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Assistant professor INSA
Head of the Molecular Physiology and Metabolism department
+33 (0) 561 559 719
INSA de Toulouse
135 avenue de Rangueil
31077 Toulouse cedex 4 - FRANCE
brice.enjalbert @ insa-toulouse.fr





  • Since 2011- Lecturer in the Biosystems and Process Engineering Laboratory (LISBP) of Toulouse, France.

Model organism: gram- bacterium Escherichia coli.

Key words : metabolic adaptation, system biology, multi-omic data production.


  • 2009-2011- Lecturer in the Biosystems and Process Engineering Laboratory (LISBP) of Toulouse, France.

Model organism: gram+ bacterium Clostridium acetobutylicum.

Key words : improvement of hydrogen production, directed evolution, HPLC.


  • 2009- Postdoctoral researcher in the Biosystems and Process Engineering Laboratory (LISBP) of Toulouse, France.

Model organism: gram+ bacterium Streptococcus pneumoniae.

Key words : Physiology and gene expression related to carbon metabolism.


  • 2007-2009- Postdoctoral researcher in the Biosystems and Process Engineering Laboratory (LISBP) of Toulouse, France.

Model organism: gram- bacterium Escherichia coli.

Key words : Metabolic adaptation, system biology, transcriptomic, metabolomics.


  • 2004-2007- Postdoctoral researcher in the Institute of Medical Sciences of Aberdeen, Scotland.

Model organism: pathogen yeast Candida albicans.

Key words : stress responses in vivo, transcriptomic, proteomic, bioinformatic, microscopy, models of infection.


  • 2001-2003- Postdoctoral researcher in the Biotechnologies Research Institute of Montréal, Canada.

Model organism: pathogen yeast Candida albicans.

Key words :Stress responses in vitro, transcriptomic, bioinformatic.


  • 2001- Engineer in the CRITT-INSA (Research Center for Technologies Transfer of the INSA high school of Toulouse, France).

Key words :DNA chips, technology development.


  • 1997-2000- PhD student in the Biosystems and Process Engineering Laboratory (LISBP) of Toulouse, France.

Model organism: yeast Saccharomyces cerevisiae.

Key words :Regulation of glycogen synthesis, molecular biology, genetic, fermentation, biochemistry and enzymology.


  • 1996-1997- Post Graduate degree stages at the Institute for Cellular Biology and Genetic (IBCG ) of Toulouse, France.

Key words :molecular biology, cell culture (prokaryotic, mammalian cells).






My research works aim to unravel how microorganisms adapt to fluctuations in their environment (stresses and carbon sources). During my researches, I explored the physiology and mechanisms of adaptation of Gram positive and negative bacteria as well as pathogenic and commensal yeasts. I used transcriptomic, proteomic, and metabolomics approaches combined to system biology strategies.







27 articles,  h-index=19.


Lien vers Google Scholar


Morin,M., Ropers,D., Cinquemani,E., Portais,JC., Cocaign-Bousquet,M., & Enjalbert,B. (2017) The CSR system controls Escherichia coli energetic levels after the glucose-acetate transition through glycogen accumulation. MBio. 8(5). doi: 10.1128/mBio.01628-17


Enjalbert,B., Millard,P., Dinclaux,M., Portais,JC., & Letisse,F. (2017) Acetate fluxes in Escherichia coli are determined by the thermodynamic control of the Pta-AckA pathway. Scientific Reports 7: 42135.


Treitz,C., Enjalbert,B., Portais,JC., Letisse,F., & Tholey,A. (2016) Differential quantitative proteome analysis of Escherichia coli grown on acetate versus glucose. Proteomics. 16: 2742-6.


Morin,M., Ropers,D., Letisse,F., Laguerre,S., Portais,JC., Cocaign-Bousquet,M., & Enjalbert,B. (2016) The post-transcriptional regulatory system CSR controls the balance of metabolic pools in upper glycolysis of Escherichia coli. Mol Microbiol 100: 686-700.


Saulou-Bérion,C., Gonzalez, I., Enjalbert, B., Audinot, J.N., Fourquaux, I., Jamme, F., Cocaign-Bousquet, M., Mercier-Bonin, & M., Girbal, L. (2015) Escherichia coli under ionic silver stress: an integrative approach to explore transcriptional, physiological and biochemical responses. PLoS One. 10(12):e0145748. doi.


 Enjalbert, B., Cocaign-Bousquet, M., Portais, J.C., & Letisse, F. (2015) Acetate exposure determines the diauxic behavior of Escherichia coli during the glucose-acetate transition. J.Bact. 197:3173-81.


Enjalbert,B., Letisse,F., & Portais,J.C. (2013) Physiological and molecular timing of the glucose to acetate transition in Escherichia coliMetabolites. 3:820-37


 Pietrella, D., Enjalbert, B., Zeidler, U., Znaidi, S., Rachini, A., Vecchiarelli, A., & d'Enfert, C. (2012) A luciferase reporter for gene expression studies and dynamic imaging of superficial Candida albicans infections.Methods.Mol.Biol. 845:537-46.


 Enjalbert,B., Jourdan,F., & Portais,J.C. (2011) Intuitive visualization and analysis of multi-omics data and application to Escherichia coli carbon metabolism. PLoS One. 6:e21318. 


  Holcombe,L.J., McAlester,G., Munro,C.A., Enjalbert,B., Brown,A.J., Gow,N.A., Ding,C., Butler,G., O'Gara,F., & Morrissey,J.P. (2010) Pseudomonas aeruginosa secreted factors impair biofilm development in Candida albicans.Microbiology-SGM. 156:1476-86.


 Rodaki,A., Bohovych,I.M., Enjalbert,B., Young,T., Odds,F.C., Gow,N.A.R. & Brown,A.J.P. (2009) Glucose promotes stress resistance in the fungal pathogen, Candida albicansMol.Biol.Cell. 77:4847-58.


 Enjalbert,B., Rachini,A., Vediyappan,G., Pietrella,D., Spaccapelo,R., Vecchiarelli,A., Brown,A.J.P & d’Enfert,C. (2009) A multifunctional, synthetic Gaussia princeps luciferase reporter for live imaging of Candida albicans infections.Infect.Immun. 77:4847-58.


 Enjalbert,B., Moran,G.P., Vaughan,C., Yeomans,T., MacCallum,D.M., Quinn,J., Coleman,D.C., Brown,A.J.P., & Sullivan,D.J. (2009) Genome-wide gene expression profiling and a forward genetic screen show that differential expression of the sodium ion transporter Ena21 contributes to the differential tolerance of Candida albicans and Candida dubliniensis to osmotic Stress. Mol.Microbiology. 72:216-28. 


 Wimalasena,T.T., Enjalbert,B., Guillemette,T., Plumridge,A., Budge,S., Yin,Z., Brown,A.J.P., Archer,D.B. (2008) Impact of the unfolded protein response upon genome-wide expression patterns, and the role of Hac1 in the polarized growth, of Candida albicansFungal.Genet.Biol. 45:1235-47.


 Schmidt,P., Walker,J., Selway,L., Stead,D., Yin,Z., Enjalbert,B., Weig,M., & Brown,A.J.P. (2008) Proteomic analysis of the pH response in the fungal pathogen Candida glabrataProteomics. 8:534-544.


 Enjalbert,B., MacCallum,D.M., Odds,F.C., & Brown,A.J.P. (2007) Niche-specific activation of the oxidative stress response by the pathogenic fungus Candida albicansInfect.Immun. 75:2143-51.


 Argimón,S., Wishart,J.A., Leng,R., Macaskill,S., Mavor,A., Alexandris,T., Nicholls,S., Knight,A.W., Enjalbert,B., Walmsley,R., Odds,F.C., Gow,N.A.R., & Brown,A.J.P. (2007) Developmental regulation of an adhesin gene during cellular morphogenesis in the fungal pathogen Candida albicansEukaryot.Cell.  6:682-92.


 Enjalbert,B. Smith,DA., Nicholls,S., Brown,AJP. & Quinn,J. (2006) Role of the Hog1 stress-activated protein kinase in the global transcriptional response to stress in the fungal pathogen Candida albicansMol.Biol.Cell. 17:1018-32.


 Enjalbert,B. & Whiteway,M. (2005) Release from quorum sensing molecules triggers hyphal formation during Candida albicans resumption of growth. Eukaryot.Cell. 4:1203-10.


 García-Sánchez,S., Mavor,A., Russell,C.L., Argimon,S., Dennison,P., Enjalbert,B. & Brown, A.J.P. (2005) Roles of Ssn6 in Tup1- and Nrg1-dependent gene regulation in the fungal pathogen, Candida albicansMol.Biol.Cell. 16:2913-25.


 Nicholls,S., Straffon,M., Enjalbert,B., Nantel,A., Macaskill,S., Whiteway,M. and Brown,A.J.P. (2004) Msn2- and Msn4-like transcription factors play no obvious roles in the stress responses of the fungal pathogen Candida albicans.Eukaryot.Cell. 3:1111-23.


 Enjalbert,B., Parrou,J.L., Teste,M.A., & François,J. (2004) Combinatorial control by the protein kinases PKA, PHO85 and SNF1 of transcriptional induction of the Saccharomyces cerevisiae GSY2 gene at the diauxic shift.Mol.Genet.Genomics. 271: 697-708.


 Enjalbert,B., Nantel,A., & Whiteway,M. (2002) Stress induced gene expression in Candida albicans: Absence of a general stress response. Mol.Biol.Cell. 14:1460-67.


 Teste,M.A., Enjalbert,B., Parrou,J.L., & François,J. (2000) The Saccharomyces cerevisiae YPR184w gene encodes the glycogen debranching enzyme. FEMS.Microbiol.Lett. 193:105-10.


 Enjalbert,B., Parrou,J.L., Olivier,V., & François,J. (2000) Mitochondrial respiratory mutants of Saccharomyces cerevisiae accumulate glycogen and readily mobilize it in a glucose-depleted medium. Microbiology-SGM. 146:2685-2694.


 Parrou,J.L., Enjalbert,B., & François,J. (1999) STRE and cAMP-independent transcriptional induction of Saccharomyces cerevisiae GSY2 encoding glycogen synthase during the diauxic growth on glucose. Yeast. 15:1471-84.


 Parrou,J.L., Enjalbert,B., Plourde,L., Bauche,A., Gonzalez,B. & François,J. (1999) Dynamic responses of reserve carbohydrate metabolism under carbon and nitrogen limitations in Saccharomyces cerevisiaeYeast. 15:191-203.