{"id":6158,"date":"2022-03-30T14:33:01","date_gmt":"2022-03-30T12:33:01","guid":{"rendered":"http:\/\/v2tbi.christelle-labruyere.com\/?page_id=6158"},"modified":"2023-04-06T17:04:57","modified_gmt":"2023-04-06T15:04:57","slug":"muriel-cocaign-bousquet","status":"publish","type":"page","link":"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/muriel-cocaign-bousquet\/","title":{"rendered":"Muriel COCAIGN-BOUSQUET"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"6158\" class=\"elementor elementor-6158\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1b37fa63 elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"1b37fa63\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;,&quot;shape_divider_bottom&quot;:&quot;waves&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t<div class=\"elementor-shape elementor-shape-bottom\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 1000 100\" preserveaspectratio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M421.9,6.5c22.6-2.5,51.5,0.4,75.5,5.3c23.6,4.9,70.9,23.5,100.5,35.7c75.8,32.2,133.7,44.5,192.6,49.7\tc23.6,2.1,48.7,3.5,103.4-2.5c54.7-6,106.2-25.6,106.2-25.6V0H0v30.3c0,0,72,32.6,158.4,30.5c39.2-0.7,92.8-6.7,134-22.4\tc21.2-8.1,52.2-18.2,79.7-24.2C399.3,7.9,411.6,7.5,421.9,6.5z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-125cd54\" data-id=\"125cd54\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4239c945 elementor-widget elementor-widget-heading\" data-id=\"4239c945\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Muriel COCAIGN-BOUSQUET <\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-762e9b9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"762e9b9\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-2f523c4\" data-id=\"2f523c4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-feae8ca elementor-position-left elementor-vertical-align-top elementor-widget elementor-widget-image-box\" data-id=\"feae8ca\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" width=\"192\" height=\"192\" src=\"https:\/\/www.toulouse-biotechnology-institute.fr\/wp-content\/uploads\/2022\/03\/Muriel-COCAIGN-BOUSQUET.jpg\" class=\"attachment-full size-full wp-image-6061\" alt=\"\" srcset=\"https:\/\/www.toulouse-biotechnology-institute.fr\/wp-content\/uploads\/2022\/03\/Muriel-COCAIGN-BOUSQUET.jpg 192w, https:\/\/www.toulouse-biotechnology-institute.fr\/wp-content\/uploads\/2022\/03\/Muriel-COCAIGN-BOUSQUET-12x12.jpg 12w, https:\/\/www.toulouse-biotechnology-institute.fr\/wp-content\/uploads\/2022\/03\/Muriel-COCAIGN-BOUSQUET-50x50.jpg 50w\" sizes=\"(max-width: 192px) 100vw, 192px\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Muriel COCAIGN-BOUSQUET <\/h3><p class=\"elementor-image-box-description\">INRAE Research Director <br>\nBLADE Team leader<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c285827 elementor-widget elementor-widget-button\" data-id=\"c285827\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-xs\" href=\"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/poles\/equipe-blade\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">BLADE team<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-92c1b19\" data-id=\"92c1b19\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-19daa50 elementor-align-start elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"19daa50\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-phone\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">+33 (0) 5 61 55 94 65<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-mail-bulk\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">cocaign@insa-toulouse.fr<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a 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d=\"M485.98,510.35c0-47.25,0-94.5,0-141.76c0-1.26-0.02-2.51,0.01-3.77c0.1-3.99,0.11-4.12,3.89-4.1  c34.06,0.18,68.14-0.88,102.17,0.54c23.69,0.99,46.65,6.06,68.25,16.2c36.05,16.93,60.42,44.33,72.2,82.41  c12.13,39.21,9.95,77.86-7.02,115.28c-18.4,40.55-49.76,66.15-92.53,77.92c-16.27,4.48-32.91,6.61-49.77,6.67  c-30.77,0.11-61.53,0.06-92.3,0.06c-4.85,0-4.89-0.03-4.89-4.88C485.98,606.74,485.98,558.55,485.98,510.35z\"><\/path><\/g><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Orcid<\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-bc836c5 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"bc836c5\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-07a549e\" data-id=\"07a549e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5879caf elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"5879caf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4c71302 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4c71302\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-889e2b0\" data-id=\"889e2b0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-dfd8563 elementor-widget elementor-widget-heading\" data-id=\"dfd8563\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Actual position and research subject<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2e9438f elementor-widget elementor-widget-text-editor\" data-id=\"2e9438f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>I am a scientist in the \u201c<em>Microbiology and Food Chain<\/em>\u201d division of the French National Institute for Agricultural, Food and Environmental Research, currently working at the <em>Toulouse Biotechnology Institute<\/em> as head of the research group BLADE (Bacterial Adaptation Diversity and Engineering).<\/p><p>I am interested in the study of Bacterial Physiology and Metabolism to better understand mechanisms of adaptation of bacteria to their environment and to engineer bacteria for applications in biotechnology.<\/p><p>My major area of study is RNA dynamics in bacteria to better understand genome-wide post-transcriptional regulations, their role in the regulation of gene expression and their potential for engineering bacteria. More recently, I have also initiated studies on bacterial diversity and heterogeneity, working on various bacteria strains alone, in consortia or in interaction with non-equivalent monoclonal subpopulations.<\/p><p>My research concerns predominantly two model bacteria, <em>Lactococcus lactis<\/em> and <em>Escherichia coli<\/em>, using a systems biology approach to elucidate the different levels of metabolic regulation and notably genome wide omic regulations. I initiated collaborations with mathematicians to rationalise the use of large-scale genomic data-sets to investigate bacterial physiology. I am currently an associated member of the group Microcosm at INRIA Grenoble to combine computational and experimental approaches.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8a6f373 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8a6f373\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2cf13c6\" data-id=\"2cf13c6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-cbe7f0d elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"cbe7f0d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-eba8b04 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"eba8b04\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8b5e687\" data-id=\"8b5e687\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-86b9cdc elementor-widget elementor-widget-heading\" data-id=\"86b9cdc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Education and Diploma<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-beda416 elementor-tabs-view-horizontal elementor-widget elementor-widget-tabs\" data-id=\"beda416\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"tabs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-tabs\">\n\t\t\t<div class=\"elementor-tabs-wrapper\" role=\"tablist\" >\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-2001\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"elementor-tab-content-2001\" aria-expanded=\"false\">2005<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-2002\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2002\" aria-expanded=\"false\">1992<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-2003\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2003\" aria-expanded=\"false\">1989<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"elementor-tabs-content-wrapper\" role=\"tablist\" aria-orientation=\"vertical\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"elementor-tab-content-2001\" aria-expanded=\"false\">2005<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2001\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2001\" tabindex=\"0\" hidden=\"false\"><p>Habilitation \u00e0 Diriger les Recherches, INP Toulouse<\/p><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2002\" aria-expanded=\"false\">1992<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2002\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2002\" tabindex=\"0\" hidden=\"hidden\"><p>PhD in Microbiology-Biotechnology, INSA Toulouse<\/p><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2003\" aria-expanded=\"false\">1989<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2003\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2003\" tabindex=\"0\" hidden=\"hidden\"><ul><li>Master&#8217;s degree, speciality Microbiology-Biotechnology, INSA Toulouse<\/li><li>Engineering diploma of INSA Toulouse, Dpt Biochemical and Food Engineering<\/li><\/ul><\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3253b9c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3253b9c\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0660aec\" data-id=\"0660aec\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-540bb2c elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"540bb2c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-25ed5ca elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"25ed5ca\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ef30f39\" data-id=\"ef30f39\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-99ba7aa elementor-widget elementor-widget-heading\" data-id=\"99ba7aa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Others<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-88c3bbf elementor-widget elementor-widget-text-editor\" data-id=\"88c3bbf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Supervised or co-supervised: 22 PhD students and 9 post-docs<\/li><li>Contribution to research projects: Coordination of 28 regional, national or international research projects<\/li><li>Major ongoing projects:<ul><li><p>2018-2023-ANR-18-CE43-0010, RIBECO, RNA life cycle engineering for an economic approach to microbial energetics: application to the bioconversion of biomass-derived carbon sources. Coordination<\/p><\/li><li><p>2019-2024-ANR-19-CE43-0004-01, JANUS, Control and Optimization of Metabolic Transitions. \u00a0Work package leader<\/p><\/li><li><p>2018-2024-Toulouse Tech Transfert maturation program and collaboration project with Lesaffre, health properties of <em>L. lactis.<\/em> Co-coordination<\/p><\/li><\/ul><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-26aa7ce elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"26aa7ce\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0900ee2\" data-id=\"0900ee2\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-25dce21 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"25dce21\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a76ee75 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a76ee75\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c8a37c6\" data-id=\"c8a37c6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f8d64f2 elementor-widget elementor-widget-heading\" data-id=\"f8d64f2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">List of selected publications<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-79d3ae9 elementor-widget elementor-widget-text-editor\" data-id=\"79d3ae9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Roux C., Etienne T.A., Hajnsdorf E., Ropers D., Carpousis A.J., <strong>Cocaign-Bousquet M<\/strong>.#, GIRBAL L.# 2022. The essential role of mRNA degradation in understanding and engineering <em>E. coli<\/em> metabolism. <em>Biotechnol Adv<\/em>. 2022 Jan-Feb;<strong>54<\/strong>: 107805, doi: 10.1016\/j.biotechadv.2021.107805. hal-03325744v1.<\/li><li>Nguyen H.L., Duviau M.P., Laguerre S., Nouaille S., <strong>Cocaign-Bousquet M<\/strong>.#, GIRBAL L#. 2022. Synergistic regulation of transcription and translation in <em>Escherichia coli <\/em>revealed by co-directional increases in mRNA concentration and translation efficiency. <em>Microbiol Spectr.<\/em> 2022 Feb 9:e0204121. doi: 10.1128\/spectrum.02041-21. hal-03546610v2.<\/li><li>Laroute V., Mazzoli R., Loubi\u00e8re P., Pessione E., <strong>Cocaign-Bousquet M.<\/strong> (2021) Environmental conditions affecting GABA production in <em>Lactococcus lactis<\/em> NCDO 2118. <em>Microorganisms.<\/em> Jan 7;9(1):122. doi: 10.3390\/microorganisms9010122. hal-03277774v1<\/li><li>Etienne T., <strong>Cocaign-Bousquet M.<\/strong>, Ropers D. (2020) Competitive effects in bacterial mRNA decay. <em>J. Theor. Biol.<\/em> 504(7)110333. doi.org\/10.1016\/j.jtbi.2020.110333. hal-2967513v1.<\/li><li>Barthe M., Tchouanti J., Henrique-Gomes P., Bideaux C., Lestrade D., Graham C., Steyer J.-P., Meleard S., Harmand J., Gorret N., <strong>Cocaign-Bousquet M.<\/strong>#, Enjalbert B.# (2020) Availability of the molecular switch XylR controls phenotypic heterogeneity and lag duration during <em>Escherichia coli<\/em> adaptation from glucose to xylose, <em>mBio<\/em>. 2020 Dec 22;11(6), doi: 10.1128\/mBio.02938-20. hal-03096881v1.<\/li><li>Morin M., Enjalbert B., Ropers D., GIRBAL L., <strong>Cocaign-Bousquet M<\/strong>. 2020. Genome-wide stabilization of mRNA during a &#8216;feast-to-famine&#8217; growth transition in <em>Escherichia coli<\/em>. <em>mSphere<\/em>, doi: 10.1128\/mSphere.00276-20. hal-02967494v1<em>.<\/em><\/li><li><strong>Patent n\u00b0 WO 2020\/157297<\/strong> Extension PCT <strong>Cocaign-Bousquet M<\/strong>, ML Daveran Mingot, V Laroute, V Theodorou, MH Eutamene, M Mercier-Bonin. <em>Lactococcus lactis<\/em> strains for the prevention and\/or the treatment of visceral pain.<\/li><li>Hadjeras L., Poljak L., Bouvier M., Morin-Ogier Q., Canal I., <strong>Cocaign-Bousquet M<\/strong>., Girbal L., Carpousis A-J. (2019) Detachment of the RNA degradosome from the inner membrane of <em>Escherichia coli<\/em> results in a global slowdown of mRNA degradation, proteolysis of RNase E and increased turnover of ribosome-free transcripts. <em>Mol. Microbiol.<\/em> <strong>111<\/strong>(6):1715-1731. doi: 10.1111\/mmi.14248. hal-02317164v1.<\/li><li>Dressaire C., Pobre V., Laguerre S., Girbal L., Arraiano C.M., <strong>Cocaign-Bousquet M.<\/strong> (2018) PNPase is involved in the coordination of mRNA degradation and expression in stationary phase cells of <em>Escherichia coli<\/em>. <em>BMC Genomics <\/em><strong>19<\/strong>(1):848. doi: 10.1186\/s12864-018-5259-8. hal-01954725v1.<\/li><li>Nouaille S., Mondeil S., Finoux A-L., Moulis C., Girbal L., <strong>Cocaign-Bousquet M.<\/strong> (2017) The stability of an mRNA is influenced by its concentration: a potential physical mechanism to regulate gene expression. <em>Nucleic Acids Res. <\/em><strong>45<\/strong>(20):11711-11724. hal-01882991v1. doi: 10.1093\/nar\/gkx781. hal-01882991v1.<\/li><li>Morin M., Ropers D., Letisse F., Laguerre S., Portais J-C., <strong>Cocaign-Bousquet M<\/strong>.#, Enjalbert B# (2016) The post-transcriptional regulatory system CSR controls the balance of metabolic pools in upper glycolysis of <em>Escherichia coli<\/em>. <em>Mol. Microbiol.<\/em> <strong>100<\/strong>(4):686-700; doi: 10.1111\/mmi.13343. hal-02147255v1<\/li><li>EsquerrE T., Turlan C., Bouvier M., Carpousis A.J., Girbal L.#, <strong>Cocaign-Bousquet M<\/strong>.# (2016) The Csr system regulates genome-wide mRNA stability and transcription and thus gene expression in <em>Escherichia coli<\/em>. <em>Sci Rep.<\/em> 2016 Apr 26;<strong>6<\/strong>:25057. doi: 10.1038\/srep25057.<\/li><li>Esquerre T., Laguerre S., Turland C., Carpousis A.J., Girbal L., <strong>Cocaign-Bousquet M<\/strong><strong>.<\/strong> (2014) Dual role of transcription and transcript stability in the regulation of gene expression in <em>Escherichia coli<\/em> cells cultured on glucose at very different growth rates. <em>Nucleic Acids Res.<\/em> <strong>42<\/strong>:2460-2472. \u27e810.1093\/nar\/gkt1150\u27e9. hal-02129879v1.<\/li><li>Dressaire C., Picard F., Redon E., Queinnec I., Loubi\u00e8re P., Girbal L., <strong>Cocaign-Bousquet M.<\/strong> (2013) Role of mRNA stability during bacterial adaptation, <em>PLoS One<\/em>. <strong>8<\/strong>(3):e59059.\u00a0 \u00a0 \u00a0 \u00a0<\/li><li>Racle J., Picard F., Girbal L., <strong>Cocaign-Bousquet M<\/strong>., Hatzimanikatis V. (2013) A genome-scale integration and analysis of <em>Lactococcus lactis<\/em> translation data.<em> PLoS Comput. Biol. <\/em>2013 Oct;<strong>9<\/strong>(10):e1003240.<\/li><li>DRESSAIRE C., GITTON C., LOUBIERE P., MONNET V.\u00a0 QUEINNEC I., <strong>COCAIGN-BOUSQUET M<\/strong>. (2009) Transcriptome and Proteome Exploration to Model Translation Efficiency and Protein Stability in <em>Lactococcus lactis<\/em>, <em>PLoS Comput. Biol.<\/em> Dec;<strong>5<\/strong>(12):e1000606.<\/li><li>Nouaille S., Even S., Charlier C., Le Loir Y., <strong>Cocaign-Bousquet M.<\/strong>, Loubi\u00e8re P. (2009) Transcriptomic response of <em>Lactococcus lactis<\/em> in mixed culture with <em>Staphylococcus aureus<\/em>. <em>App. Environ. Microbiol.<\/em>, <strong>75<\/strong>: 4473-82.<\/li><li>MALIGOY M., MERCADE M., <strong>Cocaign-Bousquet M.<\/strong>, Loubiere P. (2008) Transcriptome analysis in mixed culture: the response of <em>Lactococcus lactis <\/em>faced to <em>Saccharomyces cerevisiae.<\/em> <em>App. Environ. Microbiol.<\/em><em>,<\/em><strong> 74<\/strong>: 485-494.<\/li><li>REDON E., LOUBIERE P., <strong>COCAIGN-BOUSQUET M. <\/strong>(2005) Role of mRNA stability during the genome-wide adaptation of <em>Lactococcus lactis<\/em> to carbon starvation. <em>J. Biol. Chem., <\/em><strong>280<\/strong>:36380-36385<em>.<\/em><\/li><li>REDON E., LOUBIERE P., <strong>COCAIGN-BOUSQUET M., <\/strong>(2005) Transcriptome analysis of the progressive adaptation of <em>Lactococcus lactis<\/em> to carbon starvation. <em>J. Bacteriol.,<\/em> <strong>187<\/strong>:3589-3592<\/li><li>Even S., Lindley N. D., Loubiere P., <strong>Cocaign-Bousquet M.<\/strong> (2002) Dynamic response of catabolic pathways to auto-acidification in <em>Lactococcus lactis<\/em>: transcript profiling in relation to metabolic and energetic constraints. <em>Mol. Microbiol.<\/em><em>, <\/em><strong>45<\/strong>:1143-1152.<\/li><li>DOMINGUEZ H., ROLLIN C., GUYONVARCH A., GUERQUIN-KERN J-L., <strong>COCAIGN-BOUSQUET M.,<\/strong> LINDLEY N.D. (1998) Carbon-flux distribution in the central metabolic pathways of <em>Corynebacterium glutamicum<\/em> during growth on fructose. <em>Eur. J. Biochem.<\/em>, <strong>254<\/strong>:96-102.<\/li><li>Garrigues C., Loubiere P., Lindley N.D., <strong>Cocaign-Bousquet M.<\/strong> (1997) Control of the shift from homolactic to mixed acid fermentation in <em>Lactococcus lactis<\/em>: predominant role of the NADH:NAD+ ratio. <em>J. Bacteriol.<\/em>, <strong>179<\/strong>:5282-5287.<\/li><li><strong>Cocaign-Bousquet M.<\/strong>, Guyonvarch A., Lindley N.D. (1996) Growth rate dependent modulation of carbon flux through central metabolism and the kinetic consequences for glucose-limited chemostat cultures of <em>Corynebacterium glutamicum<\/em>. <em>App. Environ. Microbiol.<\/em>, <strong>62<\/strong>:429-436.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Muriel COCAIGN-BOUSQUET Muriel COCAIGN-BOUSQUET INRAE Research Director BLADE Team leader Equipe BLADE +33 (0) 5 61 55 94 65 cocaign@insa-toulouse.fr Orcid Actual position and research subject I am a scientist in the \u201cMicrobiology and Food Chain\u201d division of the French National Institute for Agricultural, Food and Environmental Research, currently working at the Toulouse Biotechnology Institute [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-6158","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - 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