Metabolomics & Fluxomics Facilities


Head: Jean-Charles PORTAIS (jean-charles.portais @ (Professor at the University Paul Sabatier)



Metabolomics is the most recent development in systems biology and aims at the analysis of all small molecules (the metabolome”) in a living system. Because the composition of the metabolome is highly sensitive to any biological or chemical changes, metabolomics provides a valuable metrics of the response of biological systems to genetic or environmental perturbations, or to the action of drugs, toxins, and other biological effectors. The Toulouse – Midi-Pyrénées Facilities for Metabolomics & Fluxomics provides support for the global analysis of the metabolism of cells, tissues or organisms of different size and complexity, with two main scientific orientations:

1.      Analysis of metabolic changes (metabolite fingerprinting or metabolite profiling) related to the action of food, diseases, drugs, toxics, or pathogens, with applications in Health, Pharmacology, Toxicology, Nutrition, etc.

2.      Functional analysis of metabolic networks (global metabolomics, 13C-fluxomics), to get a comprehensive understanding of the actual metabolic behaviour of living systems and how this behaviour relates to genome expression, with applications in all areas of Biology and in Biotechnology.

The Toulouse – Midi-Pyrénées Facilities for Metabolomics & Fluxomics are located mainly at the LISBP-INSA with extensions at INSERM-Purpan, INRA-Saint-Martin & UPS-Rangueil. It includes modern, state-of-the-art equipments (Nuclear Magnetic Resonance, Mass spectrometry, etc.) and internationally-recognized expertise in metabolic biochemistry, analytical chemistry, biophysics, bioinformatics, & biomathematics.



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