{"id":5338,"date":"2022-03-10T16:11:28","date_gmt":"2022-03-10T15:11:28","guid":{"rendered":"http:\/\/v2tbi.christelle-labruyere.com\/?page_id=5338"},"modified":"2022-06-08T19:27:08","modified_gmt":"2022-06-08T17:27:08","slug":"ingenierie-metabolique","status":"publish","type":"page","link":"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/poles\/equipe-i2m\/ingenierie-metabolique\/","title":{"rendered":"Ing\u00e9nierie M\u00e9tabolique"},"content":{"rendered":"\t\t
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Equipe I2M<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Th\u00e8me \"Ing\u00e9nierie M\u00e9tabolique\" <\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Quelques mots sur le th\u00e8me<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Etudier la plasticit\u00e9 du m\u00e9tabolisme et le dialogue entre la voie synth\u00e9tique<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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L\u2019ing\u00e9nierie m\u00e9tabolique s\u2019inscrit dans une d\u00e9marche de d\u00e9veloppement durable centr\u00e9e sur la transition \u00e9nerg\u00e9tique, pour remplacer la synth\u00e8se chimique par des proc\u00e9d\u00e9s de fermentation, une technologie beaucoup plus douce pour l\u2019environnement. La conception de voies de biosynth\u00e8se artificielles implique le transfert, l\u2019expression et le couplage fonctionnel de multiples \u00e9tapes enzymatiques au sein d\u2019un m\u00eame organisme-h\u00f4te ce qui peut entra\u00eener des cons\u00e9quences physiologiques pour la cellule. Cette question de l\u2019hom\u00e9ostasie entre m\u00e9tabolismes endog\u00e8ne et synth\u00e9tique est abord\u00e9e par l\u2019\u00e9tude de la plasticit\u00e9 du m\u00e9tabolisme de la cellule h\u00f4te et du dialogue entre la voie synth\u00e9tique introduite et le m\u00e9tabolisme endog\u00e8ne de l\u2019h\u00f4te. Une compr\u00e9hension multi-\u00e9chelle de ces ph\u00e9nom\u00e8nes n\u00e9cessite la mise en \u0153uvre d\u2019approches omiques nouvelles, en particulier l\u2019analyse des activit\u00e9s enzymatiques directement in vivo<\/em><\/span> et une analyse physiologique du m\u00e9tabolisme, en relation notamment avec la compartimentation cellulaire<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Les projets<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Projet<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Localisation intracellulaire chez l\u2019organisme h\u00f4te des produits du m\u00e9tabolisme h\u00e9t\u00e9rologue<\/strong><\/p>

Nous \u00e9tudions la r\u00e9partition des interm\u00e9diaires et produits finaux de cette voie de biosynth\u00e8se au sein des diff\u00e9rents compartiments cellulaires membranaires afin d\u2019appr\u00e9hender leur influence sur le fonctionnement des organelles accumulant ces mol\u00e9cules. Chez les plantes ces compos\u00e9s sont synth\u00e9tis\u00e9s dans les (chloro)plastes, avec de nombreux \u00e9changes avec le cytosol et les mitochondries pour les pr\u00e9curseurs, puis avec le r\u00e9ticulum endoplasmique pour les produits finaux. Conna\u00eetre avec pr\u00e9cision la localisation cellulaire de chacun de ces \u00e9l\u00e9ments au cours du processus de synth\u00e8se h\u00e9t\u00e9rologue chez les levures, qui sont d\u00e9pourvues de plastes, devrait nous permettre de r\u00e9soudre nombre de questionnements rencontr\u00e9s pr\u00e9c\u00e9demment par les chercheurs de ce domaine. Ma\u00eetriser cette localisation appara\u00eet comme des \u00e9tapes n\u00e9cessaires pour pouvoir par la suite d\u00e9velopper des strat\u00e9gies d\u2019ing\u00e9nierie de la compartimentation intracellulaire.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Projet <\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Biosenseur des mol\u00e9cules antioxydantes produites chez la levure<\/strong><\/p>

Notre projet vise \u00e0 d\u00e9velopper une technologie innovante de mesure du potentiel antioxydant in<\/em> vivo, radicalement distincte des m\u00e9thodes de dosage existantes chimiques et analytiques. La mise au point de notre syst\u00e8me biosenseur et son impl\u00e9mentation dans la levure dans un premier temps puis dans d\u2019autres micro-organismes producteurs d\u2019antioxydants par la suite, permettra de suivre la synth\u00e8se des mol\u00e9cules produites gr\u00e2ce \u00e0 leur pouvoir antioxydant, directement in vivo<\/em>, en \u00e9vitant ainsi les \u00e9tapes d\u2019extraction et l\u2019analyse chimique, plus polluantes et gourmandes en \u00e9nergie.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Equipe I2M Retour vers l’\u00e9quipe Th\u00e8me “Ing\u00e9nierie M\u00e9tabolique” Quelques mots sur le th\u00e8me Etudier la plasticit\u00e9 du m\u00e9tabolisme et le dialogue entre la voie synth\u00e9tique L\u2019ing\u00e9nierie m\u00e9tabolique s\u2019inscrit dans une d\u00e9marche de d\u00e9veloppement durable centr\u00e9e sur la transition \u00e9nerg\u00e9tique, pour remplacer la synth\u00e8se chimique par des proc\u00e9d\u00e9s de fermentation, une technologie beaucoup plus douce pour […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":5039,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-5338","page","type-page","status-publish","hentry"],"yoast_head":"\nIng\u00e9nierie M\u00e9tabolique | TBI, Toulouse Biotechnology Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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