{"id":16172,"date":"2025-07-03T15:17:46","date_gmt":"2025-07-03T13:17:46","guid":{"rendered":"https:\/\/www.toulouse-biotechnology-institute.fr\/?page_id=16172"},"modified":"2025-07-03T15:24:27","modified_gmt":"2025-07-03T13:24:27","slug":"bioreacteurs","status":"publish","type":"page","link":"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/poles\/equipe-metasys\/bioreacteurs\/","title":{"rendered":"Implementing microorganisms and bioreactors"},"content":{"rendered":"\t\t
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Equipe METASYS<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Th\u00e8me \"Mettre en \u0153uvre les microorganismes dans les bior\u00e9acteurs\"<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Quelques mots sur le th\u00e8me<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Mettre en \u0153uvre les microorganismes dans les bior\u00e9acteurs<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Ce th\u00e8me porte sur l\u2019\u00e9valuation de la cin\u00e9tique microbienne au sein de bior\u00e9acteurs op\u00e9rant dans des conditions de culture sp\u00e9cifiques. L\u2019objectif est d\u2019\u00e9tudier les relations dynamiques entre les param\u00e8tres du proc\u00e9d\u00e9, les facteurs environnementaux et le comportement microbien. Cela permet d\u2019identifier les \u00e9l\u00e9ments critiques influen\u00e7ant la physiologie microbienne et limitant l\u2019efficacit\u00e9 des usines cellulaires microbiennes, afin d\u2019orienter les strat\u00e9gies d\u2019am\u00e9lioration des proc\u00e9d\u00e9s via des techniques de microbiologie ou d\u2019ing\u00e9nierie m\u00e9tabolique (voir th\u00e8me 2). Ce th\u00e8me int\u00e8gre \u00e9galement l\u2019ing\u00e9nierie des bior\u00e9acteurs en fonction des sp\u00e9cificit\u00e9s de la fermentation \u00e9tudi\u00e9e, notamment le couple micro-organisme\/substrat\/produit. En particulier, l\u2019\u00e9tude des proc\u00e9d\u00e9s de fermentation gazeuse n\u00e9cessite le d\u00e9veloppement de nouveaux syst\u00e8mes de culture microbienne optimis\u00e9s pour atteindre de hauts taux de transfert de gaz, permettant d\u2019obtenir des densit\u00e9s cellulaires \u00e9lev\u00e9es et de hautes performances en mol\u00e9cules d\u00e9sir\u00e9es. Des strat\u00e9gies de gestion des bior\u00e9acteurs sont alors d\u00e9velopp\u00e9es selon l\u2019objectif de production et\/ou d\u2019investigation m\u00e9tabolique\/physiologique.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Les projets<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Projet ConCO2rde <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Dans le cadre de ce r\u00e9seau H2020-ITN, la bact\u00e9rie lithoautotrophe C. necator<\/em> est ing\u00e9nier\u00e9e pour la production d\u2019isopropanol \u00e0 partir de CO2<\/sub>. Des configurations de bior\u00e9acteurs gazeux sont d\u00e9velopp\u00e9es afin d\u2019am\u00e9liorer les taux de transfert de gaz pour augmenter les performances de production d\u2019isopropanol (bior\u00e9acteurs \u00e0 gaz haute pression, contacteur \u00e0 membrane \u00e0 fibres creuses coupl\u00e9 au bior\u00e9acteur \u00e0 gaz).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Projet CnegSAF <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Heberg\u00e9 par le CNRS@CREATE, le programme \u00ab Carbon Negative production of advanced Sustainable Aviation Fuels using twin synthetic bacterial consortia Project \u00bb (CNegSAF) est une collaboration internationale entre des institutions de premier plan en France et \u00e0 Singapour, incluant le Toulouse Biotechnology Institute (TBI : \u00e9quipes METASYS, PHYGE, CIME, BLADE), la National University of Singapore, A*Star (SIFBI) et la Nanyang Technological University. CNegSAF vise \u00e0 d\u00e9montrer la faisabilit\u00e9 d\u2019utiliser un consortium bact\u00e9rien synth\u00e9tique pour convertir l\u2019hydrog\u00e8ne vert et le CO2<\/sub> concentr\u00e9 issu des d\u00e9chets (\u00e9mis par des entreprises chimiques) en biocarburants durables pour l\u2019aviation. L\u2019un de nos objectifs est de concevoir un nouveau bior\u00e9acteur \u00e0 gaz et d\u2019optimiser la strat\u00e9gie de fermentation pour cultiver ce consortium synth\u00e9tique avec des \u00e9missions gazeuses nulles.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Projet Bio-Mining<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Financ\u00e9 par le programme Spaceship.FR (CNES), ce projet consiste \u00e0 \u00e9tudier la faisabilit\u00e9 de la r\u00e9cup\u00e9ration des sources min\u00e9rales pr\u00e9sentes dans le r\u00e9golithe par des micro-organismes. Dans la perspective de futures missions habit\u00e9es de longue dur\u00e9e (Lune, Mars), l\u2019autonomie logistique de la station lunaire repr\u00e9sente un enjeu majeur et n\u00e9cessitera notamment l\u2019utilisation des ressources locales pour assurer la survie des astronautes. En collaboration avec l\u2019\u00e9quipe PHYGE, nous \u00e9tudions l\u2019int\u00e9gration des ressources min\u00e9rales locales dans des bioproc\u00e9d\u00e9s microbiens constituant un syst\u00e8me de support de vie.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Projet BIOVAL <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Dans le cadre de ce projet europ\u00e9en Horizon-RIA visant \u00e0 cr\u00e9er, d\u00e9velopper et industrialiser une bioraffinerie circulaire int\u00e9gr\u00e9e, \u00e9nerg\u00e9tiquement autonome, avec des \u00e9missions quasi nulles de d\u00e9chets et de carbone, nous \u00e9tudions la production d\u2019isopropanol \u00e0 partir de CO2<\/sub> avec C. necator<\/em>, en concentrant nos efforts sur l\u2019am\u00e9lioration de la stabilit\u00e9 de la souche pour un proc\u00e9d\u00e9 continu de fermentation gazeuse.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Equipe METASYS Retour vers l’\u00e9quipe Th\u00e8me “Mettre en \u0153uvre les microorganismes dans les bior\u00e9acteurs” Quelques mots sur le th\u00e8me Mettre en \u0153uvre les microorganismes dans les bior\u00e9acteurs Ce th\u00e8me porte sur l\u2019\u00e9valuation de la cin\u00e9tique microbienne au sein de bior\u00e9acteurs op\u00e9rant dans des conditions de culture sp\u00e9cifiques. L\u2019objectif est d\u2019\u00e9tudier les relations dynamiques entre les […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":3253,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-16172","page","type-page","status-publish","hentry"],"yoast_head":"\nMettre en \u0153uvre les microorganismes dans les bior\u00e9acteurs | TBI, Toulouse Biotechnology Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.toulouse-biotechnology-institute.fr\/en\/poles\/equipe-metasys\/bioreacteurs\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mettre en \u0153uvre les microorganismes dans les bior\u00e9acteurs | TBI, Toulouse Biotechnology Institute\" \/>\n<meta property=\"og:description\" content=\"Equipe METASYS Retour vers l’\u00e9quipe Th\u00e8me “Mettre en \u0153uvre les microorganismes dans les bior\u00e9acteurs” Quelques mots sur le th\u00e8me Mettre en \u0153uvre les microorganismes dans les bior\u00e9acteurs Ce th\u00e8me porte sur l\u2019\u00e9valuation de la cin\u00e9tique microbienne au sein de bior\u00e9acteurs op\u00e9rant dans des conditions de culture sp\u00e9cifiques. 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