{"id":4586,"date":"2022-02-21T16:09:13","date_gmt":"2022-02-21T15:09:13","guid":{"rendered":"http:\/\/v2tbi.christelle-labruyere.com\/?page_id=4586"},"modified":"2025-07-03T15:47:38","modified_gmt":"2025-07-03T13:47:38","slug":"nouveaux-reseaux-metaboliques","status":"publish","type":"page","link":"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/poles\/equipe-metasys\/nouveaux-reseaux-metaboliques\/","title":{"rendered":"Cr\u00e9er de nouveau r\u00e9seaux m\u00e9taboliques et de r\u00e9gulations"},"content":{"rendered":"\t\t
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Equipe METASYS<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Th\u00e8me \"Cr\u00e9er des micro-organismes performants\"<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Quelques mots sur le th\u00e8me<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Cr\u00e9er des micro-organismes performants<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tDans ce th\u00e8me, nous cherchons \u00e0 d\u00e9velopper des processus biotechnologiques innovants et originaux en utilisant des microorganismes comme usine cellulaire pour valoriser des ressources renouvelables en bioproduits. Nous cr\u00e9ons des usines cellulaires microbiennes en dotant divers micro-organismes d\u2019int\u00e9r\u00eat industriel (E. coli, B. methanolicus, Y. lipolytica, C. necator<\/em>) de nouvelles fonctions qui n\u2019existent pas n\u00e9cessairement dans la nature. Nous m\u00e9langeons et associons des enzymes m\u00e9taboliques ou des prot\u00e9ines r\u00e9gulatrices de diff\u00e9rentes esp\u00e8ces afin d\u2019\u00e9largir le portefeuille de substrats et de produits de ces micro-organismes. L\u2019analyse de la r\u00e9ponse int\u00e9gr\u00e9e du microorganisme \u00e0 ces nouvelles fonctionnalit\u00e9s m\u00e9taboliques ou r\u00e9gulatrices permet de comprendre leur fonctionnement et donc de les am\u00e9liorer (voir th\u00e8me 1).<\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Les projets<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Projet METHYLO<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Dans ce projet, nous proposons de remplacer les mati\u00e8res premi\u00e8res entrant en concurrence avec l’alimentation, actuellement utilis\u00e9es en biotechnologie industrielle, par le m\u00e9thanol, afin de promouvoir une bio\u00e9conomie circulaire et durable. Le m\u00e9thanol constitue une alternative prometteuse en tant que source de carbone renouvelable, puisqu\u2019il peut \u00eatre synth\u00e9tis\u00e9 \u00e0 partir de CO\u2082, contribuant ainsi aux efforts de lutte contre le changement climatique. Notre travail consiste \u00e0 reprogrammer l\u2019architecture m\u00e9tabolique d\u2019E. coli <\/em>pour lui permettre d\u2019assimiler du m\u00e9thanol en tant que source principale de carbone et d\u2019\u00e9nergie. La reprogrammation du r\u00e9gime alimentaire d\u2019E coli <\/em>pour l\u2019assimilation d\u2019une nouvelle source de carbone tel que le m\u00e9thanol est une t\u00e2che difficile. Elle ne n\u00e9cessite pas seulement d\u2019\u00e9quiper E. coli<\/em> avec une voie m\u00e9thylotrophique synth\u00e9tique. Il est \u00e9galement indispensable d\u2019int\u00e9grer cette nouvelle fonctionnalit\u00e9 m\u00e9tabolique avec les processus cellulaires globaux. C\u2019est ce que nous proposons de faire dans ce projet : (i) en construisant un r\u00e9seau de r\u00e9gulation semi-synth\u00e9tique qui r\u00e9pond au m\u00e9thanol et active l\u2019ensemble des processus cellulaires natifs d\u2019 E. coli\u00a0<\/em>; et (ii) en isolant la voie m\u00e9thylotrophique synth\u00e9tique au sein de microcompartiments bact\u00e9riens (BMCs). Ces structures sp\u00e9cialis\u00e9es concentreront les \u00e9l\u00e9ments biochimiques n\u00e9cessaires, optimisant ainsi les vitesses de r\u00e9action et la performance m\u00e9tabolique globale.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Projet COBIOMACE <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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En collaboration avec l\u2019\u00e9quipe SYMBIOSE, ce projet vise \u00e0 produire des biomol\u00e9cules \u00e0 partir de CO\u2082 via l\u2019ac\u00e9tate, en utilisant un syst\u00e8me microbien en deux \u00e9tapes. Dans la premi\u00e8re \u00e9tape, le CO\u2082 est converti en ac\u00e9tate par des communaut\u00e9s microbiennes ana\u00e9robies, dans des conditions contr\u00f4l\u00e9es en bior\u00e9acteurs. Dans la seconde \u00e9tape, cet ac\u00e9tate est utilis\u00e9 comme source de carbone par des souches d\u2019E. coli <\/em>modifi\u00e9es g\u00e9n\u00e9tiquement pour produire diverses biomol\u00e9cules d\u2019int\u00e9r\u00eat industriel. En couplant ces deux \u00e9tapes, notre objectif est de d\u00e9velopper un proc\u00e9d\u00e9 biotechnologique durable utilisant des micro-organismes comme usines cellulaires pour valoriser des ressources carbon\u00e9es renouvelables en bioproduits.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Projet LIPIDS <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Dans ce projet, nous modifions la levure ol\u00e9agineuse Yarrowia lipolytica<\/em> afin de produire des lipides microbiens inhabituels. Nous combinons l\u2019ing\u00e9nierie enzymatique (en collaboration avec l\u2019\u00e9quipe CIMES) et l\u2019ing\u00e9nierie m\u00e9tabolique pour adapter la composition en acides gras en fonction des compos\u00e9s d\u2019int\u00e9r\u00eat. Nos recherches nous ont \u00e9galement conduits \u00e0 d\u00e9velopper des outils g\u00e9n\u00e9tiques innovants afin de faciliter l\u2019ing\u00e9nierie de cette levure non conventionnelle.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Projet MELANGE <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Ce projet franco-indien vise \u00e0 d\u00e9velopper un consortium en culture mixte de micro-organismes g\u00e9n\u00e9tiquement modifi\u00e9s pour la production de flavono\u00efdes glycosyl\u00e9s. Ce proc\u00e9d\u00e9 implique des voies biosynth\u00e9tiques co\u00fbteuses en \u00e9nergie m\u00e9tabolique, ce qui affecte la viabilit\u00e9 des cellules microbiennes et entra\u00eene une bioconversion sous-optimale. Nous abordons ce probl\u00e8me en d\u00e9composant la voie m\u00e9tabolique en quatre modules, chacun \u00e9tant pris en charge par une cellule microbienne sp\u00e9cialis\u00e9e.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Projet Optisfuel <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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En collaboration avec l\u2019\u00e9quipe PHYGE et la plateforme GeT-Biopuces, nous modifions la bact\u00e9rie lithoautotrophe C. necator<\/em> pour produire des hydrocarbures (alcanes et alc\u00e8nes) afin de fabriquer des carburants \u00e0 partir de CO2 comme unique source de carbone. L\u2019ing\u00e9nierie m\u00e9tabolique et l\u2019analyse des sous-populations sont combin\u00e9es pour d\u00e9velopper des souches modifi\u00e9es robustes.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Projet BioFaced <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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En collaboration avec l\u2019\u00e9quipe PHYGE, l\u2019Institut Cl\u00e9ment Ader et le CNES, nous visons \u00e0 identifier des m\u00e9thodes pour synth\u00e9tiser des additifs organiques \u00e0 partir de d\u00e9chets en utilisant un syst\u00e8me bior\u00e9g\u00e9n\u00e9ratif, fabriquer un filament imprimable via la fabrication par d\u00e9p\u00f4t de filament fondu (FFF), ma\u00eetriser l\u2019impression 3D d\u2019un objet, le traiter thermiquement de mani\u00e8re contr\u00f4l\u00e9e, et recycler les gaz de combustion pour reproduire des additifs organiques. Des micro-organismes sont g\u00e9n\u00e9tiquement modifi\u00e9s afin de produire des additifs organiques personnalis\u00e9s \u00e0 partir de d\u00e9chets organiques et de gaz de combustion recycl\u00e9s.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Equipe METASYS Retour vers l’\u00e9quipe Th\u00e8me “Cr\u00e9er des micro-organismes performants” Quelques mots sur le th\u00e8me Cr\u00e9er des micro-organismes performants Dans ce th\u00e8me, nous cherchons \u00e0 d\u00e9velopper des processus biotechnologiques innovants et originaux en utilisant des microorganismes comme usine cellulaire pour valoriser des ressources renouvelables en bioproduits. Nous cr\u00e9ons des usines cellulaires microbiennes en dotant divers […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":3253,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-4586","page","type-page","status-publish","hentry"],"yoast_head":"\nCr\u00e9er de nouveau r\u00e9seaux m\u00e9taboliques et de r\u00e9gulations | TBI, Toulouse Biotechnology Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/poles\/equipe-metasys\/nouveaux-reseaux-metaboliques\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cr\u00e9er de nouveau r\u00e9seaux m\u00e9taboliques et de r\u00e9gulations | TBI, Toulouse Biotechnology Institute\" \/>\n<meta property=\"og:description\" content=\"Equipe METASYS Retour vers l’\u00e9quipe Th\u00e8me “Cr\u00e9er des micro-organismes performants” Quelques mots sur le th\u00e8me Cr\u00e9er des micro-organismes performants Dans ce th\u00e8me, nous cherchons \u00e0 d\u00e9velopper des processus biotechnologiques innovants et originaux en utilisant des microorganismes comme usine cellulaire pour valoriser des ressources renouvelables en bioproduits. 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