Stéphanie HEUXORCID: 0000-0003-1312-3002

CV

•   2017- now : Leader of the MetaSys Team, TBI, Toulouse, France.
•   2019- now : Director of research at National Institute for Agronomic Research (INRAE), TBI, Toulouse, France.
•   2009- 2019 : Researcher at National Institute for Agronomic Research (INRAE), LISBP, Toulouse, France.
•  2006-2008: Post-doctoral position at the Institute of Molecular Systems Biology, ETH, Zürich, Switzerland. Funded by Marie Curie Intra-European Fellowships (FP6-2005)
•   2006: PhD in Microbiology and Molecular Biology. INRA, UMR-SPO, Montpellier, France.
•   2002: Engineer degree in agro-business and biotechnology, AgroSup, Dijon.

KEY SKILLS

Microbiology: Fermentation process (small and high throughput) in batch or chemostat with S.cerevisiae and E. coli. Metabolic engineering. Synthetic biology. Metabolomics and fluxomics.
Biophysics: NMR, mass spectrometry and chromatography (GC‐MS, GC‐TOF, LC‐MS‐MS, DIMS‐MS), fluorimetry.
Mathematics: Statistical analysis, Machine Learning, modelling, R, and Matlab.
Molecular biology: PCR, cloning, transformation.

RESEARCH TOPICS

My research aimed at developing innovative and original biotechnological processes using microorganisms as a cell factory for upgrading renewable carbon resource for biofuels, power and/or bioproducts. Specifically, I try to understand the organization and functioning of natural and synthetic metabolic networks at the cellular level using metabolomics and fluxomics. I then use this knowledge to design and optimize new synthetic metabolic pathways. To do that I that, I developed in silico (reconstruction and modelling of the metabolism) and experimental methods (metabolomics, fluxomics).

The renewable carbon resource, I am interested in, is the methanol  and the microbial cells factories are Escherichia coli and Bacillus methanolicus. My work focus on natural and synthetic methylotrophy, a process which represents a real metabolic challenge. My goal is both to improve the fundamental understanding of methylotrophy and to develop microbial cell factories for the sustainable production of value-added products from methanol.

 PUBLICATIONS

To see all my publications, please check my google scholar profile.

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