqu\u00e9e dans le WP1, T\u00e2che 2.1, \u00e0 savoir la valorisation des flux gazeux (CO<sub>2<\/sub>\/H<sub>2<\/sub>) en alcanes par des souches de <em> necator<\/em> g\u00e9n\u00e9tiquement modifi\u00e9es. Nous nous int\u00e9ressons notamment \u00e0 l\u2019\u00e9tude des facteurs impactants la stabilit\u00e9 et la robustesse de souches g\u00e9n\u00e9tiquement modifi\u00e9es de <em>C. necator<\/em> pour la production d\u2019hydrocarbures en bior\u00e9acteur \u00e0 partir de CO<sub>2<\/sub>.<\/li><\/ul><p>\u00a0<\/p><p><a href=\"https:\/\/www.pepr-bioproductions.fr\/projets-finances\/nouveaux-schemas-de-transformation-de-la-biomasse\/optisfuel\"><em>https:\/\/www.pepr-bioproductions.fr\/projets-finances\/nouveaux-schemas-de-transformation-de-la-biomasse\/optisfuel<\/em><\/a><em>)<\/em><em>\u00a0<\/em><\/p><p><strong>Partenaires <\/strong>: IFPEN(Coord.), CNRS, INSA, CEA, CNRS, INRAE<\/p><ul><li>Pour INSA (TBI)<\/li><li>Pour CNRS (TBI, IRCELYON &#8211; UMR5256)<\/li><li>Pour CEA (DRT \/ LITEN \/ D\u00e9partement Thermique, Conversion et Hydrog\u00e8ne)<\/li><li>Pour INRAE (TBI)<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-bcc9055 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"bcc9055\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-cd76c1d\" data-id=\"cd76c1d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e559f32 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"e559f32\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-642a6f7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"642a6f7\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-d8b8af9\" data-id=\"d8b8af9\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-90078e5 elementor-widget elementor-widget-heading\" data-id=\"90078e5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Projet PolyMorphoil<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-2cf70cc\" data-id=\"2cf70cc\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8155dc7 elementor-widget elementor-widget-text-editor\" data-id=\"8155dc7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>PolyMorphoil (2023-2026)<\/strong><\/p><p><em>Etude de la transition dimorphique de Yarrowia lipolytica dans des conditions de production de lipides : analyse quantitative de la distribution de sous-populations avec diff\u00e9rents morphotypes et capacit\u00e9s d&#8217;accumulation. <\/em>Au cours des 30 derni\u00e8res ann\u00e9es, la production mondiale d&#8217;huiles et de graisses est pass\u00e9e d&#8217;environ 83,5 \u00e0 plus de 223,0 millions de tonnes et devrait augmenter de mani\u00e8re significative dans les d\u00e9cennies \u00e0 venir. Afin de r\u00e9pondre aux grands enjeux soci\u00e9taux de lutte contre le r\u00e9chauffement climatique, l\u2019\u00e9puisement des ressources fossiles, la mobilisation des surfaces agricoles, l\u2019accroissement rapide de la population, il est devenu essentiel de rechercher des solutions de diversification des sources d\u2019approvisionnement. \u00c0 cet \u00e9gard, les levures ol\u00e9agineuses sont des candidats prometteurs, de par leur capacit\u00e9 \u00e0 cro\u00eetre rapidement en bior\u00e9acteur, ainsi que pour leur capacit\u00e9 \u00e0 moduler leur m\u00e9tabolisme et leur composition macroscopique en fonction des conditions de croissance. <em>Yarrowia lipolytica<\/em> connue pour ses capacit\u00e9s naturelles d\u2019accumulation de lipides, et d\u2019utilisation de sources de carbone diverses a \u00e9t\u00e9 choisie. Cependant, en r\u00e9ponse aux fluctuations environnementales, <em> lipolytica<\/em> d\u00e9clenche des transitions dimorphiques g\u00e9n\u00e9rant des difficult\u00e9s de mise en \u0153uvre des bioproc\u00e9d\u00e9s (perte de rendement, limitation des transferts, impact sur la rh\u00e9ologie des milieux). Dans ce contexte, le projet porte sur l\u2019\u00e9tude de l\u2019impact de la filamentation sur les capacit\u00e9s de production de lipides (titre et composition) et r\u00e9ciproquement. Diff\u00e9rentes conditions environnementales et nutritionnelles sont \u00e9tudi\u00e9es afin d\u2019identifier les m\u00e9canismes de r\u00e9gulation mis en \u0153uvre. Par ailleurs, afin d\u2019\u00e9tudier l\u2019impact des conditions environnementales sur la morphologie et la capacit\u00e9 d\u2019accumulation lipidique des cellules, une analyse dynamique de la distribution des sous-populations sur la base des morphotypes et de l\u2019accumulation de lipides est suivie par une approche de \u00ab single-cell analysis \u00bb (cytom\u00e9trie en\/hors-ligne \/ cytom\u00e9trie en image).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-cf10343 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"cf10343\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-35379a9\" data-id=\"35379a9\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d5e25a5 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"d5e25a5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Equipe PHYGE Retour vers l&#8217;\u00e9quipe Th\u00e8me &#8220;Understanding cell heterogeneity for mastering robustness in bioproduction&#8221; Quelques mots sur le th\u00e8me Compr\u00e9hension de l&#8217;h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 cellulaire Cet axe concerne la compr\u00e9hension de l&#8217;h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 cellulaire pour ma\u00eetriser la robustesse des souches microbiennes en condition de bioproduction intensive. Les recherches d\u00e9velopp\u00e9es dans cet axe portent sur la caract\u00e9risation et la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":16502,"parent":5061,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-7046","page","type-page","status-publish","has-post-thumbnail","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>H\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 cellulaire | TBI, Toulouse Biotechnology Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/poles\/equipe-phyge\/heterogeneite-cellulaire\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"H\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 cellulaire | TBI, Toulouse Biotechnology Institute\" \/>\n<meta property=\"og:description\" content=\"Equipe PHYGE Retour vers l&#8217;\u00e9quipe Th\u00e8me &#8220;Understanding cell heterogeneity for mastering robustness in bioproduction&#8221; Quelques mots sur le th\u00e8me Compr\u00e9hension de l&#8217;h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 cellulaire Cet axe concerne la compr\u00e9hension de l&#8217;h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 cellulaire pour ma\u00eetriser la robustesse des souches microbiennes en condition de bioproduction intensive. 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