Llanos, A., Dejean, S., Neugnot-Roux, V., François, J.M. & Parrou, JL (2019) Carbon sources and XlnR—dependent transcriptional landscape of CAZymes in the industrial fungus Talaromyces versatilis: when exception seems to be the rule. Microbial Cell


Frazao, C.R; Trichez, D., Spina, L., Lozano-Huguet, L., Serrano-Bataillé, H., Dagkesamankaya, A., Topham, C., Walther, T & Francois, J. (2019). Construction of a synthetic pathway for the production of 1,3-propanediol from glucose. Sci. Rep (in revision)


Deshors, M., Guais, O., Neugnot-Roux, V., Cameleyre, X., Fillaudeau, L., Francois, J.M. (2019). Enzymatic deconstruction mechanism of complex polysaccharides in wheat revealed by combined in situ physical and ex-situ biochemical studies. Front. Bioeng. Biotechnol (in revision)


Jian, L., François, J. M & Capp, JP (2019) Gene expression noise produces cell-to-cell heterogeneity in eukaryotic homologous recombination rate. Front. Genet. 10, 475, DOI : 10.3389/fgene.2019.00475


Cox, N., Kuemmerle, R., Millard, P., Cahoreau, E., François, J.M., Parrou, J.ML. & Lippens, G. (2019). An integated pH meter during reaction monoitoring with dual reception 1H, 31P NMR spectroscopy. Anal. Chem. 91, 3959 -3963.


Paloque, L., Père-Berezo, T., Abot, A., Dalloux-Chioccioli, J., Bourgeade-Delmas, S. ? Le Faouder, P., Pijo, J., Teste, MA., Francois, J., Helge Schebb, N, Mainka, M., Rolland, C., Blanpied, C., Dietrich, G., Bretrand-Michel, J., Deraison, C., Valentin, A. & Cenas. N. (2019) Polyinsaturate fatty metabolites: biostynthesis in Leishmania and role in parasite/host invasion. J. lipid Res., 60, 2019, DOI 10.1194/jlr.M091736.


Ageorges V., Schiavone M., Jubelin G., Caccia N., Ruiz P., Bailly X., Dague E., Leroy S., Paxman J, Heras B., Chaucheyras-Durand F., Rossiter A. E., Henderson I. R. and Desvaux M. (2019) Differential homotypic and heterotypic interactions of antigen 43 variants in autotransporter-mediated bacterial autoaggregation. Scientific Reports (In press)


Rawling MD, Mark D. Rawling, Pontefract N., Rodiles A., Anagnostara I., Leclercq E., Schiavone M., Castex M., Merrifield D. L. (2019) The effect of feeding a novel multistrain yeast fraction on European seabass (Dicentrachus labrax) intestinal health and growth performance. Journal of the World Aquaculture Society, 1–15 ; doi : 10.1111/jwas.12591.


Schiavone, M., Sieczkowski, N., Castex, M., Dague, E. & François J.M (2019) AFM dendritips functionalized with molecular probes specific to cell wall polysaccharides as a tool to investigate cell surface structure and organization. The Cell Surface (accepted)


Other papers not directly related to the thematic

Giraudeau M, Sepp T, Ujvari B, Renaud F, Tasiemski A, Roche B, Thomas F, Capp JP. (2019) Equal contribution, Differences in mutational processes and intratumoral heterogeneity between organs: the local selective filter hypothesis. Evol Med Public Health. In press.


Capp JP, 2019, Cancer stem cells: from historical roots to a new perspective.J Oncol. (accepted)



Schiavone, M., Bringe, K., Martin-Yken, H., François, J M., Castelain, M., Sletmoen, M. & Dague, E (2018) Single molecule dynamic force spectroscopy reveals specific binding of concanavalin A to yeast cell wall mannoproteins. Nanoscale Horizons (submitted)


Walther, T., Calvayrac F., Malbert, Y., Alkim, C., Dressaire, C., Cordier, H., and Francois, J.M (2018) Construction of a synthetic pathway for the production of 2,4-dihydroxybutyric acid from homoserine. Metab. Eng 45, 237-245 DOI/10.1016/j.ymben.2017.12.005


Irague, R., Topham, C., Martineau N, Baylac A, , Stodel M., Auriol C., Walther,Th., François Jean M., ,André I. & Remaud-Siméon M. (2018) Conversion of an aspartate kinase into a malate kinase using a generic HTS assay for kinase screening. PlosOne 13 (2) e0193036


Chuppa-Tostain, G., Hoarau, J., Watson, M., Adelard, L., Cheong Sing, A., Caro, Y., Grondin, I., Bourven, I., Francois, J.M., Girbal-Neuhauser, E. & Petit T. (2018) Production of Aspergillus niger biomass on sugracan distillery wastemwater: physiological aspects and potential for biodiesel production. Fungal Biol. Biotechnol., 5: 1


Jian, L., François, J. & Capp, JP (2018) Bimodality of gene expression from yeast promoter can be instigated by DNA context, inducing condition and strain background. FEMS Yeast Res., 18 (4). doi: 10.1093/femsyr/foy047.


Trichez, D., Auriol, C., Baylac, A., Irague, R. , Dressaire, C., Carnicer-Heras, M., Heux, S., François, JM & Walther, T (2018). Engineering of Escherichia coli for Krebs cycle dependent production of malic acid. Microbial Cell Fact.17: 113, DOI: 10.1186/s12934-018-0959-y


Jian, L. Lestrade, D., Cescut, J. François, J & Capp, JP (2018) A GRX1 promoter variant confers constitutive noisy bimodal expression that increases oxidtaive stress resistance in yeast. Frontiers in Microbiology, 9, 2158. DOI 10.3384/fmicb.2018.02158


Lopez, R.V., Gomez, J.L., Spina, L., Dejean, S., Parrou, JL & François, J M. (2018). Trehalose-6-phosphate promotes fermentation and glucose repression in Saccharomyces cerevisiaeMicrobial Cell 5, 444-459. DOI: 10.15698/mic2018.10.651


Frazao C.R, Maton, V., Walther, T. & François J.M (2018) Development of a metabolite sensor for high-throughput detection of aldehydes in Escherichia coli. Front. Bioeng Biotechnol, section Synth. Biol., 6: 118, DOI: 10.3389/fbioe.2018.00118


Frazao C.R., Topham, C., Malbert, Y., François, J.M. & Walther, T. (2018).Rational engineering of a malate dehydrogenase for microbial production of 2,4 dihydroxybutyric acid production via homoserine pathway. Biochem. J. 475: 3887 -3901. DOI: 10.1042/BCJ20180765


Other papers not directly related to the thematic

Senescau, A., Kempowsky, T., Bernard, E., Messier, S., Besse, Ph., Fabre, R. & François, J. M. (2018) Innovative DendrisChips® technology for a syndromic approach of in vitro diagnosis: Application to the Respiratory infectious diseases. Diagnostics MDPI, 8: 77, doi: 10.3390/diagnostics8040077.


Capp JP and Bataille R, (2018) Multiple myeloma exemplifies a model of cancer based on tissue disruption as the initiator event, Front Oncol. 8:355.


Review papers

Formosa-Dague C., Castelain M.,  Martin-Yken H.,  Dunker K., Dague E. and Sletmoen M., (2018). The Role of Glycans in Bacterial Adhesion to Mucosal Surfaces: How Can single-molecule techniques advance our understanding? Microorganisms, 6(2), 39. DOI: 10.3390/microorganisms6020039.



Grondin, E., Shum Cheong Sing, A., Caroa, Y., James, S., Nueno-Palop,C., François, JM.& Petit, T (2017) Flavour production by Saprochaete and Geotrichum yeasts and their close relatives. Food Chem. 237: 677-684.


Turanlı-Yıldız, B., Benbadis, L., Alkım, C., Sezgin, T.,  Aksit, A., Gökçe, A., Öztürk,Y., Tarık Baykal, A., Çakar, Z.P. and François J M (2017) In vivo evolutionary engineering for ethanol-tolerance of Saccharomyces cerevisiae haploid cells triggers diploidization. J Biosci. Bioeng.


Walther Th., Topham, C.M., Irague, R., Auriol, C., Baylac, A., Cordier, H., Dressaire, C., Lozano-Huguet, L., Tarrat, N., Martineau, N., Stodel, M., Malbert, Y., Maestracci, M., Huet, R., André, I., Remaud-Siméon, M & François J M. (2017) Construction of a synthetic metabolic pathway for biosynthesis of the non-natural methionine precursor 2,4-dihydroxybutyric acid. Nature Comm., 8, 15828 doi:10.1038/ncomms15828.


Schiavone, M., Déjean, S., Sieczkowski, N., Castex, M., Dague, E. and François J M (2017) Integration of biochemical, biophysical and transcriptomics data for investigating the structural and nanomechanical properties of the yeast cell wall. Frontiers in Microbiology, 8: 1809; DOI: 10.3389/fmicb.2017.01806


YangDD., De Billerberck, G., ZhangJ-J, Rosenzweig, F. & François, J M. (2017) Deciphering the origin, evolutionary fate and the physiological function of the subtelomeric multi-aryl-alcohol dehydrogenases encoded genes family in the yeast Saccharomyces cerevisiaeApplied Env. Microbiol 10.1128/AEM.01553.17


Other papers not directly related to the thematic

Capp JP (2017), Tissue disruption increases stochastic gene expression thus producing tumors: Cancer initiation without driver mutation. Int J Cancer.,140(11):2408-2413.



Schiavone, M., Elsztein, C., Formosa-Dague, C., Teste, M-A., Martin-Yken, H., Morais, M.A.jr, Dague, E. & François, J. (2016). An Atomic Force Microscopy study of the response of the yeast Saccharomyces cerevisiae to ethanol stressAppl.Env Microbiol., 82: 4789-4801


Petitjean, M., Teste, M-A., Leger-Silvestre, I. François, J M. & Parrou, JL (2016). A new function for the yeast trehalose-6-P synthase (Tps1) protein, as key prosurvival factor during growth, chronological ageing and apoptotic stress. Mech. Ageing & Devel.


Alkim, C., Trichez, D., Cam, Y., François, J & Walther, T (2016). The synthetic xylulose 1-phosphate pathway increases production of glycolic acid from xylose-rich sugar mixtures. BMC Biotechnol. Biofuels, 9:201


Other papers not directly related to the thematic

Fredonnet, J., Foncy, J., Severac, C., François, J.M.& Trevisiol, E (2016) Innovative automation device employing soft lithography for the production of low density DNA microarrays. Microarrays, 5, 25; doi:10.3390/microarrays5040025


Capp JP (2016) Stochastic phenomena and the tumoral process, Med Sci (Paris) 30(6-7):693-698


Review papers

Liu, J., François, J & Capp, JC (2016) Use of gene expression as experimental parameters to test phenotypic effects. Yeast, 33 209-216


Walther, T. & François, J (2016) Microbial production of propanol. Biotechnol Adv., 34: 984-996


Martin-Yken, H., François, J. & Zerbib, D (2016) Knr4: a disordered hub protein at the heart of fungal cell wall signalling. Cellular Microbiology, 18(9) 1217-1227



Formosa, C., lachaize, V., Galès, C., MP Roles, Martin-Yken, H., François, JM., Duval, RE & Dague, E (2015) Mapping HA-taggeed protein at the surface of living cells by Atomic force microscopy. J. Mol. Recognit., 28: 1-9.


Julien, S., P. Tondl, Durand, F., Dagkessamanskaia, A., van Tilbeurgh, H., Francois, J. M., Mourey, L., Zerbib, D., Martin-Yken, H., Maveyraud, L. (2015). "Crystallographic studies of the structured core domain of Knr4 from Saccharomyces cerevisiae." Acta Crystallogr F Struct Biol Commun 71(Pt 9): 1120-1124


Hassan, H., Goma, G & François J. (2015). The influence of carbon/nitrogen ratio on red pigment and citrinin production by filamentous fungi Monascus ruber is dependent on the cultivation mode. Int. Journal Food Science & Technology. DOI: 10.1111/ijfs.12803


LLanos A, François JM, Parrou JL (2015). Tracking the best reference genes for RT-qPCR data normalisation in filamentous fungi. BMC genomics, 16: 71


Schiavone, M., Castex, M., Siekowzki, N., Dague, E & François, J. (2015). Atomic force microscopy allows revealing effects of autolysis processes and differences in nanomechanical properties of industrial yeast strains FEMS Yeast Res., 15, (2) 1-9.


Formosa C., Pillet F., Schiavone M., Duval R. E., Ressier L., Dague E. (2015) Generation of living cell arrays for atomic force microscopy studies.  Nature Protocols, 10(1):199-204, doi: 10.1038/nprot.2015.004.


Liu, J., Martin-Yken, H., Bigey, F., Dequin, S., Francois, J. & Capp, JP (2015) Natural yeast promoter variants exhibit different noise levels conferring distinct selective advantages. Genome Biol Evol., (4) 969 -984.

Petitjean, M., Teste, MA., François, J & Parrou JL (2015). Yeast tolerance to stress relies on Tps1 protein, not on trehalose. J.Biol.Chem. 290, 16177 -16190.


Grondin, E., Cheong Sing, A.S., Caro, Y., Raheminadimbny, M., Randrianierenana, A., James, S., Nueno-Palop, C., François J. & Petit, T (2015). A comparative study on the potential of epiphytic yeasts isolated from tropicla fruits to produce flavoring compounds. Int J Food Microbiol. 203, 101 -108.


Ran L., Formosa, C., Dagkessamanskaia, A., Dague, E. François, J & Martin-Yken, H. (2015). Combining Atomic Force Micsroscopy and genetics to investigate the role of Knr4 in Saccharomyces cerevisiae sensitivity to K9 killer toxin.Lett. App. NanoBioSc., 4, 306-315


Cam, Y., Alkim, C., Trichez, D., Vax, A., Bartolo, F., Besse, Ph., François J & Walther, T (2015) Engineering of a synthetic metabolic pathway for the assimilation of (D)-xylose into added-value chemical. ACS Synthetic Biology, DOI10.1021.acssynbio.5b00103


Julien, S., Tondl, P., Durand,F., Dagkessamanskaia,A., van Tilbeurgh, H., Francois,J, Mourey, L., Zerbib, D., Yken-Martin, H. and Maveyraud, L. (2015) Crystallization and preliminary crystallographic studies of the structured core domain of Knr4 from Saccharomyces cerevisiaeActa Cryst F, F71.


Alkim, C., Cam, Y., Trichez, D., Auriol, C., Vax, A., Spina, L., Bartolo, F., Besse, P., François, J & Walther, T (2015). Optimisation of ethylene glycol production from (D) xylose via a synthetic pathway implemented in Escherichia coliMicrob. Cell Fact. 14 :127 DOI 10.1186/s12934-015-0312-7


Ene IV, Walker LA, Schiavone M., Lee KK, Martin-Yken H., Dague E., Gow NA., Munro CA., Brown AJ (2015) Cell Wall Remodeling Enzymes Modulate Fungal Cell Wall Elasticity and Osmotic Stress Resistance. mBio, 6(4): e00986-15; DOI: 10.1128/mBio.00986-15.


Kempowsky-HamonT, Valle, C., Lacroix-Triki, M., Hedjazi, L., Sophie Lamarre S., Trouihl, L., Laurence Roger., L., Mhamdi, L., Dalenc, F., Filleron, T., Favre, G., François, JM., Le Lann, MF. & Anton Leberre, V. (2015) Fuzzy logic selection as a new reliable tool to identify gene signatures in breast cancer - the INNODIAG study. BMC Medical Genomics, 8: 3


Review papers

Ceroni, F., Haynes, K.A., Carbonell, P and François, J.M(2015)Synthetic biology engineering complexity and refactoring cell capabilities. Lausanne: Frontiers Media doi:10.3389/978-2-88919-685-2


François, J.M (2015) Cell Surface Interference with Plasma Membrane and Transport Processes in Yeasts in Advances in Experimental Medicine and Biology, Volume 892 pp 11-31, doi: 10.1007/978-3-319-25304-6_2. Springer Verlag



Pillet, F., Lemonier, S., Schiavone, M., Formosa, C., Martin-Yken, H., François, J & Dague, E (2014). Uncovering by Atomic Force Microscopy of an original circular structure at the yeast cell surface in response to heat shockBMC Biology, 12:6


Francois, J., Formosa, C., Pillet, F., Schiavone, M., Martin-Yken, H; & Dague, E (2014). Use of Atomic Force Microscopy (AFM) to explore cell wall properties and response to stress in the yeast Saccharomyces cerevisiae Curr Genet, 59: 187 -196.


Deng, X., Petitjean, M., Teste, M.A., Trannier, S., François J. & Parrou JL (2014) Similarities and differences in the biochemical and enzymological properties of the four isomaltases from the yeast Saccharomyces cerevisiaeFEBS Open Bio 4, 200-212


Walther T., Peyriga L., Alkim C., Liu Y., Agrawal U., Bechter, B., Guo, S., Lardenois, A., Loret, M.O., Martin-Yken, H., Letisse, F., Primig, M. and François J.M (2014). Cell cycle associated metabolic regulation during meiotic development in yeast. BMC Biology, 12: 60


Schiavone, M., Formosa, C., Martin-Yken, M., Dague, E & François, J (2014) Combined chemical and enzymatic digestion for a quantitative analysis of the cell wall components in yeasts. FEMS Yeast Res. 14: 933 -947.


Grondin, E., Cheong Sing, A.S., Caro, Y., DeBillerbeck, G., François, J & Petit, T (2014). Physiological and biochemical characteristics of ethyl-tiglate production pathway in the yeast Geotrichum fragransYeast, DOI: 10.1002/yea.3057


Poueymiro, M., Caalé, AC, François, J., Parrou JL., Peeters, N & Genin, S (2014) A Ralstonia solnacearum type III effector directs the production of the plant metabolites trehalose-6-phosphate. mBio, 5 (6) e062065-14


Vidal, E., Morais, MA, François, J. & deBillerbeck, G (2015) Biosynthesis of higher alcohol flavour compounds by the yeast Saccharomyces cerevisiae: Impact of oxygen availability and responses to glucose pulse in minimal growth medium with leucine as sole nitrogen source. Yeast, DOI: 10.10002/yea.3045


Delmas S, Llanos A, Parrou JL, Kokolski M, Pullan ST, Shunburne L & Archer DB. (2014) Development of an Unmarked Gene Deletion System for the filamentous Fungi Aspergillus niger and Penicillium funiculosum.  Appl Environ Microbiol., 80 (11):3484-3487. 



  • Zhang, H., Fauré, R., François, J., Blanc, PJ & De Billerbeck, G. (2013) Xylosylation as an effective means for reducing yeast growth inhibition by 2-phenylethanol. J Basic Microbiol 53, 1 -4
  • Vidal Espinosa E., De Billerbeck, G., Ardaillon Simoes, D., Schuler, A., François, J & Morias M.A. (2013) Influence of nitrogen supply on the production of higher alcohol/esters and expression of the flavor - related genes in cachaça like-industrial fermentation. Food Chemistry, 138: 701 -708.
  • Alkim, C., Benbadis, L., Cakar, Z.P. & François, J. (2013) Mechanisms other than activation of iron regulon account for the hyper resistance to cobalt of a yeast strain obtained by evolutionary engineering. Metallomics 5 (8), 1043 - 1060
  • Formosa, C., Schiavone, M., Martin-Yken, H., Duval, R.E., François, JM. & Dague, E. (2013)Nanoscale effects of caspofungin on Saccharomyces cerevisiae and Candida albicans.Ant. Agents Chemoth. 57 (8) 3498 -3406.
  • Walther, T., Mtimet, N., Alkim, C., Vax, A., Loret, M-A., Ullah, AZ., Gancedo, G., Smits, G.J & François J (2013) Metabolic phenotypes of Saccharomyces cerevisiae mutants with altered trehalose-6-phosphate dynamicsBiochem.J. 454: 227-237
  • Rezki, M.A, Benbadis, L., Bendayer, Z., de Billerbeck, G., & François J. (2013) Identification and physiologiocal characterization of indigenous yeasts from Algerian food and dairy products. J.Yeast and Fungal Res. 4: 75 -83.
  • De la Mare Marion, Guais, O., Bonnin, E., Weber, J. & Francois J (2013) Molecular and biochemical characterization of three GH62 a-L-arabinofuranosidases from the soil deuteromycete Penicillium funiculosumEnz. Microbiol Technol. 51 : 351-358
  • Francois, J., Formosa, C., Pillet, F., Schiavone, M., Martin-Yken, M; & Dague, E (2013).Use of Atomic Force Microscopy (AFM) to explore cell wall properties and response to stress in the yeast Saccharomyces cerevisiae Curr Genet DOI 10.1007/s00294-0113
  • Coutable, A., Noireaux, V., Lepioufle, B., Français, O., Vieu C., François, J., Thibault, C & Trevisiol, E (2013) Insertion of Functional Proteins into Bilayer Lipid Membrane using a Cell-Free Expression System. Biophys. J. 104, 578A
  • Foncy, J., Cau, JC, François, JM., Trevisiol, E.& Severac, C (2013). Comparaison of polyurethane and epoxy resist master molds for nanoscale soft lithography.Microelectronic Engineering, 110: 183 -187
  • Fredonnet J., Foncy, J., Cau, J-C., Trévisiol., E., Peyrade J.P., François, JM. & Séverac, C. (2013) Dynamic PDMS inking for DNA patterning by soft lithography.Microelectronic Engineering, 110: 379 -383
  • Muszkieta, L., Beauvais, A., Pahtz, V., Gibbons, J.G., Anton-Leberre, V., Beau, R., Shibuya, K., Rokas, A., François, JM., Kniemeyer, O., Brakhage, A. & Latge, JP (2013). Investigation of Aspergillus fumigatus biofilm formation by various omics approaches. Frontiers in Microbiology, doi 10.339/micb.2013.00013
  • Hmaïed, F., Helel,S., V. Le berre, V., François J.M., Leclercq,A., M. Lecuit,M.,, H. Smaoui,H., A. Kechrid, A. & Boudabous, A. and Barkallah.I. (2013) Prevalence, identification by a DNA microarray-based assay of human and food isolates Listeria spp. from Tunisia. Patho. Biol. (in press))



  • Yang, D-D., François, JM & De Billerbeck, G (2012) Cloning and characterization of cDNA encoding an aryl-alcohol dehydrogenase from the white-rot fungus Phanerochate chrysosporium. BMC Microbiology (in press)
  • SchlechtU., St.Onge R.P., WaltherT., FrançoisJ. and DavisRW (2012) Cationic amphiphilic drugs are potent inhibitors of yeast sporulation. PLos One, 7, e42853
  • Walther, T., Baylac, A., Alkim, C., Vax, A., Cordier, H. & François J (2012) The PGM3 gens encodes the major phosphoribomutase in the yeast Saccharomyces cerevisiae. FEBS Lett., 5864114 -4118
  • Egea, A., Foncy, J., Cau JC., Paveau V., François, J & Vieu C. (2012) Optical Label-Free Biodetection Based on the Diffraction of DNA Molecular Gratings for In Vitro Diagnostic. Biophys. J., 102, 727A
  • Hassan H., François, JM & Blanc, P.J. (2012) Effect of amino acids on red pigments and citrinin production in Monascus ruber. J. Food Sci., 77, 156 -159.



  • Bechet-Baily, M., Borgs, C., Brauntsein,A. Chayes, J., Dagkessamanskaia, A., François, JM., and Zecchina, R. (2011) Finding undetected protein associations in cell signaling by belief propagation. Proc Natl Acad Sci USA 108 (2):882-88
  • Joubert A., Simoneau P., Campion C., Bataillé-Simoneau N., Iacomi-VasilescuB., Poupard P., François J.M., Georgeault S., Sellier E., Guillemette T (2011). Impact of the unfolded protein response on the pathogenicity of the necrotrophic fungus Alternaria brassicicola.Mol Microbiol., 79, 1305 -1324.
  • Mendes, F., Gonzalez-Pajuelo, M., Cordier, H., François, J & Vasconcelos, I (2011) 1,3 propanediol production in a two-step process fermentation from renewable feedstock. Appl Microbiol Biotechnol. 92, 519 -527.
  • Vidal Espinosa E., De Billerbeck, G., Ardaillon Simoes, D., Schuler, A., François, J & Morias M.A. (2011) Influence of nitrogen supplementation on fermentation kinetics and flavours production during industrial sugar cane juice fermentation for cachaça production. J Food Microbiology (in revision)
  • Hassan H., François, JM & Blanc, P.J. (2011) Effect of amino acids on red pigments and citrinin production in Monascus ruber. J. Food Sci., 77, 156 -159.



  • Walther, T., Novo, MA., Rossger, K., Letisse, F. M., Loret, Portais, JC and François, J (2010). Implication of the purine salvage pathway in the ATP homeostasis upon sudden transition from respiratory to fermentative growth conditions. Mol. Syst. Biol. 6: 344 -356.
  • Guais, O., Tourrasse O., Dourdoigne, M., Parrou J.L. and François J. (2010). Characterization of family GH54-a-L- arabinofuranosidases, including a novel protein bearing a cellulose binding domain in P. funiculosumApplied Microbiol Biotechnol. 871007 -1021.
  • Dagkessamanskaia, A. Durand, F., Uversky, V.U., BindaM., LopezF., El AzzouziK., Francois, JM and Martin-YkenH. (2010). Functional dissection of an intrinsically disordered protein: Understanding the role of different domains of Knr4 protein in protein-protein interactions. Proteins Sci. 19, 1375 -1383.
  • Teste M.A., Francois J M. and Parrou J.L. (2010) Characterization of a new multigenes family encoding isomaltases in the yeast Saccharomyces cerevisiae: the IMA family. J. Biol Chem. 285, 26815 -26824.
  • Dague, E., Bitar, R., Ranchon, H., Durand, F., Martin-Yken, H., François, J.M (2010) An Atomic Force Microscopy analysis of yeast mutants defective in cell wall architecture. Yeast, 8, 673-684.
  • Dagkessamanskaia,A., El AzzouziK., Kikuchi, Y., Timmers, T., Ohya, Y., Francois,JM and Martin-YkenH (2010) Knr4 N-terminal domain controls its localization and function during sexual differentiation and vegetative growth. Yeast, 8, 563-574.


  • Guais O., Pichereau C., Borderies G., Maestracci, M., Rossignol M. and François J. (2008) Proteomics analysis of a secreted proteins cocktail produced by Penicillium funiculosum under industrial process fermentation. J. Ind. Microbiol. Biotechnol. 35: 1659 -1668.
  • Kuranda, K., Grabinska,K., Berges, T., Le Berre, V., Sokol, S., François, J & Palamarczyk, G(2009). The YTA7 gene is involved in theregulation of the isoprenoid pathway in the yeast Saccharomyces cerevisiae.FEMS Yeast Res. 9: 381 - 390.
  • Petek Cakar, Z., Alkim, C., Turanli, B.,Tokman, N., Akman, Süleyman, Sarikaya, M., Tamerler, C. Benbadis, L. andFrançois, J. (2009). Isolation of cobalt hyper-resistant mutants of Saccharomyces cerevisiae by in vivo evolutionary engineering. J. Biotechnol 143, 130-138
  • Kitanovic, A., Walther, T.,Loret, M.O., Holzwarth, J., Kitanovic, I., Bonowski, F., Van Ngoc, B.,Francois, J. and and Wölfl, S. (2009) Metabolic response to MMS-mediated DNAdamage in S.cerevisiae is dependenton glucose concentration in the medium. FEMS Yeast Res. DOI:10.1111/j.1567-1364.2009.00505.x
  • Benbadis, L., Cot, M.,Rigoulet, M. and François, J (2009). Isolation of twocell populations from yeast during high-level alcoholic fermentation thatresemble quiescent and non quiescent cells from stationary phase on glucose. FEMS Yeast Res. Epub ahead of print . PMID 19686340.
  • He, S., Bystricky, K., Leon, S., François, J., Parrou, J. (2009) The Saccharomyces cerevisiae vacuolaracid trehalase is targeted at the cell surface for its physiological function. FEBS J 276, 5432-5446
  • Walther, T., Novo, M., Rossger, K., Benbadis, L.,Letisse, F.,  Loret, MA., Portais, JC andFrançois, J (2009). Implication of the purine salvagepathway in the ATP homeostasis upon sudden transition from respiratory tofermentative growth conditions. Mol. Syst. Biol. (in revision).
  • Teste M.A., Duquenne M.,Francois J. and Parrou J.L. (2009). Validation ofreference genes for quantitative expression analysis by real time-PCR in theyeast Saccharomyces cerevisiaeBMCMol Biol .



  • Jules, M., Beltran, G., François, J. and Parrou,JL. (2008). New insight in yeast trehalose metabolism. NTH2encodes a functional cytosolic trehalase and deletion of TPS1 reveals aAth1p-dependent trehalose mobilisation. Appl. Env. Microbiol. 74, 605 -614.
  • Ansel, J., Bottin, H., Rodriguez-Beltran,C., Damon, C., Nagajaran, M., Ferhmann, S., François, J. and Yvert, G. (2008)Cell to cell stochastic variation in gene expression is a complex genetictrait. PLos Genetics, 4,e1000049
  • Guimarães, P.M., Parrou, J.L., François, J., Teixeira,J.A. and Domingues L. (2008). Adaptive evolution of a lactose - consuming Saccharomycescerevisiae recombinant. Appl.Env. Microbiol. 74, 1748 -1756.
  • Durand F.,Dagkessamanskaia A., Martin-Yken H., Graille, M., Van Tilbeurgh, H., Uversky,V.N. and François J. (2008). Structure-functionanalysis of Knr4/Smi1, a protein indispensable in the absence of a functionalPkc1-Slt2 pathway. Yeast, 25, 563 -576.
  • Guais O., Pichereau C., Borderies G.,Maestracci, M., Rossignol M. and François J. (2008) Proteomics analysis of asecreted proteins cocktail produced by Penicillium funiculosum underindustrial process fermentation. J. Ind. Microbiol. Biotechnol. 35: 1659 -1668.



  • Cot,M., Loret, M-O, François, J. and Benbadis, L. (2007). Physiological behaviourof Saccharomyces cerevisiae in aerated fed-batch process for very highproduction of bioethanol. FEMS Yeast Res. 7, 22 - 32.
  • Cordiez, H., Mendes-Soares, F., Vasconcelos,I. and François, J. (2007) Metabolic and genomic investigation of engineered Saccharomycescerevisiae strains for high glycerol production. Metab. Eng. 9, 364 -378.
  • Frison, M., Parrou, JL., Guillamot, D.,Masquelier, D., François, J., Chaumont, F. and Batoko, H. (2007). The Arabidopsis thaliana Ath1 is a plasma membrane-bound enzyme withextracellular activity. FEBSLett., 581, 4010 -4016.



  • Basmaji, F., Martin-Yken, H. Durand, F.,Dakgessamanskaia, A., Pichereau, C., Rossignol, M. and François, J. (2006). The ‘interactome’ of Knr4/Smi1, a protein implicated in thecoordination of cell wall assembly and cell growth in the yeast SaccharomycescerevisiaeMol Genet.Genomics, 275, 217-230.
  • Kuranda, K., Leberre,V., Sokol, S., Palamarczyk, G. and François, J. (2006). Investigating thecaffeine effects in the yeast Saccharomyces cerevisiae brings newinsights into the connection between TOR, PKC and Ras/cAMP signalling pathways.Mol. Microbiol. 61(5), 1147 - 1166.
  • Loret, M.O., Pedersen, L., and François, J.(2006). Revised procedures for yeast metabolites extraction. Application to aglucose pulse to carbon-limited yeast cultures, which revealed a transientactivation of the purine salvage pathway. Yeast, 24, 47 -60.
  • François J. (2006). A simple method forquantitative determination of polysaccharides in fungal cell walls. NatureProtocols, 6, (1) 2995 – 3000.



  • Parrou, JL., Jules, M., Beltran, G. andFrançois, J. (2005). Acid trehalases in yeast and fungi: Localisation,regulation and physiological function. FEMS Yeast Res. 5, 503 - 511.
  • Jules, M., Parrou, J.L.and François, J. (2005). Autonomous oscillations in Saccharomycescerevisiae during batch cultures on trehalose. FEBS Journal. 272,1490 - 1500.
  • Torija, M-J., Lemassu, A., Wilson, W., Roach, P.J., François, J. andParrou, J.L. (2005). Glycogen synthesis in the absence of glycogenin in theyeast Saccharomyces cerevisiaeFEBS Lett .579, 3999 - 4004.