{"id":6138,"date":"2022-03-30T14:25:07","date_gmt":"2022-03-30T12:25:07","guid":{"rendered":"http:\/\/v2tbi.christelle-labruyere.com\/?page_id=6138"},"modified":"2022-06-08T19:35:53","modified_gmt":"2022-06-08T17:35:53","slug":"sebastien-nouaille","status":"publish","type":"page","link":"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/sebastien-nouaille\/","title":{"rendered":"S\u00e9bastien NOUAILLE"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"6138\" class=\"elementor elementor-6138\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1b37fa63 elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"1b37fa63\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;,&quot;shape_divider_bottom&quot;:&quot;waves&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t<div class=\"elementor-shape elementor-shape-bottom\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 1000 100\" preserveaspectratio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M421.9,6.5c22.6-2.5,51.5,0.4,75.5,5.3c23.6,4.9,70.9,23.5,100.5,35.7c75.8,32.2,133.7,44.5,192.6,49.7\tc23.6,2.1,48.7,3.5,103.4-2.5c54.7-6,106.2-25.6,106.2-25.6V0H0v30.3c0,0,72,32.6,158.4,30.5c39.2-0.7,92.8-6.7,134-22.4\tc21.2-8.1,52.2-18.2,79.7-24.2C399.3,7.9,411.6,7.5,421.9,6.5z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-125cd54\" data-id=\"125cd54\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4239c945 elementor-widget elementor-widget-heading\" data-id=\"4239c945\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">S\u00e9bastien NOUAILLE<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-762e9b9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"762e9b9\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-2f523c4\" data-id=\"2f523c4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-feae8ca elementor-position-left elementor-vertical-align-top elementor-widget elementor-widget-image-box\" data-id=\"feae8ca\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img fetchpriority=\"high\" decoding=\"async\" width=\"404\" height=\"454\" src=\"https:\/\/www.toulouse-biotechnology-institute.fr\/wp-content\/uploads\/2022\/03\/Sebastien-NOUAILLE.jpg\" class=\"attachment-full size-full wp-image-6096\" alt=\"S\u00e9bastien NOUAILLE\" srcset=\"https:\/\/www.toulouse-biotechnology-institute.fr\/wp-content\/uploads\/2022\/03\/Sebastien-NOUAILLE.jpg 404w, https:\/\/www.toulouse-biotechnology-institute.fr\/wp-content\/uploads\/2022\/03\/Sebastien-NOUAILLE-11x12.jpg 11w\" sizes=\"(max-width: 404px) 100vw, 404px\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">S\u00e9bastien NOUAILLE<\/h3><p class=\"elementor-image-box-description\">Charg\u00e9 de Recherches INRAE<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c285827 elementor-widget elementor-widget-button\" data-id=\"c285827\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-xs\" href=\"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/poles\/equipe-blade\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">BLADE team<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-92c1b19\" data-id=\"92c1b19\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-19daa50 elementor-align-start elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"19daa50\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-phone\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">+33 (0) 5 61 55 94 38<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-mail-bulk\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">sebastien.nouaille@insa-toulouse.fr<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/orcid.org\/0000-0003-2038-098X\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg 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c34.06,0.18,68.14-0.88,102.17,0.54c23.69,0.99,46.65,6.06,68.25,16.2c36.05,16.93,60.42,44.33,72.2,82.41  c12.13,39.21,9.95,77.86-7.02,115.28c-18.4,40.55-49.76,66.15-92.53,77.92c-16.27,4.48-32.91,6.61-49.77,6.67  c-30.77,0.11-61.53,0.06-92.3,0.06c-4.85,0-4.89-0.03-4.89-4.88C485.98,606.74,485.98,558.55,485.98,510.35z\"><\/path><\/g><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Orcid<\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-bc836c5 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"bc836c5\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-07a549e\" data-id=\"07a549e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5879caf elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"5879caf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4c71302 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4c71302\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-889e2b0\" data-id=\"889e2b0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-dfd8563 elementor-widget elementor-widget-heading\" data-id=\"dfd8563\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Actual position and research subject<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2e9438f elementor-widget elementor-widget-text-editor\" data-id=\"2e9438f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>My researches focus on understanding the reprogramming of gene expression in the bacterium <em>Escherichia coli<\/em>. Messenger RNAs are at the crossroads of transcriptional and post-transcriptional processes. Their concentrations are finely regulated by the bacterium to best adjust its metabolic capacities to the resources available in its environment. In the adaptation phase, the bacterium very quickly reshapes its transcriptome, particularly by controlling the stabilization or destabilization of mRNAs. We are looking for the molecular and cellular determinants that control mRNA stability. We are more particularly developing approaches at the molecular level centered on the weight of the 5&#8217;UTR sequences in this control (UTR shuffling, exhaustive library, etc.). The knowledge is then transposed to the creation of new tools for expressing proteins of biotechnological interest. A second part of research focuses on the incorporation of non-canonical amino acids into proteins of biotechnological interest to create new enzymatic capacities or properties. We study and optimize the expression of the orthogonal genes involved in non-canonical amino-acids incorporation as well as their repercussions on the transcriptome and the physiology of the bacterium.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8a6f373 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8a6f373\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2cf13c6\" data-id=\"2cf13c6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-cbe7f0d elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"cbe7f0d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-eba8b04 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"eba8b04\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8b5e687\" data-id=\"8b5e687\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-86b9cdc elementor-widget elementor-widget-heading\" data-id=\"86b9cdc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Education and Diploma<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-beda416 elementor-tabs-view-horizontal elementor-widget elementor-widget-tabs\" data-id=\"beda416\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"tabs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-tabs\">\n\t\t\t<div class=\"elementor-tabs-wrapper\" role=\"tablist\" >\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-2001\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"elementor-tab-content-2001\" aria-expanded=\"false\">2005-now<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-2002\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2002\" aria-expanded=\"false\">2003-2005<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-2003\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2003\" aria-expanded=\"false\">1999-2003<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-2004\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"4\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2004\" aria-expanded=\"false\">1998-1999<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-2005\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"5\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2005\" aria-expanded=\"false\">1997-1998<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"elementor-tabs-content-wrapper\" role=\"tablist\" aria-orientation=\"vertical\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"elementor-tab-content-2001\" aria-expanded=\"false\">2005-now<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2001\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2001\" tabindex=\"0\" hidden=\"false\"><p>TBI \u2013 Toulouse Biotechnological Institute, Toulouse, FR<\/p><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2002\" aria-expanded=\"false\">2003-2005<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2002\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2002\" tabindex=\"0\" hidden=\"hidden\"><p>Post-Doc Institut Cochin, Paris, FR<\/p><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2003\" aria-expanded=\"false\">1999-2003<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2003\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2003\" tabindex=\"0\" hidden=\"hidden\"><p>PhD, INRAE\/Saclay University, FR<\/p><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"4\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2004\" aria-expanded=\"false\">1998-1999<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2004\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"4\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2004\" tabindex=\"0\" hidden=\"hidden\"><p>DEA Food Science, Saclay University, FR<\/p><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"5\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2005\" aria-expanded=\"false\">1997-1998<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2005\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"5\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2005\" tabindex=\"0\" hidden=\"hidden\"><p>Master of Science, Imperial College, London, UK<\/p><\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3253b9c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3253b9c\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0660aec\" data-id=\"0660aec\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-540bb2c elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"540bb2c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a76ee75 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a76ee75\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c8a37c6\" data-id=\"c8a37c6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f8d64f2 elementor-widget elementor-widget-heading\" data-id=\"f8d64f2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">List of selected publications<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-79d3ae9 elementor-widget elementor-widget-text-editor\" data-id=\"79d3ae9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Nguyen HL, Duviau MP, Laguerre S, Nouaille S, Cocaign-Bousquet M, Girbal L. 2022. Synergistic Regulation of Transcription and Translation in Escherichia coli Revealed by Codirectional Increases in mRNA Concentration and Translation Efficiency. Microbiology Spetrum. Feb 23;10(1):e0204121. DOI: <a href=\"https:\/\/doi-org.insb.bib.cnrs.fr\/10.1128\/spectrum.02041-21\">10.1128\/spectrum.02041-21<\/a><\/li><li>Nguyen HL, Duviau MP, Cocaign-Bousquet M, Nouaille S, Girbal L. 2019. Multiplexing polysome profiling experiments to study translation in Escherichia coli. PLoS One. 19;14(2):e0212297. doi: 10.1371<\/li><li>Laguerre S, Gonz\u00e1lez I, Nouaille S, Moisan A, Villa-Vialaneix N, Gaspin C, Bouvier M, Carpousis AJ, Cocaign-Bousquet M, Girbal L. 2018. Large-Scale Measurement of mRNA Degradation in Escherichia coli: To Delay or Not to Delay. Methods Enzymol. 2018;612:47-66. doi: 10.1016.<\/li><li>Nouaille S, Mondeil S , Finoux AL, Moulis C, Girbal L and Cocaign-Bousquet M. 2017. The stability of an mRNA is influenced by its concentration: a potential physical mechanism to regulate gene expression. Nucleic Acid Research. 45(20):11711-11724.<\/li><li>Tauzin AS, Laville E, Xiao Y, Nouaille S, Le Bourgeois P, Heux S, Portais JC, Monsan P, Martens EC, Potocki-Veronese G, Bordes F. 2016. Functional characterization of a gene locus from an uncultured gut Bacteroides conferring xylo-oligosaccharides utilization to Escherichia coli. Mol Microbiol. 102(4):579-592. doi: 10.1111\/mmi.13480<\/li><li>Nouaille S, Rault L, Jeanson S, Loubi\u00e8re P, Le Loir Y, Even S. 2014. Contribution of Lactococcus lactis reducing properties to the modulation of virulence expression in Staphylococcus aureus. Appl Environ Microbiol, 80(22):7028-35. doi: 10.1128\/AEM.02287-14<\/li><li>Falentin H, Naquin D, Loux V, Barloy-Hubler F, Loubi\u00e8re P, Nouaille S, Lavenier D, Le Bourgeois P, Fran\u00e7ois P, Schrenzel J, Hernandez D, Even S, Le Loir Y. 2014. Genome Sequence of Lactococcus lactis subsp. lactis bv. diacetylactis LD6. Genome Announcements 2(1) e01176-13<\/li><li>Morello E, Nouaille S, Cortes-Perez N, Blugeon S, Medina L, Azevedo V, Gratadoux JJ, Berm\u00fadez-Humar\u00e1n LG, Le Loir Y, Langella P. 2012. Inactivation of YbdD gene in Lactococcus lactis increases the amounts of exported proteins. Appl Environ Microbiol 78(19):7148-51.<\/li><li>Cretenet M,\u00a0 Nouaille S, Thouin J, Rault L, Stenz L, Fran\u00e7ois P, Hennekinne JA, Piot M, Maillard MB, Fauquant J, Loubi\u00e8re P, Le Loir Y and Sergine Even. 2011. Staphylococcus aureus virulence and metabolism are dramatically affected by Lactococcus lactis in cheese matrix. Environmental Microbiology Reports 3(3):340-351.<\/li><li>Cretenet M, Laroute V, Ulv\u00e9 V, Jeanson S, Nouaille S, Even S, Piot M, Girbal L, Le Loir Y, Loubi\u00e8re P, Lortal S, Cocaign-Bousquet M. 2011 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21075879\">Dynamic analysis of the Lactococcus lactis transcriptome in cheeses made from milk concentrated by ultrafiltration reveals multiple strategies of adaptation to stresses.<\/a> Appl Environ Microbiol. 77(1):247-57.<\/li><li>Nouaille S, Even S, Charlier C, Le Loir Y, Cocaign-Bousquet M, Loubi\u00e8re P. 2009 Transcriptomic response of Lactococcus lactis in mixed culture with Staphylococcus aureus. Appl Environ Microbiol. 75(13):4473-82.<\/li><li>Even E, Charlier C, Nouaille S, Ben Zakour N, Cretenet M, Cousin F, Gautier M, Cocaign-Bousquet M, Loubi\u00e8re P, Le Loir Y. 2009. Staphylococcus aureus virulence expression is impaired by Lactococcus lactis during mixed cultures. Appl Environ Microbiol. 75(13):4459-72.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>S\u00e9bastien NOUAILLE S\u00e9bastien NOUAILLE Charg\u00e9 de Recherches INRAE Equipe BLADE +33 (0) 5 61 55 94 38 sebastien.nouaille@insa-toulouse.fr Orcid Actual position and research subject My researches focus on understanding the reprogramming of gene expression in the bacterium Escherichia coli. Messenger RNAs are at the crossroads of transcriptional and post-transcriptional processes. Their concentrations are finely regulated [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-6138","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>S\u00e9bastien NOUAILLE | TBI, Toulouse Biotechnology Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/sebastien-nouaille\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"S\u00e9bastien NOUAILLE | TBI, Toulouse Biotechnology Institute\" \/>\n<meta property=\"og:description\" content=\"S\u00e9bastien NOUAILLE S\u00e9bastien NOUAILLE Charg\u00e9 de Recherches INRAE Equipe BLADE +33 (0) 5 61 55 94 38 sebastien.nouaille@insa-toulouse.fr Orcid Actual position and research subject My researches focus on understanding the reprogramming of gene expression in the bacterium Escherichia coli. Messenger RNAs are at the crossroads of transcriptional and post-transcriptional processes. 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