Topic "Populations/Sub-Populations & Heterogeneity"

A few words

Populations/Sub-Populations & Heterogeneity

The objective is to quantify the dynamics of the microbial responses and the robustness of the strains (at global population and subpopulations scales) to environmental fluctuations, stress conditions and intensive production conditions in order to intensify/optimize bioprocesses and their scaling up. The studies focus on the dynamic analysis as well as the modeling of physiological heterogeneities (physiological, metabolic, morphological, genetic states) of subpopulations in relation to environmental disturbances.

Ongoing projects

AstroPOU Project


Study, feasibility of production of food sources (proteins), and biopolymers for astronauts (INSA/CNES)

  • The objective is to define ways of valorisation of organic waste by microbial transformation for the production of POU and biopolymers within a Life Support system of a future Lunar and Martian station.
  • Partners: TBI-FAME (Coord.), CNES

ConCO2rde Project


Training network on the conversion of CO2 by smart autotrophic biorefineries (H2020 – ITN)

  • The CONCO2RDE EJD NTI is a research training network of 11 PhD students on cutting-edge research projects combining synthetic biology, metabolic engineering and bio-process engineering for the microbial transformation of CO2/H2/air into various molecules of interest. The final objective will be to establish a roadmap for the implementation of autotrophic biotransformations on an industrial scale.
  • Partners: 5 Universities (INSA, Groningen, Aahcen, Graz, Porto), 9 industrial companies (Total, Suez, Polymem, Evonik, Silantes, Zeta, ..)

JANUS project


Control and Optimization of Metabolic Transitions

  • The ambitions of the ANR JANUS project are (i) to understand the control and role of metabolic heterogeneity in axenic bacterial culture and (ii) to propose innovative strategies to improve the use of multi-carbon sources by controlling metabolic heterogeneity.
  • Partners: TBI (BLADE, FAME), ESPCI, LBE, Polytechnique Paris



How to build new eco-designed biotransformation routes (ANR – PRC)

  • The ANR New Ecoroutes proposes to develop a methodology for the eco-design of emerging biotechnological processes based on the coupling of predictive modelling of bioprocesses and life cycle analysis that can be extrapolated to the industrial scale.
  • Partners: TBI-FAME (Coord), UCAI UMR 1010 INRAe INP Toulouse, SAYFOOD UMR 782 INRAe AgroPArisTech