{"id":4548,"date":"2022-02-21T15:43:52","date_gmt":"2022-02-21T14:43:52","guid":{"rendered":"http:\/\/v2tbi.christelle-labruyere.com\/?page_id=4548"},"modified":"2025-07-03T15:33:31","modified_gmt":"2025-07-03T13:33:31","slug":"reseaux-metaboliques","status":"publish","type":"page","link":"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/poles\/equipe-metasys\/reseaux-metaboliques\/","title":{"rendered":"Understanding metabolic & regulatory networks of microorganisms"},"content":{"rendered":"\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
<\/div>\n\t\t\t\t\t\t
\n\t\t\t\n\t\n<\/svg>\t\t<\/div>\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

Equipe METASYS<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t
\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t<\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\tRetour vers l'\u00e9quipe<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

Th\u00e8me \"Comprendre les r\u00e9ponses m\u00e9taboliques des micro-organismes\"<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n\t\t\t\t\t\t\t
<\/div>\n\t\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

Quelques mots sur le th\u00e8me<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

Comprendre les r\u00e9ponses m\u00e9taboliques des micro-organismes<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\tDans ce th\u00e8me, l\u2019objectif est de comprendre comment les microorganismes (en particulier E. coli, B. methanolicus, P. pastoris<\/em>, C. tetani<\/em>) d\u00e9veloppent des r\u00e9ponses m\u00e9taboliques int\u00e9gr\u00e9es aux changements environnementaux et\/ou g\u00e9n\u00e9tiques. Classiquement, une telle r\u00e9ponse implique des m\u00e9canismes complexes et notre objectif est de comprendre pr\u00e9cis\u00e9ment comment les r\u00e9seaux m\u00e9taboliques et de r\u00e9gulations (naturels ou synth\u00e9tiques !) coop\u00e8rent dans la r\u00e9ponse int\u00e9gr\u00e9e de la cellule. Nous exploitons ensuite ces connaissances pour am\u00e9liorer la conception de microorganismes utiles \u00e0 l\u2019industrie\u00a0(voir th\u00e8me 2).<\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

Les projets<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

Projet ACEMOD<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

L\u2019ac\u00e9tyl-phosphate (AcP) est un interm\u00e9diaire de la voie de l\u2019ac\u00e9tate mais il peut \u00e9galement modifier les prot\u00e9ines par phosphorylation ou ac\u00e9tylation. L\u2019ac\u00e9tylation des prot\u00e9ines chez les bact\u00e9ries se produit par l\u2019action d\u2019une ac\u00e9tyltransf\u00e9rase utilisant l\u2019ac\u00e9tyl-CoA ou de mani\u00e8re non enzymatique par l\u2019AcP. Une grande partie des enzymes du m\u00e9tabolisme central peuvent \u00eatre ac\u00e9tyl\u00e9es, ce qui sugg\u00e8re un r\u00f4le de l\u2019ac\u00e9tylation dans la r\u00e9gulation du m\u00e9tabolisme. Ce projet de recherche vise \u00e0 comprendre comment l\u2019AcP contr\u00f4le le m\u00e9tabolisme bact\u00e9rien via l\u2019ac\u00e9tylation des prot\u00e9ines en corr\u00e9lant le niveau d\u2019AcP dans la cellule bact\u00e9rienne aux changements de sites prot\u00e9iques ac\u00e9tyl\u00e9s par l\u2019AcP.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

Projet ColiMATTERS <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

Les bact\u00e9ries ont longtemps \u00e9t\u00e9 consid\u00e9r\u00e9es comme de simples \u201cpoches \u00e0 enzymes\u201d, sans v\u00e9ritable organisation m\u00e9tabolique sub-cellulaire. Cette vision a commenc\u00e9 \u00e0 \u00e9voluer avec la d\u00e9couverte des microcompartiments bact\u00e9riens (BMCs). Les BMCs sont des structures prot\u00e9iques hautement organis\u00e9es, constitu\u00e9es d\u2019une enveloppe semi-perm\u00e9able qui encapsule des enzymes sp\u00e9cifiques. Ce projet vise \u00e0 caract\u00e9riser le syst\u00e8me de BMC natif d\u2019utilisation de l\u2019\u00e9thanolamine (EUT) chez E. coli<\/em> afin de comprendre\u00a0: (i) comment les BMCs Eut permettent de transformer l\u2019\u00e9thanolamine en sources utilisables d\u2019azote et de carbone\u00a0; (ii) comment le m\u00e9tabolisme de l\u2019\u00e9thanolamine se connecte au m\u00e9tabolisme central\u00a0; et (iii) la pertinence de l\u2019utilisation de l\u2019\u00e9thanolamine dans l\u2019environnement intestinal comp\u00e9titif.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

Projet COCA-COLI<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

L\u2019ac\u00e9tate est un sous-produit majeur du m\u00e9tabolisme microbien glycolytique. L\u2019ac\u00e9tate d\u00e9tourne le carbone du m\u00e9tabolisme cellulaire et il est toxique pour les cellules, diminuant ainsi la productivit\u00e9 des bioproc\u00e9d\u00e9s. L\u2019origine, le contr\u00f4le et la r\u00e9gulation de la production d\u2019ac\u00e9tate restent \u00e0 clarifier. Dans ce projet, nous abordons des questions fondamentales et appliqu\u00e9es sur le r\u00f4le et la r\u00e9gulation de la production d\u2019ac\u00e9tate chez E. coli<\/em>, dans le but de proposer des strat\u00e9gies pour am\u00e9liorer la productivit\u00e9 des bioproc\u00e9d\u00e9s bas\u00e9s sur E. coli<\/em>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

Projet NMRExtract<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

Dans ce projet, nous d\u00e9veloppons une m\u00e9thodologie permettant l\u2019analyse en temps r\u00e9el de la dynamique des syst\u00e8mes m\u00e9taboliques dans des extraits cellulaires par RMN, avec pour objectif de mettre en place une plateforme de criblage rapide et d\u2019optimisation des r\u00e9seaux m\u00e9taboliques pour des applications biotechnologiques.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

Projet TETAX <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

En collaboration avec l\u2019\u00e9quipe PEEP et Sanofi, nous analysons la physiologie de la bact\u00e9rie Clostridium tetani<\/em> aux niveaux macroscopique, m\u00e9tabolique et prot\u00e9omique afin de d\u00e9crypter les m\u00e9canismes d\u2019induction de la synth\u00e8se de la toxine t\u00e9tanique. Une meilleure compr\u00e9hension des r\u00e9gulations m\u00e9taboliques chez C. tetani<\/em> devrait nous permettre de d\u00e9velopper des milieux synth\u00e9tiques afin de remplacer l\u2019utilisation de milieux complexes d\u2019origine animale en industrie.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Equipe METASYS Retour vers l’\u00e9quipe Th\u00e8me “Comprendre les r\u00e9ponses m\u00e9taboliques des micro-organismes” Quelques mots sur le th\u00e8me Comprendre les r\u00e9ponses m\u00e9taboliques des micro-organismes Dans ce th\u00e8me, l\u2019objectif est de comprendre comment les microorganismes (en particulier E. coli, B. methanolicus, P. pastoris, C. tetani) d\u00e9veloppent des r\u00e9ponses m\u00e9taboliques int\u00e9gr\u00e9es aux changements environnementaux et\/ou g\u00e9n\u00e9tiques. Classiquement, une […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":3253,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-4548","page","type-page","status-publish","hentry"],"yoast_head":"\nComprendre les r\u00e9seaux m\u00e9taboliques et leur r\u00e9gulations | TBI, Toulouse Biotechnology Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/poles\/equipe-metasys\/reseaux-metaboliques\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Comprendre les r\u00e9seaux m\u00e9taboliques et leur r\u00e9gulations | TBI, Toulouse Biotechnology Institute\" \/>\n<meta property=\"og:description\" content=\"Equipe METASYS Retour vers l’\u00e9quipe Th\u00e8me “Comprendre les r\u00e9ponses m\u00e9taboliques des micro-organismes” Quelques mots sur le th\u00e8me Comprendre les r\u00e9ponses m\u00e9taboliques des micro-organismes Dans ce th\u00e8me, l\u2019objectif est de comprendre comment les microorganismes (en particulier E. coli, B. methanolicus, P. pastoris, C. tetani) d\u00e9veloppent des r\u00e9ponses m\u00e9taboliques int\u00e9gr\u00e9es aux changements environnementaux et\/ou g\u00e9n\u00e9tiques. Classiquement, une […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/poles\/equipe-metasys\/reseaux-metaboliques\/\" \/>\n<meta property=\"og:site_name\" content=\"TBI, Toulouse Biotechnology Institute\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/TBI-Toulouse-Biotechnology-Institute-Bio-Chemical-Engineering-360428497952306\" \/>\n<meta property=\"article:modified_time\" content=\"2025-07-03T13:33:31+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.toulouse-biotechnology-institute.fr\/wp-content\/uploads\/2025\/07\/Image-Topic-1.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@TBI_Biotech\" \/>\n<meta name=\"twitter:label1\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/poles\\\/equipe-metasys\\\/reseaux-metaboliques\\\/\",\"url\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/poles\\\/equipe-metasys\\\/reseaux-metaboliques\\\/\",\"name\":\"Comprendre les r\u00e9seaux m\u00e9taboliques et leur r\u00e9gulations | TBI, Toulouse Biotechnology Institute\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/poles\\\/equipe-metasys\\\/reseaux-metaboliques\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/poles\\\/equipe-metasys\\\/reseaux-metaboliques\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/wp-content\\\/uploads\\\/2025\\\/07\\\/Image-Topic-1.png\",\"datePublished\":\"2022-02-21T14:43:52+00:00\",\"dateModified\":\"2025-07-03T13:33:31+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/poles\\\/equipe-metasys\\\/reseaux-metaboliques\\\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/poles\\\/equipe-metasys\\\/reseaux-metaboliques\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/poles\\\/equipe-metasys\\\/reseaux-metaboliques\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/wp-content\\\/uploads\\\/2025\\\/07\\\/Image-Topic-1.png\",\"contentUrl\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/wp-content\\\/uploads\\\/2025\\\/07\\\/Image-Topic-1.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/poles\\\/equipe-metasys\\\/reseaux-metaboliques\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Poles\",\"item\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/poles\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Equipe METASYS\",\"item\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/poles\\\/equipe-metasys\\\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Comprendre les r\u00e9seaux m\u00e9taboliques et leur r\u00e9gulations\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/#website\",\"url\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/\",\"name\":\"TBI, Toulouse Biotechnology Institute\",\"description\":\"Bio & Chemical Engineering\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/#organization\"},\"alternateName\":\"TBI, Toulouse Biotechnology Institute\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/#organization\",\"name\":\"TBI - Toulouse Biotechnology Institute\",\"url\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/i0.wp.com\\\/www.toulouse-biotechnology-institute.fr\\\/wp-content\\\/uploads\\\/2021\\\/11\\\/100LOGO-TBITransp-BD.png?fit=100%2C56&ssl=1\",\"contentUrl\":\"https:\\\/\\\/i0.wp.com\\\/www.toulouse-biotechnology-institute.fr\\\/wp-content\\\/uploads\\\/2021\\\/11\\\/100LOGO-TBITransp-BD.png?fit=100%2C56&ssl=1\",\"width\":100,\"height\":56,\"caption\":\"TBI - Toulouse Biotechnology Institute\"},\"image\":{\"@id\":\"https:\\\/\\\/www.toulouse-biotechnology-institute.fr\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/TBI-Toulouse-Biotechnology-Institute-Bio-Chemical-Engineering-360428497952306\",\"https:\\\/\\\/x.com\\\/TBI_Biotech\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Comprendre les r\u00e9seaux m\u00e9taboliques et leur r\u00e9gulations | TBI, Toulouse Biotechnology Institute","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/poles\/equipe-metasys\/reseaux-metaboliques\/","og_locale":"en_GB","og_type":"article","og_title":"Comprendre les r\u00e9seaux m\u00e9taboliques et leur r\u00e9gulations | TBI, Toulouse Biotechnology Institute","og_description":"Equipe METASYS Retour vers l’\u00e9quipe Th\u00e8me “Comprendre les r\u00e9ponses m\u00e9taboliques des micro-organismes” Quelques mots sur le th\u00e8me Comprendre les r\u00e9ponses m\u00e9taboliques des micro-organismes Dans ce th\u00e8me, l\u2019objectif est de comprendre comment les microorganismes (en particulier E. coli, B. methanolicus, P. pastoris, C. tetani) d\u00e9veloppent des r\u00e9ponses m\u00e9taboliques int\u00e9gr\u00e9es aux changements environnementaux et\/ou g\u00e9n\u00e9tiques. Classiquement, une […]","og_url":"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/poles\/equipe-metasys\/reseaux-metaboliques\/","og_site_name":"TBI, Toulouse Biotechnology Institute","article_publisher":"https:\/\/www.facebook.com\/TBI-Toulouse-Biotechnology-Institute-Bio-Chemical-Engineering-360428497952306","article_modified_time":"2025-07-03T13:33:31+00:00","og_image":[{"url":"https:\/\/www.toulouse-biotechnology-institute.fr\/wp-content\/uploads\/2025\/07\/Image-Topic-1.png","type":"","width":"","height":""}],"twitter_card":"summary_large_image","twitter_site":"@TBI_Biotech","twitter_misc":{"Estimated reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.toulouse-biotechnology-institute.fr\/poles\/equipe-metasys\/reseaux-metaboliques\/","url":"https:\/\/www.toulouse-biotechnology-institute.fr\/poles\/equipe-metasys\/reseaux-metaboliques\/","name":"Comprendre les r\u00e9seaux m\u00e9taboliques et leur r\u00e9gulations | TBI, Toulouse Biotechnology Institute","isPartOf":{"@id":"https:\/\/www.toulouse-biotechnology-institute.fr\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.toulouse-biotechnology-institute.fr\/poles\/equipe-metasys\/reseaux-metaboliques\/#primaryimage"},"image":{"@id":"https:\/\/www.toulouse-biotechnology-institute.fr\/poles\/equipe-metasys\/reseaux-metaboliques\/#primaryimage"},"thumbnailUrl":"https:\/\/www.toulouse-biotechnology-institute.fr\/wp-content\/uploads\/2025\/07\/Image-Topic-1.png","datePublished":"2022-02-21T14:43:52+00:00","dateModified":"2025-07-03T13:33:31+00:00","breadcrumb":{"@id":"https:\/\/www.toulouse-biotechnology-institute.fr\/poles\/equipe-metasys\/reseaux-metaboliques\/#breadcrumb"},"inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.toulouse-biotechnology-institute.fr\/poles\/equipe-metasys\/reseaux-metaboliques\/"]}]},{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/www.toulouse-biotechnology-institute.fr\/poles\/equipe-metasys\/reseaux-metaboliques\/#primaryimage","url":"https:\/\/www.toulouse-biotechnology-institute.fr\/wp-content\/uploads\/2025\/07\/Image-Topic-1.png","contentUrl":"https:\/\/www.toulouse-biotechnology-institute.fr\/wp-content\/uploads\/2025\/07\/Image-Topic-1.png"},{"@type":"BreadcrumbList","@id":"https:\/\/www.toulouse-biotechnology-institute.fr\/poles\/equipe-metasys\/reseaux-metaboliques\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/www.toulouse-biotechnology-institute.fr\/"},{"@type":"ListItem","position":2,"name":"Poles","item":"https:\/\/www.toulouse-biotechnology-institute.fr\/poles\/"},{"@type":"ListItem","position":3,"name":"Equipe METASYS","item":"https:\/\/www.toulouse-biotechnology-institute.fr\/poles\/equipe-metasys\/"},{"@type":"ListItem","position":4,"name":"Comprendre les r\u00e9seaux m\u00e9taboliques et leur r\u00e9gulations"}]},{"@type":"WebSite","@id":"https:\/\/www.toulouse-biotechnology-institute.fr\/#website","url":"https:\/\/www.toulouse-biotechnology-institute.fr\/","name":"TBI, Toulouse Biotechnology Institute","description":"Bio & Chemical Engineering","publisher":{"@id":"https:\/\/www.toulouse-biotechnology-institute.fr\/#organization"},"alternateName":"TBI, Toulouse Biotechnology Institute","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.toulouse-biotechnology-institute.fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-GB"},{"@type":"Organization","@id":"https:\/\/www.toulouse-biotechnology-institute.fr\/#organization","name":"TBI - Toulouse Biotechnology Institute","url":"https:\/\/www.toulouse-biotechnology-institute.fr\/","logo":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/www.toulouse-biotechnology-institute.fr\/#\/schema\/logo\/image\/","url":"https:\/\/i0.wp.com\/www.toulouse-biotechnology-institute.fr\/wp-content\/uploads\/2021\/11\/100LOGO-TBITransp-BD.png?fit=100%2C56&ssl=1","contentUrl":"https:\/\/i0.wp.com\/www.toulouse-biotechnology-institute.fr\/wp-content\/uploads\/2021\/11\/100LOGO-TBITransp-BD.png?fit=100%2C56&ssl=1","width":100,"height":56,"caption":"TBI - Toulouse Biotechnology Institute"},"image":{"@id":"https:\/\/www.toulouse-biotechnology-institute.fr\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/TBI-Toulouse-Biotechnology-Institute-Bio-Chemical-Engineering-360428497952306","https:\/\/x.com\/TBI_Biotech"]}]}},"_links":{"self":[{"href":"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/wp-json\/wp\/v2\/pages\/4548","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/wp-json\/wp\/v2\/comments?post=4548"}],"version-history":[{"count":40,"href":"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/wp-json\/wp\/v2\/pages\/4548\/revisions"}],"predecessor-version":[{"id":16189,"href":"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/wp-json\/wp\/v2\/pages\/4548\/revisions\/16189"}],"up":[{"embeddable":true,"href":"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/wp-json\/wp\/v2\/pages\/3253"}],"wp:attachment":[{"href":"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/wp-json\/wp\/v2\/media?parent=4548"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}