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Articles EAD3


Foulquier C, Huang CN, Nguyen NP, Thiel A, Wilding-Steel T, Soula J, Yoo M, Ehrenreich A, Meynial-Salles I, Liebl W, Soucaille P. 2019. An efficient method for markerless mutant generation by allelic exchange in Clostridium acetobutylicum and Clostridium saccharobutylicum using suicide vectors, Biotechnol. Biofuels, 12-31 (Impact Factor 2017 5,497 from.



Nguyen, L. T. H., Raynaud, C., Meynial Salles, I., Soucaille, P. 2018. Reviving the Weizmann process for commercial n-butanol production. Nature Communications, 9 (1), 8 (Impact Factor 2017 12,353 from J C R).


Gauquelin C, Baffert C, Richaud P, Kamionka E, Etienne E, Guieysse D, Girbal L, Fourmond V, André I, Guigliarelli B, Léger C, Soucaille P, Meynial-Salles I. 2018 Roles of the F-domain in [FeFe] hydrogenase: Biochim. Biophys. Acta. Bioenerg. 1859:69-77 ((Impact Factor 2017 4,280 from J C R).


Caserta, G., Papini, Adamska-Venkatesh, A., Pecqueur, L., Sommer, C., Reijerse, E., Lubitz, W., Gauquelin, C., Meynial Salles I., Pramanik, D., Artero, Atta, del Barrio, M., Faivre, Fourmond, Léger, Fontecave, M. 2018. Engineering an [FeFe]-Hydrogenase: Do Accessory Clusters Influence O2 Resistance and Catalytic Bias ? J. Am. Chem. Soc., 140 (16), 5516-5526 (Impact Factor 2017 14,357 from J C R).



Kubas A, Orain C, De Sancho D, Saujet L, Sensi M, Gauquelin C, Meynial-Salles I, Soucaille P, Bottin H, Baffert C, Fourmond V, Best RB, Blumberger J, Léger C.2017. Mechanism of O2 diffusion and reduction in FeFe hydrogenases. Nat. Chem. (1):88-95 (Impact Factor 2017 26,201 from J C R).


Yoo M, Croux C, Meynial-Salles I, Soucaille P 2017. Metabolic flexibility of a butyrate pathway mutant of Clostridium acetobutylicum. Metab. Eng. 40:138-147 (Impact Factor 2017 7,674 from J C R).



Sensi M, Baffert C, Greco C, Caserta G, Gauquelin C, Saujet L, Fontecave M, Roy S, Artero V, Soucaille P, Meynial-Salles I., Bottin H, de Gioia L, Fourmond V, Léger C, Bertini L. 2016. Reactivity of the Excited States of the H-Cluster of FeFe Hydrogenases. J. Am. Chem. Soc. Oct 6, (Impact Factor 2017 14,357 from J C R).


Yoo M, Croux C, Meynial-Salles I., Soucaille P. 2016. Elucidation of the roles of adhE1 and adhE2 in the primary metabolism of Clostridium acetobutylicum by combining in-frame gene deletion and a quantitative system-scale approach. Biotechnol. Biofuels. Apr 26;9:92. (Impact Factor 2017 5,497 from J C R).


Croux C, Nguyen NP, Lee J, Raynaud C, Saint-Prix F, Gonzalez-Pajuelo M, Meynial-Salles I, Soucaille P. 2016. Construction of a restriction-less, marker-less mutant useful for functional genomic and metabolic engineering of the biofuel producer Clostridium acetobutylicum. Biotechnol. Biofuels. 9:23 (Impact Factor 2017 5,497 from J C R).


Rouvre I, Gauquelin C, Meynial-Salles I, Basseguy R. 2016. Impact of the chemicals, essential for the purification process of strict Fe-hydrogenase, on the corrosion of mild steel. Bioelectrochemistry. 109:9-23 (Impact Factor 2017 3,789 from J C R).


Nguyen NP, Linder S, Flitsch SK, Schiel-Bengelsdorf B, Dürre P, Soucaille P. 2016 Cap0037, a Novel Global Regulator of Clostridium acetobutylicum Metabolism, MBio. volume 7 Issue 5 e01218-16 (Impact Factor 2017 6.689 from J C R).



Yoo M, Bestel-Corre G, Croux C, Riviere A, Meynial-Salles I, Soucaille P. 2015. A Quantitative System-Scale Characterization of the Metabolism of Clostridium acetobutylicum MBio. Nov 24;6 (Impact Factor 2017 6.689 from J C R).


Orain C, Saujet L, Gauquelin C, Soucaille P, Meynial-Salles I, Baffert C, Fourmond V, Bottin H, Léger C. 2015. Electrochemical Measurements of the Kinetics of Inhibition of Two FeFe Hydrogenases by O2 Demonstrate That the Reaction Is Partly Reversible. J. Am. Chem. Soc. 12580-7 (Impact Factor 2017 14,357 from J C R).


Heux S, Meynial-Salles I, O'Donohue MJ, Dumon C. 2015. White biotechnology: State of the art strategies for the development of biocatalysts for biorefining : Biotechnol. Adv. 1653-70 (Impact Factor 2017 11,452 from J C R).


Ravachol J, Borne R, Meynial-Salles I, Soucaille P, Pagès S, Tardif C, Fierobe HP. 2015. Combining free and aggregated cellulolytic systems in the cellulosome-producing bacterium Ruminiclostridium cellulolyticum. Biotechnol. Biofuels. 114 (Impact Factor 2017 5,497 from J C R).




Fourmond V, Greco C, Sybirna K, Baffert C, Wang PH, Ezanno P, Montefiori M, Bruschi M, Meynial-Salles I, Soucaille P, Blumberger J, Bottin H, De Gioia L, Léger C. (2014) The oxidative inactivation of FeFe hydrogenase reveals the flexibility of the H-cluster, Nat Chem. 336-342 (Impact Factor  21,757 from J  C  R).












17.Auriol C, Bestel-Corre G, Claude JB, Soucaille P, Meynial-Salles I.(2011) Stress-induced evolution of Escherichiacoli points to original concepts in respiratory cofactor selectivity. ProcNatl Acad Sci U S A., 108, 1278-83. (impactFactor 2009  9.432 from J C R)

18. Baffert C, Bertini L,Lautier T, Greco C, Sybirna K, Ezanno P, Etienne E, Soucaille P, Bertrand P,Bottin H, Meynial-Salles I, De Gioia L, Léger C. (2011) CO disrupts the reducedH-cluster of FeFe hydrogenase. A combined DFT and protein film voltammetrystudy. J Am Chem Soc,133,2096-9 (impact Factor 2009 8.580 from J C R)

19. Lautier T, Ezanno P, Baffert C, Fourmond V, Cournac L, Fontecilla-CampsJC, Soucaille P, Bertrand P, Meynial-Salles I, Léger C. (2011)  The quest for a functional substrate accesstunnel in FeFe hydrogenase: Faraday Discuss. 148:385-407.(impact Factor 2009  3.700 from J C R)

20. Meynial-Salles I, Soucaille P. (2011) Creationof new metabolic pathways or improvement of existing metabolic enzymes by in vivo evolution in Escherichia coli: Chapter book in "Microbial Metabolic Engineering: Methods and Protocols" in Methods in MolecularBiology published, Humana Press, sous presse.

21. Raynaud C, Lee J, Sarçabal P, Croux C, Meynial-Salles I, SoucailleP. (2011) Molecular Characterization of the glycerol oxidative pathway ofClostridium butyricum VPI 1718. J. Bacteriol, sous presse. (impactFactor 2009  3.940 from J C R)


16. Liebgott PP, Leroux F, Burlat B, Dementin S, Baffert C,Lautier T, Fourmond V, Ceccaldi P, Cavazza C, Meynial-Salles I, Soucaille P,Fontecilla-Camps JC, Guigliarelli B, Bertrand P, Rousset M, Léger C (2010)Relating diffusion along the substrate tunnel and oxygen sensitivity inhydrogenase Nat ChemBiol., 6, 63-70. (impactFactor 16.056 2009  from J C R)



14. Fourmond V, Lautier T, Baffert C, Leroux F, Liebgott PP, Dementin S, Rousset M, Arnoux P, Pignol D, Meynial-Salles I, Soucaille P, Bertrand P, Léger C. 2009.   Correcting for electrocatalyst desorption and inactivation in chronoamperometry experiments, Anal. Chem., 81, 2962-8. (impact Factor 2007 5,287 from J C R)

15. Bordes F,Cambon E, Dossat-Létisse V,André I,Croux C,Nicaud JM, and Marty A. 2009.Improvement of Yarrowia lipolytica lipase enantioselectivity by site-directed mutagenesis targeted at the substrate binding site. Chem Biochem, 10, 1705-13 (impact Factor 2007 3.322 from J C R)



11. André G, Even S, Putzer H, Burguière P, Croux C, Danchin A, Martin-Verstraete I, Soutourina O. 2008. S-box and T-box riboswitches and antisense RNA control a sulfur metabolic operon of Clostridium acetobutylicum. Nucleic Acids Res, 36:5955-69. (impact Factor 2007 6.954 from J C R)

12. Hillmann F, Fischer RJ, Saint-Prix F, Girbal L, Bahl H. 2008. PerR acts as a switch for oxygen tolerance in the strict anaerobe Clostridium acetobutylicum. Mol. Microbiol.; 68:848-60. (impact Factor 2007 5.462 from J C R)

13. Baffert C, Demuez M, Cournac L, Burlat B, Guigliarelli B, Bertrand P, Girbal L, Léger C. 2008. Hydrogen-activating enzymes: activity does not correlate with oxygen sensitivity. Angew Chem Int Ed Engl, 47:2052-4. (impact Factor 2007 10.061 from J C R)



1. Meynial-Salles I., Cervin M. A. and Soucaille P. 2005. New tool for metabolic pathway engineering in E. coli : one step method to modulate the expression of chromosomal genes : Appl. Environ. Microbiol., 71, 2140-2144. (impact Factor 2007 4.004 from J C Rt)

2. Girbal L., Von AbendrothG., WinklerM., BentonP. M. C., Meynial-SallesI., Croux C., PetersJ., Happe T. and Soucaille P. 2005. Homologous/heterologous over-expression in Clostridium acetobutylicum and characterization of purified clostridial and algal Fe-only hydrogenases with high specific activity : Appl. Environ. Microbiol., 71, 2777-2781. (impact Factor 2007 4,004 from J C R)

3. Meynial-Salles I., Gonzalez-Pajuelo M., , Mendes P., Andrade J. C., Vasconcelos I. and Soucaille P. 2005. Metabolic engineering of Clostridium acetobutylicum for the industrial production of 1.3 propanediol from glycerol : Met. Eng., 7, 329-336. (impact Factor 2007 3.444 from J C R)

4. Gonzalez-Pajuelo M., Meynial-Salles I., Mendes P., Soucaille P. and Vasconcelos I. .2006. Microbial conversion of glycerol to 1, 3 propanediol: physiological comparison of a natural producer, Clostridium butyricum and an engineered strain, Clostridium acetobutylicum DG1 (pSPD5): Appl. Environ. Microbiol., 1 , 96-101. (impact Factor 2007 4.004 from J C R).

5. Collet C, Girbal L, Péringer P, Schwitzguébel JP, Soucaille P. 2006. Metabolism of lactose by Clostridium thermolacticum growing in continuous culture : Arch Microbiol, 185:331-9 (impact Factor 2007 1.838 from J C R)

6. Meynial-Salles I., Forchammer N., Croux C. Girbal L., and Soucaille P. 2007. Evolution of a Saccharomyces cerevisiae metabolic pathway in Escherichia coli : Met Eng., 9, 152-159. (impact Factor 2007 3.444 from J C R)

7. Nicolas C, Kiefer P, Letisse F, Krömer J, Massou S, Soucaille P, Wittmann C, Lindley ND, Portais JC. 2007. Response of the central metabolism of Escherichia coli to modified expression of the gene encoding the glucose-6-phosphate dehydrogenase: FEBS Lett ., 581:3771-6 (impact Factor 2007 3.263 from J C R)

8. Demuez M, Cournac L, Guerrini O, Soucaille P, Girbal L. 2007. Complete activity profile of Clostridium acetobutylicum [FeFe]-hydrogenase and kinetic parameters for endogenous redox partners : FEMS Microbiol Lett., 275,113-21 (impact Factor 2007 2.274 from J C R).

9. Meynial-Salles I., Dorotyn S. and Soucaille P. 2008. A new process for the continuous production of succinic acid from glucose at high titer and productivity : Biotech. Bioeng., 99, 129-135. (impact Factor 2007 3,037 from J C R)

10. Guerrini O, Burlat B, Léger C, Guigliarelli B, Soucaille P, Girbal L. 2008 Characterization of two 2[4Fe4S] ferredoxins from Clostridium acetobutylicum: Curr Microbiol, 56:261-7. (impact Factor 2007 1.167 from J C R)