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Researcher INRA
MetaSys team
+33 (0) 561 559 355
INSA de Toulouse
135 avenue de Rangueil
31077 Toulouse cedex 4 - FRANCE




since 2014

INRA Researcher

MICA Department


Post-doctoral position at the Manchester Center for Integrative Systems Biology, Manchester, UK
Project: Towards a digital E. coli
Keywords: predictive biology, synthetic biology, modeling of metabolic systems, control, regulation


PhD in Microbial and enzymatic engineering at LISBP, INSA de Toulouse, France
Project: Role of the Csr system in carbon nutrition and in control of central metabolism of Escherichia coli K12 MG1655 and Nissle 1917
Keywords: systems biology, metabolism, Escherichia coli, 13C-metabolic flux analysis, metabolomics, mass spectrometry, nuclear magnetic resonance


Master degree in Structural biochemistry, Proteomics and Metabolomics, Université Toulouse 3, France
Project: Functional characterization of E. coli metabolism during growth on fucose
Keywords: deoxysugars metabolism, Escherichia coli, 13C-metabolic flux analysis, metabolomics




My research works aim at a better understanding of the organization, functioning and regulation of natural and synthetic metabolic systems at the cellular level, by using a Systems biology approach. This strategy combines experimental (growth phenotyping, metabolomics, 13C-metabolic flux analysis, etc) and computational (stoichiometric and kinetic modeling, statistics, etc) tools. In particular, I develop, validate and exploit explicative and predictive models of metabolism which integrate a broad range of functional data (stoichiometry, thermodynamics, metabolite pools, enzyme activities and kinetics, metabolic fluxes, isotopic measurements, etc) to investigate the control and regulation of metabolic fluxes. I then use this knowledge to understand the role of metabolism in the adaptation of Escherichia coli to its environment, and to design robust and efficient strains as cell factories for innovative and original biotechnological applications.



 see ORCID profile.