{"id":4697,"date":"2022-02-22T16:14:42","date_gmt":"2022-02-22T15:14:42","guid":{"rendered":"http:\/\/v2tbi.christelle-labruyere.com\/?page_id=4697"},"modified":"2025-07-29T17:46:32","modified_gmt":"2025-07-29T15:46:32","slug":"production-scientifique","status":"publish","type":"page","link":"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/poles\/equipe-metasys\/production-scientifique\/","title":{"rendered":"Production scientifique METASYS"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"4697\" class=\"elementor elementor-4697\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2ec79ae8 elementor-section-height-min-height elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"2ec79ae8\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;,&quot;shape_divider_bottom&quot;:&quot;waves&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t<div class=\"elementor-shape elementor-shape-bottom\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 1000 100\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M421.9,6.5c22.6-2.5,51.5,0.4,75.5,5.3c23.6,4.9,70.9,23.5,100.5,35.7c75.8,32.2,133.7,44.5,192.6,49.7\n\tc23.6,2.1,48.7,3.5,103.4-2.5c54.7-6,106.2-25.6,106.2-25.6V0H0v30.3c0,0,72,32.6,158.4,30.5c39.2-0.7,92.8-6.7,134-22.4\n\tc21.2-8.1,52.2-18.2,79.7-24.2C399.3,7.9,411.6,7.5,421.9,6.5z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-649bd3c5\" data-id=\"649bd3c5\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-05bb2cd elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"05bb2cd\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-d2d82b9\" data-id=\"d2d82b9\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-6df0057\" data-id=\"6df0057\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-bf57318 elementor-widget elementor-widget-heading\" data-id=\"bf57318\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Equipe METASYS<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-f4529a1\" data-id=\"f4529a1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3b180dd elementor-align-right elementor-widget elementor-widget-button\" data-id=\"3b180dd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-xs\" href=\"https:\/\/www.toulouse-biotechnology-institute.fr\/poles\/equipe-metasys\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-left\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Retour vers l'\u00e9quipe<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-253c4e66 elementor-widget elementor-widget-heading\" data-id=\"253c4e66\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Production scientifique<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2d91756 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2d91756\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e4c0e78\" data-id=\"e4c0e78\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9dc752a elementor-widget elementor-widget-heading\" data-id=\"9dc752a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Articles<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8883498 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8883498\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2a1283d\" data-id=\"2a1283d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2b7c32e elementor-widget__width-initial elementor-widget elementor-widget-toggle\" data-id=\"2b7c32e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-4551\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-4551\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">2025<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-4551\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-4551\"><ul><li>Manzotti, A., Monteil, R., Cheminant Navarro, S., Croteau, D., Charreton, L., Hoguin, A., Strumpen, N.F., Jallet, D., Daboussi, F., Kroth, P.G., Bouget, F.Y., Jaubert, M., Bailleul, B., Bouly, J.P. <strong>2025<\/strong>. Circadian regulation of key physiological processes by the RITMO 1 clock protein in the marine diatom <em>Phaeodactylum tricornutum<\/em>. <em>New Phytologist<\/em>. <a href=\"https:\/\/doi.org\/10.1111\/nph.70099\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1111\/nph.70099<\/a><\/li><li>Irla, M., N\u00e6rdal, I., Virant, D., Brautaset, T., Busche, T., Goranovi\u010d, D., Haupka, C., Heux, S., Kosec, G., R\u00fcckert-Reed, C., Wendisch, V.F., Brito, L.F., Vicente, C.M. <strong>2025<\/strong>. Systems-level analysis provides insights on methanol-based production of l-glutamate and its decarboxylation product \u03b3-aminobutyric acid by <em>Bacillus methanolicus<\/em>. <em>Metabolic Engineering<\/em>. <a href=\"https:\/\/doi.org\/10.1016\/j.ymben.2025.06.002\">https:\/\/doi.org\/10.1016\/j.ymben.2025.06.002<\/a><\/li><li>Gosselin-Monplaisir, T., Jallet, D., Harscoet, E., Uttenweiler-Joseph, S., Heux, S., Millard, P. <strong>2025<\/strong>. Acetate as a metabolic booster for glucose-based bioproduction in <em>Escherichia coli<\/em>. <em>bioRxiv preprint.<\/em> <a href=\"https:\/\/doi.org\/10.1101\/2025.06.17.659982\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1101\/2025.06.17.659982<\/a><\/li><li>Sokol, S., Dubiley, S., Rouan, P., Charlier, C., Lippens, G., Millard, P. <strong>2025<\/strong>. Estimating flux dynamics from metabolite concentration time courses with dynafluxr. <em>bioRxiv preprint<\/em>. <a href=\"https:\/\/doi.org\/10.1101\/2025.07.22.666125\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1101\/2025.07.22.666125<\/a><\/li><li>Millard, P., Le Gr\u00e9gam, L., Dubiley, S., Gabrielli, V., Gosselin-Monplaisir, T., Lippens, G., Charlier, C. <strong>2025<\/strong>. MultiNMRFit: A software to fit 1D and pseudo-2D NMR spectra. <em>bioRxiv preprint<\/em>, <a href=\"https:\/\/doi.org\/10.1101\/2024.12.19.629408\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1101\/2024.12.19.629408<\/a><\/li><li>Schoenmakers, P., Rad, R., Ihl, A., Weickardt, I., Guillouet, S., Apfel, U.P., Lauterbach, L. <strong>2025<\/strong>. Isopropanol production from carbon dioxide by <em>Cupriavidus necator<\/em> using a zero-gap cell with culture broth as catholyte. <em>IScience<\/em>. <a href=\"https:\/\/doi.org\/10.1016\/j.isci.2025.113018\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.isci.2025.113018<\/a><\/li><li>Weickardt, I., Lombard, E., Zhang, A., Blank, L., Guillouet, S.E. Comparative characterisation of autotrophic and heterotrophic isopropanol formation by <em>Cupriavidus necator<\/em> in shake flasks. <em>Journal of Biotechnology<\/em>. <a href=\"https:\/\/doi.org\/10.1016\/j.jbiotec.2025.03.011\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.jbiotec.2025.03.011<\/a><\/li><li>Di Bisceglie, F., Garc\u00eda Navarro, J., Lombard, E., Kratzer, R., Kourist, R., Guillouet, S.E. <strong>2025<\/strong>.Conceptual approach for aerobic autotrophic gas cultivation in shake flasks: Overcoming the inhibitory effects of oxygen in <em>Cupriavidus necator<\/em>. <em>Biotechnology Journal<\/em>. <a href=\"https:\/\/doi.org\/10.1002\/biot.202400641\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1002\/biot.202400641<\/a><\/li><li>Gelain, L., Yeoh, J.W., Hossain, G. S., Alfenore, S., Guillouet, S., Ling, H., Poh, C. L., Gorret, N., Foo, J. L. <strong>2025<\/strong>. Identification and monitoring of cell heterogeneity from plasmid recombination during limonene production. <em>Applied Microbiology and Biotechnology<\/em>. <a href=\"https:\/\/doi.org\/10.1007\/s00253-024-13273-5\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1007\/s00253-024-13273-5<\/a><\/li><li>Buron-Moles, G., Vandenbossche, V., Gorret, N., Santonja-Blasco, L., Gonzalez-Aranda, T., Cameleyre, X., Guillouet, S. <strong>2025<\/strong>. Biodegradation of pre-treated low-density polyethylene (LDPE) by <em>Yarrowia lipolytica<\/em> determined by oxidation and molecular weight reduction. <em>Polymer Degradation and Stability<\/em>. <a href=\"https:\/\/doi.org\/10.1016\/j.polymdegradstab.2025.111292\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.polymdegradstab.2025.111292<\/a><\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-4552\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-4552\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">2024<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-4552\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-4552\"><ul><li>Ismail, S., Giacinti, G., Delagado Raynaud, C., Cameleyre, X., Alfenore, S., Guillouet, S., Gorret N. <strong>2024<\/strong>. Impact of the environmental parameters on single cell protein production and composition by <em>Cupriavidus necator<\/em>. <em>J. Biotechnol.<\/em> <strong>388<\/strong>: 83-95. <a href=\"https:\/\/doi.org\/10.1016\/j.jbiotec.2024.04.009\">https:\/\/doi.org\/10.1016\/j.jbiotec.2024.04.009<\/a><\/li><li>Vogeleer, P., Millard, P., Ortega Arbulu A.S., Pfl\u00fcger-Grau, K., Kremling, A., L\u00e9tisse, F. <strong>2024<\/strong>. Metabolic impact of heterologous protein production in <em>Pseudomonas putida<\/em>: Insights into carbon and energy flux control. <em>Metabolic engineering<\/em> <strong>81<\/strong>:26-37, <a href=\"https:\/\/doi.org\/10.1016\/j.ymben.2023.10.005\">https:\/\/doi.org\/10.1016\/j.ymben.2023.10.005<\/a><\/li><li>Ph\u00e9gnon, L., P\u00e9rochon, J., Uttenweiler-Joseph, S., Cahoreau, E., Millard, P., L\u00e9tisse, F. <strong>2024<\/strong>. 6-Phosphogluconolactonase is critical for the efficient functioning of the pentose phosphate pathway. Accepted in FEBS Journal. BiorXiv version. <a href=\"https:\/\/doi.org\/10.1101\/2023.11.29.569206\">https:\/\/doi.org\/10.1101\/2023.11.29.569206<\/a><\/li><li>Jallet, D., Soldan, V., Shayan, R., Stella, A., Ismail, N., Zenati, R., Cahoreau, E., Burlet-Schiltz, O., Balor, S., Millard, P., Heux, S. <strong>2024<\/strong>. Integrative <em>in vivo<\/em> analysis of the ethanolamine utilization bacterial microcompartment in <em>Escherichia coli<\/em>. BiorXiv preprint. <a href=\"https:\/\/doi.org\/10.1101\/2024.03.04.583360\">https:\/\/doi.org\/10.1101\/2024.03.04.583360<\/a><\/li><li>Castano-Cerezo, S., Chamas, A., Kulyk, H., Treitz, C., Bellvert, F., Tholey, A., Gal\u00e9ote, V., Camarasa, C., Heux, S., Garcia-Alles, L., Millard, P. Truan, G. <strong>2024<\/strong>. Combining systems and synthetic biology for <em>in vivo<\/em> enzymology. BiorXiv preprint. <a href=\"https:\/\/doi.org\/10.1101\/2024.02.02.578620\">https:\/\/doi.org\/10.1101\/2024.02.02.578620<\/a><\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-4553\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"button\" aria-controls=\"elementor-tab-content-4553\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">2023<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-4553\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"region\" aria-labelledby=\"elementor-tab-title-4553\"><ul><li>Garc\u00eda-Calvo, L., Rodr\u00edguez-Castro, R., Ull\u00e1n, R.V., Albillos, S.M., Fern\u00e1ndez-Aguado, M., Vicente, C.M., Degnes, K.F., Sletta, H., Barreiro, C<em>.<\/em><strong>2023<\/strong>. <em>Penicillium chrysogenum<\/em>\u00a0as a fungal factory for feruloyl esterases.\u00a0<em>Appl Microbiol. Biotechnol<\/em>. <a href=\"https:\/\/doi.org\/10.1007\/s00253-022-12335-w\">https:\/\/doi.org\/10.1007\/s00253-022-12335-w<\/a><\/li><li>Millard, P., Gosselin Monplaisir, T., Uttenweiler-Joseph, S., Enjalbert, B.\u00a0<strong>2023<\/strong>. Acetate is a beneficial nutrient for <em>E. coli<\/em> at low glycolytic flux. <em>EMBO J.<\/em> <strong>42<\/strong>: e113079. <a href=\"https:\/\/doi.org\/10.15252\/embj.2022113079\">https:\/\/doi.org\/10.15252\/embj.2022113079<\/a><\/li><li>Le Gr\u00e9gam, L., Guitton, Y., Bellvert, F., Heux, S., Jourdan, F., Portais, J.C., Millard, P. <strong>2023<\/strong>. PhysioFit: a software to quantify cell growth parameters and extracellular fluxes. BiorXiv preprint. <a href=\"https:\/\/doi.org\/10.1101\/2023.10.12.561695\">https:\/\/doi.org\/10.1101\/2023.10.12.561695<\/a><\/li><li>Fina, A., Millard, P., Albiol, J., Ferrer, P., Heux, S. <strong>2023<\/strong>. High throughput <sup>13<\/sup>C-metabolic flux analysis of 3-hydroxypropionic acid producing <em>Pichia pastoris<\/em> reveals limited availability of acetyl-CoA and ATP due to tight control of the glycolytic flux. <em>Microbial Cell Factories<\/em> <strong>22<\/strong>(1):117. <a href=\"https:\/\/doi.org\/10.1186\/s12934-023-02123-0\">https:\/\/doi.org\/10.1186\/s12934-023-02123-0<\/a><\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-4554\" class=\"elementor-tab-title\" data-tab=\"4\" role=\"button\" aria-controls=\"elementor-tab-content-4554\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">2022<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-4554\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"4\" role=\"region\" aria-labelledby=\"elementor-tab-title-4554\"><ul><li>Peiro, C., Vicente, C.M., Jallet, D., Heux, S. <strong>2022<\/strong>. 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(2015). &#8220;Impact of kinetic isotope effects in isotopic studies of metabolic systems.&#8221;\u00a0 9: 64. BMC Syst. Biol.<\/li><li>Muller, J. E., Meyer, F., Litsanov, B., Kiefer, P., Potthoff, E., Heux, S., Quax, W. J., Wendisch, V. F., Brautaset, T., Portais, J. C. and Vorholt, J. A. (2015). &#8220;Engineering Escherichia coli for methanol conversion.&#8221;\u00a0 28: 190-201. Metab. Eng.<\/li><li>Sokol, S. and Portais, J. C. (2015). &#8220;Theoretical Basis for Dynamic Label Propagation in Stationary Metabolic Networks under Step and Periodic Inputs.&#8221;\u00a0 10(12): e0144652. PLoS One.<\/li><li>Stanford, N. J., Millard, P. and Swainston, N. (2015). &#8220;RobOKoD: microbial strain design for (over)production of target compounds.&#8221;\u00a0 3: 17. 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C. (2014). &#8220;A novel platform for automated high-throughput fluxome profiling of metabolic variants.&#8221;\u00a0 25: 8-19. Metab. Eng.<\/li><li>Millard, P., Letisse, F., Sokol, S. and Portais, J. C. (2014). &#8220;Correction of MS data for naturally occurring isotopes in isotope labelling experiments.&#8221;\u00a0 1191: 197-207. Methods Mol Biol.<\/li><li>Millard, P., Massou, S., Portais, J. C. and Letisse, F. (2014). &#8220;Isotopic studies of metabolic systems by mass spectrometry: using Pascal&#8217;s triangle to produce biological standards with fully controlled labeling patterns.&#8221;\u00a0 86(20): 10288-10295. Anal. Chem.<\/li><li>Millard, P., Massou, S., Wittmann, C., Portais, J. C. and Letisse, F. (2014). &#8220;Sampling of intracellular metabolites for stationary and non-stationary (13)C metabolic flux analysis in Escherichia coli.&#8221;\u00a0 465: 38-49. Anal. Biochem.<\/li><li>Millard, P., Sokol, S., Letisse, F. and Portais, J. C. (2014). &#8220;IsoDesign: a software for optimizing the design of 13C-metabolic flux analysis experiments.&#8221;\u00a0 111(1): 202-208. Biotechnol. Bioeng.<\/li><li>Silva, R. R., Jourdan, F., Salvanha, D. M., Letisse, F., Jamin, E. L., Guidetti-Gonzalez, S., Labate, C. A. and Vencio, R. Z. (2014). &#8220;ProbMetab: an R package for Bayesian probabilistic annotation of LC-MS-based metabolomics.&#8221;\u00a0 30(9): 1336-1337. Bioinformatics.<\/li><li>Vieira, G., Carnicer, M., Portais, J. C. and Heux, S. (2014). &#8220;FindPath: a Matlab solution for in silico design of synthetic metabolic pathways.&#8221;\u00a0 30(20): 2986-2988. 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Biol.<\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-45514\" class=\"elementor-tab-title\" data-tab=\"14\" role=\"button\" aria-controls=\"elementor-tab-content-45514\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">2012<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-45514\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"14\" role=\"region\" aria-labelledby=\"elementor-tab-title-45514\"><ul><li>Cahoreau, E., Peyriga, L., Hubert, J., Bringaud, F., Massou, S. and Portais, J. C. (2012). &#8220;Isotopic profiling of (1)(3)C-labeled biological samples by two-dimensional heteronuclear J-resolved nuclear magnetic resonance spectroscopy.&#8221;\u00a0 427(2): 158-163. Anal. Biochem.<\/li><li>Giraudeau, P., Cahoreau, E., Massou, S., Pathan, M., Portais, J. C. and Akoka, S. (2012). &#8220;UFJCOSY: a fast 3D NMR method for measuring isotopic enrichments in complex samples.&#8221;\u00a0 13(13): 3098-3101. ChemPhysChem.<\/li><li>Millard, P., Letisse, F., Sokol, S. and Portais, J. C. (2012). &#8220;IsoCor: correcting MS data in isotope labeling experiments.&#8221;\u00a0 28(9): 1294-1296. Bioinformatics.<\/li><li>Peyraud, R., Kiefer, P., Christen, P., Portais, J. C. and Vorholt, J. A. (2012). &#8220;Co-consumption of methanol and succinate by Methylobacterium extorquens AM1.&#8221;\u00a0 7(11): e48271. PLoS One.<\/li><li>Schneider, K., Peyraud, R., Kiefer, P., Christen, P., Delmotte, N., Massou, S., Portais, J. C. and Vorholt, J. A. 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C. (2011). &#8220;Intuitive visualization and analysis of multi-omics data and application to Escherichia coli carbon metabolism.&#8221;\u00a0 6(6): e21318. PLoS One.<\/li><li>Giraudeau, P., Massou, S., Robin, Y., Cahoreau, E., Portais, J. C. and Akoka, S. (2011). &#8220;Ultrafast quantitative 2D NMR: an efficient tool for the measurement of specific isotopic enrichments in complex biological mixtures.&#8221;\u00a0 83(8): 3112-3119. Anal. Chem.<\/li><li>Heux, S., Philippe, B. and Portais, J. C. (2011). &#8220;High-throughput workflow for monitoring and mining bioprocess data and its application to inferring the physiological response of Escherichia coli to perturbations.&#8221;\u00a0 77(19): 7040-7049. Appl. Environ. Microbiol.<\/li><li>Peyraud, R., Schneider, K., Kiefer, P., Massou, S., Vorholt, J. A. and Portais, J. C. (2011). &#8220;Genome-scale reconstruction and system level investigation of the metabolic network of Methylobacterium extorquens AM1.&#8221;\u00a0 5: 189. BMC Syst. Biol.<\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-45516\" class=\"elementor-tab-title\" data-tab=\"16\" role=\"button\" aria-controls=\"elementor-tab-content-45516\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">2009<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-45516\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"16\" role=\"region\" aria-labelledby=\"elementor-tab-title-45516\"><ul><li>Peyraud, R., Kiefer, P., Christen, P., Massou, S., Portais, J. C. and Vorholt, J. A. (2009). &#8220;Demonstration of the ethylmalonyl-CoA pathway by using 13C metabolomics.&#8221;\u00a0 106(12): 4846-4851. Proc. Natl. Acad. Sci. U. S. A.<\/li><li>Rodriguez-Prados, J. C., de Atauri, P., Maury, J., Ortega, F., Portais, J. C., Chassagnole, C., Acerenza, L., Lindley, N. D. and Cascante, M. (2009). &#8220;In silico strategy to rationally engineer metabolite production: A case study for threonine in Escherichia coli.&#8221;\u00a0 103(3): 609-620. Biotechnol. Bioeng.<\/li><li>Walther, T., Novo, M., Rossger, K., Letisse, F., Loret, M. O., Portais, J. C. and Francois, J. M. (2010). &#8220;Control of ATP homeostasis during the respiro-fermentative transition in yeast.&#8221;\u00a0 6: 344. Mol. Syst. Biol.<\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-45517\" class=\"elementor-tab-title\" data-tab=\"17\" role=\"button\" aria-controls=\"elementor-tab-content-45517\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">2008<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-45517\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"17\" role=\"region\" aria-labelledby=\"elementor-tab-title-45517\"><ul><li>Kiefer, P., Portais, J. C. and Vorholt, J. A. (2008). &#8220;Quantitative metabolome analysis using liquid chromatography-high-resolution mass spectrometry.&#8221;\u00a0 382(2): 94-100. Anal. Biochem.<\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-45518\" class=\"elementor-tab-title\" data-tab=\"18\" role=\"button\" aria-controls=\"elementor-tab-content-45518\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">2007<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-45518\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"18\" role=\"region\" aria-labelledby=\"elementor-tab-title-45518\"><ul><li>Bolten, C. J., Kiefer, P., Letisse, F., Portais, J. C. and Wittmann, C. (2007). &#8220;Sampling for metabolome analysis of microorganisms.&#8221;\u00a0 79(10): 3843-3849. Anal. Chem.<\/li><li>Chistoserdova, L., Crowther, G. J., Vorholt, J. A., Skovran, E., Portais, J. C. and Lidstrom, M. E. (2007). &#8220;Identification of a fourth formate dehydrogenase in Methylobacterium extorquens AM1 and confirmation of the essential role of formate oxidation in methylotrophy.&#8221;\u00a0 189(24): 9076-9081. J. Bacteriol.<\/li><li>Kiefer, P., Nicolas, C., Letisse, F. and Portais, J. C. (2007). &#8220;Determination of carbon labeling distribution of intracellular metabolites from single fragment ions by ion chromatography tandem mass spectrometry.&#8221;\u00a0 360(2): 182-188. Anal. Biochem.<\/li><li>Massou, S., Nicolas, C., Letisse, F. and Portais, J. C. (2007). &#8220;Application of 2D-TOCSY NMR to the measurement of specific(13C-enrichments in complex mixtures of 13C-labeled metabolites.&#8221;\u00a0 9(3): 252-257. Metab. Eng.<\/li><li>Massou, S., Nicolas, C., Letisse, F. and Portais, J. C. (2007). &#8220;NMR-based fluxomics: quantitative 2D NMR methods for isotopomers analysis.&#8221;\u00a0 68(16-18): 2330-2340. Phytochemistry.<\/li><li>Nicolas, C., Kiefer, P., Letisse, F., Kromer, J., Massou, S., Soucaille, P., Wittmann, C., Lindley, N. D. and Portais, J. C. (2007). &#8220;Response of the central metabolism of Escherichia coli to modified expression of the gene encoding the glucose-6-phosphate dehydrogenase.&#8221;\u00a0 581(20): 3771-3776. FEBS Lett.<\/li><\/ul><p>Troufflard, S., Roscher, A., Thomasset, B., Barbotin, J. N., Rawsthorne, S. and Portais, J. C. (2007). &#8220;In vivo 13C NMR determines metabolic fluxes and steady state in linseed embryos.&#8221;\u00a0 68(16-18): 2341-2350. Phytochemistry.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-04686b6 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"04686b6\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-44800ac\" data-id=\"44800ac\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-654fec4 elementor-widget elementor-widget-heading\" data-id=\"654fec4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Brevets<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5db2a2c elementor-widget elementor-widget-toggle\" data-id=\"5db2a2c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-9821\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-9821\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">2021<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-9821\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-9821\"><p>Patent WO2021229185 Durand J., L\u00e9tisse F., Tedesco P., Veronese G..\u00a0<em>Souches bact\u00e9riennes et proc\u00e9d\u00e9 de production d&#8217;oligosaccharides<\/em><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-9822\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-9822\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">2018<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-9822\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-9822\"><p>Patent\u00a0 PCT\/EP2018\/066762 &#8211; WO\/2018\/234546. SYNTHETIC METHYLOTROPHY by HEUX St\u00e9phanie, DE SIMONE Alessandro, PORTAIS, Jean-Charles<\/p><p>\u00a0<\/p><p>Patent N\u00b0 PCT\/EP2013\/051516 &#8211; WO 2013110797. Sinvent AS.\u00a0<strong>Novel Methanol Dehydrogenase Enzymes from Bacillus<\/strong>. Inventors: BRAUTASET, Trygve, HEGGESET, Tonje Marita Bjerkan, KROG, Anne, QUAX, Wilhelmus Johannes, SIBBALD, Mark Jan Jacobus Bernhard, VORHOLT, Julia, M\u00dcLLER, Jonas, KIEFER, Patrick, POTTHOFF, Eva, WENDISCH, Volker F, LESSMEIER, Lennart, HEUX, St\u00e9phanie, PORTAIS, Jean-Charles.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-9823\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"button\" aria-controls=\"elementor-tab-content-9823\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">2014<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-9823\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"region\" aria-labelledby=\"elementor-tab-title-9823\"><p>Patent Application N\u00b0 61979327. Filed April 2014. Princeton University, USA.\u00a0<strong>Methods and Materials for producing polyols and electron rich compounds<\/strong>&#8220;. Yi Fan Xu, Joshua D Rabinowitz, Fabien L\u00e9tissse, Sarah Johnson<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0bcecfc elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0bcecfc\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-60c5e75\" data-id=\"60c5e75\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9f004be elementor-widget elementor-widget-heading\" data-id=\"9f004be\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Logciels<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-88395ee elementor-widget elementor-widget-toggle\" data-id=\"88395ee\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1421\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1421\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">https:\/\/github.com\/MetaSys-LISBP<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1421\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1421\"><p><a href=\"https:\/\/github.com\/MetaSys-LISBP\" target=\"_blank\" rel=\"noopener\">https:\/\/github.com\/MetaSys-LISBP<\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Equipe METASYS Retour vers l&#8217;\u00e9quipe Production scientifique Articles 2025 Manzotti, A., Monteil, R., Cheminant Navarro, S., Croteau, D., Charreton, L., Hoguin, A., Strumpen, N.F., Jallet, D., Daboussi, F., Kroth, P.G., Bouget, F.Y., Jaubert, M., Bailleul, B., Bouly, J.P. 2025. Circadian regulation of key physiological processes by the RITMO 1 clock protein in the marine diatom [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":3253,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-4697","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Production scientifique METASYS | TBI, Toulouse Biotechnology Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/poles\/equipe-metasys\/production-scientifique\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Production scientifique METASYS | TBI, Toulouse Biotechnology Institute\" \/>\n<meta property=\"og:description\" content=\"Equipe METASYS Retour vers l&#8217;\u00e9quipe Production scientifique Articles 2025 Manzotti, A., Monteil, R., Cheminant Navarro, S., Croteau, D., Charreton, L., Hoguin, A., Strumpen, N.F., Jallet, D., Daboussi, F., Kroth, P.G., Bouget, F.Y., Jaubert, M., Bailleul, B., Bouly, J.P. 2025. 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